WO1998050343A3 - (hetero)aryl carboxamide derivatives, process for their preparation and their use in the treatment of cns disorders - Google Patents

(hetero)aryl carboxamide derivatives, process for their preparation and their use in the treatment of cns disorders Download PDF

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Publication number
WO1998050343A3
WO1998050343A3 PCT/EP1998/002266 EP9802266W WO9850343A3 WO 1998050343 A3 WO1998050343 A3 WO 1998050343A3 EP 9802266 W EP9802266 W EP 9802266W WO 9850343 A3 WO9850343 A3 WO 9850343A3
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WO
WIPO (PCT)
Prior art keywords
group
oxygen
sulphur
nitrogen
formula
Prior art date
Application number
PCT/EP1998/002266
Other languages
French (fr)
Other versions
WO1998050343A2 (en
Inventor
Paul Adrian Wyman
Original Assignee
Smithkline Beecham Plc
Paul Adrian Wyman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Paul Adrian Wyman filed Critical Smithkline Beecham Plc
Publication of WO1998050343A2 publication Critical patent/WO1998050343A2/en
Publication of WO1998050343A3 publication Critical patent/WO1998050343A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which Ra is a group of formula (i), in which P1 is bicyclic aryl, a bicyclic heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur; or Ra is a group of formula (ii), wherein P?2 and P3¿ are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a bicyclic heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur providing that at least one of P?2 and P3¿ is a bicyclic aryl or bicyclic heterocyclic group; A is a bond or oxygen, S(O)¿m? where m is 0 to 2, carbonyl, or CH2 or NR?4¿; L is a group of formula -C(=V)-DG - or -DG-C(=V)-; V is oxygen or sulphur; D is nitrogen, carbon or a CH group, G is hydrogen or C¿1-6?alkyl, providing that D is nitrogen or a CH group, or G together with R?b1¿ forms a group W where W is (CR16R17)t or (CR16R17)u-J where u is 0, 1, 2 or 3 and J is oxygen, sulphur, CR?16=CR17, CR16=N, =CR16O, =CR16¿S or =CR16-NR17; B is oxygen, S(O)p where p is 0, 1 or 2, NR6 where R6 is hydrogen or C¿1-6?alkyl or B is CR?7=CR8¿ where R?7 and R8¿ are independently hydrogen or C¿1-6?alkyl; R?c and Rd¿ are independently hydrogen or C¿1-6?alkyl; R?y¿ is a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or Ry is a group of formula -NReRf.
PCT/EP1998/002266 1997-04-18 1998-04-14 (hetero)aryl carboxamide derivatives, process for their preparation and their use in the treatment of cns disorders WO1998050343A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9707830.7 1997-04-18
GBGB9707830.7A GB9707830D0 (en) 1997-04-18 1997-04-18 Novel compounds

Publications (2)

Publication Number Publication Date
WO1998050343A2 WO1998050343A2 (en) 1998-11-12
WO1998050343A3 true WO1998050343A3 (en) 2001-04-12

Family

ID=10810957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/002266 WO1998050343A2 (en) 1997-04-18 1998-04-14 (hetero)aryl carboxamide derivatives, process for their preparation and their use in the treatment of cns disorders

Country Status (2)

Country Link
GB (1) GB9707830D0 (en)
WO (1) WO1998050343A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002544186A (en) 1999-05-10 2002-12-24 ワーナー−ランバート・カンパニー Aromatic amide
MX2008009581A (en) 2006-01-27 2009-01-07 Fibrogen Inc Cyanoisoquinoline compounds and methods of use thereof.
BRPI0710527B8 (en) 2006-04-04 2021-05-25 Fibrogen Inc pyrrolo- and thiazolo-pyridine compounds and pharmaceutical composition comprising them
PE20090236A1 (en) 2007-04-06 2009-03-13 Neurocrine Biosciences Inc GONADOTROPIN RELEASING HORMONE RECEPTORS ANTAGONISTS AND PROCEDURES RELATED TO THEM
NZ580457A (en) 2007-04-06 2012-03-30 Neurocrine Biosciences Inc Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
CN105037323A (en) 2008-11-14 2015-11-11 菲布罗根有限公司 Thiochromene derivatives as HIF hydroxylase inhibitors
KR102233081B1 (en) 2013-01-24 2021-03-29 피브로겐, 인크. Crystalline forms of 〔[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino〕-acetic acid
US11325883B2 (en) 2017-11-22 2022-05-10 Temple University—Of the Commonwealth System of Higher Education Functionalized N,N-dialkylamino phenyl ethers and their method of use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015954A1 (en) * 1993-12-07 1995-06-15 Smithkline Beecham Plc Heterocyclic biphenylylamides useful as 5ht1d antagonists
WO1995017398A1 (en) * 1993-12-21 1995-06-29 Smithkline Beecham Plc Indole, indoline and quinoline derivatives with 5ht1d (anti-depressive) activity
WO1995026328A1 (en) * 1994-03-26 1995-10-05 Smithkline Beecham Plc Biphenyl derivatives as 5ht1d antagonists
WO1996006079A1 (en) * 1994-08-23 1996-02-29 Smithkline Beecham Plc Biphenylamide derivatives as 5ht1d antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015954A1 (en) * 1993-12-07 1995-06-15 Smithkline Beecham Plc Heterocyclic biphenylylamides useful as 5ht1d antagonists
WO1995017398A1 (en) * 1993-12-21 1995-06-29 Smithkline Beecham Plc Indole, indoline and quinoline derivatives with 5ht1d (anti-depressive) activity
WO1995026328A1 (en) * 1994-03-26 1995-10-05 Smithkline Beecham Plc Biphenyl derivatives as 5ht1d antagonists
WO1996006079A1 (en) * 1994-08-23 1996-02-29 Smithkline Beecham Plc Biphenylamide derivatives as 5ht1d antagonists

Also Published As

Publication number Publication date
WO1998050343A2 (en) 1998-11-12
GB9707830D0 (en) 1997-06-04

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