NO995590L - 20-Aryl-5<alfa>-pregnan-derivater - Google Patents
20-Aryl-5<alfa>-pregnan-derivaterInfo
- Publication number
- NO995590L NO995590L NO995590A NO995590A NO995590L NO 995590 L NO995590 L NO 995590L NO 995590 A NO995590 A NO 995590A NO 995590 A NO995590 A NO 995590A NO 995590 L NO995590 L NO 995590L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- halogen
- independently hydrogen
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- YYQGUWHFXVXQOO-GFCCVEGCSA-N 2-chloro-4-[[3-[(2R)-2-hydroxybutyl]-1-methyl-2-oxobenzimidazol-5-yl]amino]pyridine-3-carbonitrile Chemical compound ClC1=C(C#N)C(=CC=N1)NC1=CC2=C(N(C(N2C[C@@H](CC)O)=O)C)C=C1 YYQGUWHFXVXQOO-GFCCVEGCSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000021121 meiosis Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201474 | 1997-05-16 | ||
| PCT/EP1998/002989 WO1998052965A1 (en) | 1997-05-16 | 1998-05-11 | 20-ARALKYL-5α-PREGNANE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO995590D0 NO995590D0 (no) | 1999-11-15 |
| NO995590L true NO995590L (no) | 2000-01-11 |
Family
ID=8228325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO995590A NO995590L (no) | 1997-05-16 | 1999-11-15 | 20-Aryl-5<alfa>-pregnan-derivater |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6177420B1 (da) |
| EP (1) | EP0984980B1 (da) |
| JP (1) | JP2001526673A (da) |
| KR (1) | KR20010012643A (da) |
| CN (1) | CN1260802A (da) |
| AT (1) | ATE229032T1 (da) |
| AU (1) | AU726016B2 (da) |
| BR (1) | BR9808803A (da) |
| CA (1) | CA2289675A1 (da) |
| DE (1) | DE69809905T2 (da) |
| DK (1) | DK0984980T3 (da) |
| ES (1) | ES2189173T3 (da) |
| HU (1) | HUP0002331A3 (da) |
| NO (1) | NO995590L (da) |
| PL (1) | PL337008A1 (da) |
| TR (1) | TR199902793T2 (da) |
| WO (1) | WO1998052965A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2181321T3 (es) * | 1997-12-18 | 2003-02-16 | Akzo Nobel Nv | Derivados 17beta-aril(arilmetil)oxi(tio)alquilandrostano. |
| DE69913513T2 (de) * | 1998-05-13 | 2004-09-30 | Novo Nordisk A/S | Verwendung von verbindungen mit der fähigkeit die meiose zu regulieren |
| AU4498299A (en) * | 1998-06-19 | 2000-01-10 | Novo Nordisk A/S | Meiosis regulating compounds |
| JP2002538123A (ja) * | 1999-03-02 | 2002-11-12 | アクゾ・ノベル・エヌ・ベー | （アンドロスト−５−エン−１７β−イル）アルキルスルホキシドおよびスルホンならびに受胎能の調節のためのその使用 |
| US6756366B1 (en) * | 1999-04-06 | 2004-06-29 | Akzo Nobel N.V. | Orally active androgens |
| EP1127890A1 (en) | 2000-02-22 | 2001-08-29 | Schering Aktiengesellschaft | Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments |
| US6988613B2 (en) * | 2001-02-06 | 2006-01-24 | Novo Nordisk A/S | Composition for IVF |
| WO2005020928A2 (en) | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| CN1906207A (zh) | 2004-01-15 | 2007-01-31 | 沃纳奇尔科特公司 | 乙炔雌二醇的二－甾族前体药物 |
| US7067505B2 (en) | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of estradiol |
| CN101218245B (zh) | 2005-07-12 | 2011-08-17 | 沃纳奇尔科特有限责任公司 | 炔雌醇的3-酯前药 |
| US9670244B2 (en) | 2006-02-27 | 2017-06-06 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| CN101951915A (zh) | 2007-12-03 | 2011-01-19 | 加利福尼亚大学董事会 | 用于刺猬蛋白信号、骨诱导、抗脂肪形成和wnt信号的激活的氧固醇 |
| WO2013169399A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
| US9683009B2 (en) | 2013-05-02 | 2017-06-20 | The Regents Of The University Of California | Bone-selective osteogenic oxysterol-bone targeting agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716777A (en) * | 1994-06-23 | 1998-02-10 | Novo Nordisk A/S | Regulation of meiosis using sterols |
| PL322106A1 (en) | 1995-03-06 | 1998-01-05 | Novo Nordisk As | Meiosis stimulation |
| PL185622B1 (pl) * | 1995-06-23 | 2003-06-30 | Novo Nordisk As | Zastosowanie związku steroidowego i sposób regulacji mejozy w komórce rozrodczej ssaka |
-
1998
- 1998-05-11 US US09/423,743 patent/US6177420B1/en not_active Expired - Fee Related
- 1998-05-11 WO PCT/EP1998/002989 patent/WO1998052965A1/en not_active Ceased
- 1998-05-11 HU HU0002331A patent/HUP0002331A3/hu unknown
- 1998-05-11 BR BR9808803-3A patent/BR9808803A/pt not_active Application Discontinuation
- 1998-05-11 DE DE69809905T patent/DE69809905T2/de not_active Expired - Fee Related
- 1998-05-11 CN CN98806290A patent/CN1260802A/zh active Pending
- 1998-05-11 AU AU76549/98A patent/AU726016B2/en not_active Ceased
- 1998-05-11 KR KR1019997010604A patent/KR20010012643A/ko not_active Withdrawn
- 1998-05-11 TR TR1999/02793T patent/TR199902793T2/xx unknown
- 1998-05-11 AT AT98924316T patent/ATE229032T1/de not_active IP Right Cessation
- 1998-05-11 JP JP54995898A patent/JP2001526673A/ja not_active Ceased
- 1998-05-11 EP EP98924316A patent/EP0984980B1/en not_active Expired - Lifetime
- 1998-05-11 PL PL98337008A patent/PL337008A1/xx unknown
- 1998-05-11 CA CA002289675A patent/CA2289675A1/en not_active Abandoned
- 1998-05-11 DK DK98924316T patent/DK0984980T3/da active
- 1998-05-11 ES ES98924316T patent/ES2189173T3/es not_active Expired - Lifetime
-
1999
- 1999-11-15 NO NO995590A patent/NO995590L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0984980B1 (en) | 2002-12-04 |
| WO1998052965A1 (en) | 1998-11-26 |
| AU726016B2 (en) | 2000-10-26 |
| JP2001526673A (ja) | 2001-12-18 |
| US6177420B1 (en) | 2001-01-23 |
| PL337008A1 (en) | 2000-07-31 |
| AU7654998A (en) | 1998-12-11 |
| ATE229032T1 (de) | 2002-12-15 |
| NO995590D0 (no) | 1999-11-15 |
| CA2289675A1 (en) | 1998-11-26 |
| CN1260802A (zh) | 2000-07-19 |
| KR20010012643A (ko) | 2001-02-26 |
| EP0984980A1 (en) | 2000-03-15 |
| HUP0002331A3 (en) | 2001-05-28 |
| DE69809905D1 (de) | 2003-01-16 |
| ES2189173T3 (es) | 2003-07-01 |
| DE69809905T2 (de) | 2003-08-28 |
| HUP0002331A2 (hu) | 2000-12-28 |
| DK0984980T3 (da) | 2003-03-17 |
| BR9808803A (pt) | 2000-07-18 |
| TR199902793T2 (xx) | 2000-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |