NZ207965A - Proline derivatives and pharmaceutical compositions - Google Patents

Proline derivatives and pharmaceutical compositions

Info

Publication number
NZ207965A
NZ207965A NZ207965A NZ20796584A NZ207965A NZ 207965 A NZ207965 A NZ 207965A NZ 207965 A NZ207965 A NZ 207965A NZ 20796584 A NZ20796584 A NZ 20796584A NZ 207965 A NZ207965 A NZ 207965A
Authority
NZ
New Zealand
Prior art keywords
mmol
product
valyl
prolyl
valinal
Prior art date
Application number
NZ207965A
Other languages
English (en)
Inventor
A S Dutta
R L Stein
D A Trainor
R A Wildonger
Original Assignee
Ici Plc
Ici America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838311423A external-priority patent/GB8311423D0/en
Priority claimed from GB838314708A external-priority patent/GB8314708D0/en
Application filed by Ici Plc, Ici America Inc filed Critical Ici Plc
Publication of NZ207965A publication Critical patent/NZ207965A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ207965A 1983-04-27 1984-04-26 Proline derivatives and pharmaceutical compositions NZ207965A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838311423A GB8311423D0 (en) 1983-04-27 1983-04-27 Proline derivatives
GB838314708A GB8314708D0 (en) 1983-05-27 1983-05-27 Proline derivatives

Publications (1)

Publication Number Publication Date
NZ207965A true NZ207965A (en) 1987-08-31

Family

ID=26285956

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ207965A NZ207965A (en) 1983-04-27 1984-04-26 Proline derivatives and pharmaceutical compositions

Country Status (15)

Country Link
US (2) US4596789A (forum.php)
EP (1) EP0124317B1 (forum.php)
AU (1) AU580955B2 (forum.php)
CA (1) CA1253297A (forum.php)
DE (1) DE3481913D1 (forum.php)
DK (1) DK209784A (forum.php)
ES (2) ES8701154A1 (forum.php)
FI (1) FI841601A7 (forum.php)
GR (1) GR81937B (forum.php)
HU (1) HUT34041A (forum.php)
IE (1) IE57350B1 (forum.php)
IL (1) IL71614A0 (forum.php)
NO (1) NO841665L (forum.php)
NZ (1) NZ207965A (forum.php)
PT (1) PT78502B (forum.php)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes
DD248961A1 (de) * 1984-05-22 1987-08-26 Akad Wissenschaften Ddr Verfahren zur herstellung wundheilungsfoerdernder praeparationen
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
DE3683541D1 (de) 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
GB8613704D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro keto compounds
DE3782191T2 (de) * 1986-06-05 1993-02-25 Ici America Inc Difluorketoverbindungen.
GB8711747D0 (en) * 1986-06-05 1987-06-24 Ici America Inc Difluoro peptide compounds
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
JPH075634B2 (ja) * 1987-10-30 1995-01-25 日東紡績株式会社 トリペプチド類及びこれを含有する抗プラスミン剤
FR2622581B1 (fr) * 1987-11-03 1990-02-16 Inorgan Sa Rech Develop Pharm Nouveaux derives de l-proline, leur preparation et leurs applications biologiques
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
AU629259B2 (en) * 1988-10-27 1992-10-01 University Of Kentucky Research Foundation, The Human leukocyte elastase inhibitors and methods of producing and using same
EP0490379A3 (de) * 1990-12-13 1992-06-24 BERLIN-CHEMIE Aktiengesellschaft Diaminosäurederivate und pharmazeutische Zusammensetzungen
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
FR2700165B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2700166B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
WO1997021690A1 (en) * 1995-11-28 1997-06-19 Cephalon, Inc. D-amino acid derived inhibitors of cysteine and serine proteases
ES2252831T3 (es) 1997-04-18 2006-05-16 Cephalon, Inc. Acidos peptidil-2-amino-1-hidroxialcanosulfonico utilizado como inhibidor de la cisteina proteasa.
AU757072B2 (en) * 1997-08-11 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptide analogues
IL153670A0 (en) * 2000-07-21 2003-07-06 Schering Corp Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
ATE454469T1 (de) 2002-01-28 2010-01-15 Ambion Inc Für den nachweis von nukleinsäuren kompetente biologische rohderivate
MY143076A (en) * 2003-05-21 2011-02-28 Boehringer Ingelheim Int Hepatitis c inhibitors compounds
ATE512971T1 (de) * 2004-07-20 2011-07-15 Boehringer Ingelheim Int Peptidanaloga als hepatitis c-hemmer
UY29016A1 (es) * 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
AR064235A1 (es) * 2006-07-24 2009-03-25 Tetralogic Pharmaceuticals Cor Dipeptidos antagonistas de iap, una composicion farmaceutica que los comprende y el uso de los mismos para el tratamiento del cancer
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
US20080319221A1 (en) * 2007-06-22 2008-12-25 Bernd Junker Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
DE102007054497B3 (de) * 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
EP2367954B1 (en) 2008-12-19 2015-02-18 Life Technologies Corporation Proteinase k inhibitors, methods and compositions therefor
WO2013004636A1 (en) * 2011-07-01 2013-01-10 Novozymes A/S Stabilized subtilisin composition
US11161859B2 (en) 2017-03-21 2021-11-02 The Scripps Research Institute Cu- and Ni-catalyzed decarboxylative borylation reactions
CN114008068A (zh) 2019-07-01 2022-02-01 巴斯夫欧洲公司 稳定酶的肽缩醛

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE629254C (de) * 1934-06-28 1936-04-25 Fried Krupp Grusonwerk Akt Ges Vorrichtung zum Glaetten der Arbeitswalzen eines Walzwerks waehrend des Betriebes
US3867364A (en) * 1968-11-21 1975-02-18 Microbial Chem Res Found Process for the synthesis of leupeptins and their analogues
US3935280A (en) * 1975-01-10 1976-01-27 Aldrich-Boranes, Inc. Reduction of amino acids in the presence of boron trifluoride
CH629254A5 (en) * 1976-10-14 1982-04-15 Nippon Kayaku Kk Process for preparing L-leupeptins
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
CS226907B1 (en) * 1981-08-07 1984-04-16 Kasafirek Evzen Alkylamides of carboxyalkanoylpeptides
FR2546164B1 (fr) * 1983-05-16 1987-07-17 Centre Nat Rech Scient Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes

Also Published As

Publication number Publication date
FI841601A0 (fi) 1984-04-24
HUT34041A (en) 1985-01-28
US4596789A (en) 1986-06-24
AU580955B2 (en) 1989-02-09
NO841665L (no) 1984-10-29
DE3481913D1 (de) 1990-05-17
EP0124317B1 (en) 1990-04-11
CA1253297A (en) 1989-04-25
GR81937B (forum.php) 1984-12-12
ES540029A0 (es) 1987-05-01
EP0124317A3 (en) 1987-01-14
ES8701154A1 (es) 1986-11-16
DK209784A (da) 1984-10-28
DK209784D0 (da) 1984-04-26
IE57350B1 (en) 1992-08-12
ES532007A0 (es) 1986-11-16
PT78502B (en) 1986-07-22
EP0124317A2 (en) 1984-11-07
IE840985L (en) 1984-10-27
PT78502A (en) 1984-05-01
US4691007A (en) 1987-09-01
ES8705465A1 (es) 1987-05-01
FI841601A7 (fi) 1984-10-28
IL71614A0 (en) 1984-07-31
AU2744484A (en) 1984-11-01

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