ES2189173T3 - Derivados de 20-aril-5alfa-pregnano. - Google Patents
Derivados de 20-aril-5alfa-pregnano.Info
- Publication number
- ES2189173T3 ES2189173T3 ES98924316T ES98924316T ES2189173T3 ES 2189173 T3 ES2189173 T3 ES 2189173T3 ES 98924316 T ES98924316 T ES 98924316T ES 98924316 T ES98924316 T ES 98924316T ES 2189173 T3 ES2189173 T3 ES 2189173T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- delta
- alkyl
- alkoxide
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 150000004703 alkoxides Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000021121 meiosis Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Las invención se refiere a un derivado del 20-aralquil-5a-pregnan que tiene la fórmula general (I), o a una sal farmacológicamente aceptable del mismo, en donde R{sub, 1} es (H, OR), (H, OSO{sub, 3}H) o NOR; R es H, alquilo C{sub,1-6} o acilo C{sub,1-6}; cada R{sub, 2} y R{sub, 3} es independientemente hidrógeno o alquilo C{sub,1-6}; X es un radical hidrocarburo divalente de cadena recta C{sub,1-8}, que comprende opcionalmente un enlace doble o triple; o X es -(CH{sub,2}){sub,m}-CR{sub,7}R{sub,8}-; m = 0-4; al menos una de R{sub,7} y R{sub,8} es alquilo C{sub,1-4} hidróxido, alcóxido C{sub,1-4} o halógeno; el otro, si estuviera presente, es hidrógeno; o R{sub,7} y R{sub,8} representan juntos O o NOR''; R'' es H, alquilo C{sub,1-6} o acilo C{sub,1-6}; cada R{sub,4}, R{sub,5} y R{sub,6} son independientemente hidrógeno, hidróxido, alcóxido C{sub,1-4}, halógeno, NR{sub,9}R{sub,10} o alquilo C{sub,1-4}, opcionalmente sustituido por hidróxido, alcóxido, halógeno u oxo; cada R{sub,9} y R{sub,10} es independientemente hidrógeno o alquilo C{sub,1-4} y las líneas punteadas indican un enlace doble "DELTA" 7 o "DELTA" 8 o bien un par de enlaces dobles conjugados seleccionados entre "DELTA" 7,14, "DELTA" 8,14, "DELTA" 6,8(14). Los compuestos de la invención tienen actividad activadora de la meiosis y pueden utilizarse para el control de la fertilidad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201474 | 1997-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2189173T3 true ES2189173T3 (es) | 2003-07-01 |
Family
ID=8228325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98924316T Expired - Lifetime ES2189173T3 (es) | 1997-05-16 | 1998-05-11 | Derivados de 20-aril-5alfa-pregnano. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6177420B1 (es) |
| EP (1) | EP0984980B1 (es) |
| JP (1) | JP2001526673A (es) |
| KR (1) | KR20010012643A (es) |
| CN (1) | CN1260802A (es) |
| AT (1) | ATE229032T1 (es) |
| AU (1) | AU726016B2 (es) |
| BR (1) | BR9808803A (es) |
| CA (1) | CA2289675A1 (es) |
| DE (1) | DE69809905T2 (es) |
| DK (1) | DK0984980T3 (es) |
| ES (1) | ES2189173T3 (es) |
| HU (1) | HUP0002331A3 (es) |
| NO (1) | NO995590L (es) |
| PL (1) | PL337008A1 (es) |
| TR (1) | TR199902793T2 (es) |
| WO (1) | WO1998052965A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1042353T3 (da) * | 1997-12-18 | 2002-11-04 | Akzo Nobel Nv | 17-beta-aryl(arylmethyl)oxy(thio)alkylandrostanderivater |
| AU3701199A (en) * | 1998-05-13 | 1999-11-29 | Novo Nordisk A/S | Meiosis regulating compounds |
| AU4498299A (en) * | 1998-06-19 | 2000-01-10 | Novo Nordisk A/S | Meiosis regulating compounds |
| WO2000051618A1 (en) * | 1999-03-02 | 2000-09-08 | Akzo Nobel N.V. | (ANDROST-5-EN-17β-YL)ALKYL SULFOXIDES AND SULFONES AND THEIR USE FOR CONTROL OF FERTILITY |
| EP1212345B1 (en) * | 1999-04-06 | 2003-08-06 | Akzo Nobel N.V. | Orally active 7-alpha-alkyl androgens |
| EP1127890A1 (en) | 2000-02-22 | 2001-08-29 | Schering Aktiengesellschaft | Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments |
| US6988613B2 (en) * | 2001-02-06 | 2006-01-24 | Novo Nordisk A/S | Composition for IVF |
| WO2005020928A2 (en) | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| WO2005070950A1 (en) | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| JP2007517877A (ja) | 2004-01-15 | 2007-07-05 | ワーナー・チルコット・カンパニー・インコーポレーテッド | エストラジオールのジ−ステロイド型プロドラッグ |
| US7795241B2 (en) | 2005-07-12 | 2010-09-14 | Warner Chilcott Company, Llc | Derivative prodrugs of ethinyl estradiol |
| EP1993558B1 (en) | 2006-02-27 | 2014-07-30 | The Regents of The University of California | Oxysterol compounds and the hedgehog pathway |
| AU2008331808B2 (en) | 2007-03-16 | 2014-08-21 | The Regents Of The University Of California | Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling |
| KR20150013232A (ko) | 2012-05-07 | 2015-02-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 골형성 및 헤지호그 신호전달을 유도하고 지방생성을 억제하는 옥시스테롤 유사체 oxy133 |
| JP2016517888A (ja) | 2013-05-02 | 2016-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 骨選択的骨形成のオキシステロール骨標的薬剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716777A (en) * | 1994-06-23 | 1998-02-10 | Novo Nordisk A/S | Regulation of meiosis using sterols |
| RU2188006C2 (ru) | 1995-03-06 | 2002-08-27 | Ново Нордиск А/С | Стимуляция мейоза |
| AU718246B2 (en) | 1995-06-23 | 2000-04-13 | Novo Nordisk A/S | Meiosis regulating compounds |
-
1998
- 1998-05-11 DK DK98924316T patent/DK0984980T3/da active
- 1998-05-11 AT AT98924316T patent/ATE229032T1/de not_active IP Right Cessation
- 1998-05-11 TR TR1999/02793T patent/TR199902793T2/xx unknown
- 1998-05-11 WO PCT/EP1998/002989 patent/WO1998052965A1/en not_active Application Discontinuation
- 1998-05-11 DE DE69809905T patent/DE69809905T2/de not_active Expired - Fee Related
- 1998-05-11 PL PL98337008A patent/PL337008A1/xx unknown
- 1998-05-11 CN CN98806290A patent/CN1260802A/zh active Pending
- 1998-05-11 US US09/423,743 patent/US6177420B1/en not_active Expired - Fee Related
- 1998-05-11 AU AU76549/98A patent/AU726016B2/en not_active Ceased
- 1998-05-11 EP EP98924316A patent/EP0984980B1/en not_active Expired - Lifetime
- 1998-05-11 KR KR1019997010604A patent/KR20010012643A/ko not_active Application Discontinuation
- 1998-05-11 HU HU0002331A patent/HUP0002331A3/hu unknown
- 1998-05-11 BR BR9808803-3A patent/BR9808803A/pt not_active Application Discontinuation
- 1998-05-11 CA CA002289675A patent/CA2289675A1/en not_active Abandoned
- 1998-05-11 JP JP54995898A patent/JP2001526673A/ja not_active Ceased
- 1998-05-11 ES ES98924316T patent/ES2189173T3/es not_active Expired - Lifetime
-
1999
- 1999-11-15 NO NO995590A patent/NO995590L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1260802A (zh) | 2000-07-19 |
| HUP0002331A3 (en) | 2001-05-28 |
| DE69809905D1 (de) | 2003-01-16 |
| EP0984980B1 (en) | 2002-12-04 |
| AU726016B2 (en) | 2000-10-26 |
| EP0984980A1 (en) | 2000-03-15 |
| JP2001526673A (ja) | 2001-12-18 |
| BR9808803A (pt) | 2000-07-18 |
| NO995590D0 (no) | 1999-11-15 |
| DE69809905T2 (de) | 2003-08-28 |
| AU7654998A (en) | 1998-12-11 |
| US6177420B1 (en) | 2001-01-23 |
| ATE229032T1 (de) | 2002-12-15 |
| PL337008A1 (en) | 2000-07-31 |
| NO995590L (no) | 2000-01-11 |
| DK0984980T3 (da) | 2003-03-17 |
| CA2289675A1 (en) | 1998-11-26 |
| HUP0002331A2 (hu) | 2000-12-28 |
| KR20010012643A (ko) | 2001-02-26 |
| TR199902793T2 (xx) | 2000-06-21 |
| WO1998052965A1 (en) | 1998-11-26 |
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