NZ224170A - Tertiary arylethyl amine derivatives having opiate-antagonistic activity and their pharmaceutical compositions - Google Patents

Tertiary arylethyl amine derivatives having opiate-antagonistic activity and their pharmaceutical compositions

Info

Publication number
NZ224170A
NZ224170A NZ224170A NZ22417088A NZ224170A NZ 224170 A NZ224170 A NZ 224170A NZ 224170 A NZ224170 A NZ 224170A NZ 22417088 A NZ22417088 A NZ 22417088A NZ 224170 A NZ224170 A NZ 224170A
Authority
NZ
New Zealand
Prior art keywords
group
formula
atoms
hydrogen
alkyl
Prior art date
Application number
NZ224170A
Other languages
English (en)
Inventor
Wijngaarden Ineke Van
Hartog Jacobus Antonius Jo Den
Martinus Theodorus Maria Tulp
Marinus Willem Lobbezoo
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of NZ224170A publication Critical patent/NZ224170A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ224170A 1987-04-10 1988-04-07 Tertiary arylethyl amine derivatives having opiate-antagonistic activity and their pharmaceutical compositions NZ224170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8700842A NL8700842A (enExample) 1987-04-10 1987-04-10

Publications (1)

Publication Number Publication Date
NZ224170A true NZ224170A (en) 1991-06-25

Family

ID=19849836

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ224170A NZ224170A (en) 1987-04-10 1988-04-07 Tertiary arylethyl amine derivatives having opiate-antagonistic activity and their pharmaceutical compositions

Country Status (8)

Country Link
EP (1) EP0289070A1 (enExample)
JP (1) JPS63290848A (enExample)
AU (1) AU611141B2 (enExample)
DK (1) DK187288A (enExample)
IL (1) IL85996A (enExample)
NL (1) NL8700842A (enExample)
NZ (1) NZ224170A (enExample)
ZA (1) ZA882385B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2249548B (en) * 1988-06-03 1992-10-14 Wyeth John & Brother Ltd Aralkyl amine intermediates
GB8813185D0 (en) * 1988-06-03 1988-07-06 Wyeth John & Brother Ltd New method & amines used therein
AU641394B2 (en) * 1989-06-02 1993-09-23 John Wyeth & Brother Limited Amines
FR2681322B1 (fr) * 1991-09-12 1993-12-17 Laboratorios Dr Esteve Sa Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments .
GB9324244D0 (en) * 1993-11-25 1994-01-12 Merck Sharp & Dohme Therapeutic agents
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
US7101980B2 (en) 2002-03-01 2006-09-05 Roche Diagnostics Operations, Inc. Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes
US20030170917A1 (en) * 2002-03-01 2003-09-11 Roche Diagnostics Corporation Compounds, antibodies, reagent kits, methods of producing antibodies, and methods of detecting analytes
PT2368553E (pt) 2003-04-08 2015-03-03 Progenics Pharm Inc Formulações farmacêuticas contendo metilnaltrexona
EP1861096B1 (en) 2005-03-07 2018-12-26 The University of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
WO2008121352A2 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof
DK2565195T3 (en) 2007-03-29 2015-06-29 Wyeth Llc PERIPHERAL OPIOID RECEPTOR AND ANTAGONISTS AND USES THEREOF
TWI553009B (zh) 2007-03-29 2016-10-11 普吉尼製藥公司 末梢性類鴉片受體拮抗劑及其用途
KR101581480B1 (ko) 2008-02-06 2015-12-30 프로제닉스 파머슈티컬스, 인코포레이티드 (ｒ),(ｒ)-2,2'-비스-메틸날트렉손의 제조법 및 용도
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB586645A (en) * 1944-07-19 1947-03-26 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
GB587244A (en) * 1944-07-21 1947-04-18 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
DE1493602B2 (de) * 1965-04-13 1976-08-26 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Verfahren zur herstellung von aminoketonen
DK129033B (da) * 1968-05-02 1974-08-12 Degussa Analogifremgangsmåde til fremstilling af propiophenonforbindelser eller deres optisk aktive isomere eller diastereomere eller salte eller kvaternære ammoniumforbindelser deraf.
NL7404732A (nl) * 1974-04-08 1975-10-10 Philips Nv Spasmolytice.
NL178686C (nl) * 1974-04-08 1986-05-01 Duphar Int Res Werkwijze ter bereiding of vervaardiging van spasmolytisch werkzame preparaten en werkwijze ter bereiding van n-alkyl-n-gesubstitueerd alkylbeta-fenylethylaminen met spasmolytische werking.
US4097500A (en) * 1977-07-25 1978-06-27 Morton-Norwich Products, Inc. N-Methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine hydrochloride
US4337207A (en) * 1980-09-04 1982-06-29 Regents Of The University Of California Biologically active catecholamine derivatives
NL8202810A (nl) * 1982-07-12 1984-02-01 Duphar Int Res Spasmolytisch werkzaam (+)-secoverine.
NL8300392A (nl) * 1983-02-03 1984-09-03 Duphar Int Res Nieuwe spasmolytisch werkzame propylcyclohexylketonderivaten.
EP0211254A3 (de) * 1985-07-31 1988-05-04 ASTA Pharma Aktiengesellschaft Neue cycloaliphatische Ketoamine
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents

Also Published As

Publication number Publication date
JPS63290848A (ja) 1988-11-28
ZA882385B (en) 1988-09-23
NL8700842A (enExample) 1988-11-01
IL85996A (en) 1991-12-12
DK187288A (da) 1988-10-11
DK187288D0 (da) 1988-04-06
AU611141B2 (en) 1991-06-06
IL85996A0 (en) 1988-09-30
AU1434488A (en) 1988-10-13
EP0289070A1 (en) 1988-11-02

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