NZ564129A - Phosphopeptide or phosphoprotein stabilised amorphous calcium complexes - Google Patents
Phosphopeptide or phosphoprotein stabilised amorphous calcium complexesInfo
- Publication number
- NZ564129A NZ564129A NZ564129A NZ56412906A NZ564129A NZ 564129 A NZ564129 A NZ 564129A NZ 564129 A NZ564129 A NZ 564129A NZ 56412906 A NZ56412906 A NZ 56412906A NZ 564129 A NZ564129 A NZ 564129A
- Authority
- NZ
- New Zealand
- Prior art keywords
- calcium
- phosphate
- acp
- complex
- dental
- Prior art date
Links
- 102000007982 Phosphoproteins Human genes 0.000 title claims abstract description 75
- 108010089430 Phosphoproteins Proteins 0.000 title claims abstract description 75
- 108010001441 Phosphopeptides Proteins 0.000 title claims abstract description 36
- 150000001669 calcium Chemical class 0.000 title 1
- 239000011575 calcium Substances 0.000 claims abstract description 58
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 54
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 54
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 51
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 50
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 48
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 47
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 26
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 22
- 208000002925 dental caries Diseases 0.000 claims abstract description 21
- GUYBGCBOZOALMT-UHFFFAOYSA-J dicalcium;fluoride;phosphate Chemical compound [F-].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O GUYBGCBOZOALMT-UHFFFAOYSA-J 0.000 claims abstract description 21
- 206010020751 Hypersensitivity Diseases 0.000 claims abstract description 12
- 208000026935 allergic disease Diseases 0.000 claims abstract description 12
- 230000007797 corrosion Effects 0.000 claims abstract description 11
- 238000005260 corrosion Methods 0.000 claims abstract description 11
- 230000009610 hypersensitivity Effects 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- 208000006558 Dental Calculus Diseases 0.000 claims abstract description 10
- 206010044029 Tooth deposit Diseases 0.000 claims abstract description 10
- 230000003628 erosive effect Effects 0.000 claims abstract description 10
- 230000000395 remineralizing effect Effects 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 85
- 238000009472 formulation Methods 0.000 claims description 27
- 239000005018 casein Substances 0.000 claims description 24
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 21
- 235000021240 caseins Nutrition 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 17
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- 210000000214 mouth Anatomy 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 3
- 239000000758 substrate Substances 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 description 45
- 239000000463 material Substances 0.000 description 33
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 210000003298 dental enamel Anatomy 0.000 description 22
- 239000000606 toothpaste Substances 0.000 description 22
- 108010076119 Caseins Proteins 0.000 description 21
- 102000011632 Caseins Human genes 0.000 description 21
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 19
- 230000003902 lesion Effects 0.000 description 18
- -1 phosphoseryl residue Chemical group 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
- 238000002360 preparation method Methods 0.000 description 17
- 239000000243 solution Substances 0.000 description 17
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 16
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- 239000002253 acid Substances 0.000 description 13
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- 229910019142 PO4 Inorganic materials 0.000 description 9
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- 239000010452 phosphate Substances 0.000 description 9
- 235000021317 phosphate Nutrition 0.000 description 9
- 238000005498 polishing Methods 0.000 description 9
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 9
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 8
- 229940091249 fluoride supplement Drugs 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
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- 229960004711 sodium monofluorophosphate Drugs 0.000 description 8
- 239000004141 Sodium laurylsulphate Substances 0.000 description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 7
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- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
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- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 6
- 210000000988 bone and bone Anatomy 0.000 description 5
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- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 241000283725 Bos Species 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 230000009471 action Effects 0.000 description 4
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- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 4
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 4
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
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- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
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- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 3
- 241000206575 Chondrus crispus Species 0.000 description 3
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- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 239000004411 aluminium Substances 0.000 description 3
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000008119 colloidal silica Substances 0.000 description 3
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- 238000005115 demineralization Methods 0.000 description 3
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- 229950006137 dexfosfoserine Drugs 0.000 description 3
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- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
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- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 3
- 239000003178 glass ionomer cement Substances 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 3
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- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
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- AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical group [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69401905P | 2005-06-24 | 2005-06-24 | |
| PCT/AU2006/000885 WO2006135982A1 (en) | 2005-06-24 | 2006-06-23 | Ionic complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ564129A true NZ564129A (en) | 2010-02-26 |
Family
ID=37570039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ564129A NZ564129A (en) | 2005-06-24 | 2006-06-23 | Phosphopeptide or phosphoprotein stabilised amorphous calcium complexes |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8603988B2 (enExample) |
| EP (1) | EP1901702B1 (enExample) |
| JP (2) | JP2008543887A (enExample) |
| CN (1) | CN101208070B (enExample) |
| AR (1) | AR057402A1 (enExample) |
| AU (1) | AU2006261597B2 (enExample) |
| BR (1) | BRPI0611976B1 (enExample) |
| CA (1) | CA2612172C (enExample) |
| ES (1) | ES2530396T3 (enExample) |
| MX (1) | MX2007016312A (enExample) |
| NZ (1) | NZ564129A (enExample) |
| PL (1) | PL1901702T3 (enExample) |
| RU (1) | RU2413497C2 (enExample) |
| WO (1) | WO2006135982A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8609071B2 (en) | 2004-11-25 | 2013-12-17 | The University Of Melbourne | Stabilized calcium phosphate complexes |
| ES2530396T3 (es) * | 2005-06-24 | 2015-03-02 | Univ Melbourne | Complejos iónicos |
| PL2705826T3 (pl) | 2006-02-09 | 2020-11-02 | The University Of Melbourne | Kompozycja fluorku i sposoby mineralizacji zębów |
| AU2007235359B2 (en) | 2006-04-05 | 2011-03-10 | Intercontinental Great Brands Llc | Calcium phosphate complex and salts in oral delivery systems |
| AU2007235269B2 (en) * | 2006-04-05 | 2011-02-10 | Intercontinental Great Brands Llc | Impact of calcium phosphate complex on dental caries |
| JP2009532065A (ja) * | 2006-04-05 | 2009-09-10 | キャドバリー アダムス ユーエスエー エルエルシー | 酸含有チューインガム中のリン酸カルシウム錯体 |
| US9061076B2 (en) | 2007-05-25 | 2015-06-23 | North Carolina State University | Viral nanoparticle cell-targeted delivery platform |
| DE102008014225A1 (de) * | 2008-03-16 | 2009-09-17 | MEDERER Süßwarenvertriebs GmbH | Remineralisierende Zahnpflegemittel und Verfahren zu deren Herstellung |
| DE102008014227A1 (de) * | 2008-03-16 | 2009-10-01 | Nova Dentalia Zahnpflege Gmbh | Remineralisierende Speichelersatzmittel und Verfahren zu deren Herstellung |
| JP2010047494A (ja) * | 2008-08-20 | 2010-03-04 | Gc Corp | 歯牙塗布用組成物 |
| US8951505B2 (en) | 2008-10-08 | 2015-02-10 | Georgia Health Sciences University Rsearch Institute, Inc. | Methods and systems for mineralization of demineralized tissue |
| GB0908433D0 (en) * | 2009-05-15 | 2009-06-24 | Glaxo Group Ltd | Movel composition |
| EP2561878B1 (en) * | 2010-03-31 | 2018-03-07 | Toyo Suisan Kaisha, Ltd. | Calcium preparation and production method therefor |
| CA2808538A1 (en) * | 2010-08-24 | 2012-03-01 | Safewhite Llc | Methods and materials for providing teeth with a white appearance |
| US9107838B2 (en) | 2012-04-25 | 2015-08-18 | Therametrics Technologies, Inc. | Fluoride varnish |
| EA034376B1 (ru) * | 2013-07-05 | 2020-01-31 | Интегра Медикал Инк. | Композиции для оздоровления полости рта |
| WO2015010166A1 (en) | 2013-07-23 | 2015-01-29 | The University Of Melbourne | Compositions and methods for dental mineralization |
| WO2015095932A1 (en) | 2013-12-24 | 2015-07-02 | The University Of Melbourne | Stabilized stannous compositions |
| JP2016102069A (ja) * | 2014-11-27 | 2016-06-02 | 株式会社ジーシー | 歯面清掃方法、歯面清掃用組成物、及びその使用方法 |
| US20180008518A1 (en) * | 2014-12-24 | 2018-01-11 | The University Of Melbourne | Mineralization fluoride compositions |
| ES2971113T3 (es) | 2016-05-26 | 2024-06-03 | Solventum Intellectual Properties Company | Pastas dentales terapéuticas y su aplicación |
| CN107811872B (zh) * | 2016-09-13 | 2020-09-15 | 北京大学 | 一种快速牙釉质矿化的方法 |
| US12109284B2 (en) | 2016-11-08 | 2024-10-08 | Dentherapy Ltd | Compositions comprising fluoride and calcium and method for preparing them |
| KR101772449B1 (ko) | 2016-12-27 | 2017-08-30 | 주식회사 하이센스바이오 | 신규한 펩타이드 |
| BR112019018871A2 (pt) | 2017-03-14 | 2020-04-14 | Univ Melbourne | complexos para tratar sensibilidade |
| CA3055091A1 (en) | 2017-03-14 | 2018-09-20 | The University Of Melbourne | Treatment for gingivitis |
| CN108524290A (zh) * | 2018-06-28 | 2018-09-14 | 吉林省登泰克牙科材料有限公司 | 牙科预防龋齿组合物及其制备方法 |
| KR102674595B1 (ko) * | 2019-05-27 | 2024-06-11 | 가부시키가이샤 지씨 | 치과용 키트 및 우식 예방 방법 |
| WO2021001529A1 (de) | 2019-07-04 | 2021-01-07 | Ferton Holding S.A. | Zusammensetzung zur remineralisierung von zähnen |
| US11529295B2 (en) * | 2019-09-25 | 2022-12-20 | Church & Dwight Co., Inc. | Oral care composition |
| CN111715408B (zh) * | 2020-06-30 | 2021-07-02 | 中南大学 | 一种用于浮选白钨矿中萤石的浮选药剂及其浮选方法 |
| GB202010987D0 (en) | 2020-07-16 | 2020-09-02 | Dentherapy Ltd | Oral care compositions and methods |
| GB202110114D0 (en) | 2021-07-14 | 2021-08-25 | Dentherapy Ltd | Oral care compositions for use in treaatment |
| WO2025008636A1 (en) | 2023-07-06 | 2025-01-09 | Dentherapy Ltd | Oral care compositions for use in the treatment of dental health conditions |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522805A (en) | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
| US5015628A (en) * | 1986-06-12 | 1991-05-14 | The University Of Melbourne | Anticariogenic phosphopeptides |
| CA1315480C (en) | 1986-06-12 | 1993-03-30 | Eric Charles Reynolds | Phosphopeptides |
| US6056930A (en) | 1989-05-24 | 2000-05-02 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| US5227154A (en) | 1991-08-22 | 1993-07-13 | The University Of Melbourne | Phosphopeptides for the treatment of dental calculus |
| EP0651652B1 (en) | 1992-06-29 | 2000-02-09 | The University Of Melbourne | Treatment for sensitive teeth |
| JP2975337B2 (ja) * | 1997-02-20 | 1999-11-10 | 雪印乳業株式会社 | カルシウム複合体 |
| AUPO566297A0 (en) * | 1997-03-13 | 1997-04-10 | University Of Melbourne, The | Calcium phosphopeptide complexes |
| JP3742523B2 (ja) | 1998-02-27 | 2006-02-08 | 雪印乳業株式会社 | 高分子型カルシウム・ホスホペプチド複合体 |
| FR2791573B1 (fr) | 1999-03-30 | 2003-04-11 | Pf Medicament | Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate |
| US6521215B2 (en) | 1999-05-28 | 2003-02-18 | Devin Okay | Compositions and methods for tooth treatment |
| US6685920B2 (en) | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| GB9929919D0 (en) | 1999-12-17 | 2000-02-09 | Hannah Research Inst The | Calcium phosphate nanoclusters and their applications |
| AUPR517701A0 (en) | 2001-05-21 | 2001-06-14 | University Of Melbourne, The | Dental restorative materials |
| EP1461005A2 (en) | 2002-01-03 | 2004-09-29 | The Procter & Gamble Company | Stable oral compositions comprising casein phosphopeptide complexes and fluoride |
| CA2469431C (en) * | 2002-01-03 | 2009-05-26 | The Procter & Gamble Company | Stable oral compositions comprising casein phosphopeptide complexes and fluoride |
| NZ522071A (en) | 2002-10-18 | 2005-07-29 | Patrick Joseph Silcock | Hydrolysed casein phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation |
| JP4340069B2 (ja) * | 2003-01-10 | 2009-10-07 | 雪印乳業株式会社 | カルシウム複合体の製造法 |
| US20050089481A1 (en) * | 2003-10-23 | 2005-04-28 | Gc Corporation | Composition for caries prevention |
| EP1888014B1 (en) | 2005-06-07 | 2012-11-14 | The University of Melbourne | Dental mineralization |
| ES2530396T3 (es) * | 2005-06-24 | 2015-03-02 | Univ Melbourne | Complejos iónicos |
-
2006
- 2006-06-23 ES ES06752630T patent/ES2530396T3/es active Active
- 2006-06-23 US US11/917,395 patent/US8603988B2/en active Active
- 2006-06-23 EP EP06752630.1A patent/EP1901702B1/en active Active
- 2006-06-23 PL PL06752630T patent/PL1901702T3/pl unknown
- 2006-06-23 NZ NZ564129A patent/NZ564129A/en unknown
- 2006-06-23 AR ARP060102716A patent/AR057402A1/es active IP Right Grant
- 2006-06-23 CA CA2612172A patent/CA2612172C/en active Active
- 2006-06-23 CN CN2006800227822A patent/CN101208070B/zh active Active
- 2006-06-23 WO PCT/AU2006/000885 patent/WO2006135982A1/en not_active Ceased
- 2006-06-23 AU AU2006261597A patent/AU2006261597B2/en active Active
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- 2006-06-23 RU RU2008102637/15A patent/RU2413497C2/ru active
- 2006-06-23 BR BRPI0611976-0A patent/BRPI0611976B1/pt active IP Right Grant
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2012
- 2012-10-29 JP JP2012237656A patent/JP5709818B2/ja active Active
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2008102637A (ru) | 2009-07-27 |
| AR057402A1 (es) | 2007-12-05 |
| EP1901702B1 (en) | 2014-11-26 |
| JP2008543887A (ja) | 2008-12-04 |
| CN101208070B (zh) | 2011-08-31 |
| BRPI0611976B1 (pt) | 2018-07-10 |
| EP1901702A4 (en) | 2012-01-18 |
| WO2006135982A1 (en) | 2006-12-28 |
| RU2413497C2 (ru) | 2011-03-10 |
| AU2006261597B2 (en) | 2011-06-23 |
| MX2007016312A (es) | 2008-03-05 |
| CN101208070A (zh) | 2008-06-25 |
| EP1901702A1 (en) | 2008-03-26 |
| US20140056824A1 (en) | 2014-02-27 |
| US8603988B2 (en) | 2013-12-10 |
| US9241883B2 (en) | 2016-01-26 |
| CA2612172A1 (en) | 2006-12-28 |
| BRPI0611976A2 (pt) | 2010-10-13 |
| US20100215593A1 (en) | 2010-08-26 |
| JP2013028644A (ja) | 2013-02-07 |
| AU2006261597A1 (en) | 2006-12-28 |
| ES2530396T3 (es) | 2015-03-02 |
| CA2612172C (en) | 2013-05-14 |
| PL1901702T3 (pl) | 2015-07-31 |
| JP5709818B2 (ja) | 2015-04-30 |
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