NZ535754A - Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity - Google Patents

Info

Publication number

NZ535754A

NZ535754A NZ535754A NZ53575403A NZ535754A NZ 535754 A NZ535754 A NZ 535754A NZ 535754 A NZ535754 A NZ 535754A NZ 53575403 A NZ53575403 A NZ 53575403A NZ 535754 A NZ535754 A NZ 535754A

Authority

NZ

New Zealand

Prior art keywords

protein

seq

amino acid

wild

ala

Prior art date

2002-03-15

Links

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• 102000004169 proteins and genes Human genes 0.000 title claims abstract description 420
• 241000606768 Haemophilus influenzae Species 0.000 title claims abstract description 41
• 230000002255 enzymatic effect Effects 0.000 title claims abstract description 39
• 230000002829 reductive effect Effects 0.000 title claims abstract description 20
• 229940047650 haemophilus influenzae Drugs 0.000 title claims abstract description 8
• 235000018102 proteins Nutrition 0.000 claims abstract description 415
• 239000000203 mixture Substances 0.000 claims abstract description 124
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• 125000000539 amino acid group Chemical group 0.000 claims abstract description 97
• 230000002163 immunogen Effects 0.000 claims abstract description 87
• 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 55
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims abstract description 34
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 32
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims abstract description 31
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• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims abstract description 27
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• 235000004554 glutamine Nutrition 0.000 claims abstract description 26
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