CO6220840A2 - Formulaciones para el tratamiento de cancer - Google Patents

Formulaciones para el tratamiento de cancer

Info

Publication number
CO6220840A2
CO6220840A2 CO09085583A CO09085583A CO6220840A2 CO 6220840 A2 CO6220840 A2 CO 6220840A2 CO 09085583 A CO09085583 A CO 09085583A CO 09085583 A CO09085583 A CO 09085583A CO 6220840 A2 CO6220840 A2 CO 6220840A2
Authority
CO
Colombia
Prior art keywords
solubility
compound
pharmaceutical composition
formula
pure water
Prior art date
Application number
CO09085583A
Other languages
English (en)
Inventor
Valeria Ossovskaya
Lingyun Li
Barry Sherman
Original Assignee
Bipar Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39350967&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6220840(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bipar Sciences Inc filed Critical Bipar Sciences Inc
Publication of CO6220840A2 publication Critical patent/CO6220840A2/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención proporciona composiciones, kits y métodos para uso en el tratamiento de cánceres y afecciones víricas. En particular, la invención proporciona composiciones farmacéuticas que contienen compuestos de nitrobenzamida que tienen mayor solubilidad en soluciones acuosas. 1.- Una composición farmacéutica que comprende un compuesto de fórmula (la)en la que R1, R2, R3, R4 y R5 se seleccionan independientemente entre el grupo que consiste en hidrógeno, hidroxi, amino, nitro, yodo, bromo, flúor, cloro, alquilo (C1-C6), alcoxi (C1-C6), cicloalquilo (C3-C7) y fenilo, donde al menos dos de los cinco sustituyentes R1, R2, R3, R4 y R5 son siempre hidrógeno, al menos uno de los cinco sustituyentes es siempre nitro, y al menos un sustituyente situado adyacente a un nitro es siempre yodo, y sales farmacéuticamente aceptables, solvatos, isómeros, tautómeros, metabolitos, análogos o profármacos del mismo, y al menos un solubilizante farmacéuticamente aceptable. 2.- La composición farmacéutica de la reivindicación 1, donde el solubilizante comprende una ciclodextrina, un tensioactivo, un codisolvente o mezclas de dos o más de los mismos. 3.- La composición farmacéutica de la reivindicación 1, donde la solubilidad del compuesto de fórmula la es al menos aproximadamente 1,5 veces a solubilidad del compuesto en agua pura. 4.- La composición farmacéutica de la reivindicación 1, donde la solubilidad del compuesto de fórmula la es al menos aproximadamente 2 veces la solubilidad del compuesto en agua pura. 5.- La composición farmacéutica de la reivindicación 1, donde la solubilidad del compuesto de fórmula la es al menos aproximadamente 5 veces la solubilidad del compuesto en agua pura. 6.- La composición farmacéutica de la reivindicación 1, donde la solubilidad del compuesto de fórmula la es al menos aproximadamente 10 veces la solubilidad del compuesto en agua pura. 7.- La composición farmacéutica de la reivindicación 1, donde la solubilidad del compuesto de fórmula la es al menos aproximadamente 50 veces la solubilidad del compuesto en agua pura.
CO09085583A 2007-01-16 2009-08-14 Formulaciones para el tratamiento de cancer CO6220840A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88075507P 2007-01-16 2007-01-16

Publications (1)

Publication Number Publication Date
CO6220840A2 true CO6220840A2 (es) 2010-11-19

Family

ID=39350967

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09085583A CO6220840A2 (es) 2007-01-16 2009-08-14 Formulaciones para el tratamiento de cancer

Country Status (33)

Country Link
US (1) US20080176946A1 (es)
EP (2) EP2121139B1 (es)
JP (1) JP2010516626A (es)
KR (1) KR20090113852A (es)
CN (1) CN101668561A (es)
AU (1) AU2008206294A1 (es)
BR (1) BRPI0806590A2 (es)
CA (1) CA2674600A1 (es)
CO (1) CO6220840A2 (es)
CR (1) CR10975A (es)
CY (1) CY1113819T1 (es)
DK (1) DK2121139T3 (es)
DO (1) DOP2009000178A (es)
EC (1) ECSP099577A (es)
ES (1) ES2395690T3 (es)
GB (1) GB2447796C (es)
GT (1) GT200900201A (es)
HK (2) HK1121697A1 (es)
HR (1) HRP20120960T1 (es)
IL (1) IL199682A0 (es)
MA (1) MA34559B1 (es)
MX (1) MX2009007596A (es)
NZ (1) NZ579098A (es)
PL (1) PL2121139T3 (es)
PT (1) PT2121139E (es)
RS (1) RS52633B (es)
RU (2) RU2481830C2 (es)
SG (1) SG178714A1 (es)
SI (1) SI2121139T1 (es)
SV (1) SV2009003335A (es)
TN (1) TN2009000292A1 (es)
UA (1) UA100852C2 (es)
WO (1) WO2008089272A1 (es)

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Also Published As

Publication number Publication date
CA2674600A1 (en) 2008-07-24
JP2010516626A (ja) 2010-05-20
HK1121697A1 (en) 2009-04-30
SV2009003335A (es) 2010-02-05
RS52633B (en) 2013-06-28
UA100852C2 (ru) 2013-02-11
GB2447796C (en) 2009-11-12
SI2121139T1 (sl) 2013-01-31
NZ579098A (en) 2012-07-27
PT2121139E (pt) 2012-12-12
AU2008206294A1 (en) 2008-07-24
RU2009130599A (ru) 2011-02-27
EP2121139B1 (en) 2012-10-10
GB2447796B (en) 2009-03-04
TN2009000292A1 (en) 2010-12-31
HK1137158A1 (en) 2010-07-23
GB2447796A (en) 2008-09-24
RU2012151571A (ru) 2014-06-10
DK2121139T3 (da) 2013-01-14
DOP2009000178A (es) 2009-10-31
CR10975A (es) 2009-10-15
EP2476461A2 (en) 2012-07-18
WO2008089272A1 (en) 2008-07-24
CY1113819T1 (el) 2016-07-27
MX2009007596A (es) 2009-08-13
CN101668561A (zh) 2010-03-10
HRP20120960T1 (hr) 2012-12-31
KR20090113852A (ko) 2009-11-02
ECSP099577A (es) 2009-10-30
IL199682A0 (en) 2010-04-15
GT200900201A (es) 2011-06-23
GB0807263D0 (en) 2008-05-28
EP2121139A1 (en) 2009-11-25
RU2481830C2 (ru) 2013-05-20
US20080176946A1 (en) 2008-07-24
SG178714A1 (en) 2012-03-29
ES2395690T3 (es) 2013-02-14
PL2121139T3 (pl) 2013-03-29
EP2476461A3 (en) 2012-10-24
BRPI0806590A2 (pt) 2013-07-23
MA34559B1 (fr) 2013-10-02

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