KR100981471B1 - 효소 활성이 감소된 형별불능 헤모필러스 인플루엔자의ｐ4 변형 단백질 - Google Patents

효소 활성이 감소된 형별불능 헤모필러스 인플루엔자의ｐ4 변형 단백질 Download PDF

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KR100981471B1
KR100981471B1 KR1020047014502A KR20047014502A KR100981471B1 KR 100981471 B1 KR100981471 B1 KR 100981471B1 KR 1020047014502 A KR1020047014502 A KR 1020047014502A KR 20047014502 A KR20047014502 A KR 20047014502A KR 100981471 B1 KR100981471 B1 KR 100981471B1
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protein
delete delete
seq
amino acid
modified protein
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KR20050016307A (ko
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그린브루스에이.
즐로트닉게리더블유.
플레춰리어디.
스미스아놀드엘.
리일리토마스제이.
Original Assignee
더 큐레이터스 오브 더 유니버시티 오브 미주리
와이어쓰 홀딩스 코포레이션
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Application filed by 더 큐레이터스 오브 더 유니버시티 오브 미주리, 와이어쓰 홀딩스 코포레이션 filed Critical 더 큐레이터스 오브 더 유니버시티 오브 미주리
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020047014502A 2002-03-15 2003-03-13 효소 활성이 감소된 형별불능 헤모필러스 인플루엔자의ｐ4 변형 단백질 Expired - Fee Related KR100981471B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36468802P 2002-03-15 2002-03-15
US60/364,688 2002-03-15
PCT/US2003/007895 WO2003078453A1 (en) 2002-03-15 2003-03-13 Mutants of the p4 protein of nontypable haemophilus influenzae with reduced enzymatic activity

Publications (2)

Publication Number Publication Date
KR20050016307A KR20050016307A (ko) 2005-02-21
KR100981471B1 true KR100981471B1 (ko) 2010-09-10

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KR1020047014502A Expired - Fee Related KR100981471B1 (ko) 2002-03-15 2003-03-13 효소 활성이 감소된 형별불능 헤모필러스 인플루엔자의ｐ4 변형 단백질

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Country Link
US (2) US7615229B2 (enExample)
EP (1) EP1490395A4 (enExample)
JP (1) JP2005532789A (enExample)
KR (1) KR100981471B1 (enExample)
CN (1) CN100593544C (enExample)
AU (1) AU2003218162B2 (enExample)
BR (1) BR0308441A (enExample)
CA (1) CA2479118A1 (enExample)
IL (1) IL163988A0 (enExample)
MX (1) MXPA04008890A (enExample)
NZ (1) NZ535754A (enExample)
WO (1) WO2003078453A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012203017B2 (en) * 2003-12-23 2014-10-09 Nationwide Children's Hospital, Inc. Haemophilus Influenzae Type IV Pili
ATE557033T1 (de) * 2003-12-23 2012-05-15 Nationwide Children S Hospital Inc Pili von haemophilus influenzae typ iv
EP2425856A1 (en) 2005-04-08 2012-03-07 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
KR101359953B1 (ko) * 2005-06-27 2014-02-21 글락소스미스클라인 바이오로지칼즈 에스.에이. 면역원성 조성물
JP4996934B2 (ja) * 2007-02-05 2012-08-08 独立行政法人農業・食品産業技術総合研究機構 組換え型リゾチームの製造法
JP2014516028A (ja) * 2011-05-11 2014-07-07 リースベック ヘルスケア スウェーデン アクティエボラーグ ラミニン及びビトロネクチン結合特性を有するタンパク質ｆ−新規インフルエンザ菌付着因子
WO2020081548A1 (en) * 2018-10-15 2020-04-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Vaccine polypeptide compositions and methods
WO2022056195A1 (en) * 2020-09-10 2022-03-17 The Rochester General Hospital Haemophilus infuluenzae vaccine and methods of use

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US5955580A (en) 1989-03-09 1999-09-21 Praxis Biologies, Inc. Vaccines for nontypable haemophilus influenzae

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Publication number Publication date
CA2479118A1 (en) 2003-09-25
IL163988A0 (en) 2005-12-18
CN1653084A (zh) 2005-08-10
KR20050016307A (ko) 2005-02-21
US20090148465A1 (en) 2009-06-11
CN100593544C (zh) 2010-03-10
JP2005532789A (ja) 2005-11-04
EP1490395A1 (en) 2004-12-29
EP1490395A4 (en) 2006-06-21
MXPA04008890A (es) 2005-10-18
BR0308441A (pt) 2005-01-18
AU2003218162A1 (en) 2003-09-29
US7666626B2 (en) 2010-02-23
WO2003078453A1 (en) 2003-09-25
US20050249746A1 (en) 2005-11-10
US7615229B2 (en) 2009-11-10
AU2003218162B2 (en) 2009-10-29
NZ535754A (en) 2007-01-26

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Not in force date: 20130904

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St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000