NZ206458A - Phenothiazine derivatives and pharmaceutical compositions - Google Patents

Phenothiazine derivatives and pharmaceutical compositions

Info

Publication number
NZ206458A
NZ206458A NZ206458A NZ20645883A NZ206458A NZ 206458 A NZ206458 A NZ 206458A NZ 206458 A NZ206458 A NZ 206458A NZ 20645883 A NZ20645883 A NZ 20645883A NZ 206458 A NZ206458 A NZ 206458A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
group
dimethylaminopropyl
acid
Prior art date
Application number
NZ206458A
Other languages
English (en)
Inventor
G G Coker
J W A Findlay
H J Leighton
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838318832A external-priority patent/GB8318832D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NZ206458A publication Critical patent/NZ206458A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • C07D279/20[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • C07D279/22[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ206458A 1982-12-02 1983-12-01 Phenothiazine derivatives and pharmaceutical compositions NZ206458A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8234398 1982-12-02
GB838318832A GB8318832D0 (en) 1983-07-12 1983-07-12 Chemical compounds

Publications (1)

Publication Number Publication Date
NZ206458A true NZ206458A (en) 1987-07-31

Family

ID=26284560

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ206458A NZ206458A (en) 1982-12-02 1983-12-01 Phenothiazine derivatives and pharmaceutical compositions

Country Status (22)

Country Link
EP (1) EP0117302B1 (cg-RX-API-DMAC7.html)
JP (1) JPH06767B2 (cg-RX-API-DMAC7.html)
KR (1) KR890000638B1 (cg-RX-API-DMAC7.html)
AU (1) AU572105B2 (cg-RX-API-DMAC7.html)
BG (2) BG50158A3 (cg-RX-API-DMAC7.html)
CA (1) CA1280749C (cg-RX-API-DMAC7.html)
DD (1) DD213922A5 (cg-RX-API-DMAC7.html)
DE (1) DE3381689D1 (cg-RX-API-DMAC7.html)
DK (1) DK551283A (cg-RX-API-DMAC7.html)
ES (7) ES527705A0 (cg-RX-API-DMAC7.html)
FI (1) FI81788C (cg-RX-API-DMAC7.html)
GR (1) GR81958B (cg-RX-API-DMAC7.html)
HU (1) HU193274B (cg-RX-API-DMAC7.html)
IE (1) IE56998B1 (cg-RX-API-DMAC7.html)
IL (2) IL70359A (cg-RX-API-DMAC7.html)
MC (1) MC1562A1 (cg-RX-API-DMAC7.html)
NO (1) NO160203C (cg-RX-API-DMAC7.html)
NZ (1) NZ206458A (cg-RX-API-DMAC7.html)
PH (1) PH20433A (cg-RX-API-DMAC7.html)
PL (2) PL145778B1 (cg-RX-API-DMAC7.html)
PT (1) PT77766B (cg-RX-API-DMAC7.html)
YU (1) YU44758B (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413915D0 (en) * 1984-05-31 1984-07-04 Wellcome Found Phenothiazine compounds
JPS6256489A (ja) * 1985-09-04 1987-03-12 Sanwa Kagaku Kenkyusho:Kk 新規なピロリチジン化合物及びその塩、これらの製法並びにこれらを有効成分とする消化性潰瘍治療剤
US6333322B1 (en) 1996-03-13 2001-12-25 Eisai Co., Ltd. Nitrogen-containing tricyclic compounds and drugs containing the same
CN101896811B (zh) 2007-12-10 2014-04-16 拜尔健康护理有限责任公司 制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法
EP2758403B1 (en) 2011-09-21 2016-04-27 Inception Orion, Inc. Tricyclic compounds useful as neurogenic and neuroprotective agents
KR101646962B1 (ko) 2014-09-29 2016-08-10 한국과학기술연구원 CaM 저해활성을 가지는 페노싸이아진 유도체
US10035795B1 (en) 2017-04-06 2018-07-31 Korea Institute Of Science And Technology Phenothiazine derivatives having CaM inhibitory activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956996A (en) * 1960-10-18 Alkylated phenotfflazenecarboxamede
NL97951C (cg-RX-API-DMAC7.html) * 1955-11-15
NL96990C (cg-RX-API-DMAC7.html) * 1956-01-10
NL58901C (cg-RX-API-DMAC7.html) * 1957-02-07 1947-02-15
NL273878A (cg-RX-API-DMAC7.html) * 1961-01-24
US3112310A (en) * 1962-01-15 1963-11-26 Searle & Co 10-alkylaminoalkylphenothiazine-2-carboxamides

Also Published As

Publication number Publication date
DD213922A5 (de) 1984-09-26
ES8504752A1 (es) 1985-04-16
ES8506676A1 (es) 1985-07-16
KR840006996A (ko) 1984-12-04
ES534355A0 (es) 1985-07-16
ES8506674A1 (es) 1985-07-16
ES8506673A1 (es) 1985-07-16
ES534358A0 (es) 1985-07-16
EP0117302B1 (en) 1990-06-27
NO160203C (no) 1989-03-22
PH20433A (en) 1987-01-05
PL145778B1 (en) 1988-10-31
NO160203B (no) 1988-12-12
ES8506296A1 (es) 1985-07-01
ES534354A0 (es) 1985-07-16
AU2190083A (en) 1984-06-07
YU234983A (en) 1986-02-28
PL252164A1 (en) 1985-11-19
PT77766B (en) 1986-05-30
FI81788B (fi) 1990-08-31
IL70359A0 (en) 1984-03-30
ES8506672A1 (es) 1985-07-16
PT77766A (en) 1984-01-01
BG47647A3 (bg) 1990-08-15
ES534356A0 (es) 1985-07-01
FI834401A0 (fi) 1983-12-01
FI81788C (fi) 1990-12-10
IL70359A (en) 1988-05-31
ES534353A0 (es) 1985-07-16
FI834401L (fi) 1984-06-03
DK551283D0 (da) 1983-12-01
BG50158A3 (bg) 1992-05-15
PL252163A1 (en) 1985-11-05
CA1280749C (en) 1991-02-26
NO834424L (no) 1984-06-04
EP0117302A3 (en) 1984-10-17
ES8506675A1 (es) 1985-08-01
HU193274B (en) 1987-09-28
GR81958B (cg-RX-API-DMAC7.html) 1984-12-12
ES534357A0 (es) 1985-08-01
IE832825L (en) 1984-06-02
AU572105B2 (en) 1988-05-05
DE3381689D1 (de) 1990-08-02
ES527705A0 (es) 1985-04-16
JPS59110684A (ja) 1984-06-26
JPH06767B2 (ja) 1994-01-05
IE56998B1 (en) 1992-03-11
MC1562A1 (fr) 1984-11-12
EP0117302A2 (en) 1984-09-05
DK551283A (da) 1984-06-03
KR890000638B1 (ko) 1989-03-22
YU44758B (en) 1991-02-28

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