NZ630219A - Lyophilization of synthetic liposomal pulmonary surfactant - Google Patents
Lyophilization of synthetic liposomal pulmonary surfactantInfo
- Publication number
- NZ630219A NZ630219A NZ630219A NZ63021913A NZ630219A NZ 630219 A NZ630219 A NZ 630219A NZ 630219 A NZ630219 A NZ 630219A NZ 63021913 A NZ63021913 A NZ 63021913A NZ 630219 A NZ630219 A NZ 630219A
- Authority
- NZ
- New Zealand
- Prior art keywords
- integer
- amino acid
- lyophilization
- pulmonary surfactant
- lyophilization mixture
- Prior art date
Links
- 238000004108 freeze drying Methods 0.000 title abstract 5
- 239000003580 lung surfactant Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 238000005339 levitation Methods 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000000137 annealing Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616827P | 2012-03-28 | 2012-03-28 | |
| PCT/US2013/034464 WO2013149074A1 (en) | 2012-03-28 | 2013-03-28 | Lyophilization of synthetic liposomal pulmonary surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ630219A true NZ630219A (en) | 2016-09-30 |
Family
ID=48096305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ630219A NZ630219A (en) | 2012-03-28 | 2013-03-28 | Lyophilization of synthetic liposomal pulmonary surfactant |
Country Status (35)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013149074A1 (en) * | 2012-03-28 | 2013-10-03 | Discovery Laboratories, Inc. | Lyophilization of synthetic liposomal pulmonary surfactant |
| EP3222273B1 (en) * | 2014-11-18 | 2019-09-25 | National Institute for Materials Science | Method for producing porous particle |
| EP3241546B1 (en) * | 2014-12-30 | 2021-02-17 | Samyang Biopharmaceuticals Corporation | Polymer nanoparticle freeze-dried product, and preparation method therefor |
| AU2016292759B2 (en) * | 2015-07-10 | 2021-05-20 | Byondis B.V. | Compositions comprising antibody-duocarmycin drug conjugates |
| LT3324932T (lt) | 2015-07-22 | 2021-04-26 | Nitto Denko Corporation | Kompozicijos ir būdai, skirti liofilinėms nanodalelių formoms |
| JP7012512B2 (ja) * | 2017-11-13 | 2022-01-28 | 清水建設株式会社 | 管理装置、製造システムおよび管理方法 |
| WO2019126289A1 (en) * | 2017-12-21 | 2019-06-27 | Civitas Therapeutics, Inc. | Surfactant formulations for inhalation |
| CN108853061A (zh) * | 2018-10-09 | 2018-11-23 | 兆科药业（合肥）有限公司 | 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途 |
| WO2020142420A1 (en) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| KR102545292B1 (ko) * | 2021-01-28 | 2023-06-16 | 인천대학교 산학협력단 | 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법 |
| WO2023280737A1 (en) * | 2021-07-05 | 2023-01-12 | Chiesi Farmaceutici S.P.A. | Process for the preparation of a pulmonary surfactant |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE751108R (fr) | 1969-06-06 | 1970-11-03 | Berliet Automobiles | Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion |
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| PT877602E (pt) | 1996-01-24 | 2002-07-31 | Byk Gulden Lomberg Chem Fab | Processo para o fabrico de composicoes de surfactantes pulmonares em po |
| WO1997035882A1 (en) | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| JPWO2005105111A1 (ja) | 2004-04-29 | 2008-07-31 | 相男 李 | 人工肺サーファクタント組成物およびその使用方法 |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| CA2612937C (en) | 2005-07-22 | 2014-05-06 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| WO2013149074A1 (en) * | 2012-03-28 | 2013-10-03 | Discovery Laboratories, Inc. | Lyophilization of synthetic liposomal pulmonary surfactant |
-
2013
- 2013-03-28 WO PCT/US2013/034464 patent/WO2013149074A1/en active Application Filing
- 2013-03-28 MX MX2014011483A patent/MX359654B/es active IP Right Grant
- 2013-03-28 RU RU2014143247A patent/RU2671500C2/ru active
- 2013-03-28 PE PE2014001494A patent/PE20142302A1/es not_active Application Discontinuation
- 2013-03-28 EP EP14188473.4A patent/EP2837377A1/en not_active Withdrawn
- 2013-03-28 PL PL13716655T patent/PL2723323T3/pl unknown
- 2013-03-28 PT PT137166559T patent/PT2723323E/pt unknown
- 2013-03-28 IN IN8538DEN2014 patent/IN2014DN08538A/en unknown
- 2013-03-28 KR KR1020147029784A patent/KR102123129B1/ko active Active
- 2013-03-28 SG SG11201405944PA patent/SG11201405944PA/en unknown
- 2013-03-28 HR HRP20151392T patent/HRP20151392T1/hr unknown
- 2013-03-28 MY MYPI2014002699A patent/MY164868A/en unknown
- 2013-03-28 CA CA2867649A patent/CA2867649C/en active Active
- 2013-03-28 JP JP2015503612A patent/JP6178402B2/ja active Active
- 2013-03-28 WO PCT/US2013/034364 patent/WO2013149013A1/en active Application Filing
- 2013-03-28 RS RS20150867A patent/RS54513B1/en unknown
- 2013-03-28 HU HUE13716655A patent/HUE026363T2/en unknown
- 2013-03-28 US US14/387,707 patent/US9554999B2/en active Active
- 2013-03-28 AU AU2013237985A patent/AU2013237985B2/en not_active Ceased
- 2013-03-28 DK DK13716655.9T patent/DK2723323T3/en active
- 2013-03-28 EP EP13716655.9A patent/EP2723323B1/en active Active
- 2013-03-28 ES ES13716655.9T patent/ES2557805T3/es active Active
- 2013-03-28 BR BR112014024057A patent/BR112014024057A8/pt not_active Application Discontinuation
- 2013-03-28 CN CN201380022948.0A patent/CN104271118B/zh active Active
- 2013-03-28 SI SI201330112T patent/SI2723323T1/sl unknown
- 2013-03-28 NZ NZ630219A patent/NZ630219A/en not_active IP Right Cessation
- 2013-11-27 US US14/091,608 patent/US8748396B2/en active Active
- 2013-11-27 US US14/091,712 patent/US8748397B2/en active Active
-
2014
- 2014-09-16 IL IL234688A patent/IL234688B/en active IP Right Grant
- 2014-09-25 ZA ZA2014/06982A patent/ZA201406982B/en unknown
- 2014-09-25 CR CR20140449A patent/CR20140449A/es unknown
- 2014-09-25 CL CL2014002553A patent/CL2014002553A1/es unknown
- 2014-09-29 CU CUP2014000116A patent/CU20140116A7/es unknown
- 2014-09-30 CO CO14216241A patent/CO7081146A2/es unknown
- 2014-10-22 MA MA37445A patent/MA37445B1/fr unknown
- 2014-10-24 EC ECIEPI201424363A patent/ECSP14024363A/es unknown
-
2015
- 2015-08-06 HK HK15107596.6A patent/HK1206979A1/en unknown
- 2015-12-21 SM SM201500320T patent/SMT201500320B/it unknown
- 2015-12-22 CY CY20151101180T patent/CY1117380T1/el unknown
-
2017
- 2017-10-06 AU AU2017239624A patent/AU2017239624B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ630219A (en) | Lyophilization of synthetic liposomal pulmonary surfactant | |
| JP2015514714A5 (en:Method) | ||
| PH12014502092B1 (en) | Stabilizing composition for biological materials | |
| WO2022232585A8 (en) | Lyophilization methods for preparing lipid formulated therapeutics | |
| EA201892446A1 (ru) | Фармацевтическая композиция | |
| ES2543795T3 (es) | Estabilización de partículas virales | |
| EA201490723A1 (ru) | Технологическая линия для производства лиофилизированных частиц | |
| AR099838A1 (es) | Formulación de factor ix liofilizada, vial, kit y método para producir un polvo liofilizado | |
| WO2015157535A3 (en) | Synthetic peptides, enzymatic formation of pericellular hydrogels/nanofibrils, and methods of use | |
| NZ726315A (en) | Methods for freeze-drying and rehydrating biologics | |
| RU2016146121A (ru) | Лиофилизированный состав на основе hgf | |
| WO2012036391A3 (ko) | 돼지 써코바이러스２(ｐｃｖ２) 유전자의 표면발현용 벡터 및 이로 형질전환된 살모넬라 백신 균주 | |
| JP2013517886A5 (en:Method) | ||
| RU2466958C1 (ru) | Керамическая масса | |
| WO2015108856A3 (en) | Methods for enhancing the delivery of active agents | |
| FR2979297B1 (fr) | Vehicule de transport frigorifique de produits dont la consommation energetique est amelioree par l'incorporation d'un materiau a changement de phase dans les parois de la caisse | |
| WO2020210480A3 (en) | Factor h vectors and uses thereof | |
| CN107340387B (zh) | 一种细胞因子elisa标准品的制备方法 | |
| RU2499783C1 (ru) | Фарфоровая масса | |
| CN106174189A (zh) | 水果干的制备方法 | |
| RU2471746C1 (ru) | Керамическая масса | |
| CN103585118B (zh) | 一种重组猪干扰素α1产品的冻干方法 | |
| RU2487848C1 (ru) | Керамическая масса | |
| RU2459779C1 (ru) | Керамическая масса | |
| RU2469983C1 (ru) | Керамическая масса |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2018 BY CPA GLOBAL Effective date: 20170318 |
|
| LAPS | Patent lapsed |