NZ513041A - N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists; their preparation and medicaments containing them - Google Patents

N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists; their preparation and medicaments containing them

Info

Publication number
NZ513041A
NZ513041A NZ513041A NZ51304101A NZ513041A NZ 513041 A NZ513041 A NZ 513041A NZ 513041 A NZ513041 A NZ 513041A NZ 51304101 A NZ51304101 A NZ 51304101A NZ 513041 A NZ513041 A NZ 513041A
Authority
NZ
New Zealand
Prior art keywords
triazolylmethyl
preparation
receptor antagonists
piperazine derivatives
medicaments containing
Prior art date
Application number
NZ513041A
Other languages
English (en)
Inventor
Daniel Jasserand
Uwe Schon
Holger Sann
Reinhard Bruckner
Christian Eeckhout
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NZ513041A publication Critical patent/NZ513041A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ513041A 2000-07-28 2001-07-18 N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists; their preparation and medicaments containing them NZ513041A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
NZ513041A true NZ513041A (en) 2002-12-20

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ513041A NZ513041A (en) 2000-07-28 2001-07-18 N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists; their preparation and medicaments containing them

Country Status (27)

Country Link
US (1) US6407106B1 (https=)
EP (1) EP1176144B1 (https=)
JP (1) JP2002053577A (https=)
KR (1) KR100924405B1 (https=)
CN (1) CN1167698C (https=)
AR (1) AR028743A1 (https=)
AT (1) ATE244716T1 (https=)
AU (1) AU779318B2 (https=)
BR (1) BR0103048A (https=)
CA (1) CA2354213C (https=)
CZ (1) CZ301695B6 (https=)
DE (2) DE10036818A1 (https=)
DK (1) DK1176144T3 (https=)
DZ (1) DZ3119A1 (https=)
ES (1) ES2201007T3 (https=)
HU (1) HU226687B1 (https=)
IL (1) IL144299A (https=)
IN (1) IN191021B (https=)
NO (1) NO323233B1 (https=)
NZ (1) NZ513041A (https=)
PL (1) PL210436B1 (https=)
PT (1) PT1176144E (https=)
RU (1) RU2288918C2 (https=)
SK (1) SK284802B6 (https=)
TW (1) TWI304403B (https=)
UA (1) UA73728C2 (https=)
ZA (1) ZA200105737B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
AU2003230829B8 (en) * 2002-04-26 2008-12-11 Eli Lilly And Company Triazole derivatives as tachykinin receptor antagonists
ES2307925T3 (es) * 2002-04-26 2008-12-01 Eli Lilly And Company Antagonistas de los receptores de la taquiquinina.
WO2005000821A1 (en) * 2003-06-12 2005-01-06 Eli Lilly And Company Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
CN101228137B (zh) * 2005-07-25 2010-09-29 弗·哈夫曼-拉罗切有限公司 被取代的三唑衍生物和它们作为神经激肽3受体拮抗剂的用途
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
EP2467159A1 (en) 2009-08-20 2012-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
US20210015834A1 (en) 2018-02-26 2021-01-21 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
NZ307625A (en) * 1995-05-25 1999-02-25 Fujisawa Pharmaceutical Co 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
AU714931B2 (en) * 1995-12-18 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as tachykinin antagonists
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
EP0899270B1 (de) * 1997-08-27 2008-05-21 Solvay Pharmaceuticals GmbH Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Also Published As

Publication number Publication date
IL144299A0 (en) 2002-05-23
JP2002053577A (ja) 2002-02-19
EP1176144B1 (de) 2003-07-09
KR100924405B1 (ko) 2009-10-29
CA2354213C (en) 2010-04-27
CZ20011813A3 (cs) 2002-03-13
HU0102931D0 (en) 2001-09-28
PT1176144E (pt) 2003-11-28
KR20020010482A (ko) 2002-02-04
HUP0102931A2 (hu) 2002-11-28
US6407106B1 (en) 2002-06-18
UA73728C2 (en) 2005-09-15
HK1042699A1 (en) 2002-08-23
ATE244716T1 (de) 2003-07-15
US20020065276A1 (en) 2002-05-30
IN191021B (https=) 2003-09-13
CA2354213A1 (en) 2002-01-28
EP1176144A1 (de) 2002-01-30
CN1335316A (zh) 2002-02-13
DE50100358D1 (de) 2003-08-14
BR0103048A (pt) 2002-04-02
CN1167698C (zh) 2004-09-22
AU779318B2 (en) 2005-01-13
NO20013709L (no) 2002-01-29
TWI304403B (en) 2008-12-21
CZ301695B6 (cs) 2010-05-26
SK284802B6 (sk) 2005-11-03
HU226687B1 (en) 2009-06-29
NO323233B1 (no) 2007-02-05
PL210436B1 (pl) 2012-01-31
AU5767501A (en) 2002-01-31
DE10036818A1 (de) 2002-02-07
ES2201007T3 (es) 2004-03-16
AR028743A1 (es) 2003-05-21
ZA200105737B (en) 2002-01-22
IL144299A (en) 2004-08-31
NO20013709D0 (no) 2001-07-27
HUP0102931A3 (en) 2003-07-28
SK7572001A3 (en) 2002-02-05
DZ3119A1 (fr) 2004-09-19
RU2288918C2 (ru) 2006-12-10
DK1176144T3 (da) 2003-10-27
PL348946A1 (en) 2002-02-11

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Legal Events

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