JP2005532789A - 減少した酵素活性を有する型別不能なインフルエンザ菌（Ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａ）のＰ４タンパク質の変異体 - Google Patents

減少した酵素活性を有する型別不能なインフルエンザ菌（Ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａ）のＰ４タンパク質の変異体 Download PDF

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JP2005532789A
JP2005532789A JP2003576457A JP2003576457A JP2005532789A JP 2005532789 A JP2005532789 A JP 2005532789A JP 2003576457 A JP2003576457 A JP 2003576457A JP 2003576457 A JP2003576457 A JP 2003576457A JP 2005532789 A JP2005532789 A JP 2005532789A
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protein
seq
amino acid
mutation
wild
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JP2005532789A5 (enExample
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グリーン，ブルース・エイ
ズロトニク，ゲイリー・ダブリユー
フレツチヤー，レー・デイ
スミス，アーノルド・エル
レイリー，トーマス・ジエイ
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ワイス・ホールデイングス・コーポレーシヨン
ザ・キユレーターズ・オブ・ザ・ユニバーシテイ・オブ・ミズーリ
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Application filed by ワイス・ホールデイングス・コーポレーシヨン, ザ・キユレーターズ・オブ・ザ・ユニバーシテイ・オブ・ミズーリ filed Critical ワイス・ホールデイングス・コーポレーシヨン
Publication of JP2005532789A publication Critical patent/JP2005532789A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2003576457A 2002-03-15 2003-03-13 減少した酵素活性を有する型別不能なインフルエンザ菌（Ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａ）のＰ４タンパク質の変異体 Pending JP2005532789A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36468802P 2002-03-15 2002-03-15
PCT/US2003/007895 WO2003078453A1 (en) 2002-03-15 2003-03-13 Mutants of the p4 protein of nontypable haemophilus influenzae with reduced enzymatic activity

Publications (2)

Publication Number Publication Date
JP2005532789A true JP2005532789A (ja) 2005-11-04
JP2005532789A5 JP2005532789A5 (enExample) 2008-05-08

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JP2003576457A Pending JP2005532789A (ja) 2002-03-15 2003-03-13 減少した酵素活性を有する型別不能なインフルエンザ菌（Ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａ）のＰ４タンパク質の変異体

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US (2) US7615229B2 (enExample)
EP (1) EP1490395A4 (enExample)
JP (1) JP2005532789A (enExample)
KR (1) KR100981471B1 (enExample)
CN (1) CN100593544C (enExample)
AU (1) AU2003218162B2 (enExample)
BR (1) BR0308441A (enExample)
CA (1) CA2479118A1 (enExample)
IL (1) IL163988A0 (enExample)
MX (1) MXPA04008890A (enExample)
NZ (1) NZ535754A (enExample)
WO (1) WO2003078453A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008187954A (ja) * 2007-02-05 2008-08-21 National Agriculture & Food Research Organization 組換え型リゾチームの製造法
JP2023544250A (ja) * 2020-09-10 2023-10-23 ザ ロチェスター ジェネラル ホスピタル インフルエンザ菌ワクチン及びその使用方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012203017B2 (en) * 2003-12-23 2014-10-09 Nationwide Children's Hospital, Inc. Haemophilus Influenzae Type IV Pili
ATE557033T1 (de) * 2003-12-23 2012-05-15 Nationwide Children S Hospital Inc Pili von haemophilus influenzae typ iv
EP2425856A1 (en) 2005-04-08 2012-03-07 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
KR101359953B1 (ko) * 2005-06-27 2014-02-21 글락소스미스클라인 바이오로지칼즈 에스.에이. 면역원성 조성물
JP2014516028A (ja) * 2011-05-11 2014-07-07 リースベック ヘルスケア スウェーデン アクティエボラーグ ラミニン及びビトロネクチン結合特性を有するタンパク質ｆ−新規インフルエンザ菌付着因子
WO2020081548A1 (en) * 2018-10-15 2020-04-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Vaccine polypeptide compositions and methods

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008187954A (ja) * 2007-02-05 2008-08-21 National Agriculture & Food Research Organization 組換え型リゾチームの製造法
JP2023544250A (ja) * 2020-09-10 2023-10-23 ザ ロチェスター ジェネラル ホスピタル インフルエンザ菌ワクチン及びその使用方法

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CA2479118A1 (en) 2003-09-25
IL163988A0 (en) 2005-12-18
CN1653084A (zh) 2005-08-10
KR20050016307A (ko) 2005-02-21
US20090148465A1 (en) 2009-06-11
CN100593544C (zh) 2010-03-10
EP1490395A1 (en) 2004-12-29
EP1490395A4 (en) 2006-06-21
MXPA04008890A (es) 2005-10-18
BR0308441A (pt) 2005-01-18
AU2003218162A1 (en) 2003-09-29
US7666626B2 (en) 2010-02-23
WO2003078453A1 (en) 2003-09-25
US20050249746A1 (en) 2005-11-10
KR100981471B1 (ko) 2010-09-10
US7615229B2 (en) 2009-11-10
AU2003218162B2 (en) 2009-10-29
NZ535754A (en) 2007-01-26

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