AU2013326579B2 - 1,2,4-triazine derivatives for the treatment of viral infections. - Google Patents
1,2,4-triazine derivatives for the treatment of viral infections. Download PDFInfo
- Publication number
- AU2013326579B2 AU2013326579B2 AU2013326579A AU2013326579A AU2013326579B2 AU 2013326579 B2 AU2013326579 B2 AU 2013326579B2 AU 2013326579 A AU2013326579 A AU 2013326579A AU 2013326579 A AU2013326579 A AU 2013326579A AU 2013326579 B2 AU2013326579 B2 AU 2013326579B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- alkylamino
- compound
- heteroarylalkyl
- carboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306196.2A EP2712866A1 (en) | 2012-10-01 | 2012-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections |
| EP12306196.2 | 2012-10-01 | ||
| PCT/EP2013/070488 WO2014053516A1 (en) | 2012-10-01 | 2013-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013326579A1 AU2013326579A1 (en) | 2015-04-09 |
| AU2013326579B2 true AU2013326579B2 (en) | 2017-04-27 |
Family
ID=46982496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013326579A Ceased AU2013326579B2 (en) | 2012-10-01 | 2013-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9416114B2 (en:Method) |
| EP (2) | EP2712866A1 (en:Method) |
| JP (1) | JP6298998B2 (en:Method) |
| KR (1) | KR102138393B1 (en:Method) |
| CN (1) | CN104812747B (en:Method) |
| AU (1) | AU2013326579B2 (en:Method) |
| BR (1) | BR112015007310B1 (en:Method) |
| CA (1) | CA2886630C (en:Method) |
| CL (1) | CL2015000787A1 (en:Method) |
| EA (1) | EA026236B1 (en:Method) |
| ES (1) | ES2616496T3 (en:Method) |
| IL (1) | IL237871A (en:Method) |
| IN (1) | IN2015DN03327A (en:Method) |
| MX (1) | MX348229B (en:Method) |
| MY (1) | MY182558A (en:Method) |
| NZ (1) | NZ706354A (en:Method) |
| PH (1) | PH12015500724A1 (en:Method) |
| SG (1) | SG11201502522WA (en:Method) |
| UA (1) | UA114644C2 (en:Method) |
| WO (1) | WO2014053516A1 (en:Method) |
| ZA (1) | ZA201502240B (en:Method) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012136834A1 (en) | 2011-04-08 | 2012-10-11 | Janssen R&D Ireland | Pyrimidine derivatives for the treatment of viral infections |
| RS57851B1 (sr) | 2011-11-09 | 2018-12-31 | Janssen Sciences Ireland Uc | Purinski derivati za tretman viralnih infekcija |
| CA2874800C (en) | 2012-07-13 | 2021-04-06 | Janssen R&D Ireland | Macrocyclic purines for the treatment of viral infections |
| EA202090662A3 (ru) | 2012-10-10 | 2020-08-31 | Янссен Сайенсиз Айрлэнд Юси | ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ И ДРУГИХ ЗАБОЛЕВАНИЙ |
| EA035431B1 (ru) | 2012-11-16 | 2020-06-15 | Янссен Сайенсиз Айрлэнд Юси | Гетероциклические замещенные производные 2-амино-хиназолина в качестве модуляторов tlr7 и/или tlr8 для лечения вирусных инфекций |
| DK2958900T3 (da) | 2013-02-21 | 2019-07-01 | Janssen Sciences Ireland Unlimited Co | 2-aminopyrimidinderivater til behandling af virusinfektioner |
| EA035110B1 (ru) | 2013-03-29 | 2020-04-28 | Янссен Сайенсиз Айрлэнд Юси | Макроциклические деаза-оксипурины в качестве модуляторов tlr7 |
| AU2014270418B2 (en) | 2013-05-24 | 2017-11-30 | Janssen Sciences Ireland Uc | Pyridone derivatives for the treatment of viral infections and further diseases |
| ES2645950T3 (es) | 2013-06-27 | 2017-12-11 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina para el tratamiento de infecciones víricas y otras enfermedades |
| UA117253C2 (uk) | 2013-07-30 | 2018-07-10 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | ПОХІДНІ ТІЄНО[3,2-d]ПІРИМІДИНІВ ДЛЯ ЛІКУВАННЯ ВІРУСНИХ ІНФЕКЦІЙ |
| MA45539A (fr) | 2016-07-01 | 2019-05-08 | Janssen Sciences Ireland Unlimited Co | Dihydropyranopyrimidines pour le traitement d'infections virales |
| AU2017335205B2 (en) * | 2016-09-29 | 2021-11-04 | Janssen Sciences Ireland Unlimited Company | Pyrimidine prodrugs for the treatment of viral infections and further diseases |
| TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| MX2021009496A (es) | 2019-02-08 | 2021-09-08 | Progeneer Inc | Complejo de colesterol-agonista del receptor 7 u 8 tipo larga distancia, y uso del mismo. |
| JP2023516372A (ja) | 2020-03-02 | 2023-04-19 | プロジェニア インコーポレイテッド | 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法 |
| JP7690222B2 (ja) | 2020-08-04 | 2025-06-10 | プロジェニア インコーポレイテッド | 動力学的制御が可能なアジュバントを含むｍＲＮＡワクチン |
| WO2022031011A1 (ko) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | 동력학적으로 작용하는 아주번트 앙상블 |
| EP4194010A4 (en) | 2020-08-04 | 2025-03-26 | Progeneer Inc. | Conjugate of a functional drug and a toll-like receptor 7 or 8 agonist with a temporarily inactivated drug site, and use thereof |
| WO2024151953A1 (en) * | 2023-01-15 | 2024-07-18 | Viradem Inc. | Compounds and methods for treating diseases caused by sars-cov-2 and other coronaviruses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485531A1 (fr) * | 1980-06-25 | 1981-12-31 | Fabre Sa Pierre | Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| ATE283855T1 (de) | 1996-07-03 | 2004-12-15 | Sumitomo Pharma | Neue purinderivate |
| KR100613634B1 (ko) | 1997-11-28 | 2006-08-18 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 복소환 화합물 |
| US7923554B2 (en) * | 2004-08-10 | 2011-04-12 | Janssen Pharmaceutica N.V. | HIV inhibiting 1,2,4-triazin-6-one derivatives |
| KR20080006004A (ko) | 2005-05-04 | 2008-01-15 | 화이자 리미티드 | 암 및 ｃ형 간염과 같은 바이러스 감염의 치료를 위한톨-유사 수용체 조절제인 2-아미도-6-아미노-8-옥소퓨린유도체 |
| EP1924564B1 (en) * | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| RU2352565C1 (ru) * | 2007-10-08 | 2009-04-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения |
| PE20091236A1 (es) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| WO2012067269A1 (en) * | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Aminoalkoxyphenyl compounds and their use in the treatment of disease |
-
2012
- 2012-10-01 EP EP12306196.2A patent/EP2712866A1/en not_active Withdrawn
-
2013
- 2013-10-01 WO PCT/EP2013/070488 patent/WO2014053516A1/en not_active Ceased
- 2013-10-01 SG SG11201502522WA patent/SG11201502522WA/en unknown
- 2013-10-01 MY MYPI2015000804A patent/MY182558A/en unknown
- 2013-10-01 ES ES13773690.6T patent/ES2616496T3/es active Active
- 2013-10-01 UA UAA201504222A patent/UA114644C2/uk unknown
- 2013-10-01 AU AU2013326579A patent/AU2013326579B2/en not_active Ceased
- 2013-10-01 EP EP13773690.6A patent/EP2903976B1/en active Active
- 2013-10-01 JP JP2015533635A patent/JP6298998B2/ja not_active Expired - Fee Related
- 2013-10-01 NZ NZ706354A patent/NZ706354A/en not_active IP Right Cessation
- 2013-10-01 KR KR1020157009515A patent/KR102138393B1/ko not_active Expired - Fee Related
- 2013-10-01 CN CN201380050972.5A patent/CN104812747B/zh not_active Expired - Fee Related
- 2013-10-01 BR BR112015007310-7A patent/BR112015007310B1/pt not_active IP Right Cessation
- 2013-10-01 MX MX2015004160A patent/MX348229B/es active IP Right Grant
- 2013-10-01 CA CA2886630A patent/CA2886630C/en active Active
- 2013-10-01 EA EA201500383A patent/EA026236B1/ru not_active IP Right Cessation
- 2013-10-01 IN IN3327DEN2015 patent/IN2015DN03327A/en unknown
- 2013-10-01 US US14/432,269 patent/US9416114B2/en active Active
-
2015
- 2015-03-22 IL IL237871A patent/IL237871A/en active IP Right Grant
- 2015-03-30 CL CL2015000787A patent/CL2015000787A1/es unknown
- 2015-03-31 PH PH12015500724A patent/PH12015500724A1/en unknown
- 2015-03-31 ZA ZA2015/02240A patent/ZA201502240B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |