MX359654B - Liofilizacion de agente tensioactivo pulmonar liposomico sintetico. - Google Patents
Liofilizacion de agente tensioactivo pulmonar liposomico sintetico.Info
- Publication number
- MX359654B MX359654B MX2014011483A MX2014011483A MX359654B MX 359654 B MX359654 B MX 359654B MX 2014011483 A MX2014011483 A MX 2014011483A MX 2014011483 A MX2014011483 A MX 2014011483A MX 359654 B MX359654 B MX 359654B
- Authority
- MX
- Mexico
- Prior art keywords
- lyophilization
- pulmonary surfactant
- synthetic
- synthetic liposomal
- liposomal pulmonary
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a agentes tensioactivos pulmonares liofilizados que tienen una porosidad y un área superficial específica incrementadas. También se describen métodos de fabricación de los agentes tensioactivos pulmonares liofilizados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616827P | 2012-03-28 | 2012-03-28 | |
| PCT/US2013/034464 WO2013149074A1 (en) | 2012-03-28 | 2013-03-28 | Lyophilization of synthetic liposomal pulmonary surfactant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014011483A MX2014011483A (es) | 2014-12-08 |
| MX359654B true MX359654B (es) | 2018-10-05 |
Family
ID=48096305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014011483A MX359654B (es) | 2012-03-28 | 2013-03-28 | Liofilizacion de agente tensioactivo pulmonar liposomico sintetico. |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US9554999B2 (es) |
| EP (2) | EP2723323B1 (es) |
| JP (1) | JP6178402B2 (es) |
| KR (1) | KR102123129B1 (es) |
| CN (1) | CN104271118B (es) |
| AU (2) | AU2013237985B2 (es) |
| BR (1) | BR112014024057A8 (es) |
| CA (1) | CA2867649C (es) |
| CL (1) | CL2014002553A1 (es) |
| CO (1) | CO7081146A2 (es) |
| CR (1) | CR20140449A (es) |
| CU (1) | CU20140116A7 (es) |
| CY (1) | CY1117380T1 (es) |
| DK (1) | DK2723323T3 (es) |
| EC (1) | ECSP14024363A (es) |
| ES (1) | ES2557805T3 (es) |
| HK (3) | HK1197174A1 (es) |
| HR (1) | HRP20151392T1 (es) |
| HU (1) | HUE026363T2 (es) |
| IL (1) | IL234688B (es) |
| IN (1) | IN2014DN08538A (es) |
| MA (1) | MA37445B1 (es) |
| MX (1) | MX359654B (es) |
| MY (1) | MY164868A (es) |
| NZ (1) | NZ630219A (es) |
| PE (1) | PE20142302A1 (es) |
| PL (1) | PL2723323T3 (es) |
| PT (1) | PT2723323E (es) |
| RS (1) | RS54513B1 (es) |
| RU (1) | RU2671500C2 (es) |
| SG (1) | SG11201405944PA (es) |
| SI (1) | SI2723323T1 (es) |
| SM (1) | SMT201500320B (es) |
| WO (2) | WO2013149013A1 (es) |
| ZA (1) | ZA201406982B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164868A (en) * | 2012-03-28 | 2018-01-30 | Discovery Lab Inc | Lyophilization of synthetic liposomal pulmonary surfactant |
| EP3222273B1 (en) * | 2014-11-18 | 2019-09-25 | National Institute for Materials Science | Method for producing porous particle |
| JP6487051B2 (ja) * | 2014-12-30 | 2019-03-20 | サムヤン バイオファーマシューティカルズ コーポレイションＳａｍｙａｎｇ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | ポリマーナノ粒子の凍結乾燥物、及びその製造方法 |
| CA2986508C (en) * | 2015-07-10 | 2021-06-15 | Synthon Biopharmaceuticals B.V. | Compositions comprising antibody-duocarmycin drug conjugates |
| LT3324932T (lt) | 2015-07-22 | 2021-04-26 | Nitto Denko Corporation | Kompozicijos ir būdai, skirti liofilinėms nanodalelių formoms |
| JP7012512B2 (ja) * | 2017-11-13 | 2022-01-28 | 清水建設株式会社 | 管理装置、製造システムおよび管理方法 |
| WO2019126289A1 (en) * | 2017-12-21 | 2019-06-27 | Civitas Therapeutics, Inc. | Surfactant formulations for inhalation |
| CN108853061A (zh) * | 2018-10-09 | 2018-11-23 | 兆科药业（合肥）有限公司 | 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途 |
| WO2020142420A1 (en) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| KR102545292B1 (ko) * | 2021-01-28 | 2023-06-16 | 인천대학교 산학협력단 | 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법 |
| WO2023280737A1 (en) * | 2021-07-05 | 2023-01-12 | Chiesi Farmaceutici S.P.A. | Process for the preparation of a pulmonary surfactant |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE751108R (fr) | 1969-06-06 | 1970-11-03 | Berliet Automobiles | Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion |
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| UA59358C2 (uk) | 1996-01-24 | 2003-09-15 | Бик Гулден Ломберг Хеміше Фабрік Гмбх | Спосіб приготування порошкоподібного пульмонологічного порошкоподібного препарату та препарат, одержаний в такий спосіб |
| WO1997035882A1 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| JPWO2005105111A1 (ja) | 2004-04-29 | 2008-07-31 | 相男 李 | 人工肺サーファクタント組成物およびその使用方法 |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| US7956160B2 (en) | 2005-07-22 | 2011-06-07 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| MY164868A (en) * | 2012-03-28 | 2018-01-30 | Discovery Lab Inc | Lyophilization of synthetic liposomal pulmonary surfactant |
-
2013
- 2013-03-28 MY MYPI2014002699A patent/MY164868A/en unknown
- 2013-03-28 ES ES13716655.9T patent/ES2557805T3/es active Active
- 2013-03-28 AU AU2013237985A patent/AU2013237985B2/en not_active Ceased
- 2013-03-28 WO PCT/US2013/034364 patent/WO2013149013A1/en active Application Filing
- 2013-03-28 JP JP2015503612A patent/JP6178402B2/ja active Active
- 2013-03-28 WO PCT/US2013/034464 patent/WO2013149074A1/en active Application Filing
- 2013-03-28 CA CA2867649A patent/CA2867649C/en active Active
- 2013-03-28 PL PL13716655T patent/PL2723323T3/pl unknown
- 2013-03-28 PE PE2014001494A patent/PE20142302A1/es not_active Application Discontinuation
- 2013-03-28 DK DK13716655.9T patent/DK2723323T3/en active
- 2013-03-28 US US14/387,707 patent/US9554999B2/en active Active
- 2013-03-28 EP EP13716655.9A patent/EP2723323B1/en active Active
- 2013-03-28 BR BR112014024057A patent/BR112014024057A8/pt not_active Application Discontinuation
- 2013-03-28 MX MX2014011483A patent/MX359654B/es active IP Right Grant
- 2013-03-28 RS RS20150867A patent/RS54513B1/en unknown
- 2013-03-28 EP EP14188473.4A patent/EP2837377A1/en not_active Withdrawn
- 2013-03-28 SI SI201330112T patent/SI2723323T1/sl unknown
- 2013-03-28 NZ NZ630219A patent/NZ630219A/en not_active IP Right Cessation
- 2013-03-28 SG SG11201405944PA patent/SG11201405944PA/en unknown
- 2013-03-28 RU RU2014143247A patent/RU2671500C2/ru active
- 2013-03-28 PT PT137166559T patent/PT2723323E/pt unknown
- 2013-03-28 IN IN8538DEN2014 patent/IN2014DN08538A/en unknown
- 2013-03-28 HU HUE13716655A patent/HUE026363T2/en unknown
- 2013-03-28 CN CN201380022948.0A patent/CN104271118B/zh active Active
- 2013-03-28 KR KR1020147029784A patent/KR102123129B1/ko active IP Right Grant
- 2013-11-27 US US14/091,608 patent/US8748396B2/en active Active
- 2013-11-27 US US14/091,712 patent/US8748397B2/en active Active
-
2014
- 2014-08-29 HK HK14108816.9A patent/HK1197174A1/zh unknown
- 2014-09-16 IL IL234688A patent/IL234688B/en active IP Right Grant
- 2014-09-25 CR CR20140449A patent/CR20140449A/es unknown
- 2014-09-25 ZA ZA2014/06982A patent/ZA201406982B/en unknown
- 2014-09-25 CL CL2014002553A patent/CL2014002553A1/es unknown
- 2014-09-29 CU CUP2014000116A patent/CU20140116A7/es unknown
- 2014-09-30 CO CO14216241A patent/CO7081146A2/es unknown
- 2014-10-22 MA MA37445A patent/MA37445B1/fr unknown
- 2014-10-24 EC ECIEPI201424363A patent/ECSP14024363A/es unknown
-
2015
- 2015-07-02 HK HK15106290.7A patent/HK1205685A1/xx unknown
- 2015-08-06 HK HK15107596.6A patent/HK1206979A1/xx unknown
- 2015-12-18 HR HRP20151392T patent/HRP20151392T1/hr unknown
- 2015-12-21 SM SM201500320T patent/SMT201500320B/it unknown
- 2015-12-22 CY CY20151101180T patent/CY1117380T1/el unknown
-
2017
- 2017-10-06 AU AU2017239624A patent/AU2017239624B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |