NZ523787A - Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation - Google Patents

Info

Publication number

NZ523787A

NZ523787A NZ523787A NZ52378701A NZ523787A NZ 523787 A NZ523787 A NZ 523787A NZ 523787 A NZ523787 A NZ 523787A NZ 52378701 A NZ52378701 A NZ 52378701A NZ 523787 A NZ523787 A NZ 523787A

Authority

NZ

New Zealand

Prior art keywords

sulphamoyl

compound

formula

pyrimidine

acceptable salt

Prior art date

2000-09-05

Links

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• Global Dossier
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• 230000004663 cell proliferation Effects 0.000 title description 6
• 238000000034 method Methods 0.000 claims abstract description 184
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• 239000003814 drug Substances 0.000 claims abstract description 19
• 150000001875 compounds Chemical class 0.000 claims description 262
• -1 nitro, cyano, hydroxy, amino, carboxy, carbamoyl Chemical group 0.000 claims description 259
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• 239000000243 solution Substances 0.000 claims description 94
• 239000000203 mixture Substances 0.000 claims description 93
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 82
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 59
• 125000000623 heterocyclic group Chemical group 0.000 claims description 57
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• 239000001257 hydrogen Substances 0.000 claims description 49
• 229910052739 hydrogen Inorganic materials 0.000 claims description 49
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 48
• 125000005843 halogen group Chemical group 0.000 claims description 44
• 229910052757 nitrogen Inorganic materials 0.000 claims description 37
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 36
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
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• PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 23
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 23
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 23
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• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 19
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 18
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 17
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• 125000006239 protecting group Chemical group 0.000 claims description 12
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• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 10
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• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 3
• SRVXSISGYBMIHR-UHFFFAOYSA-N 3-[3-[3-(2-amino-2-oxoethyl)phenyl]-5-chlorophenyl]-3-(5-methyl-1,3-thiazol-2-yl)propanoic acid Chemical compound S1C(C)=CN=C1C(CC(O)=O)C1=CC(Cl)=CC(C=2C=C(CC(N)=O)C=CC=2)=C1 SRVXSISGYBMIHR-UHFFFAOYSA-N 0.000 claims description 2
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