NZ544890A - Palatable ductile chewable veterinary composition - Google Patents

Info

Publication number

NZ544890A

NZ544890A NZ544890A NZ54489004A NZ544890A NZ 544890 A NZ544890 A NZ 544890A NZ 544890 A NZ544890 A NZ 544890A NZ 54489004 A NZ54489004 A NZ 54489004A NZ 544890 A NZ544890 A NZ 544890A

Authority

NZ

New Zealand

Prior art keywords

veterinary composition

chewable veterinary

effective amount

composition according

animal

Prior art date

2003-07-30

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 title claims abstract description 171
• 241001465754 Metazoa Species 0.000 claims abstract description 104
• 229920002472 Starch Polymers 0.000 claims abstract description 43
• 235000019698 starch Nutrition 0.000 claims abstract description 43
• 239000008107 starch Substances 0.000 claims abstract description 40
• 235000013372 meat Nutrition 0.000 claims abstract description 37
• 241000607479 Yersinia pestis Species 0.000 claims abstract description 28
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
• 208000031295 Animal disease Diseases 0.000 claims abstract description 20
• 239000004615 ingredient Substances 0.000 claims abstract description 15
• 244000052769 pathogen Species 0.000 claims abstract description 15
• 239000004480 active ingredient Substances 0.000 claims description 79
• 238000000034 method Methods 0.000 claims description 41
• 241000282472 Canis lupus familiaris Species 0.000 claims description 32
• 239000000642 acaricide Substances 0.000 claims description 32
• 230000000895 acaricidal effect Effects 0.000 claims description 31
• 150000001875 compounds Chemical class 0.000 claims description 30
• PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
• 150000002596 lactones Chemical class 0.000 claims description 30
• -1 pro-benzimidazoles Chemical class 0.000 claims description 30
• FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims description 28
• 229960002957 praziquantel Drugs 0.000 claims description 28
• CKVMAPHTVCTEMM-ALPQRHTBSA-N milbemycin oxime Chemical compound O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)C(=N/O)/[C@H]3OC\2)O)C[C@H]4C1.C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)C(=N/O)/[C@H]3OC\1)O)C[C@H]4C2 CKVMAPHTVCTEMM-ALPQRHTBSA-N 0.000 claims description 27
• 229940099245 milbemycin oxime Drugs 0.000 claims description 27
• 230000008569 process Effects 0.000 claims description 27
• 125000004429 atom Chemical group 0.000 claims description 25
• 241000282326 Felis catus Species 0.000 claims description 24
• 238000009472 formulation Methods 0.000 claims description 24
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 22
• 239000002297 parasiticide Substances 0.000 claims description 21
• 241000238631 Hexapoda Species 0.000 claims description 19
• 239000002917 insecticide Substances 0.000 claims description 19
• RFEJUZJILGIRHQ-XRIOVQLTSA-N 2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)C(O)C(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-XRIOVQLTSA-N 0.000 claims description 17
• 239000013057 ectoparasiticide Substances 0.000 claims description 17
• 238000001125 extrusion Methods 0.000 claims description 17
• 239000003963 antioxidant agent Substances 0.000 claims description 15
• 150000003254 radicals Chemical class 0.000 claims description 15
• 150000003839 salts Chemical class 0.000 claims description 15
• 238000011282 treatment Methods 0.000 claims description 15
• 239000005660 Abamectin Substances 0.000 claims description 14
• 230000000507 anthelmentic effect Effects 0.000 claims description 14
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
• 239000001257 hydrogen Substances 0.000 claims description 14
• 229910052739 hydrogen Inorganic materials 0.000 claims description 14
• 239000005912 Lufenuron Substances 0.000 claims description 13
• 229960000521 lufenuron Drugs 0.000 claims description 13
• PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims description 13
• HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims description 12
• 229960001614 levamisole Drugs 0.000 claims description 12
• ZLBGSRMUSVULIE-GSMJGMFJSA-N milbemycin A3 Chemical class O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 ZLBGSRMUSVULIE-GSMJGMFJSA-N 0.000 claims description 12
• YZBLFMPOMVTDJY-CBYMMZEQSA-N moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-CBYMMZEQSA-N 0.000 claims description 12
• SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 11
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 11
• 230000003078 antioxidant effect Effects 0.000 claims description 11
• 239000003086 colorant Substances 0.000 claims description 11
• 239000002949 juvenile hormone Substances 0.000 claims description 11
• BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 claims description 11
• 229960004454 oxfendazole Drugs 0.000 claims description 11
• 239000011780 sodium chloride Substances 0.000 claims description 11
• 239000004308 thiabendazole Substances 0.000 claims description 11
• WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 claims description 11
• 235000010296 thiabendazole Nutrition 0.000 claims description 11
• 229960004546 thiabendazole Drugs 0.000 claims description 11
• 241000238876 Acari Species 0.000 claims description 10
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 10
• 230000003542 behavioural effect Effects 0.000 claims description 10
• 229910052799 carbon Inorganic materials 0.000 claims description 10
• 125000004432 carbon atom Chemical group C* 0.000 claims description 10
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 10
• IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims description 9
• 235000003599 food sweetener Nutrition 0.000 claims description 9
• 238000004519 manufacturing process Methods 0.000 claims description 9
• 239000003765 sweetening agent Substances 0.000 claims description 9
• AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 8
• 229950008167 abamectin Drugs 0.000 claims description 8
• 230000002506 adulticidal effect Effects 0.000 claims description 8
• 244000000054 animal parasite Species 0.000 claims description 8
• 201000010099 disease Diseases 0.000 claims description 8
• QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 claims description 8
• 229960003997 doramectin Drugs 0.000 claims description 8
• 230000001793 endectocide Effects 0.000 claims description 8
• WPNHOHPRXXCPRA-TVXIRPTOSA-N eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 claims description 8
• 229960002346 eprinomectin Drugs 0.000 claims description 8
• 229960002418 ivermectin Drugs 0.000 claims description 8
• YNFMRVVYUVPIAN-AQUURSMBSA-N nemadectin Chemical compound C1[C@H](O)[C@H](C)[C@@H](C(/C)=C/C(C)C)O[C@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YNFMRVVYUVPIAN-AQUURSMBSA-N 0.000 claims description 8
• AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 claims description 8
• 229960002245 selamectin Drugs 0.000 claims description 8
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 7
• 108010036949 Cyclosporine Proteins 0.000 claims description 7
• 239000005894 Emamectin Substances 0.000 claims description 7
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
• 239000005918 Milbemectin Substances 0.000 claims description 7
• 229960001265 ciclosporin Drugs 0.000 claims description 7
• 238000001816 cooling Methods 0.000 claims description 7
• 229930182912 cyclosporin Natural products 0.000 claims description 7
• CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims description 7
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 7
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
• OPXLLQIJSORQAM-UHFFFAOYSA-N mebendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1C(=O)C1=CC=CC=C1 OPXLLQIJSORQAM-UHFFFAOYSA-N 0.000 claims description 7
• FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 claims description 7
• 229960004816 moxidectin Drugs 0.000 claims description 7
• 229950009729 nemadectin Drugs 0.000 claims description 7
• YNFMRVVYUVPIAN-UHFFFAOYSA-N nemadectin alpha Natural products C1C(O)C(C)C(C(C)=CC(C)C)OC11OC(CC=C(C)CC(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 YNFMRVVYUVPIAN-UHFFFAOYSA-N 0.000 claims description 7
• NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 claims description 6
• UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical class C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 claims description 6
• 229930105110 Cyclosporin A Natural products 0.000 claims description 6
• HMCCXLBXIJMERM-UHFFFAOYSA-N Febantel Chemical compound C1=C(NC(NC(=O)OC)=NC(=O)OC)C(NC(=O)COC)=CC(SC=2C=CC=CC=2)=C1 HMCCXLBXIJMERM-UHFFFAOYSA-N 0.000 claims description 6
• RAOCRURYZCVHMG-UHFFFAOYSA-N N-(6-propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)NC2=C1 RAOCRURYZCVHMG-UHFFFAOYSA-N 0.000 claims description 6
• HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 claims description 6
• 229960002669 albendazole Drugs 0.000 claims description 6
• 244000037640 animal pathogen Species 0.000 claims description 6
• 150000001556 benzimidazoles Chemical class 0.000 claims description 6
• KULDXINYXFTXMO-UHFFFAOYSA-N bis(2-chloroethyl) (3-chloro-4-methyl-2-oxochromen-7-yl) phosphate Chemical compound C1=C(OP(=O)(OCCCl)OCCCl)C=CC2=C1OC(=O)C(Cl)=C2C KULDXINYXFTXMO-UHFFFAOYSA-N 0.000 claims description 6
• 208000035475 disorder Diseases 0.000 claims description 6
• 229960005282 febantel Drugs 0.000 claims description 6
• 229960005473 fenbendazole Drugs 0.000 claims description 6
• 229950002831 haloxon Drugs 0.000 claims description 6
• 229960003439 mebendazole Drugs 0.000 claims description 6
• 229960001952 metrifonate Drugs 0.000 claims description 6
• 229960005121 morantel Drugs 0.000 claims description 6
• 229960002762 oxibendazole Drugs 0.000 claims description 6
• 150000004885 piperazines Chemical class 0.000 claims description 6
• 238000002360 preparation method Methods 0.000 claims description 6
• 229960005134 pyrantel Drugs 0.000 claims description 6
• YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 claims description 6
• 150000005326 tetrahydropyrimidines Chemical class 0.000 claims description 6
• NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 claims description 6
• QOVTVIYTBRHADL-UHFFFAOYSA-N 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide Chemical compound NC1=CC(C(Cl)=C(Cl)Cl)=C(S(N)(=O)=O)C=C1S(N)(=O)=O QOVTVIYTBRHADL-UHFFFAOYSA-N 0.000 claims description 5
• 229930186147 Cephalosporin Natural products 0.000 claims description 5
• 229930182555 Penicillin Natural products 0.000 claims description 5
• 239000002202 Polyethylene glycol Substances 0.000 claims description 5
• 239000004098 Tetracycline Substances 0.000 claims description 5
• 208000037175 Travel-Related Illness Diseases 0.000 claims description 5
• 230000000845 anti-microbial effect Effects 0.000 claims description 5
• 230000037396 body weight Effects 0.000 claims description 5
• 229940124587 cephalosporin Drugs 0.000 claims description 5
• 150000001780 cephalosporins Chemical class 0.000 claims description 5
• 229960000275 clorsulon Drugs 0.000 claims description 5
• 238000005520 cutting process Methods 0.000 claims description 5
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 5
• 229940000188 cydectin Drugs 0.000 claims description 5
• RCKMWOKWVGPNJF-UHFFFAOYSA-N diethylcarbamazine Chemical compound CCN(CC)C(=O)N1CCN(C)CC1 RCKMWOKWVGPNJF-UHFFFAOYSA-N 0.000 claims description 5
• 229960003974 diethylcarbamazine Drugs 0.000 claims description 5
• 229960003276 erythromycin Drugs 0.000 claims description 5
• PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 claims description 5
• 229960003704 framycetin Drugs 0.000 claims description 5
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 5
• 201000003152 motion sickness Diseases 0.000 claims description 5
• XCGYUJZMCCFSRP-UHFFFAOYSA-N oxamniquine Chemical compound OCC1=C([N+]([O-])=O)C=C2NC(CNC(C)C)CCC2=C1 XCGYUJZMCCFSRP-UHFFFAOYSA-N 0.000 claims description 5
• 229960000462 oxamniquine Drugs 0.000 claims description 5
• JYWIYHUXVMAGLG-UHFFFAOYSA-N oxyclozanide Chemical compound OC1=C(Cl)C=C(Cl)C=C1NC(=O)C1=C(O)C(Cl)=CC(Cl)=C1Cl JYWIYHUXVMAGLG-UHFFFAOYSA-N 0.000 claims description 5
• 229950003126 oxyclozanide Drugs 0.000 claims description 5
• 230000000590 parasiticidal effect Effects 0.000 claims description 5
• 229960005141 piperazine Drugs 0.000 claims description 5
• 229920001223 polyethylene glycol Polymers 0.000 claims description 5
• 229920001451 polypropylene glycol Polymers 0.000 claims description 5
• 238000000926 separation method Methods 0.000 claims description 5
• 229960005322 streptomycin Drugs 0.000 claims description 5
• 229940124530 sulfonamide Drugs 0.000 claims description 5
• 150000003456 sulfonamides Chemical class 0.000 claims description 5
• 235000019364 tetracycline Nutrition 0.000 claims description 5
• 150000003522 tetracyclines Chemical class 0.000 claims description 5
• IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 5
• 229960001082 trimethoprim Drugs 0.000 claims description 5
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