NZ579098A - Formulations for cancer treatment - Google Patents

Info

Publication number

NZ579098A

NZ579098A NZ579098A NZ57909808A NZ579098A NZ 579098 A NZ579098 A NZ 579098A NZ 579098 A NZ579098 A NZ 579098A NZ 57909808 A NZ57909808 A NZ 57909808A NZ 579098 A NZ579098 A NZ 579098A

Authority

NZ

New Zealand

Prior art keywords

cancer

composition

cyclodextrin

pharmaceutical composition

iodo

Prior art date

2007-01-16

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 title claims abstract description 367
• 206010028980 Neoplasm Diseases 0.000 title claims abstract description 166
• 201000011510 cancer Diseases 0.000 title claims abstract description 84
• 238000011282 treatment Methods 0.000 title claims abstract description 63
• 238000009472 formulation Methods 0.000 title description 234
• 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 162
• 150000001875 compounds Chemical class 0.000 claims abstract description 93
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 92
• 125000001424 substituent group Chemical group 0.000 claims abstract description 57
• 150000003839 salts Chemical class 0.000 claims abstract description 51
• 239000001257 hydrogen Substances 0.000 claims abstract description 39
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 39
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 39
• 239000000872 buffer Substances 0.000 claims abstract description 26
• 125000002346 iodo group Chemical group I* 0.000 claims abstract description 19
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 9
• -1 hydroxy, amino, nitro, iodo Chemical group 0.000 claims description 143
• 238000000034 method Methods 0.000 claims description 118
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 73
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 57
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 49
• MDOJTZQKHMAPBK-UHFFFAOYSA-N 4-iodo-3-nitrobenzamide Chemical compound NC(=O)C1=CC=C(I)C([N+]([O-])=O)=C1 MDOJTZQKHMAPBK-UHFFFAOYSA-N 0.000 claims description 41
• 239000003814 drug Substances 0.000 claims description 37
• 239000011780 sodium chloride Substances 0.000 claims description 27
• 206010008342 Cervix carcinoma Diseases 0.000 claims description 23
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 23
• 201000010881 cervical cancer Diseases 0.000 claims description 23
• 208000020816 lung neoplasm Diseases 0.000 claims description 22
• 206010006187 Breast cancer Diseases 0.000 claims description 20
• 208000026310 Breast neoplasm Diseases 0.000 claims description 20
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 20
• 201000005202 lung cancer Diseases 0.000 claims description 20
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 19
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 19
• 206010060862 Prostate cancer Diseases 0.000 claims description 19
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 19
• 239000007864 aqueous solution Substances 0.000 claims description 19
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 19
• 201000002528 pancreatic cancer Diseases 0.000 claims description 19
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 19
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 18
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 18
• 125000003545 alkoxy group Chemical group 0.000 claims description 18
• 125000000217 alkyl group Chemical group 0.000 claims description 18
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
• 125000001153 fluoro group Chemical group F* 0.000 claims description 18
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
• 239000002244 precipitate Substances 0.000 claims description 18
• 206010005003 Bladder cancer Diseases 0.000 claims description 17
• 206010033128 Ovarian cancer Diseases 0.000 claims description 17
• 125000001246 bromo group Chemical group Br* 0.000 claims description 17
• 238000001990 intravenous administration Methods 0.000 claims description 17
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 17
• 230000003612 virological effect Effects 0.000 claims description 17
• 208000007766 Kaposi sarcoma Diseases 0.000 claims description 16
• 239000008363 phosphate buffer Substances 0.000 claims description 16
• 239000007924 injection Substances 0.000 claims description 15
• 238000002347 injection Methods 0.000 claims description 15
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 14
• 208000032839 leukemia Diseases 0.000 claims description 14
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 13
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 13
• 201000010099 disease Diseases 0.000 claims description 13
• 208000024770 Thyroid neoplasm Diseases 0.000 claims description 12
• 201000002510 thyroid cancer Diseases 0.000 claims description 12
• KLGQWSOYKYFBTR-UHFFFAOYSA-N 2-nitrobenzamide Chemical compound NC(=O)C1=CC=CC=C1[N+]([O-])=O KLGQWSOYKYFBTR-UHFFFAOYSA-N 0.000 claims description 11
• 208000008839 Kidney Neoplasms Diseases 0.000 claims description 10
• 229910019142 PO4 Inorganic materials 0.000 claims description 10
• 206010038389 Renal cancer Diseases 0.000 claims description 10
• 201000000582 Retinoblastoma Diseases 0.000 claims description 10
• 208000024313 Testicular Neoplasms Diseases 0.000 claims description 10
• 201000010982 kidney cancer Diseases 0.000 claims description 10
• 201000007270 liver cancer Diseases 0.000 claims description 10
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 10
• 239000010452 phosphate Substances 0.000 claims description 10
• 206010057644 Testis cancer Diseases 0.000 claims description 9
• 201000001441 melanoma Diseases 0.000 claims description 9
• 201000003120 testicular cancer Diseases 0.000 claims description 9
• 206010014733 Endometrial cancer Diseases 0.000 claims description 8
• 206010014759 Endometrial neoplasm Diseases 0.000 claims description 8
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 8
• 238000001914 filtration Methods 0.000 claims description 8
• 208000014018 liver neoplasm Diseases 0.000 claims description 8
• 239000002245 particle Substances 0.000 claims description 8
• 208000017604 Hodgkin disease Diseases 0.000 claims description 7
• 206010017758 gastric cancer Diseases 0.000 claims description 7
• 210000000214 mouth Anatomy 0.000 claims description 7
• 201000011549 stomach cancer Diseases 0.000 claims description 7
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 6
• 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims description 6
• 206010039491 Sarcoma Diseases 0.000 claims description 6
• 208000000728 Thymus Neoplasms Diseases 0.000 claims description 6
• 201000007455 central nervous system cancer Diseases 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 claims description 5
• 206010031096 Oropharyngeal cancer Diseases 0.000 claims description 5
• 208000007913 Pituitary Neoplasms Diseases 0.000 claims description 5
• 208000025997 central nervous system neoplasm Diseases 0.000 claims description 5
• 208000024519 eye neoplasm Diseases 0.000 claims description 5
• 201000008106 ocular cancer Diseases 0.000 claims description 5
• 201000005443 oral cavity cancer Diseases 0.000 claims description 5
• 201000006958 oropharynx cancer Diseases 0.000 claims description 5
• 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 claims description 5
• 201000009377 thymus cancer Diseases 0.000 claims description 5
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 4
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 4
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 4
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 4
• 206010021042 Hypopharyngeal cancer Diseases 0.000 claims description 4
• 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims description 4
• 206010023825 Laryngeal cancer Diseases 0.000 claims description 4
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 4
• 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 4
• 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 4
• 206010029260 Neuroblastoma Diseases 0.000 claims description 4
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 4
• 208000032383 Soft tissue cancer Diseases 0.000 claims description 4
• 210000000988 bone and bone Anatomy 0.000 claims description 4
• DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 claims description 4
• 201000006866 hypopharynx cancer Diseases 0.000 claims description 4
• 206010023841 laryngeal neoplasm Diseases 0.000 claims description 4
• 208000006178 malignant mesothelioma Diseases 0.000 claims description 4
• 201000008968 osteosarcoma Diseases 0.000 claims description 4
• 201000008261 skin carcinoma Diseases 0.000 claims description 4
• 206010061424 Anal cancer Diseases 0.000 claims description 3
• 208000007860 Anus Neoplasms Diseases 0.000 claims description 3
• 208000032467 Aplastic anaemia Diseases 0.000 claims description 3
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 3
• 206010004593 Bile duct cancer Diseases 0.000 claims description 3
• 206010005949 Bone cancer Diseases 0.000 claims description 3
• 208000018084 Bone neoplasm Diseases 0.000 claims description 3
• 206010007279 Carcinoid tumour of the gastrointestinal tract Diseases 0.000 claims description 3
• 208000005024 Castleman disease Diseases 0.000 claims description 3
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 3
• 208000012468 Ewing sarcoma/peripheral primitive neuroectodermal tumor Diseases 0.000 claims description 3
• 208000022072 Gallbladder Neoplasms Diseases 0.000 claims description 3
• 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims description 3
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 3
• 208000004059 Male Breast Neoplasms Diseases 0.000 claims description 3
• 208000032271 Malignant tumor of penis Diseases 0.000 claims description 3
• 206010027476 Metastases Diseases 0.000 claims description 3
• 208000034578 Multiple myelomas Diseases 0.000 claims description 3
• 208000014767 Myeloproliferative disease Diseases 0.000 claims description 3
• 208000002471 Penile Neoplasms Diseases 0.000 claims description 3
• 206010034299 Penile cancer Diseases 0.000 claims description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
• 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims description 3
• 206010061934 Salivary gland cancer Diseases 0.000 claims description 3
• 206010047741 Vulval cancer Diseases 0.000 claims description 3
• 208000004354 Vulvar Neoplasms Diseases 0.000 claims description 3
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 3
• 230000001919 adrenal effect Effects 0.000 claims description 3
• 201000011165 anus cancer Diseases 0.000 claims description 3
• 208000026900 bile duct neoplasm Diseases 0.000 claims description 3
• 208000006990 cholangiocarcinoma Diseases 0.000 claims description 3
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 3
• 210000001072 colon Anatomy 0.000 claims description 3
• 230000001054 cortical effect Effects 0.000 claims description 3
• 208000030381 cutaneous melanoma Diseases 0.000 claims description 3
• 201000004101 esophageal cancer Diseases 0.000 claims description 3
• 201000010175 gallbladder cancer Diseases 0.000 claims description 3
• 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims description 3
• 201000009277 hairy cell leukemia Diseases 0.000 claims description 3
• 208000026807 lung carcinoid tumor Diseases 0.000 claims description 3
• 201000003175 male breast cancer Diseases 0.000 claims description 3
• 208000010907 male breast carcinoma Diseases 0.000 claims description 3
• 230000009401 metastasis Effects 0.000 claims description 3
• 210000003928 nasal cavity Anatomy 0.000 claims description 3
• 208000010916 pituitary tumor Diseases 0.000 claims description 3
• 201000009410 rhabdomyosarcoma Diseases 0.000 claims description 3
• 208000037965 uterine sarcoma Diseases 0.000 claims description 3
• 206010046885 vaginal cancer Diseases 0.000 claims description 3
• 208000013139 vaginal neoplasm Diseases 0.000 claims description 3
• 201000005102 vulva cancer Diseases 0.000 claims description 3
• 206010009944 Colon cancer Diseases 0.000 claims description 2
• 208000015634 Rectal Neoplasms Diseases 0.000 claims description 2
• 208000029742 colonic neoplasm Diseases 0.000 claims description 2
• 230000002093 peripheral effect Effects 0.000 claims description 2
• 206010038038 rectal cancer Diseases 0.000 claims description 2
• 201000001275 rectum cancer Diseases 0.000 claims description 2
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
• 230000001573 trophoblastic effect Effects 0.000 claims 1
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract description 8
• 229960004853 betadex Drugs 0.000 abstract description 5
• 239000001116 FEMA 4028 Substances 0.000 abstract description 2
• 235000011175 beta-cyclodextrine Nutrition 0.000 abstract description 2
• 239000002775 capsule Substances 0.000 description 161
• 239000004094 surface-active agent Substances 0.000 description 87
• 238000001959 radiotherapy Methods 0.000 description 78
• 238000002512 chemotherapy Methods 0.000 description 71
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 66
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 66
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 62
• 239000008186 active pharmaceutical agent Substances 0.000 description 62
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 59
• 238000001356 surgical procedure Methods 0.000 description 57
• 239000002904 solvent Substances 0.000 description 54
• 239000000243 solution Substances 0.000 description 50
• 239000008187 granular material Substances 0.000 description 43
• FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 42
• 210000004027 cell Anatomy 0.000 description 40
• 239000002207 metabolite Substances 0.000 description 40
• 239000006184 cosolvent Substances 0.000 description 39
• 150000002632 lipids Chemical class 0.000 description 39
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 38
• 238000009169 immunotherapy Methods 0.000 description 38
• 239000000463 material Substances 0.000 description 37
• 239000007788 liquid Substances 0.000 description 35
• 239000007787 solid Substances 0.000 description 33
• 238000012360 testing method Methods 0.000 description 33
• 229940079593 drug Drugs 0.000 description 31
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 30
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 30
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 30
• 229920000053 polysorbate 80 Polymers 0.000 description 30
• 150000002431 hydrogen Chemical class 0.000 description 29
• 230000009286 beneficial effect Effects 0.000 description 27
• 241000282472 Canis lupus familiaris Species 0.000 description 26
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 24
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 23
• 229940068968 polysorbate 80 Drugs 0.000 description 23
• 230000001804 emulsifying effect Effects 0.000 description 22
• GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 22
• 229920006395 saturated elastomer Polymers 0.000 description 21
• 210000001519 tissue Anatomy 0.000 description 21
• 230000003211 malignant effect Effects 0.000 description 20
• 230000002829 reductive effect Effects 0.000 description 20
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 19
• 239000000843 powder Substances 0.000 description 19
• 239000003981 vehicle Substances 0.000 description 19
• 208000030507 AIDS Diseases 0.000 description 18
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 18
• 235000019441 ethanol Nutrition 0.000 description 18
• 238000009474 hot melt extrusion Methods 0.000 description 18
• 230000008569 process Effects 0.000 description 18
• 229940002612 prodrug Drugs 0.000 description 18
• 239000000651 prodrug Substances 0.000 description 18
• 239000003826 tablet Substances 0.000 description 18
• 239000012453 solvate Substances 0.000 description 17
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 16
• 239000003921 oil Substances 0.000 description 16
• 235000019198 oils Nutrition 0.000 description 16
• 229920001983 poloxamer Polymers 0.000 description 16
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
• 239000002585 base Substances 0.000 description 15
• 235000019359 magnesium stearate Nutrition 0.000 description 15
• CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 description 14
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 14
• 229920001213 Polysorbate 20 Polymers 0.000 description 14
• 208000009956 adenocarcinoma Diseases 0.000 description 14
• 239000002246 antineoplastic agent Substances 0.000 description 14
• 238000002725 brachytherapy Methods 0.000 description 14
• 239000008103 glucose Substances 0.000 description 14
• 238000002156 mixing Methods 0.000 description 14
• 239000000546 pharmaceutical excipient Substances 0.000 description 14
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 14
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 14
• 229940068977 polysorbate 20 Drugs 0.000 description 14
• 239000000523 sample Substances 0.000 description 14
• 241001465754 Metazoa Species 0.000 description 13
• 238000002710 external beam radiation therapy Methods 0.000 description 13
• 229920000642 polymer Polymers 0.000 description 13
• 238000002560 therapeutic procedure Methods 0.000 description 13
• JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 description 12
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 12
• 206010025323 Lymphomas Diseases 0.000 description 12
• 229920001304 Solutol HS 15 Polymers 0.000 description 12
• 230000008901 benefit Effects 0.000 description 12
• 210000003169 central nervous system Anatomy 0.000 description 12
• 229940097362 cyclodextrins Drugs 0.000 description 12
• 230000000694 effects Effects 0.000 description 12
• 235000019253 formic acid Nutrition 0.000 description 12
• 229920003109 sodium starch glycolate Polymers 0.000 description 12
• 239000008109 sodium starch glycolate Substances 0.000 description 12
• 229940079832 sodium starch glycolate Drugs 0.000 description 12
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 12
• 210000003932 urinary bladder Anatomy 0.000 description 12
• 208000002008 AIDS-Related Lymphoma Diseases 0.000 description 11
• 210000004369 blood Anatomy 0.000 description 11
• 239000008280 blood Substances 0.000 description 11
• 238000011049 filling Methods 0.000 description 11
• 239000012530 fluid Substances 0.000 description 11
• 229960000502 poloxamer Drugs 0.000 description 11
• 239000008389 polyethoxylated castor oil Substances 0.000 description 11
• 229940041181 antineoplastic drug Drugs 0.000 description 10
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 10
• 235000011187 glycerol Nutrition 0.000 description 10
• 229920001542 oligosaccharide Polymers 0.000 description 10
• 229920001223 polyethylene glycol Polymers 0.000 description 10
• 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 description 9
• 206010025312 Lymphoma AIDS related Diseases 0.000 description 9
• 239000002202 Polyethylene glycol Substances 0.000 description 9
• 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 9
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
• 241000700605 Viruses Species 0.000 description 9
• 201000006966 adult T-cell leukemia Diseases 0.000 description 9
• 238000001035 drying Methods 0.000 description 9
• 229960005420 etoposide Drugs 0.000 description 9
• 230000006870 function Effects 0.000 description 9
• 229920000159 gelatin Polymers 0.000 description 9
• 235000019322 gelatine Nutrition 0.000 description 9
• MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 description 9
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 9
• 208000015181 infectious disease Diseases 0.000 description 9
• 201000009020 malignant peripheral nerve sheath tumor Diseases 0.000 description 9
• 208000029974 neurofibrosarcoma Diseases 0.000 description 9
• QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 9
• 238000002360 preparation method Methods 0.000 description 9
• 239000008137 solubility enhancer Substances 0.000 description 9
• 238000003756 stirring Methods 0.000 description 9
• 239000000126 substance Substances 0.000 description 9
• WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 8
• 206010003571 Astrocytoma Diseases 0.000 description 8
• 108010010803 Gelatin Proteins 0.000 description 8
• 241000725303 Human immunodeficiency virus Species 0.000 description 8
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 8
• 241000700584 Simplexvirus Species 0.000 description 8
• 229920002472 Starch Polymers 0.000 description 8
• 238000010521 absorption reaction Methods 0.000 description 8
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 8
• 229960004316 cisplatin Drugs 0.000 description 8
• 238000010790 dilution Methods 0.000 description 8
• 239000012895 dilution Substances 0.000 description 8
• 229940088679 drug related substance Drugs 0.000 description 8
• 239000000839 emulsion Substances 0.000 description 8
• 238000001125 extrusion Methods 0.000 description 8
• 210000001508 eye Anatomy 0.000 description 8
• 239000008273 gelatin Substances 0.000 description 8
• 239000007903 gelatin capsule Substances 0.000 description 8
• 235000011852 gelatine desserts Nutrition 0.000 description 8
• 230000012010 growth Effects 0.000 description 8
• 229940088597 hormone Drugs 0.000 description 8
• 239000005556 hormone Substances 0.000 description 8
• 238000001794 hormone therapy Methods 0.000 description 8
• 239000012943 hotmelt Substances 0.000 description 8
• 229960001101 ifosfamide Drugs 0.000 description 8
• 150000002482 oligosaccharides Chemical class 0.000 description 8
• 229940068918 polyethylene glycol 400 Drugs 0.000 description 8
• 239000008213 purified water Substances 0.000 description 8
• 230000005855 radiation Effects 0.000 description 8
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 7
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 7
• 208000031839 Peripheral nerve sheath tumour malignant Diseases 0.000 description 7
• 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 7
• 208000000453 Skin Neoplasms Diseases 0.000 description 7
• 239000002253 acid Chemical group 0.000 description 7
• 239000003443 antiviral agent Substances 0.000 description 7
• 230000015572 biosynthetic process Effects 0.000 description 7
• 210000004556 brain Anatomy 0.000 description 7
• 239000007963 capsule composition Substances 0.000 description 7
• 239000003795 chemical substances by application Substances 0.000 description 7
• 238000002681 cryosurgery Methods 0.000 description 7
• 229960004679 doxorubicin Drugs 0.000 description 7
• 239000000945 filler Substances 0.000 description 7
• 239000011521 glass Substances 0.000 description 7
• 238000005469 granulation Methods 0.000 description 7
• 230000003179 granulation Effects 0.000 description 7
• 238000004128 high performance liquid chromatography Methods 0.000 description 7
• 239000007928 intraperitoneal injection Substances 0.000 description 7
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 7
• 239000008108 microcrystalline cellulose Substances 0.000 description 7
• 229940016286 microcrystalline cellulose Drugs 0.000 description 7
• 210000005036 nerve Anatomy 0.000 description 7
• 208000007538 neurilemmoma Diseases 0.000 description 7
• 150000002828 nitro derivatives Chemical class 0.000 description 7
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 7
• 238000002428 photodynamic therapy Methods 0.000 description 7
• 229920001993 poloxamer 188 Polymers 0.000 description 7
• 229940044519 poloxamer 188 Drugs 0.000 description 7
• 201000000849 skin cancer Diseases 0.000 description 7
• 235000019698 starch Nutrition 0.000 description 7
• 208000008732 thymoma Diseases 0.000 description 7
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
• 201000009030 Carcinoma Diseases 0.000 description 6
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 6
• 241000701022 Cytomegalovirus Species 0.000 description 6
• 206010018910 Haemolysis Diseases 0.000 description 6
• 206010061252 Intraocular melanoma Diseases 0.000 description 6
• 229920000881 Modified starch Polymers 0.000 description 6
• AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 6
• 201000005969 Uveal melanoma Diseases 0.000 description 6
• 210000000481 breast Anatomy 0.000 description 6
• NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 6
• 229960004397 cyclophosphamide Drugs 0.000 description 6
• 239000003085 diluting agent Substances 0.000 description 6
• 230000008588 hemolysis Effects 0.000 description 6
• 239000004530 micro-emulsion Substances 0.000 description 6
• 208000027831 neuroepithelial neoplasm Diseases 0.000 description 6
• 201000002575 ocular melanoma Diseases 0.000 description 6
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 6
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 6
• 230000009467 reduction Effects 0.000 description 6
• 206010039667 schwannoma Diseases 0.000 description 6
• 229940032147 starch Drugs 0.000 description 6
• 239000008107 starch Substances 0.000 description 6
• 210000001550 testis Anatomy 0.000 description 6
• 230000001225 therapeutic effect Effects 0.000 description 6
• 210000001541 thymus gland Anatomy 0.000 description 6
• 206010044412 transitional cell carcinoma Diseases 0.000 description 6
• 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 description 5
• 229920003148 Eudragit® E polymer Polymers 0.000 description 5
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 5
• KJQFBVYMGADDTQ-CVSPRKDYSA-N L-buthionine-(S,R)-sulfoximine Chemical compound CCCCS(=N)(=O)CC[C@H](N)C(O)=O KJQFBVYMGADDTQ-CVSPRKDYSA-N 0.000 description 5
• 229930012538 Paclitaxel Natural products 0.000 description 5
• 238000004458 analytical method Methods 0.000 description 5
• 230000000840 anti-viral effect Effects 0.000 description 5
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 5
• 229960004562 carboplatin Drugs 0.000 description 5
• 210000003679 cervix uteri Anatomy 0.000 description 5
• 239000006071 cream Substances 0.000 description 5
• 230000004069 differentiation Effects 0.000 description 5
• 208000035475 disorder Diseases 0.000 description 5
• 229960002949 fluorouracil Drugs 0.000 description 5
• 239000000314 lubricant Substances 0.000 description 5
• 230000036210 malignancy Effects 0.000 description 5
• 150000002772 monosaccharides Chemical class 0.000 description 5
• 229960001592 paclitaxel Drugs 0.000 description 5
• 230000036470 plasma concentration Effects 0.000 description 5
• 229920000136 polysorbate Polymers 0.000 description 5
• 229940080313 sodium starch Drugs 0.000 description 5
• 206010041823 squamous cell carcinoma Diseases 0.000 description 5
• 210000002784 stomach Anatomy 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• 208000024891 symptom Diseases 0.000 description 5
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 5
• CGXRJCDXGJRBHV-UHFFFAOYSA-N 4-chloro-3-nitrobenzamide Chemical compound NC(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 CGXRJCDXGJRBHV-UHFFFAOYSA-N 0.000 description 4
• 108010006654 Bleomycin Proteins 0.000 description 4
• 208000003174 Brain Neoplasms Diseases 0.000 description 4
• 206010011831 Cytomegalovirus infection Diseases 0.000 description 4
• 206010014967 Ependymoma Diseases 0.000 description 4
• 241000701806 Human papillomavirus Species 0.000 description 4
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 4
• BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 4
• 201000010133 Oligodendroglioma Diseases 0.000 description 4
• 208000007641 Pinealoma Diseases 0.000 description 4
• 229920003081 Povidone K 30 Polymers 0.000 description 4
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 4
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 4
• 238000002835 absorbance Methods 0.000 description 4
• 230000001154 acute effect Effects 0.000 description 4
• 238000013103 analytical ultracentrifugation Methods 0.000 description 4
• 239000003098 androgen Substances 0.000 description 4
• 238000001815 biotherapy Methods 0.000 description 4
• 210000001185 bone marrow Anatomy 0.000 description 4
• 208000002458 carcinoid tumor Diseases 0.000 description 4
• 235000014113 dietary fatty acids Nutrition 0.000 description 4
• XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 4
• 239000007884 disintegrant Substances 0.000 description 4
• 239000008298 dragée Substances 0.000 description 4
• 238000004945 emulsification Methods 0.000 description 4
• 238000009261 endocrine therapy Methods 0.000 description 4
• 229940034984 endocrine therapy antineoplastic and immunomodulating agent Drugs 0.000 description 4
• 239000000194 fatty acid Substances 0.000 description 4
• 229930195729 fatty acid Natural products 0.000 description 4
• 230000002496 gastric effect Effects 0.000 description 4
• 230000002209 hydrophobic effect Effects 0.000 description 4
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
• 238000009217 hyperthermia therapy Methods 0.000 description 4
• 210000000987 immune system Anatomy 0.000 description 4
• 230000002147 killing effect Effects 0.000 description 4
• 230000003902 lesion Effects 0.000 description 4
• 210000005075 mammary gland Anatomy 0.000 description 4
• 239000011159 matrix material Substances 0.000 description 4
• 206010027191 meningioma Diseases 0.000 description 4
• 229960000485 methotrexate Drugs 0.000 description 4
• 229960001156 mitoxantrone Drugs 0.000 description 4
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 4
• 150000002832 nitroso derivatives Chemical class 0.000 description 4
• 239000002736 nonionic surfactant Substances 0.000 description 4
• 210000000056 organ Anatomy 0.000 description 4
• 239000011236 particulate material Substances 0.000 description 4
• 210000005259 peripheral blood Anatomy 0.000 description 4
• 239000011886 peripheral blood Substances 0.000 description 4
• 238000005191 phase separation Methods 0.000 description 4
• 229940068196 placebo Drugs 0.000 description 4
• 239000000902 placebo Substances 0.000 description 4
• 238000001556 precipitation Methods 0.000 description 4
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 4
• 229960004618 prednisone Drugs 0.000 description 4
• 208000029340 primitive neuroectodermal tumor Diseases 0.000 description 4
• 210000002307 prostate Anatomy 0.000 description 4
• 238000011476 stem cell transplantation Methods 0.000 description 4
• 239000000829 suppository Substances 0.000 description 4
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 4
• 208000023747 urothelial carcinoma Diseases 0.000 description 4
• JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 4
• 238000005550 wet granulation Methods 0.000 description 4
• REGZQZHKIFOMRK-LSCFUAHRSA-N (2r,3r,4s,5r)-2-[6-[(4-amino-3-iodophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=C(I)C(N)=CC=C1CNC1=NC=NC2=C1N=CN2[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 REGZQZHKIFOMRK-LSCFUAHRSA-N 0.000 description 3
• GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
• 208000006402 Ductal Carcinoma Diseases 0.000 description 3
• 229920003134 Eudragit® polymer Polymers 0.000 description 3
• 108700012941 GNRH1 Proteins 0.000 description 3
• 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 3
• 241000711549 Hepacivirus C Species 0.000 description 3
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 3
• 241000282414 Homo sapiens Species 0.000 description 3
• XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 3
• XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 3
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 3
• 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 3
• 208000001388 Opportunistic Infections Diseases 0.000 description 3
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
• 239000004698 Polyethylene Substances 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• 230000002159 abnormal effect Effects 0.000 description 3
• 239000004480 active ingredient Substances 0.000 description 3
• 238000013459 approach Methods 0.000 description 3
• 239000012736 aqueous medium Substances 0.000 description 3
• 125000003118 aryl group Chemical group 0.000 description 3
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
• 210000000133 brain stem Anatomy 0.000 description 3
• 239000004359 castor oil Substances 0.000 description 3
• 235000019438 castor oil Nutrition 0.000 description 3
• 238000012512 characterization method Methods 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000010668 complexation reaction Methods 0.000 description 3
• 238000000315 cryotherapy Methods 0.000 description 3
• 208000031513 cyst Diseases 0.000 description 3
• 230000006378 damage Effects 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 231100000517 death Toxicity 0.000 description 3
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 3
• 229960003668 docetaxel Drugs 0.000 description 3
• 238000012377 drug delivery Methods 0.000 description 3
• 210000004696 endometrium Anatomy 0.000 description 3
• 238000011067 equilibration Methods 0.000 description 3
• 230000008029 eradication Effects 0.000 description 3
• 150000004665 fatty acids Chemical class 0.000 description 3
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 3
• 229960005277 gemcitabine Drugs 0.000 description 3
• 238000001415 gene therapy Methods 0.000 description 3
• 230000000762 glandular Effects 0.000 description 3
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 3
• 231100000844 hepatocellular carcinoma Toxicity 0.000 description 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
• 229960000908 idarubicin Drugs 0.000 description 3
• 238000001727 in vivo Methods 0.000 description 3
• 229960004768 irinotecan Drugs 0.000 description 3
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 3
• 238000002647 laser therapy Methods 0.000 description 3
• 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 3
• 210000004185 liver Anatomy 0.000 description 3
• 210000002751 lymph Anatomy 0.000 description 3
• 210000001165 lymph node Anatomy 0.000 description 3
• 239000000693 micelle Substances 0.000 description 3
• 238000002625 monoclonal antibody therapy Methods 0.000 description 3
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 3
• 210000003205 muscle Anatomy 0.000 description 3
• 238000013059 nephrectomy Methods 0.000 description 3
• 231100000252 nontoxic Toxicity 0.000 description 3
• 230000003000 nontoxic effect Effects 0.000 description 3
• 238000010422 painting Methods 0.000 description 3
• 210000000277 pancreatic duct Anatomy 0.000 description 3
• 235000020030 perry Nutrition 0.000 description 3
• 230000000649 photocoagulation Effects 0.000 description 3
• 229920000573 polyethylene Polymers 0.000 description 3
• 229940050929 polyethylene glycol 3350 Drugs 0.000 description 3
• 229950008882 polysorbate Drugs 0.000 description 3
• 230000002035 prolonged effect Effects 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 230000010076 replication Effects 0.000 description 3
• 238000005549 size reduction Methods 0.000 description 3
• 210000003625 skull Anatomy 0.000 description 3
• 239000003381 stabilizer Substances 0.000 description 3
• 210000000130 stem cell Anatomy 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 238000000015 thermotherapy Methods 0.000 description 3
• 150000003626 triacylglycerols Polymers 0.000 description 3
• 229960003048 vinblastine Drugs 0.000 description 3
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 3
• 229960004528 vincristine Drugs 0.000 description 3
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 3
• ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 2
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 2
• WFFLPVBJUXVNNI-UHFFFAOYSA-N 2-nitrosobenzamide Chemical group NC(=O)C1=CC=CC=C1N=O WFFLPVBJUXVNNI-UHFFFAOYSA-N 0.000 description 2
• WUIABRMSWOKTOF-OYALTWQYSA-N 3-[[2-[2-[2-[[(2s,3r)-2-[[(2s,3s,4r)-4-[[(2s,3r)-2-[[6-amino-2-[(1s)-3-amino-1-[[(2s)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2r,3s,4s,5s,6s)-3-[(2r,3s,4s,5r,6r)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)ox Chemical compound OS([O-])(=O)=O.N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C WUIABRMSWOKTOF-OYALTWQYSA-N 0.000 description 2
• XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 2
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
• 208000005243 Chondrosarcoma Diseases 0.000 description 2
• 206010011732 Cyst Diseases 0.000 description 2
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 2
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
• SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
• 206010014968 Ependymoma malignant Diseases 0.000 description 2
• 244000024675 Eruca sativa Species 0.000 description 2
• 235000014755 Eruca sativa Nutrition 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• 201000004066 Ganglioglioma Diseases 0.000 description 2
• 201000010915 Glioblastoma multiforme Diseases 0.000 description 2
• 206010018338 Glioma Diseases 0.000 description 2
• 108010069236 Goserelin Proteins 0.000 description 2
• BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 2
• 208000031886 HIV Infections Diseases 0.000 description 2
• 238000012752 Hepatectomy Methods 0.000 description 2
• 241000700721 Hepatitis B virus Species 0.000 description 2
• 208000009889 Herpes Simplex Diseases 0.000 description 2
• 241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 108010000817 Leuprolide Proteins 0.000 description 2
• 208000028018 Lymphocytic leukaemia Diseases 0.000 description 2
• 208000000172 Medulloblastoma Diseases 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
• 229930192392 Mitomycin Natural products 0.000 description 2
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
• 201000004404 Neurofibroma Diseases 0.000 description 2
• 208000000160 Olfactory Esthesioneuroblastoma Diseases 0.000 description 2
• 239000002033 PVDF binder Substances 0.000 description 2
• 241001494479 Pecora Species 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 206010050487 Pinealoblastoma Diseases 0.000 description 2
• QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
• 208000006265 Renal cell carcinoma Diseases 0.000 description 2
• 201000010208 Seminoma Diseases 0.000 description 2
• 239000004141 Sodium laurylsulphate Substances 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 2
• 201000009365 Thymic carcinoma Diseases 0.000 description 2
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
• 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 description 2
• 208000002495 Uterine Neoplasms Diseases 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• 229920004482 WACKER® Polymers 0.000 description 2
• 208000012018 Yolk sac tumor Diseases 0.000 description 2
• 229960004150 aciclovir Drugs 0.000 description 2
• MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 2
• 208000009621 actinic keratosis Diseases 0.000 description 2
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
• 201000008395 adenosquamous carcinoma Diseases 0.000 description 2
• 210000000577 adipose tissue Anatomy 0.000 description 2
• 230000002411 adverse Effects 0.000 description 2
• 238000009167 androgen deprivation therapy Methods 0.000 description 2
• 125000000129 anionic group Chemical group 0.000 description 2
• 230000000259 anti-tumor effect Effects 0.000 description 2
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• 210000003403 autonomic nervous system Anatomy 0.000 description 2
• 235000019445 benzyl alcohol Nutrition 0.000 description 2
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
• 235000013361 beverage Nutrition 0.000 description 2
• 230000002146 bilateral effect Effects 0.000 description 2
• 239000011230 binding agent Substances 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 229960001561 bleomycin Drugs 0.000 description 2
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 2
• 230000008499 blood brain barrier function Effects 0.000 description 2
• 210000001218 blood-brain barrier Anatomy 0.000 description 2
• 210000001124 body fluid Anatomy 0.000 description 2
• 239000008366 buffered solution Substances 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 230000001364 causal effect Effects 0.000 description 2
• 230000002490 cerebral effect Effects 0.000 description 2
• 208000006571 choroid plexus carcinoma Diseases 0.000 description 2
• 230000001684 chronic effect Effects 0.000 description 2
• 238000000576 coating method Methods 0.000 description 2
• 239000012141 concentrate Substances 0.000 description 2
• 239000002285 corn oil Substances 0.000 description 2
• 235000005687 corn oil Nutrition 0.000 description 2
• PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
• 229960000684 cytarabine Drugs 0.000 description 2
• 230000009089 cytolysis Effects 0.000 description 2
• 231100000135 cytotoxicity Toxicity 0.000 description 2
• 230000003013 cytotoxicity Effects 0.000 description 2
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 2
• 229960000975 daunorubicin Drugs 0.000 description 2
• 230000007423 decrease Effects 0.000 description 2
• 239000003405 delayed action preparation Substances 0.000 description 2
• 238000000280 densification Methods 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 235000005911 diet Nutrition 0.000 description 2
• 230000037213 diet Effects 0.000 description 2
• RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
• 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 2
• 238000004090 dissolution Methods 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 208000001991 endodermal sinus tumor Diseases 0.000 description 2
• 230000007159 enucleation Effects 0.000 description 2
• 210000003386 epithelial cell of thymus gland Anatomy 0.000 description 2
• 229960004756 ethanol Drugs 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 238000011347 external beam therapy Methods 0.000 description 2
• 230000003325 follicular Effects 0.000 description 2
• 235000013305 food Nutrition 0.000 description 2
• 230000037406 food intake Effects 0.000 description 2
• GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 2
• 239000000499 gel Substances 0.000 description 2
• 208000003884 gestational trophoblastic disease Diseases 0.000 description 2
• 208000005017 glioblastoma Diseases 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 229960002913 goserelin Drugs 0.000 description 2
• JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 2
• 210000002216 heart Anatomy 0.000 description 2
• 201000002222 hemangioblastoma Diseases 0.000 description 2
• 229940072106 hydroxystearate Drugs 0.000 description 2
• 230000028993 immune response Effects 0.000 description 2
• 238000002513 implantation Methods 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 208000000509 infertility Diseases 0.000 description 2
• 231100000535 infertility Toxicity 0.000 description 2
• 230000036512 infertility Effects 0.000 description 2
• 238000001802 infusion Methods 0.000 description 2
• 239000002563 ionic surfactant Substances 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 229960001375 lactose Drugs 0.000 description 2
• 238000002430 laser surgery Methods 0.000 description 2
• GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 2
• 229960004338 leuprorelin Drugs 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 210000004698 lymphocyte Anatomy 0.000 description 2
• 208000003747 lymphoid leukemia Diseases 0.000 description 2
• 229940057917 medium chain triglycerides Drugs 0.000 description 2
• 210000002418 meninge Anatomy 0.000 description 2
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
• 229910021645 metal ion Inorganic materials 0.000 description 2
• 229920000609 methyl cellulose Polymers 0.000 description 2
• 235000010981 methylcellulose Nutrition 0.000 description 2
• 239000001923 methylcellulose Substances 0.000 description 2
• 229960004857 mitomycin Drugs 0.000 description 2
• 210000000653 nervous system Anatomy 0.000 description 2
• 210000004412 neuroendocrine cell Anatomy 0.000 description 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
• 206010073131 oligoastrocytoma Diseases 0.000 description 2
• 238000005457 optimization Methods 0.000 description 2
• 239000006186 oral dosage form Substances 0.000 description 2
• 238000011474 orchiectomy Methods 0.000 description 2
• 239000003960 organic solvent Substances 0.000 description 2
• 210000001672 ovary Anatomy 0.000 description 2
• 208000007312 paraganglioma Diseases 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 238000012753 partial hepatectomy Methods 0.000 description 2
• 210000001428 peripheral nervous system Anatomy 0.000 description 2
• 230000035699 permeability Effects 0.000 description 2
• 239000000825 pharmaceutical preparation Substances 0.000 description 2
• 201000003113 pineoblastoma Diseases 0.000 description 2
• 206010035059 pineocytoma Diseases 0.000 description 2
• 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
• 229920006316 polyvinylpyrrolidine Polymers 0.000 description 2
• 210000004258 portal system Anatomy 0.000 description 2
• 239000013641 positive control Substances 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 238000012545 processing Methods 0.000 description 2
• 238000009803 radical hysterectomy Methods 0.000 description 2
• 150000003254 radicals Chemical class 0.000 description 2
• 230000002285 radioactive effect Effects 0.000 description 2
• 238000007674 radiofrequency ablation Methods 0.000 description 2
• 238000002271 resection Methods 0.000 description 2
• 238000010079 rubber tapping Methods 0.000 description 2
• 238000012216 screening Methods 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 229910001415 sodium ion Inorganic materials 0.000 description 2
• 210000004872 soft tissue Anatomy 0.000 description 2
• 230000000392 somatic effect Effects 0.000 description 2
• 238000000527 sonication Methods 0.000 description 2
• 229940035044 sorbitan monolaurate Drugs 0.000 description 2
• 235000011069 sorbitan monooleate Nutrition 0.000 description 2
• 239000001593 sorbitan monooleate Substances 0.000 description 2
• 229940035049 sorbitan monooleate Drugs 0.000 description 2
• 239000000600 sorbitol Substances 0.000 description 2
• 210000000278 spinal cord Anatomy 0.000 description 2
• 238000011272 standard treatment Methods 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 239000000454 talc Substances 0.000 description 2
• 229910052623 talc Inorganic materials 0.000 description 2
• 229960001603 tamoxifen Drugs 0.000 description 2
• 229960001196 thiotepa Drugs 0.000 description 2
• 208000013077 thyroid gland carcinoma Diseases 0.000 description 2
• 229960003087 tioguanine Drugs 0.000 description 2
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
• 231100000419 toxicity Toxicity 0.000 description 2
• 230000001988 toxicity Effects 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 238000002054 transplantation Methods 0.000 description 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
• 210000003741 urothelium Anatomy 0.000 description 2
• 206010046766 uterine cancer Diseases 0.000 description 2
• 210000001745 uvea Anatomy 0.000 description 2
• 210000001215 vagina Anatomy 0.000 description 2
• 210000000752 vestibulocochlear nerve Anatomy 0.000 description 2
• 230000009385 viral infection Effects 0.000 description 2
• NJWCVQBHNBLNOZ-ZRMYETLXSA-N (1S,3R,5R,6S,8R,10R,11S,13S,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,47R,48S,49R)-5,20,30,35-tetrakis(hydroxymethyl)-49-(2-hydroxypropoxy)-10,15,25-tris(2-hydroxypropoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,47,48-dodecol Chemical compound CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1C[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](OCC(C)O)[C@H]3O NJWCVQBHNBLNOZ-ZRMYETLXSA-N 0.000 description 1
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
• ITOFPJRDSCGOSA-KZLRUDJFSA-N (2s)-2-[[(4r)-4-[(3r,5r,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H](CC[C@]13C)[C@@H]2[C@@H]3CC[C@@H]1[C@H](C)CCC(=O)N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12 ITOFPJRDSCGOSA-KZLRUDJFSA-N 0.000 description 1
• ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
• MWWSFMDVAYGXBV-MYPASOLCSA-N (7r,9s)-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;hydrochloride Chemical compound Cl.O([C@@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-MYPASOLCSA-N 0.000 description 1
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
• LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 1
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
• VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• KWVPFECTOKLOBL-KTKRTIGZSA-N 2-[(z)-octadec-9-enoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCO KWVPFECTOKLOBL-KTKRTIGZSA-N 0.000 description 1
• AWFYPPSBLUWMFQ-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=C2 AWFYPPSBLUWMFQ-UHFFFAOYSA-N 0.000 description 1
• ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
• HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
• BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 description 1
• NZBUMQONDVMPDO-UHFFFAOYSA-N 2-iodo-3-nitrobenzamide Chemical compound NC(=O)C1=CC=CC([N+]([O-])=O)=C1I NZBUMQONDVMPDO-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• KWAYEPXDGHYGRW-UHFFFAOYSA-N 3-nitrobenzamide Chemical compound NC(=O)C1=CC=CC([N+]([O-])=O)=C1 KWAYEPXDGHYGRW-UHFFFAOYSA-N 0.000 description 1
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
• NOEGNKMFWQHSLB-UHFFFAOYSA-N 5-hydroxymethylfurfural Chemical compound OCC1=CC=C(C=O)O1 NOEGNKMFWQHSLB-UHFFFAOYSA-N 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• 208000029483 Acquired immunodeficiency Diseases 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 206010073127 Anaplastic meningioma Diseases 0.000 description 1
• 201000003076 Angiosarcoma Diseases 0.000 description 1
• 101100483630 Arabidopsis thaliana UCH3 gene Proteins 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 206010065869 Astrocytoma, low grade Diseases 0.000 description 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
• 241000193830 Bacillus <bacterium> Species 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 208000035821 Benign schwannoma Diseases 0.000 description 1
• GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
• 206010006458 Bronchitis chronic Diseases 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• QYOVMAREBTZLBT-KTKRTIGZSA-N CCCCCCCC\C=C/CCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO QYOVMAREBTZLBT-KTKRTIGZSA-N 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 241000282465 Canis Species 0.000 description 1
• 208000005623 Carcinogenesis Diseases 0.000 description 1
• 208000009458 Carcinoma in Situ Diseases 0.000 description 1
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
• 208000001262 Central Nervous System Cysts Diseases 0.000 description 1
• 208000033472 Chemodectoma Diseases 0.000 description 1
• 206010008583 Chloroma Diseases 0.000 description 1
• MKQWTWSXVILIKJ-LXGUWJNJSA-N Chlorozotocin Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)NC(=O)N(N=O)CCCl MKQWTWSXVILIKJ-LXGUWJNJSA-N 0.000 description 1
• 201000009047 Chordoma Diseases 0.000 description 1
• 208000006332 Choriocarcinoma Diseases 0.000 description 1
• 208000016216 Choristoma Diseases 0.000 description 1
• 208000004378 Choroid plexus papilloma Diseases 0.000 description 1
• 208000037088 Chromosome Breakage Diseases 0.000 description 1
• PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 description 1
• 208000003322 Coinfection Diseases 0.000 description 1
• 208000005812 Colloid Cysts Diseases 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 201000002847 Cowden syndrome Diseases 0.000 description 1
• 208000009798 Craniopharyngioma Diseases 0.000 description 1
• 241000870659 Crassula perfoliata var. minor Species 0.000 description 1
• 102100021906 Cyclin-O Human genes 0.000 description 1
• YTBSYETUWUMLBZ-UHFFFAOYSA-N D-Erythrose Natural products OCC(O)C(O)C=O YTBSYETUWUMLBZ-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-CBPJZXOFSA-N D-Gulose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-CBPJZXOFSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• WQZGKKKJIJFFOK-IVMDWMLBSA-N D-allopyranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@@H]1O WQZGKKKJIJFFOK-IVMDWMLBSA-N 0.000 description 1
• YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 1
• MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
• HSNZZMHEPUFJNZ-QMTIVRBISA-N D-keto-manno-heptulose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C(=O)CO HSNZZMHEPUFJNZ-QMTIVRBISA-N 0.000 description 1
• HAIWUXASLYEWLM-UHFFFAOYSA-N D-manno-Heptulose Natural products OCC1OC(O)(CO)C(O)C(O)C1O HAIWUXASLYEWLM-UHFFFAOYSA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• ZAQJHHRNXZUBTE-NQXXGFSBSA-N D-ribulose Chemical compound OC[C@@H](O)[C@@H](O)C(=O)CO ZAQJHHRNXZUBTE-NQXXGFSBSA-N 0.000 description 1
• ZAQJHHRNXZUBTE-UHFFFAOYSA-N D-threo-2-Pentulose Natural products OCC(O)C(O)C(=O)CO ZAQJHHRNXZUBTE-UHFFFAOYSA-N 0.000 description 1
• YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
• ZAQJHHRNXZUBTE-WUJLRWPWSA-N D-xylulose Chemical compound OC[C@@H](O)[C@H](O)C(=O)CO ZAQJHHRNXZUBTE-WUJLRWPWSA-N 0.000 description 1
• 230000004543 DNA replication Effects 0.000 description 1
• 108010092160 Dactinomycin Proteins 0.000 description 1
• 208000001154 Dermoid Cyst Diseases 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
• 206010058314 Dysplasia Diseases 0.000 description 1
• 208000000059 Dyspnea Diseases 0.000 description 1
• 206010013975 Dyspnoeas Diseases 0.000 description 1
• 229920005682 EO-PO block copolymer Polymers 0.000 description 1
• 201000009051 Embryonal Carcinoma Diseases 0.000 description 1
• 206010014561 Emphysema Diseases 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 201000008228 Ependymoblastoma Diseases 0.000 description 1
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
• 206010056474 Erythrosis Diseases 0.000 description 1
• 229920003149 Eudragit® E 100 Polymers 0.000 description 1
• 206010073306 Exposure to radiation Diseases 0.000 description 1
• 208000005163 Extra-Adrenal Paraganglioma Diseases 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 239000001828 Gelatine Substances 0.000 description 1
• 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
• 208000000527 Germinoma Diseases 0.000 description 1
• 201000005409 Gliomatosis cerebri Diseases 0.000 description 1
• 206010068601 Glioneuronal tumour Diseases 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 206010060980 Granular cell tumour Diseases 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 208000002927 Hamartoma Diseases 0.000 description 1
• 239000012981 Hank's balanced salt solution Substances 0.000 description 1
• 208000001258 Hemangiosarcoma Diseases 0.000 description 1
• 102000001554 Hemoglobins Human genes 0.000 description 1
• 108010054147 Hemoglobins Proteins 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000897441 Homo sapiens Cyclin-O Proteins 0.000 description 1
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
• 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
• 206010020843 Hyperthermia Diseases 0.000 description 1
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
• 206010053574 Immunoblastic lymphoma Diseases 0.000 description 1
• 208000026350 Inborn Genetic disease Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 description 1
• 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 description 1
• 102000006992 Interferon-alpha Human genes 0.000 description 1
• 108010047761 Interferon-alpha Proteins 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 description 1
• 206010073094 Intraductal proliferative breast lesion Diseases 0.000 description 1
• HSNZZMHEPUFJNZ-UHFFFAOYSA-N L-galacto-2-Heptulose Natural products OCC(O)C(O)C(O)C(O)C(=O)CO HSNZZMHEPUFJNZ-UHFFFAOYSA-N 0.000 description 1
• 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
• 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
• 208000018142 Leiomyosarcoma Diseases 0.000 description 1
• 201000004462 Leydig Cell Tumor Diseases 0.000 description 1
• 208000022010 Lhermitte-Duclos disease Diseases 0.000 description 1
• 239000000232 Lipid Bilayer Substances 0.000 description 1
• 206010073099 Lobular breast carcinoma in situ Diseases 0.000 description 1
• GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 1
• 208000019693 Lung disease Diseases 0.000 description 1
• 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 description 1
• JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
• 235000019759 Maize starch Nutrition 0.000 description 1
• 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 description 1
• 229920002774 Maltodextrin Polymers 0.000 description 1
• 239000005913 Maltodextrin Substances 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 208000007054 Medullary Carcinoma Diseases 0.000 description 1
• 206010027193 Meningioma malignant Diseases 0.000 description 1
• 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 description 1
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
• 208000008846 Neurocytoma Diseases 0.000 description 1
• 208000009905 Neurofibromatoses Diseases 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 208000012247 Oligodendroglial tumor Diseases 0.000 description 1
• 240000007594 Oryza sativa Species 0.000 description 1
• 235000007164 Oryza sativa Nutrition 0.000 description 1
• 239000012661 PARP inhibitor Substances 0.000 description 1
• 238000013494 PH determination Methods 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 208000037064 Papilloma of choroid plexus Diseases 0.000 description 1
• 208000009608 Papillomavirus Infections Diseases 0.000 description 1
• 206010061332 Paraganglion neoplasm Diseases 0.000 description 1
• 208000037581 Persistent Infection Diseases 0.000 description 1
• 201000007286 Pilocytic astrocytoma Diseases 0.000 description 1
• 208000021308 Pituicytoma Diseases 0.000 description 1
• 201000005746 Pituitary adenoma Diseases 0.000 description 1
• 201000007552 Pituitary carcinoma Diseases 0.000 description 1
• 206010061538 Pituitary tumour benign Diseases 0.000 description 1
• 208000007720 Plasma Cell Granuloma Diseases 0.000 description 1
• 208000007452 Plasmacytoma Diseases 0.000 description 1
• 201000007288 Pleomorphic xanthoastrocytoma Diseases 0.000 description 1
• 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 description 1
• 229920001214 Polysorbate 60 Polymers 0.000 description 1
• 208000004550 Postoperative Pain Diseases 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 208000015128 Rathke cleft cyst Diseases 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• HAIWUXASLYEWLM-AZEWMMITSA-N Sedoheptulose Natural products OC[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@](O)(CO)O1 HAIWUXASLYEWLM-AZEWMMITSA-N 0.000 description 1
• 208000003274 Sertoli cell tumor Diseases 0.000 description 1
• 201000001880 Sexual dysfunction Diseases 0.000 description 1
• 206010041067 Small cell lung cancer Diseases 0.000 description 1
• 229920002125 Sokalan® Polymers 0.000 description 1
• 208000001662 Subependymal Glioma Diseases 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 229940123237 Taxane Drugs 0.000 description 1
• 206010043276 Teratoma Diseases 0.000 description 1
• 208000019502 Thymic epithelial neoplasm Diseases 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
• 108010050144 Triptorelin Pamoate Proteins 0.000 description 1
• 208000026911 Tuberous sclerosis complex Diseases 0.000 description 1
• 102000007537 Type II DNA Topoisomerases Human genes 0.000 description 1
• 108010046308 Type II DNA Topoisomerases Proteins 0.000 description 1
• 208000003443 Unconsciousness Diseases 0.000 description 1
• 206010046543 Urinary incontinence Diseases 0.000 description 1
• 239000004234 Yellow 2G Substances 0.000 description 1
• 108010023617 abarelix Proteins 0.000 description 1
• AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 description 1
• 229960002184 abarelix Drugs 0.000 description 1
• 210000000683 abdominal cavity Anatomy 0.000 description 1
• 206010000210 abortion Diseases 0.000 description 1
• 231100000176 abortion Toxicity 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 208000004064 acoustic neuroma Diseases 0.000 description 1
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 201000000452 adenoid squamous cell carcinoma Diseases 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 235000010419 agar Nutrition 0.000 description 1
• 229940040563 agaric acid Drugs 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 150000005215 alkyl ethers Chemical class 0.000 description 1
• 229940100198 alkylating agent Drugs 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
• SRBFZHDQGSBBOR-STGXQOJASA-N alpha-D-lyxopyranose Chemical compound O[C@@H]1CO[C@H](O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-STGXQOJASA-N 0.000 description 1
• HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 229960000473 altretamine Drugs 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 description 1
• 229960003437 aminoglutethimide Drugs 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 239000012491 analyte Substances 0.000 description 1
• 206010002224 anaplastic astrocytoma Diseases 0.000 description 1
• 208000014534 anaplastic ependymoma Diseases 0.000 description 1
• 229940030486 androgens Drugs 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 229960004977 anhydrous lactose Drugs 0.000 description 1
• 239000003945 anionic surfactant Substances 0.000 description 1
• RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical compound C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 description 1
• 229940045799 anthracyclines and related substance Drugs 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000003527 anti-angiogenesis Effects 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 239000000051 antiandrogen Substances 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 239000003146 anticoagulant agent Substances 0.000 description 1
• 229940127219 anticoagulant drug Drugs 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 238000011225 antiretroviral therapy Methods 0.000 description 1
• 210000000436 anus Anatomy 0.000 description 1
• 239000003125 aqueous solvent Substances 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• 201000005476 astroblastoma Diseases 0.000 description 1
• 210000001130 astrocyte Anatomy 0.000 description 1
• 229940090047 auto-injector Drugs 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 208000003373 basosquamous carcinoma Diseases 0.000 description 1
• 238000010923 batch production Methods 0.000 description 1
• 206010061004 benign soft tissue neoplasm Diseases 0.000 description 1
• 150000003936 benzamides Chemical class 0.000 description 1
• 229960000997 bicalutamide Drugs 0.000 description 1
• 238000009809 bilateral salpingo-oophorectomy Methods 0.000 description 1
• 230000002902 bimodal effect Effects 0.000 description 1
• 229960004395 bleomycin sulfate Drugs 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 210000002798 bone marrow cell Anatomy 0.000 description 1
• 238000010322 bone marrow transplantation Methods 0.000 description 1
• 210000003461 brachial plexus Anatomy 0.000 description 1
• 201000005389 breast carcinoma in situ Diseases 0.000 description 1
• 201000010983 breast ductal carcinoma Diseases 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 229960002092 busulfan Drugs 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 235000014121 butter Nutrition 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910001424 calcium ion Inorganic materials 0.000 description 1
• 230000036952 cancer formation Effects 0.000 description 1
• 208000035269 cancer or benign tumor Diseases 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 229920006317 cationic polymer Polymers 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 230000010307 cell transformation Effects 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 235000010980 cellulose Nutrition 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 201000010702 central neurocytoma Diseases 0.000 description 1
• 201000005862 cerebral primitive neuroectodermal tumor Diseases 0.000 description 1
• 235000013351 cheese Nutrition 0.000 description 1
• 238000001311 chemical methods and process Methods 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 238000011342 chemoimmunotherapy Methods 0.000 description 1
• 238000009104 chemotherapy regimen Methods 0.000 description 1
• 210000000038 chest Anatomy 0.000 description 1
• 239000007910 chewable tablet Substances 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• 229960001480 chlorozotocin Drugs 0.000 description 1
• 210000003161 choroid Anatomy 0.000 description 1
• 210000002987 choroid plexus Anatomy 0.000 description 1
• 230000005886 chromosome breakage Effects 0.000 description 1
• 208000007451 chronic bronchitis Diseases 0.000 description 1
• 210000004240 ciliary body Anatomy 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 229960002436 cladribine Drugs 0.000 description 1
• 208000013243 classic Kaposi sarcoma Diseases 0.000 description 1
• 208000009060 clear cell adenocarcinoma Diseases 0.000 description 1
• 238000003759 clinical diagnosis Methods 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 238000004891 communication Methods 0.000 description 1
• 229940125810 compound 20 Drugs 0.000 description 1
• 238000013329 compounding Methods 0.000 description 1
• 230000001010 compromised effect Effects 0.000 description 1
• 238000013170 computed tomography imaging Methods 0.000 description 1
• 235000008504 concentrate Nutrition 0.000 description 1
• 235000009508 confectionery Nutrition 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 239000003246 corticosteroid Substances 0.000 description 1
• 229960001334 corticosteroids Drugs 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 238000005336 cracking Methods 0.000 description 1
• 210000003792 cranial nerve Anatomy 0.000 description 1
• 238000009799 cystectomy Methods 0.000 description 1
• 239000000824 cytostatic agent Substances 0.000 description 1
• 230000001085 cytostatic effect Effects 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• 229960000640 dactinomycin Drugs 0.000 description 1
• 238000007405 data analysis Methods 0.000 description 1
• 229940124447 delivery agent Drugs 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 238000001739 density measurement Methods 0.000 description 1
• 208000030263 desmoplastic infantile astrocytoma Diseases 0.000 description 1
• 208000030229 desmoplastic infantile ganglioglioma Diseases 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
• 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 1
• 230000001079 digestive effect Effects 0.000 description 1
• 229940120503 dihydroxyacetone Drugs 0.000 description 1
• 239000012470 diluted sample Substances 0.000 description 1
• 238000007865 diluting Methods 0.000 description 1
• VZMQWZVOXMCQKY-UHFFFAOYSA-L dimagnesium;octadecanoate Chemical compound [Mg+2].[Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O VZMQWZVOXMCQKY-UHFFFAOYSA-L 0.000 description 1
• 229910001873 dinitrogen Inorganic materials 0.000 description 1
• SDIXRDNYIMOKSG-UHFFFAOYSA-L disodium methyl arsenate Chemical compound [Na+].[Na+].C[As]([O-])([O-])=O SDIXRDNYIMOKSG-UHFFFAOYSA-L 0.000 description 1
• 238000002224 dissection Methods 0.000 description 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 208000028715 ductal breast carcinoma in situ Diseases 0.000 description 1
• 201000007273 ductal carcinoma in situ Diseases 0.000 description 1
• 201000004428 dysembryoplastic neuroepithelial tumor Diseases 0.000 description 1
• 238000010894 electron beam technology Methods 0.000 description 1
• 208000014616 embryonal neoplasm Diseases 0.000 description 1
• 239000004487 encapsulated granule Substances 0.000 description 1
• 238000005538 encapsulation Methods 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 210000000750 endocrine system Anatomy 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 210000002322 enterochromaffin cell Anatomy 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 229960001904 epirubicin Drugs 0.000 description 1
• 230000009786 epithelial differentiation Effects 0.000 description 1
• 201000008564 epithelioid malignant peripheral nerve sheath tumor Diseases 0.000 description 1
• 208000032099 esthesioneuroblastoma Diseases 0.000 description 1
• FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
• 229960001842 estramustine Drugs 0.000 description 1
• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 150000002191 fatty alcohols Chemical class 0.000 description 1
• 239000010685 fatty oil Substances 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 239000013020 final formulation Substances 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 229960000390 fludarabine Drugs 0.000 description 1
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
• YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 description 1
• 229960001751 fluoxymesterone Drugs 0.000 description 1
• 229960002074 flutamide Drugs 0.000 description 1
• MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 238000012395 formulation development Methods 0.000 description 1
• 239000003205 fragrance Substances 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• 239000012520 frozen sample Substances 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 108010068906 gamma-glutamylcysteine Proteins 0.000 description 1
• 201000005649 gangliocytoma Diseases 0.000 description 1
• 201000008361 ganglioneuroma Diseases 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
• 229960002584 gefitinib Drugs 0.000 description 1
• 229960003297 gemtuzumab ozogamicin Drugs 0.000 description 1
• 229940020967 gemzar Drugs 0.000 description 1
• 208000016361 genetic disease Diseases 0.000 description 1
• 210000004392 genitalia Anatomy 0.000 description 1
• 210000004602 germ cell Anatomy 0.000 description 1
• 201000003115 germ cell cancer Diseases 0.000 description 1
• 210000004907 gland Anatomy 0.000 description 1
• 230000002518 glial effect Effects 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 230000002710 gonadal effect Effects 0.000 description 1
• 239000002474 gonadorelin antagonist Substances 0.000 description 1
• 239000002434 gonadorelin derivative Substances 0.000 description 1
• 208000030316 grade III meningioma Diseases 0.000 description 1
• 201000006604 granular cell tumor Diseases 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 208000017750 granulocytic sarcoma Diseases 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 150000004820 halides Chemical class 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 231100000206 health hazard Toxicity 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 201000005787 hematologic cancer Diseases 0.000 description 1
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
• 230000002607 hemopoietic effect Effects 0.000 description 1
• 230000002440 hepatic effect Effects 0.000 description 1
• 150000002386 heptoses Chemical class 0.000 description 1
• UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 description 1
• 150000002402 hexoses Chemical class 0.000 description 1
• 230000002962 histologic effect Effects 0.000 description 1
• 108700020746 histrelin Proteins 0.000 description 1
• 229960002193 histrelin Drugs 0.000 description 1
• HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 description 1
• 230000036571 hydration Effects 0.000 description 1
• 238000006703 hydration reaction Methods 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
• 230000036031 hyperthermia Effects 0.000 description 1
• 239000000819 hypertonic solution Substances 0.000 description 1
• 229940021223 hypertonic solution Drugs 0.000 description 1
• 230000002267 hypothalamic effect Effects 0.000 description 1
• 238000009802 hysterectomy Methods 0.000 description 1
• 235000015243 ice cream Nutrition 0.000 description 1
• 150000002454 idoses Chemical class 0.000 description 1
• 229940090411 ifex Drugs 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 229960003444 immunosuppressant agent Drugs 0.000 description 1
• 239000003018 immunosuppressive agent Substances 0.000 description 1
• 201000001881 impotence Diseases 0.000 description 1
• 201000004933 in situ carcinoma Diseases 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 201000004653 inflammatory breast carcinoma Diseases 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 150000007529 inorganic bases Chemical class 0.000 description 1
• 229910001410 inorganic ion Inorganic materials 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 238000002721 intensity-modulated radiation therapy Methods 0.000 description 1
• 229940047124 interferons Drugs 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 239000007927 intramuscular injection Substances 0.000 description 1
• 238000010255 intramuscular injection Methods 0.000 description 1
• 229910052740 iodine Inorganic materials 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 210000004731 jugular vein Anatomy 0.000 description 1
• 206010023332 keratitis Diseases 0.000 description 1
• BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 238000009533 lab test Methods 0.000 description 1
• 239000004922 lacquer Substances 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 231100000518 lethal Toxicity 0.000 description 1
• 230000001665 lethal effect Effects 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 239000012669 liquid formulation Substances 0.000 description 1
• 229940057995 liquid paraffin Drugs 0.000 description 1
• 238000000622 liquid--liquid extraction Methods 0.000 description 1
• 201000011059 lobular neoplasia Diseases 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 238000009593 lumbar puncture Methods 0.000 description 1
• 230000001926 lymphatic effect Effects 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 229910001425 magnesium ion Inorganic materials 0.000 description 1
• 238000002595 magnetic resonance imaging Methods 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 235000011090 malic acid Nutrition 0.000 description 1
• 208000030883 malignant astrocytoma Diseases 0.000 description 1
• 206010061526 malignant mesenchymoma Diseases 0.000 description 1
• 201000001117 malignant triton tumor Diseases 0.000 description 1
• 229940035034 maltodextrin Drugs 0.000 description 1
• 238000007726 management method Methods 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• 201000008203 medulloepithelioma Diseases 0.000 description 1
• 229960004296 megestrol acetate Drugs 0.000 description 1
• RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
• 230000000684 melanotic effect Effects 0.000 description 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
• 229960001924 melphalan Drugs 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 229960001428 mercaptopurine Drugs 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 238000013508 migration Methods 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 238000003801 milling Methods 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 208000024252 mixed germ cell tumor Diseases 0.000 description 1
• 201000004058 mixed glioma Diseases 0.000 description 1
• 208000014490 mixed neuronal-glial tumor Diseases 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 201000010879 mucinous adenocarcinoma Diseases 0.000 description 1
• 210000004400 mucous membrane Anatomy 0.000 description 1
• 201000005987 myeloid sarcoma Diseases 0.000 description 1
• 201000004057 myxopapillary ependymoma Diseases 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 208000023833 nerve sheath neoplasm Diseases 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 201000004931 neurofibromatosis Diseases 0.000 description 1
• 238000010984 neurological examination Methods 0.000 description 1
• 210000002569 neuron Anatomy 0.000 description 1
• 229960002653 nilutamide Drugs 0.000 description 1
• XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• 239000012740 non-selective inhibitor Substances 0.000 description 1
• 210000004882 non-tumor cell Anatomy 0.000 description 1
• 210000001331 nose Anatomy 0.000 description 1
• 230000035764 nutrition Effects 0.000 description 1
• 235000016709 nutrition Nutrition 0.000 description 1
• 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 201000008859 olfactory neuroblastoma Diseases 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 238000009806 oophorectomy Methods 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000007530 organic bases Chemical class 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 239000003791 organic solvent mixture Substances 0.000 description 1
• 238000013495 osmolality determination method Methods 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 229960001756 oxaliplatin Drugs 0.000 description 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 238000012856 packing Methods 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 201000005163 papillary serous adenocarcinoma Diseases 0.000 description 1
• 208000024641 papillary serous cystadenocarcinoma Diseases 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
• 150000002972 pentoses Chemical class 0.000 description 1
• 230000009984 peri-natal effect Effects 0.000 description 1
• 208000029255 peripheral nervous system cancer Diseases 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 230000001766 physiological effect Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 208000011866 pituitary adenocarcinoma Diseases 0.000 description 1
• 208000021310 pituitary gland adenoma Diseases 0.000 description 1
• 239000004014 plasticizer Substances 0.000 description 1
• 229940063179 platinol Drugs 0.000 description 1
• 229920000193 polymethacrylate Polymers 0.000 description 1
• 229940068965 polysorbates Drugs 0.000 description 1
• 238000002600 positron emission tomography Methods 0.000 description 1
• 231100000683 possible toxicity Toxicity 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910001414 potassium ion Inorganic materials 0.000 description 1
• 239000008057 potassium phosphate buffer Substances 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 230000036515 potency Effects 0.000 description 1
• 208000030266 primary brain neoplasm Diseases 0.000 description 1
• CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
• 229960000624 procarbazine Drugs 0.000 description 1
• 230000002250 progressing effect Effects 0.000 description 1
• 208000023958 prostate neoplasm Diseases 0.000 description 1
• 238000011471 prostatectomy Methods 0.000 description 1
• 208000013368 pseudoglandular squamous cell carcinoma Diseases 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 238000009801 radical cystectomy Methods 0.000 description 1
• 238000011472 radical prostatectomy Methods 0.000 description 1
• 238000011473 radical retropubic prostatectomy Methods 0.000 description 1
• 238000009790 rate-determining step (RDS) Methods 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 239000013558 reference substance Substances 0.000 description 1
• 230000008929 regeneration Effects 0.000 description 1
• 238000011069 regeneration method Methods 0.000 description 1
• 208000015347 renal cell adenocarcinoma Diseases 0.000 description 1
• 201000008933 retinal cancer Diseases 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 229940100486 rice starch Drugs 0.000 description 1
• 235000014438 salad dressings Nutrition 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 239000011555 saturated liquid Substances 0.000 description 1
• 210000003497 sciatic nerve Anatomy 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 239000013049 sediment Substances 0.000 description 1
• 238000004062 sedimentation Methods 0.000 description 1
• HSNZZMHEPUFJNZ-SHUUEZRQSA-N sedoheptulose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO HSNZZMHEPUFJNZ-SHUUEZRQSA-N 0.000 description 1
• 210000000582 semen Anatomy 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 230000001953 sensory effect Effects 0.000 description 1
• 210000000413 sensory ganglia Anatomy 0.000 description 1
• 231100000872 sexual dysfunction Toxicity 0.000 description 1
• 208000013220 shortness of breath Diseases 0.000 description 1
• 239000002002 slurry Substances 0.000 description 1
• 208000000649 small cell carcinoma Diseases 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 230000000391 smoking effect Effects 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 235000010413 sodium alginate Nutrition 0.000 description 1
• 239000000661 sodium alginate Substances 0.000 description 1
• 229940005550 sodium alginate Drugs 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 229940057950 sodium laureth sulfate Drugs 0.000 description 1
• SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
• 239000007901 soft capsule Substances 0.000 description 1
• 239000012439 solid excipient Substances 0.000 description 1
• 230000007928 solubilization Effects 0.000 description 1
• 238000005063 solubilization Methods 0.000 description 1
• 230000003381 solubilizing effect Effects 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1
• 206010062261 spinal cord neoplasm Diseases 0.000 description 1
• 210000001032 spinal nerve Anatomy 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 229910001220 stainless steel Inorganic materials 0.000 description 1
• 239000010935 stainless steel Substances 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 208000002254 stillbirth Diseases 0.000 description 1
• 231100000537 stillbirth Toxicity 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 229960001052 streptozocin Drugs 0.000 description 1
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
• 208000028210 stromal sarcoma Diseases 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 201000004059 subependymal giant cell astrocytoma Diseases 0.000 description 1
• 208000030819 subependymoma Diseases 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000003319 supportive effect Effects 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 238000004885 tandem mass spectrometry Methods 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
• 150000003538 tetroses Chemical class 0.000 description 1
• 229920001169 thermoplastic Polymers 0.000 description 1
• 239000004416 thermosoftening plastic Substances 0.000 description 1
• 210000000211 third ventricle Anatomy 0.000 description 1
• 210000004367 thymic lymphocyte Anatomy 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 230000025366 tissue development Effects 0.000 description 1
• 239000004408 titanium dioxide Substances 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 229960000303 topotecan Drugs 0.000 description 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
• 238000009804 total hysterectomy Methods 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 230000037317 transdermal delivery Effects 0.000 description 1
• 239000012976 trial formulation Substances 0.000 description 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
• 210000003901 trigeminal nerve Anatomy 0.000 description 1
• 125000005457 triglyceride group Chemical group 0.000 description 1
• 150000003641 trioses Chemical class 0.000 description 1
• 229960004824 triptorelin Drugs 0.000 description 1
• VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
• UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
• GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
• 201000008827 tuberculosis Diseases 0.000 description 1
• 208000009999 tuberous sclerosis Diseases 0.000 description 1
• 210000005239 tubule Anatomy 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 201000009542 type C thymoma Diseases 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 210000003708 urethra Anatomy 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 238000002255 vaccination Methods 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
• 229960004982 vinblastine sulfate Drugs 0.000 description 1
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
• 229960002066 vinorelbine Drugs 0.000 description 1
• 210000001835 viscera Anatomy 0.000 description 1
• 235000012431 wafers Nutrition 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 229940100445 wheat starch Drugs 0.000 description 1
• RITKHVBHSGLULN-CRCLSJGQSA-N γ-glutamylcysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](CS)C(O)=O RITKHVBHSGLULN-CRCLSJGQSA-N 0.000 description 1