NZ571251A - Renin inhibitors such as aliskiren for the treatment of rebound hypertension - Google Patents
Renin inhibitors such as aliskiren for the treatment of rebound hypertensionInfo
- Publication number
- NZ571251A NZ571251A NZ571251A NZ57125107A NZ571251A NZ 571251 A NZ571251 A NZ 571251A NZ 571251 A NZ571251 A NZ 571251A NZ 57125107 A NZ57125107 A NZ 57125107A NZ 571251 A NZ571251 A NZ 571251A
- Authority
- NZ
- New Zealand
- Prior art keywords
- medicament
- time period
- weeks
- discontinuation
- hypertension
- Prior art date
Links
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- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006735 epoxidation reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
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- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
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- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000010514 hydrogenated cottonseed oil Substances 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
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- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
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- 230000001631 hypertensive effect Effects 0.000 description 1
- 201000001948 hypertensive retinopathy Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
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- 238000011835 investigation Methods 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
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- 125000003729 nucleotide group Chemical group 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 150000002917 oxazolidines Chemical class 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
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- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
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- 210000002381 plasma Anatomy 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000009862 primary prevention Effects 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
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- 210000002254 renal artery Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000009863 secondary prevention Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940071138 stearyl fumarate Drugs 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- UZQBKCWYZBHBOW-YIPNQBBMSA-N terlakiren Chemical compound C([C@@H](C(=O)N[C@@H](CSC)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)OC(C)C)NC(=O)N1CCOCC1)C1=CC=CC=C1 UZQBKCWYZBHBOW-YIPNQBBMSA-N 0.000 description 1
- 229950003204 terlakiren Drugs 0.000 description 1
- 108010069247 terlakiren Proteins 0.000 description 1
- SASWSEQJAITMKS-JJNNLWIXSA-N tert-butyl (2s)-2-[[(2s)-1-[[(2s)-1-[[(4s,5s,7s)-5-hydroxy-2,8-dimethyl-7-[[(2s,3s)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]p Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC=1N=CC=CC=1)C(C)C)N(C)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)OC(C)(C)C)C1=CN=CN1 SASWSEQJAITMKS-JJNNLWIXSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 230000001732 thrombotic effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
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- 229940100445 wheat starch Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78884206P | 2006-04-03 | 2006-04-03 | |
| PCT/US2007/065564 WO2007118023A1 (en) | 2006-04-03 | 2007-03-30 | Renin inhibitors for the treatment of hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ571251A true NZ571251A (en) | 2011-12-22 |
Family
ID=38420678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ571251A NZ571251A (en) | 2006-04-03 | 2007-03-30 | Renin inhibitors such as aliskiren for the treatment of rebound hypertension |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20090062395A1 (enExample) |
| EP (1) | EP2004167A1 (enExample) |
| JP (1) | JP2009532494A (enExample) |
| KR (1) | KR20080108515A (enExample) |
| CN (1) | CN101415413A (enExample) |
| AU (1) | AU2007234917B2 (enExample) |
| BR (1) | BRPI0710095A2 (enExample) |
| CA (1) | CA2645260A1 (enExample) |
| CL (1) | CL2007000912A1 (enExample) |
| IL (1) | IL193905A0 (enExample) |
| MA (1) | MA30387B1 (enExample) |
| MX (1) | MX2008012729A (enExample) |
| NO (1) | NO20084625L (enExample) |
| NZ (1) | NZ571251A (enExample) |
| RU (1) | RU2008143055A (enExample) |
| SG (1) | SG170830A1 (enExample) |
| TN (1) | TNSN08383A1 (enExample) |
| TW (1) | TW200806283A (enExample) |
| WO (1) | WO2007118023A1 (enExample) |
| ZA (1) | ZA200807615B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009087116A1 (en) * | 2008-01-11 | 2009-07-16 | Novartis Ag | Use of spp100 for the treatment of acute mi |
| CN102212012A (zh) * | 2010-04-12 | 2011-10-12 | 上海源力生物技术有限公司 | 一种合成阿利克伦的中间体及其制备方法 |
| US20140248284A1 (en) | 2011-10-20 | 2014-09-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the detection and the treatment of cardiac remodeling |
| CN114072205A (zh) * | 2019-04-18 | 2022-02-18 | 视点制药公司 | 用tie-2激活剂治疗高血压的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5659065A (en) * | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US5606078A (en) * | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
| US20060013852A1 (en) * | 2002-06-28 | 2006-01-19 | Prescott Margaret F | Use of organic compounds |
| US20040266743A1 (en) * | 2003-05-09 | 2004-12-30 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and a renin inhibitor |
| US20050209141A1 (en) * | 2003-10-17 | 2005-09-22 | Silver Randi B | Mast cell-derived renin |
| PE20142101A1 (es) * | 2004-03-17 | 2014-12-27 | Novartis Ag | Composiciones farmaceuticas de aliskiren |
| WO2006036054A1 (en) * | 2004-09-27 | 2006-04-06 | Pantarhei Bioscience B.V. | Treatment of prevention of unscheduled bleeding in women on progestogen containing medication |
-
2007
- 2007-03-30 SG SG201102387-6A patent/SG170830A1/en unknown
- 2007-03-30 KR KR1020087024219A patent/KR20080108515A/ko not_active Withdrawn
- 2007-03-30 AU AU2007234917A patent/AU2007234917B2/en not_active Ceased
- 2007-03-30 CN CNA2007800124642A patent/CN101415413A/zh active Pending
- 2007-03-30 BR BRPI0710095-7A patent/BRPI0710095A2/pt not_active IP Right Cessation
- 2007-03-30 CA CA002645260A patent/CA2645260A1/en not_active Abandoned
- 2007-03-30 MX MX2008012729A patent/MX2008012729A/es not_active Application Discontinuation
- 2007-03-30 EP EP07759755A patent/EP2004167A1/en not_active Withdrawn
- 2007-03-30 WO PCT/US2007/065564 patent/WO2007118023A1/en not_active Ceased
- 2007-03-30 NZ NZ571251A patent/NZ571251A/en not_active IP Right Cessation
- 2007-03-30 RU RU2008143055/14A patent/RU2008143055A/ru unknown
- 2007-03-30 US US12/293,107 patent/US20090062395A1/en not_active Abandoned
- 2007-03-30 JP JP2009504386A patent/JP2009532494A/ja active Pending
- 2007-04-02 CL CL200700912A patent/CL2007000912A1/es unknown
- 2007-04-02 TW TW096111640A patent/TW200806283A/zh unknown
-
2008
- 2008-09-04 ZA ZA200807615A patent/ZA200807615B/xx unknown
- 2008-09-04 IL IL193905A patent/IL193905A0/en unknown
- 2008-09-26 TN TNP2008000383A patent/TNSN08383A1/en unknown
- 2008-10-23 MA MA31327A patent/MA30387B1/fr unknown
- 2008-11-03 NO NO20084625A patent/NO20084625L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2645260A1 (en) | 2007-10-18 |
| CN101415413A (zh) | 2009-04-22 |
| CL2007000912A1 (es) | 2008-03-14 |
| MX2008012729A (es) | 2008-10-14 |
| ZA200807615B (en) | 2009-10-28 |
| IL193905A0 (en) | 2009-08-03 |
| KR20080108515A (ko) | 2008-12-15 |
| JP2009532494A (ja) | 2009-09-10 |
| AU2007234917A1 (en) | 2007-10-18 |
| WO2007118023A1 (en) | 2007-10-18 |
| TW200806283A (en) | 2008-02-01 |
| NO20084625L (no) | 2008-11-03 |
| TNSN08383A1 (en) | 2009-12-29 |
| MA30387B1 (fr) | 2009-05-04 |
| US20090062395A1 (en) | 2009-03-05 |
| SG170830A1 (en) | 2011-05-30 |
| BRPI0710095A2 (pt) | 2011-08-02 |
| AU2007234917B2 (en) | 2011-05-12 |
| EP2004167A1 (en) | 2008-12-24 |
| RU2008143055A (ru) | 2010-05-10 |
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