RS54513B1 - LYOPHILIZATION OF SYNTHETIC LIPOSOMAL LUNG SURFACTANT - Google Patents
LYOPHILIZATION OF SYNTHETIC LIPOSOMAL LUNG SURFACTANTInfo
- Publication number
- RS54513B1 RS54513B1 RS20150867A RSP20150867A RS54513B1 RS 54513 B1 RS54513 B1 RS 54513B1 RS 20150867 A RS20150867 A RS 20150867A RS P20150867 A RSP20150867 A RS P20150867A RS 54513 B1 RS54513 B1 RS 54513B1
- Authority
- RS
- Serbia
- Prior art keywords
- mixture
- temperature
- lyophilization
- period
- solidified
- Prior art date
Links
- 238000004108 freeze drying Methods 0.000 title abstract 9
- 239000003580 lung surfactant Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 abstract 19
- 238000005339 levitation Methods 0.000 abstract 4
- 239000003960 organic solvent Substances 0.000 abstract 4
- 238000001816 cooling Methods 0.000 abstract 3
- 238000001035 drying Methods 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 2
- 230000008014 freezing Effects 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013557 residual solvent Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000008247 solid mixture Substances 0.000 abstract 1
- 238000007711 solidification Methods 0.000 abstract 1
- 230000008023 solidification Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616827P | 2012-03-28 | 2012-03-28 | |
| PCT/US2013/034464 WO2013149074A1 (en) | 2012-03-28 | 2013-03-28 | Lyophilization of synthetic liposomal pulmonary surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS54513B1 true RS54513B1 (en) | 2016-06-30 |
Family
ID=48096305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20150867A RS54513B1 (en) | 2012-03-28 | 2013-03-28 | LYOPHILIZATION OF SYNTHETIC LIPOSOMAL LUNG SURFACTANT |
Country Status (35)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102123129B1 (ko) * | 2012-03-28 | 2020-06-15 | 디스커버리 라보라토리스, 인크. | 합성 리포솜 폐 계면활성제의 동결건조 |
| JP6557935B2 (ja) * | 2014-11-18 | 2019-08-14 | 国立研究開発法人物質・材料研究機構 | 多孔性粒子の製造方法 |
| EP3241546B1 (en) * | 2014-12-30 | 2021-02-17 | Samyang Biopharmaceuticals Corporation | Polymer nanoparticle freeze-dried product, and preparation method therefor |
| HUE053799T2 (hu) * | 2015-07-10 | 2021-07-28 | Byondis Bv | Antitest-duokarmicin gyógyszer-konjugátumokat tartalmazó készítmények |
| CN108024957B (zh) | 2015-07-22 | 2021-08-24 | 日东电工株式会社 | 用于纳米粒冷冻干燥物形式的组合物及方法 |
| JP7012512B2 (ja) * | 2017-11-13 | 2022-01-28 | 清水建設株式会社 | 管理装置、製造システムおよび管理方法 |
| AU2018392461B2 (en) * | 2017-12-21 | 2024-10-31 | Merz Pharmaceuticals, Llc | Surfactant formulations for inhalation |
| CN108853061A (zh) * | 2018-10-09 | 2018-11-23 | 兆科药业（合肥）有限公司 | 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途 |
| WO2020142420A1 (en) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| KR102545292B1 (ko) * | 2021-01-28 | 2023-06-16 | 인천대학교 산학협력단 | 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법 |
| AR126368A1 (es) * | 2021-07-05 | 2023-10-11 | Chiesi Farm Spa | Proceso para la preparación de un tensioactivo pulmonar |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE751108R (fr) | 1969-06-06 | 1970-11-03 | Berliet Automobiles | Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion |
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| JP3725166B2 (ja) | 1996-01-24 | 2005-12-07 | アルタナ ファルマ アクチエンゲゼルシャフト | 粉末状肺サーファクタント製剤の製造方法 |
| WO1997035882A1 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| JPWO2005105111A1 (ja) | 2004-04-29 | 2008-07-31 | 相男 李 | 人工肺サーファクタント組成物およびその使用方法 |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| EP2377554A1 (en) | 2005-07-22 | 2011-10-19 | Amgen, Inc | Concentrated protein lyophilates, methods and uses |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| KR102123129B1 (ko) * | 2012-03-28 | 2020-06-15 | 디스커버리 라보라토리스, 인크. | 합성 리포솜 폐 계면활성제의 동결건조 |
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2013
- 2013-03-28 KR KR1020147029784A patent/KR102123129B1/ko active Active
- 2013-03-28 HR HRP20151392T patent/HRP20151392T1/hr unknown
- 2013-03-28 IN IN8538DEN2014 patent/IN2014DN08538A/en unknown
- 2013-03-28 US US14/387,707 patent/US9554999B2/en active Active
- 2013-03-28 AU AU2013237985A patent/AU2013237985B2/en not_active Ceased
- 2013-03-28 SI SI201330112T patent/SI2723323T1/sl unknown
- 2013-03-28 CA CA2867649A patent/CA2867649C/en active Active
- 2013-03-28 WO PCT/US2013/034464 patent/WO2013149074A1/en active Application Filing
- 2013-03-28 RU RU2014143247A patent/RU2671500C2/ru active
- 2013-03-28 PT PT137166559T patent/PT2723323E/pt unknown
- 2013-03-28 SG SG11201405944PA patent/SG11201405944PA/en unknown
- 2013-03-28 BR BR112014024057A patent/BR112014024057A8/pt not_active Application Discontinuation
- 2013-03-28 MX MX2014011483A patent/MX359654B/es active IP Right Grant
- 2013-03-28 ES ES13716655.9T patent/ES2557805T3/es active Active
- 2013-03-28 EP EP13716655.9A patent/EP2723323B1/en active Active
- 2013-03-28 RS RS20150867A patent/RS54513B1/en unknown
- 2013-03-28 PL PL13716655T patent/PL2723323T3/pl unknown
- 2013-03-28 DK DK13716655.9T patent/DK2723323T3/en active
- 2013-03-28 HU HUE13716655A patent/HUE026363T2/en unknown
- 2013-03-28 WO PCT/US2013/034364 patent/WO2013149013A1/en active Application Filing
- 2013-03-28 CN CN201380022948.0A patent/CN104271118B/zh active Active
- 2013-03-28 PE PE2014001494A patent/PE20142302A1/es not_active Application Discontinuation
- 2013-03-28 EP EP14188473.4A patent/EP2837377A1/en not_active Withdrawn
- 2013-03-28 MY MYPI2014002699A patent/MY164868A/en unknown
- 2013-03-28 JP JP2015503612A patent/JP6178402B2/ja active Active
- 2013-03-28 NZ NZ630219A patent/NZ630219A/en not_active IP Right Cessation
- 2013-11-27 US US14/091,712 patent/US8748397B2/en active Active
- 2013-11-27 US US14/091,608 patent/US8748396B2/en active Active
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2014
- 2014-09-16 IL IL234688A patent/IL234688B/en active IP Right Grant
- 2014-09-25 ZA ZA2014/06982A patent/ZA201406982B/en unknown
- 2014-09-25 CL CL2014002553A patent/CL2014002553A1/es unknown
- 2014-09-25 CR CR20140449A patent/CR20140449A/es unknown
- 2014-09-29 CU CUP2014000116A patent/CU20140116A7/es unknown
- 2014-09-30 CO CO14216241A patent/CO7081146A2/es unknown
- 2014-10-22 MA MA37445A patent/MA37445B1/fr unknown
- 2014-10-24 EC ECIEPI201424363A patent/ECSP14024363A/es unknown
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2015
- 2015-08-06 HK HK15107596.6A patent/HK1206979A1/en unknown
- 2015-12-21 SM SM201500320T patent/SMT201500320B/it unknown
- 2015-12-22 CY CY20151101180T patent/CY1117380T1/el unknown
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2017
- 2017-10-06 AU AU2017239624A patent/AU2017239624B2/en active Active
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