NZ562694A - Isothiazole and isoxazole derivatives in the form of lipase and phospholipase inhibitors - Google Patents
Isothiazole and isoxazole derivatives in the form of lipase and phospholipase inhibitorsInfo
- Publication number
- NZ562694A NZ562694A NZ562694A NZ56269406A NZ562694A NZ 562694 A NZ562694 A NZ 562694A NZ 562694 A NZ562694 A NZ 562694A NZ 56269406 A NZ56269406 A NZ 56269406A NZ 562694 A NZ562694 A NZ 562694A
- Authority
- NZ
- New Zealand
- Prior art keywords
- formula
- agonists
- compounds
- alkyl
- inhibitors
- Prior art date
Links
- 102000004882 Lipase Human genes 0.000 title claims description 7
- 108090001060 Lipase Proteins 0.000 title claims description 7
- 239000004367 Lipase Substances 0.000 title claims description 6
- 235000019421 lipase Nutrition 0.000 title claims description 6
- 239000003428 phospholipase inhibitor Substances 0.000 title description 2
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 title 1
- 150000002545 isoxazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 128
- 239000003814 drug Substances 0.000 claims abstract description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 6
- 239000008103 glucose Substances 0.000 claims abstract description 6
- 230000004129 fatty acid metabolism Effects 0.000 claims abstract description 3
- 239000000556 agonist Substances 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 41
- 239000001257 hydrogen Substances 0.000 claims description 39
- -1 pentafluorosulfanyl Chemical group 0.000 claims description 39
- 239000004480 active ingredient Substances 0.000 claims description 32
- 125000004122 cyclic group Chemical group 0.000 claims description 26
- 239000003112 inhibitor Substances 0.000 claims description 25
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical group 0.000 claims description 24
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 239000005557 antagonist Substances 0.000 claims description 17
- 229920006395 saturated elastomer Polymers 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 16
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 15
- 150000002431 hydrogen Chemical group 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 125000004429 atom Chemical group 0.000 claims description 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 13
- 230000002265 prevention Effects 0.000 claims description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 125000002950 monocyclic group Chemical group 0.000 claims description 12
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 11
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- 238000000034 method Methods 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- WRROPVUNDBWCQY-UHFFFAOYSA-N 4-methylpiperidine-1-carbonyl chloride Chemical compound CC1CCN(C(Cl)=O)CC1 WRROPVUNDBWCQY-UHFFFAOYSA-N 0.000 claims description 7
- 229940100389 Sulfonylurea Drugs 0.000 claims description 7
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- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 6
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims description 6
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- SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical class COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 claims description 3
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- 102000023984 PPAR alpha Human genes 0.000 claims description 3
- 229940124754 PPAR-alpha/gamma agonist Drugs 0.000 claims description 3
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- 102000008219 Uncoupling Protein 2 Human genes 0.000 claims description 3
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- 102000008200 Uncoupling Protein 3 Human genes 0.000 claims description 3
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- 238000010521 absorption reaction Methods 0.000 claims description 3
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- DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims description 3
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 3
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- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005018389A DE102005018389A1 (de) | 2005-04-20 | 2005-04-20 | Azolderivate als Inhibitoren von Lipasen und Phospholipasen |
| PCT/EP2006/003411 WO2006111321A1 (de) | 2005-04-20 | 2006-04-13 | Azolderivate als inhibitoren von lipasen und phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ562694A true NZ562694A (en) | 2010-05-28 |
Family
ID=36694158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ562694A NZ562694A (en) | 2005-04-20 | 2006-04-13 | Isothiazole and isoxazole derivatives in the form of lipase and phospholipase inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8921404B2 (enExample) |
| EP (1) | EP1874741A1 (enExample) |
| JP (1) | JP2008536884A (enExample) |
| KR (1) | KR20080004501A (enExample) |
| CN (1) | CN101160293A (enExample) |
| AR (1) | AR053228A1 (enExample) |
| AU (1) | AU2006237127A1 (enExample) |
| BR (1) | BRPI0608495A2 (enExample) |
| CA (1) | CA2606301A1 (enExample) |
| DE (1) | DE102005018389A1 (enExample) |
| IL (1) | IL186635A0 (enExample) |
| MA (1) | MA29393B1 (enExample) |
| MX (1) | MX2007012732A (enExample) |
| MY (1) | MY142441A (enExample) |
| NO (1) | NO20075938L (enExample) |
| NZ (1) | NZ562694A (enExample) |
| RU (1) | RU2414458C2 (enExample) |
| TW (1) | TW200722421A (enExample) |
| WO (1) | WO2006111321A1 (enExample) |
| ZA (1) | ZA200707929B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| AU2008235071A1 (en) | 2007-04-05 | 2008-10-16 | Sanofi-Aventis | 5-oxo-isoxazoles as inhibitors of lipases and phospholipases |
| JP2010523503A (ja) | 2007-04-05 | 2010-07-15 | サノフィ−アベンティス | リパーゼ及びホスホリパーゼ阻害剤としてのイミダゾリジンカルボキサミド誘導体 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010044441A1 (ja) | 2008-10-17 | 2010-04-22 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| CA2784710A1 (en) | 2009-12-15 | 2011-06-23 | Shionogi & Co., Ltd. | Oxadiazole derivative having endothelial lipase inhibitory activity |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| CN103298469A (zh) | 2010-08-31 | 2013-09-11 | 首尔大学校产学协力财团 | PPARδ激动剂的胎儿重编程的用途 |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US9321787B2 (en) * | 2011-07-07 | 2016-04-26 | Sanofi | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CA2996681C (en) * | 2015-08-27 | 2024-04-09 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| BR112021002207A2 (pt) | 2018-08-10 | 2021-05-04 | Diapin Therapeutics, Llc | tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ291508A (en) * | 1994-08-30 | 1999-07-29 | Sankyo Co | Isoxazoles; preparation and medicaments |
| US20030114420A1 (en) * | 2000-06-28 | 2003-06-19 | Salvati Mark E. | Fused cyclic modulators of nuclear hormone receptor function |
| EP1355651A2 (en) * | 2001-02-02 | 2003-10-29 | Pfizer Limited | Treatment of diabetes mellitus using vardenafil |
| WO2003005184A2 (en) | 2001-07-04 | 2003-01-16 | Akodi S.A. | Web windowed graphical user interface |
| JP2003033007A (ja) | 2001-07-09 | 2003-01-31 | Sanyo Electric Co Ltd | チャージポンプ回路の制御方法 |
| BR0214967A (pt) * | 2001-12-14 | 2005-05-10 | Novo Nordisk As | Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente |
| US7226919B2 (en) | 2002-12-18 | 2007-06-05 | Vertex Pharmaceuticals Inc. | Compositions useful as inhibitors of protein kinases |
| WO2004094393A1 (en) * | 2003-04-01 | 2004-11-04 | Eli Lilly And Company | Phospholipase inhibitors |
| EP1615900A1 (en) * | 2003-04-01 | 2006-01-18 | Eli Lilly And Company | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors |
| WO2005089753A2 (en) * | 2004-03-16 | 2005-09-29 | Janssen Pharmaceutica N.V. | Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders |
| TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
-
2005
- 2005-04-20 DE DE102005018389A patent/DE102005018389A1/de not_active Withdrawn
-
2006
- 2006-04-13 CA CA002606301A patent/CA2606301A1/en not_active Abandoned
- 2006-04-13 WO PCT/EP2006/003411 patent/WO2006111321A1/de not_active Ceased
- 2006-04-13 AU AU2006237127A patent/AU2006237127A1/en not_active Abandoned
- 2006-04-13 RU RU2007142657/04A patent/RU2414458C2/ru not_active IP Right Cessation
- 2006-04-13 JP JP2008506977A patent/JP2008536884A/ja not_active Abandoned
- 2006-04-13 EP EP06761897A patent/EP1874741A1/de not_active Withdrawn
- 2006-04-13 KR KR1020077024150A patent/KR20080004501A/ko not_active Withdrawn
- 2006-04-13 CN CNA2006800127294A patent/CN101160293A/zh active Pending
- 2006-04-13 MX MX2007012732A patent/MX2007012732A/es unknown
- 2006-04-13 NZ NZ562694A patent/NZ562694A/en not_active IP Right Cessation
- 2006-04-13 BR BRPI0608495-8A patent/BRPI0608495A2/pt not_active IP Right Cessation
- 2006-04-18 AR ARP060101521A patent/AR053228A1/es not_active Application Discontinuation
- 2006-04-18 TW TW095113710A patent/TW200722421A/zh unknown
- 2006-04-19 MY MYPI20061785A patent/MY142441A/en unknown
-
2007
- 2007-09-17 ZA ZA200707929A patent/ZA200707929B/xx unknown
- 2007-10-12 MA MA30299A patent/MA29393B1/fr unknown
- 2007-10-14 IL IL186635A patent/IL186635A0/en unknown
- 2007-10-17 US US11/873,846 patent/US8921404B2/en not_active Expired - Fee Related
- 2007-11-19 NO NO20075938A patent/NO20075938L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006111321A1 (de) | 2006-10-26 |
| MX2007012732A (es) | 2008-03-14 |
| IL186635A0 (en) | 2008-01-20 |
| US8921404B2 (en) | 2014-12-30 |
| AR053228A1 (es) | 2007-04-25 |
| RU2007142657A (ru) | 2009-05-27 |
| EP1874741A1 (de) | 2008-01-09 |
| MY142441A (en) | 2010-11-30 |
| BRPI0608495A2 (pt) | 2010-01-05 |
| MA29393B1 (fr) | 2008-04-01 |
| KR20080004501A (ko) | 2008-01-09 |
| JP2008536884A (ja) | 2008-09-11 |
| US20080090867A1 (en) | 2008-04-17 |
| NO20075938L (no) | 2007-11-19 |
| DE102005018389A1 (de) | 2006-10-26 |
| TW200722421A (en) | 2007-06-16 |
| ZA200707929B (en) | 2008-12-31 |
| AU2006237127A1 (en) | 2006-10-26 |
| RU2414458C2 (ru) | 2011-03-20 |
| CA2606301A1 (en) | 2006-10-26 |
| CN101160293A (zh) | 2008-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |