NO995065L - Indolderivater med kombinert 5HT1A-, 5HT1B- og 5HT1D- reseptorantagonistaktivitet - Google Patents
Indolderivater med kombinert 5HT1A-, 5HT1B- og 5HT1D- reseptorantagonistaktivitetInfo
- Publication number
- NO995065L NO995065L NO995065A NO995065A NO995065L NO 995065 L NO995065 L NO 995065L NO 995065 A NO995065 A NO 995065A NO 995065 A NO995065 A NO 995065A NO 995065 L NO995065 L NO 995065L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- nitrogen
- oxygen
- sulfur
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9707829.9A GB9707829D0 (en) | 1997-04-18 | 1997-04-18 | Novel compounds |
| GBGB9801882.3A GB9801882D0 (en) | 1998-01-29 | 1998-01-29 | Novel compounds |
| PCT/EP1998/002262 WO1998050358A1 (en) | 1997-04-18 | 1998-04-14 | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO995065L true NO995065L (no) | 1999-10-15 |
| NO995065D0 NO995065D0 (no) | 1999-10-15 |
Family
ID=26311401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO995065A NO995065D0 (no) | 1997-04-18 | 1999-10-15 | Indolderivater med kombinert 5HT1A-, 5HT1B- og 5HT1D- reseptorantagonistaktivitet |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0975593A1 (zh) |
| JP (1) | JP2001524116A (zh) |
| KR (1) | KR20010006487A (zh) |
| CN (1) | CN1260781A (zh) |
| AR (1) | AR013076A1 (zh) |
| AU (1) | AU732863B2 (zh) |
| BR (1) | BR9809092A (zh) |
| CA (1) | CA2288662A1 (zh) |
| CO (1) | CO4950608A1 (zh) |
| HU (1) | HUP0001123A3 (zh) |
| IL (1) | IL132409A0 (zh) |
| NO (1) | NO995065D0 (zh) |
| NZ (1) | NZ500252A (zh) |
| PL (1) | PL336317A1 (zh) |
| TR (1) | TR199902590T2 (zh) |
| TW (1) | TW509687B (zh) |
| WO (1) | WO1998050358A1 (zh) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725931D0 (en) * | 1997-12-05 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
| EP1101759A4 (en) | 1998-07-31 | 2001-12-12 | Nippon Soda Co | PHENYLAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICATIONS FOR HYPERLIPEMY |
| GB9827882D0 (en) * | 1998-12-17 | 1999-02-10 | Smithkline Beecham Plc | Novel compounds |
| UA62015C2 (en) | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| AU5960300A (en) * | 1999-07-15 | 2001-02-05 | Nps Allelix Corp. | Heterocyclic compounds for the treatment of migraine |
| TR200200795T2 (tr) * | 1999-09-25 | 2002-07-22 | Smithkline Beecham P. L. C. | 5-HT1B antagonistleri olarak piperazin türevleri |
| GB9926303D0 (en) * | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| ATE286883T1 (de) * | 1999-11-05 | 2005-01-15 | Smithkline Beecham Plc | Isochinolin und chinazolinderivate mit kombinierter 5ht1a, 5ht1b und 5ht1d rezeptor aktivität |
| DE10051981A1 (de) | 2000-10-20 | 2002-05-02 | Bayer Ag | Substituierte Phenyluracile |
| GB0106419D0 (en) * | 2001-03-15 | 2001-05-02 | Smithkline Beecham Plc | Novel compounds |
| GB0106586D0 (en) * | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
| JP4187642B2 (ja) * | 2001-06-07 | 2008-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６受容体親和性を有する新規インドール誘導体 |
| ES2316777T3 (es) * | 2002-02-15 | 2009-04-16 | Glaxo Group Limited | Moduladores de receptores vainilloides. |
| DE60303376T2 (de) | 2002-05-13 | 2006-11-16 | F. Hoffmann-La Roche Ag | Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen |
| WO2005058847A1 (en) | 2003-12-09 | 2005-06-30 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives and uses thereof |
| CA2707492A1 (en) * | 2007-12-13 | 2009-06-18 | Amgen Inc. | Gamma secretase modulators |
| BR112012024380A2 (pt) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | compostos químicos |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| CN102924330A (zh) * | 2012-09-03 | 2013-02-13 | 华东理工大学 | 一种规模化制备5-氨基-1-萘腈的方法 |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| CN103467374A (zh) * | 2013-08-30 | 2013-12-25 | 江苏弘和药物研发有限公司 | 一种8-溴-4-羧基喹啉的合成方法 |
| CN105829310B (zh) | 2013-12-20 | 2019-04-12 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| CN115197099A (zh) * | 2022-05-30 | 2022-10-18 | 安徽昊帆生物有限公司 | N-Boc-1，4-苯二胺的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| ATE204262T1 (de) * | 1991-09-18 | 2001-09-15 | Glaxo Group Ltd | Benzanilidderivate als 5-ht1d-antagonisten |
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| WO1995004729A1 (en) * | 1993-08-06 | 1995-02-16 | Smithkline Beecham Plc | Amide derivatives as 5ht1d receptor antagonists |
| JPH09504004A (ja) * | 1993-08-20 | 1997-04-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ｄレセプター拮抗薬用アミドおよび尿素誘導体 |
| DE69417427T2 (de) * | 1993-09-03 | 1999-11-25 | Smithkline Beecham Plc | Indol- und indolin-derivate als 5ht1d rezeptor antagonisten |
-
1998
- 1998-04-14 HU HU0001123A patent/HUP0001123A3/hu unknown
- 1998-04-14 AU AU74310/98A patent/AU732863B2/en not_active Ceased
- 1998-04-14 IL IL13240998A patent/IL132409A0/xx unknown
- 1998-04-14 JP JP54766098A patent/JP2001524116A/ja active Pending
- 1998-04-14 BR BR9809092-5A patent/BR9809092A/pt not_active IP Right Cessation
- 1998-04-14 CN CN98806185A patent/CN1260781A/zh active Pending
- 1998-04-14 CA CA002288662A patent/CA2288662A1/en not_active Abandoned
- 1998-04-14 PL PL98336317A patent/PL336317A1/xx unknown
- 1998-04-14 NZ NZ500252A patent/NZ500252A/en unknown
- 1998-04-14 EP EP98921462A patent/EP0975593A1/en not_active Withdrawn
- 1998-04-14 TR TR1999/02590T patent/TR199902590T2/xx unknown
- 1998-04-14 WO PCT/EP1998/002262 patent/WO1998050358A1/en not_active Application Discontinuation
- 1998-04-14 KR KR1019997009577A patent/KR20010006487A/ko not_active Application Discontinuation
- 1998-04-16 AR ARP980101760A patent/AR013076A1/es not_active Application Discontinuation
- 1998-04-17 CO CO98021149A patent/CO4950608A1/es unknown
- 1998-04-17 TW TW087105843A patent/TW509687B/zh active
-
1999
- 1999-10-15 NO NO995065A patent/NO995065D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ500252A (en) | 2001-07-27 |
| CA2288662A1 (en) | 1998-11-12 |
| AU732863B2 (en) | 2001-05-03 |
| CO4950608A1 (es) | 2000-09-01 |
| TR199902590T2 (xx) | 2000-06-21 |
| HUP0001123A2 (hu) | 2001-04-28 |
| PL336317A1 (en) | 2000-06-19 |
| AU7431098A (en) | 1998-11-27 |
| JP2001524116A (ja) | 2001-11-27 |
| TW509687B (en) | 2002-11-11 |
| IL132409A0 (en) | 2001-03-19 |
| KR20010006487A (ko) | 2001-01-26 |
| CN1260781A (zh) | 2000-07-19 |
| BR9809092A (pt) | 2002-01-22 |
| NO995065D0 (no) | 1999-10-15 |
| WO1998050358A1 (en) | 1998-11-12 |
| EP0975593A1 (en) | 2000-02-02 |
| HUP0001123A3 (en) | 2002-04-29 |
| AR013076A1 (es) | 2000-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |