NZ279443A - Solubilizing difficultly soluble pharmaceutical agents using a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol - Google Patents

Solubilizing difficultly soluble pharmaceutical agents using a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol

Info

Publication number
NZ279443A
NZ279443A NZ279443A NZ27944395A NZ279443A NZ 279443 A NZ279443 A NZ 279443A NZ 279443 A NZ279443 A NZ 279443A NZ 27944395 A NZ27944395 A NZ 27944395A NZ 279443 A NZ279443 A NZ 279443A
Authority
NZ
New Zealand
Prior art keywords
process according
peg
polyethylene glycol
soluble pharmaceutical
pharmaceutical active
Prior art date
Application number
NZ279443A
Other languages
English (en)
Inventor
Dadi Jamshed Dhabhar
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NZ279443A publication Critical patent/NZ279443A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ279443A 1994-01-24 1995-01-24 Solubilizing difficultly soluble pharmaceutical agents using a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol NZ279443A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18557694A 1994-01-24 1994-01-24
PCT/US1995/001018 WO1995019759A1 (en) 1994-01-24 1995-01-24 Process for solubilizing difficultly soluble pharmaceutical actives

Publications (1)

Publication Number Publication Date
NZ279443A true NZ279443A (en) 1998-04-27

Family

ID=22681571

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ279443A NZ279443A (en) 1994-01-24 1995-01-24 Solubilizing difficultly soluble pharmaceutical agents using a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol

Country Status (14)

Country Link
EP (1) EP0741560A1 (ja)
JP (1) JPH09508128A (ja)
CN (1) CN1138827A (ja)
AU (1) AU706890B2 (ja)
BR (1) BR9506564A (ja)
CA (1) CA2181241C (ja)
CZ (1) CZ210496A3 (ja)
FI (1) FI962948A (ja)
MX (1) MX9602955A (ja)
NO (1) NO963052L (ja)
NZ (1) NZ279443A (ja)
PL (1) PL315635A1 (ja)
SK (1) SK96196A3 (ja)
WO (1) WO1995019759A1 (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058637A1 (en) * 1996-06-20 1998-12-30 Mcneil-Ppc Acetaminophen and diphenhydramine analgesics
ZA975444B (en) * 1996-06-20 1998-12-21 Mcneil Ppc Inc Acetaminophen and meclizine hydrochloride analgesics
FR2751875B1 (fr) * 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
US5763449A (en) * 1996-08-07 1998-06-09 Ascent Pediatrics, Inc. Pleasant-tasting aqueous liquid composition of a bitter-tasting drug
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
CA2318128C (en) 1998-01-20 2008-10-14 Applied Analytical Industries, Inc. Oral liquid compositions
US20020086878A1 (en) * 1999-01-11 2002-07-04 Douglas Joseph Dobrozsi Compositions having improved stability
US6846495B2 (en) 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
US20020082307A1 (en) * 1999-01-11 2002-06-27 Dobrozsi Douglas Joseph Compositions having improved stability
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
FR2796843B1 (fr) * 1999-07-29 2003-05-09 So Ge Val Sa Composition antipyretique concentree et stabilisee a usage veterinaire destine a etre incorporee a l'alimentation des animaux ainsi que procede d'incorporation de cette composition a l'eau de boisson d'animaux
US6251426B1 (en) 1999-09-02 2001-06-26 Banner Pharmacaps, Inc. Ibuprofen-containing softgels
DE10011032A1 (de) * 2000-03-07 2001-09-13 Bayer Ag Acetylsalicylsäure-Lösungen
KR20020069387A (ko) * 2001-02-26 2002-09-04 진양제약주식회사 호박산독실아민 조성물 및 이 조성물을 함유한 연질캅셀제제
NZ530889A (en) * 2001-07-31 2005-03-24 Wyeth Corp Use of sucralose as a sweetening agent combined with pH modulation of chemical formulations generates enhanced taste-masking effects
US7101572B2 (en) * 2001-12-07 2006-09-05 Unilab Pharmatech, Ltd. Taste masked aqueous liquid pharmaceutical composition
CN100379406C (zh) * 2003-09-22 2008-04-09 北京德众万全药物技术开发有限公司 一种难溶性药物微丸的制备方法及包含该微丸的制剂
EP1959935A2 (en) * 2005-10-26 2008-08-27 Banner Pharmacaps Inc. Hydrophilic vehicle-based dual controlled release matrix system as capsule fill
DE102005053066A1 (de) 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
JP2009523119A (ja) * 2005-12-09 2009-06-18 ビーエーエスエフ ソシエタス・ヨーロピア 水に溶けにくい化合物のための可溶化剤としてのポリビニルラクタム−ポリオキシアルキレンブロックコポリマーの使用
US8637076B2 (en) 2006-06-01 2014-01-28 Cima Labs Inc. Prednisolone salt formulations
JP2008184430A (ja) * 2007-01-30 2008-08-14 Ss Pharmaceut Co Ltd ソフトカプセル
CA2690488C (en) * 2010-01-19 2013-06-11 Accucaps Industries Limited Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof
CA2690490C (en) * 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
RS55491B2 (sr) * 2010-01-28 2020-11-30 Eagle Pharmaceuticals Inc Formulacije bendamustina
RS65177B1 (sr) 2012-03-20 2024-03-29 Eagle Pharmaceuticals Inc Formulacije bendamustina
EP2827863B1 (en) 2012-03-20 2019-01-16 Eagle Pharmaceuticals, Inc. Liquid composition for use in a method of treating bendamustine-responsive conditions in patients requiring reduced volumes for administration
BR112015018838B1 (pt) 2013-02-28 2020-12-15 Pfizer Inc. Composição oral líquida com estabilidade melhorada e seu processo para a preparação
GB201506755D0 (en) * 2015-04-21 2015-06-03 Reckitt Benckiser Llc Novel pharmaceutical formulation
TWI586379B (zh) * 2015-06-29 2017-06-11 永信藥品工業股份有限公司 一種製作難溶藥物固體劑型的方法
EP3364955B1 (en) 2015-10-09 2022-04-20 RB Health (US) LLC Pharmaceutical formulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives

Also Published As

Publication number Publication date
NO963052L (no) 1996-09-24
CN1138827A (zh) 1996-12-25
CA2181241C (en) 2000-04-25
EP0741560A1 (en) 1996-11-13
PL315635A1 (en) 1996-11-25
SK96196A3 (en) 1997-03-05
CZ210496A3 (en) 1996-12-11
AU1607595A (en) 1995-08-08
WO1995019759A1 (en) 1995-07-27
JPH09508128A (ja) 1997-08-19
FI962948A0 (fi) 1996-07-23
FI962948A (fi) 1996-07-23
MX9602955A (es) 1997-06-28
AU706890B2 (en) 1999-07-01
NO963052D0 (no) 1996-07-22
CA2181241A1 (en) 1995-07-27
BR9506564A (pt) 1997-09-02

Similar Documents

Publication Publication Date Title
US5484606A (en) Process for reducing the precipitation of difficulty soluble pharmaceutical actives
AU706890B2 (en) Process for solubilizing difficultly soluble pharmaceutical actives
US5141961A (en) Process for solubilizing difficulty soluble pharmaceutical actives
CA2184365C (en) Concentrated acetaminophen solution compositions
US5431916A (en) Pharmaceutical compositions and process of manufacture thereof
CA2214399C (en) Soft gelatin capsule with a gelatin shell comprising xanthine derivative
AU701771B2 (en) Gelatin capsules containing a high concentrated acetaminophen solution
JP5975884B2 (ja) ソフトゲルカプセル化のためのナプロキセンの医薬処方およびその組合せ
TWI285115B (en) Fill liquid composition for ibuprofen capsule and capsule preparation
HUT74909A (en) Process for solubilizing difficultly soluble pharmaceutical actives
MXPA97007393A (en) Soft gelatine capsule with a gelatin cover comprising xant derivative