NZ534719A - Conjugates of therapeutic or cytotoxic agents and biologically active peptides - Google Patents

Info

Publication number

NZ534719A

NZ534719A NZ534719A NZ53471903A NZ534719A NZ 534719 A NZ534719 A NZ 534719A NZ 534719 A NZ534719 A NZ 534719A NZ 53471903 A NZ53471903 A NZ 53471903A NZ 534719 A NZ534719 A NZ 534719A

Authority

NZ

New Zealand

Prior art keywords

tyr

ser

lys

peptide

compound

Prior art date

2002-03-01

Links

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• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 205
• 229940127089 cytotoxic agent Drugs 0.000 title claims abstract description 63
• 239000002254 cytotoxic agent Substances 0.000 title claims abstract description 62
• 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 58
• 239000003814 drug Substances 0.000 title claims abstract description 53
• 231100000599 cytotoxic agent Toxicity 0.000 title claims abstract description 51
• 229940124597 therapeutic agent Drugs 0.000 title claims abstract description 41
• 230000001225 therapeutic effect Effects 0.000 title abstract description 17
• 150000001875 compounds Chemical class 0.000 claims description 90
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 56
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 56
• 125000000217 alkyl group Chemical group 0.000 claims description 42
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• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 39
• 150000001413 amino acids Chemical group 0.000 claims description 38
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 38
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 37
• 229940127093 camptothecin Drugs 0.000 claims description 37
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 36
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 34
• MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims description 33
• OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims description 33
• -1 hSer Chemical compound 0.000 claims description 33
• KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims description 32
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• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 24
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• LGZKGOGODCLQHG-CYBMUJFWSA-N 5-[(2r)-2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC=C1C[C@@H](O)C1=CC(OC)=C(OC)C(OC)=C1 LGZKGOGODCLQHG-CYBMUJFWSA-N 0.000 claims description 10
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