EP0396709A4 - Human leukocyte elastase inhibitors and methods of producing and using same - Google Patents

Human leukocyte elastase inhibitors and methods of producing and using same

Info

Publication number
EP0396709A4
EP0396709A4 EP19890912611 EP89912611A EP0396709A4 EP 0396709 A4 EP0396709 A4 EP 0396709A4 EP 19890912611 EP19890912611 EP 19890912611 EP 89912611 A EP89912611 A EP 89912611A EP 0396709 A4 EP0396709 A4 EP 0396709A4
Authority
EP
European Patent Office
Prior art keywords
producing
methods
same
human leukocyte
leukocyte elastase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890912611
Other versions
EP0396709A1 (en
Inventor
George A. Digenis
Bushra J. Agha
Charles Khouri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
Original Assignee
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/263,385 external-priority patent/US5008245A/en
Priority claimed from US07/409,894 external-priority patent/US5922319A/en
Application filed by University of Kentucky Research Foundation filed Critical University of Kentucky Research Foundation
Publication of EP0396709A1 publication Critical patent/EP0396709A1/en
Publication of EP0396709A4 publication Critical patent/EP0396709A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19890912611 1988-10-27 1989-10-27 Human leukocyte elastase inhibitors and methods of producing and using same Withdrawn EP0396709A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/263,385 US5008245A (en) 1988-10-27 1988-10-27 Novel peptidyl carbamate inhibitors of the enzyme elastase
US263385 1988-10-27
US07/409,894 US5922319A (en) 1989-09-20 1989-09-20 Methods of treating eye conditions with human leukocyte elastase (HLE) inhibitory agents
US409894 1989-09-20

Publications (2)

Publication Number Publication Date
EP0396709A1 EP0396709A1 (en) 1990-11-14
EP0396709A4 true EP0396709A4 (en) 1991-05-22

Family

ID=26949819

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19890912611 Withdrawn EP0396709A4 (en) 1988-10-27 1989-10-27 Human leukocyte elastase inhibitors and methods of producing and using same
EP19890311130 Pending EP0367514A3 (en) 1988-10-27 1989-10-27 Human leukocyte elastase inhibitors and methods for producing and using same

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19890311130 Pending EP0367514A3 (en) 1988-10-27 1989-10-27 Human leukocyte elastase inhibitors and methods for producing and using same

Country Status (5)

Country Link
EP (2) EP0396709A4 (en)
JP (1) JPH03503055A (en)
AU (1) AU629259B2 (en)
CA (1) CA2001629A1 (en)
WO (1) WO1990004409A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895671A (en) * 1989-11-27 1991-05-28 Labsystems Oy SKYDDANDE AV INTRAOKULAERA STRUKTURER.
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
CZ285911B6 (en) * 1997-04-30 1999-11-17 Vúfb, A. S. Oligopeptide inhibitors of elastases
JP2002506013A (en) 1998-03-09 2002-02-26 イスタ ファーマシューティカルズ インコーポレイテッド Use of corneal sclerosing agents in enzyme keratoplasty
MXPA02002452A (en) 1999-09-06 2004-09-10 Ono Pharmaceutical Co Preventive and therapeutic agents for eye diseases.
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US20050281799A1 (en) 2004-06-16 2005-12-22 Glen Gong Targeting damaged lung tissue using compositions
WO2006014567A2 (en) 2004-07-08 2006-02-09 Pneumrx, Inc. Pleural effusion treatment device, method and material

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124317B1 (en) * 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
US4636492A (en) * 1984-08-29 1987-01-13 E. I. Du Pont De Nemours And Company Inhibition of viral protease activity by peptide halomethyl ketones
US4760130A (en) * 1984-12-06 1988-07-26 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9004409A1 *

Also Published As

Publication number Publication date
EP0396709A1 (en) 1990-11-14
AU629259B2 (en) 1992-10-01
AU4511089A (en) 1990-05-14
JPH03503055A (en) 1991-07-11
EP0367514A3 (en) 1991-05-22
EP0367514A2 (en) 1990-05-09
WO1990004409A1 (en) 1990-05-03
CA2001629A1 (en) 1990-04-27

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19900711

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A4 Supplementary search report drawn up and despatched

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Effective date: 19941028

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19970310