IE781382L - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- IE781382L IE781382L IE781382A IE138278A IE781382L IE 781382 L IE781382 L IE 781382L IE 781382 A IE781382 A IE 781382A IE 138278 A IE138278 A IE 138278A IE 781382 L IE781382 L IE 781382L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- chem
- formula
- hydrogen
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Indole compounds useful for the treatment of hypertension, of formula <CHEM> wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R1 is H or alkyl, or A together with NR1 is 4-piperidyl, R2 is hydrogen or alkyl, R3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R4 is hydrogen, chlorine, bromine or alkyl, R5 is hydrogen, alkyl, alkoxy or alkylthio, and X is -CO- or -CS, a process for their production which comprises a) acylating a compound of formula II <CHEM> wherein n, A and R1 to R5 are as defined above, or b) condensing a compound of formula III <CHEM> wherein n, R4 and R5 are as defined above, and Y is a leaving group, with a compound of formula IV <CHEM> wherein A, R1 to R3 and X are as defined above. n
[EP0000355A1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH858977 | 1977-07-12 | ||
| CH300878 | 1978-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE781382L true IE781382L (en) | 1979-01-12 |
| IE47209B1 IE47209B1 (en) | 1984-01-11 |
Family
ID=25691930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1382/78A IE47209B1 (en) | 1977-07-12 | 1978-07-10 | Improvements in or relating to organic compounds |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0000355B1 (en) |
| JP (1) | JPS5436259A (en) |
| AU (1) | AU521641B2 (en) |
| CA (1) | CA1114381A (en) |
| DE (1) | DE2861502D1 (en) |
| DK (1) | DK300978A (en) |
| ES (1) | ES471593A1 (en) |
| FI (1) | FI782138A (en) |
| IE (1) | IE47209B1 (en) |
| IL (1) | IL55116A (en) |
| IT (1) | IT7850140A0 (en) |
| NZ (1) | NZ187813A (en) |
| PH (1) | PH14993A (en) |
| PT (1) | PT68270A (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003901B1 (en) * | 1978-02-24 | 1981-08-05 | Pfizer Limited | 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them |
| US4634713A (en) * | 1982-05-28 | 1987-01-06 | Ciba-Geigy Corporation | Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives |
| JPH0283380A (en) * | 1988-09-21 | 1990-03-23 | Kotobuki Seiyaku Kk | Novel diamine derivative, antiarrhythmic agent and production thereof |
| FR2642422A1 (en) * | 1988-12-22 | 1990-08-03 | Roussel Uclaf | NOVEL ACYLATED POLYAMINES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS FUNGICIDES |
| DE69430861T2 (en) * | 1993-04-07 | 2003-01-23 | Otsuka Pharmaceutical Co., Ltd. | N-ACYLATED 4-AMINOPIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS OF PERIPHERAL VESSEL WIDING AGENTS |
| MY142362A (en) | 2004-01-29 | 2010-11-30 | Otsuka Pharma Co Ltd | Pharmaceutical composition for promoting angiogenesis |
| US11764679B2 (en) | 2020-01-15 | 2023-09-19 | Solaredge Technologies Ltd. | Power device |
| CN115433164B (en) * | 2022-09-14 | 2023-12-12 | 南京师范大学 | Nicotinamide derivative, preparation method thereof and application thereof in resisting aging and prolonging life |
-
1978
- 1978-06-12 PH PH21359A patent/PH14993A/en unknown
- 1978-06-29 DE DE7878100274T patent/DE2861502D1/en not_active Expired
- 1978-06-29 EP EP78100274A patent/EP0000355B1/en not_active Expired
- 1978-07-03 IT IT7850140A patent/IT7850140A0/en unknown
- 1978-07-03 FI FI782138A patent/FI782138A/en not_active Application Discontinuation
- 1978-07-03 DK DK783009A patent/DK300978A/en not_active Application Discontinuation
- 1978-07-10 NZ NZ187813A patent/NZ187813A/en unknown
- 1978-07-10 PT PT68270A patent/PT68270A/en unknown
- 1978-07-10 ES ES471593A patent/ES471593A1/en not_active Expired
- 1978-07-10 IE IE1382/78A patent/IE47209B1/en unknown
- 1978-07-10 IL IL55116A patent/IL55116A/en unknown
- 1978-07-11 AU AU37939/78A patent/AU521641B2/en not_active Expired
- 1978-07-11 JP JP8363778A patent/JPS5436259A/en active Pending
- 1978-07-11 CA CA307,174A patent/CA1114381A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3793978A (en) | 1980-01-17 |
| CA1114381A (en) | 1981-12-15 |
| EP0000355B1 (en) | 1982-01-06 |
| NZ187813A (en) | 1981-03-16 |
| IE47209B1 (en) | 1984-01-11 |
| AU521641B2 (en) | 1982-04-22 |
| IL55116A0 (en) | 1978-09-29 |
| EP0000355A1 (en) | 1979-01-24 |
| DE2861502D1 (en) | 1982-02-25 |
| ES471593A1 (en) | 1979-10-01 |
| FI782138A (en) | 1979-01-13 |
| IL55116A (en) | 1982-02-28 |
| IT7850140A0 (en) | 1978-07-03 |
| DK300978A (en) | 1979-01-13 |
| PH14993A (en) | 1982-03-22 |
| JPS5436259A (en) | 1979-03-16 |
| PT68270A (en) | 1978-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69433346D1 (en) | Compounds usable as intermediates for the production of piperidine derivatives | |
| NZ329374A (en) | Tricyclic amide and urea derivatives, preparation thereof | |
| FI891700A0 (en) | Method for preparing beta-lactam derivatives | |
| KR830002763A (en) | Pyrazolo quinoline, its manufacturing method, pharmaceutical preparation and application method to treatment | |
| IE781382L (en) | Indole derivatives | |
| KR960009263B1 (en) | Process of producing sulfonylurea derivatives | |
| KR870002069A (en) | Method for preparing 2- (3,5-dialkyl-4-hydroxyphenyl) indole derivative | |
| EP0335979A4 (en) | Thienopyrimidine derivatives | |
| ES2016017A6 (en) | 1,1-dioxo-cephem-4-carbothiolic acid derivatives. | |
| DK165247C (en) | 2,3,3,3-2,3,3,3-2,3,3-2,3,4-SUBLITIONATE 2,6 AND PHARMACEUTICALS CONTAINING THESE DERIVATIVES | |
| FI875251A0 (en) | FOERFARANDE FOER FRAMSTAELLNING AV 2-ARYLPROPIONSYROR. | |
| EP0127196A3 (en) | Antihypertensive lactams | |
| KR840001154A (en) | Method for preparing 1,2-dithiol-3-ylidene ammonium derivative | |
| FI861001A0 (en) | BENZO / C / -1,5-NAFTYRIDINER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH I DERAS FRAMSTAELLNING ANVAENDBARA MELLANPRODUKTER SAMT DERAS ANVAENDNING SAOSOM LAEKEMEDEL. | |
| IL86665A0 (en) | Mitomycin analogs | |
| FI842228A (en) | TRIAZOLE (2,3-C) (1,3) BENZODIAZEPINER, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDE PHARMACEUTICAL PREPARAT SAMT ANVAENDNING AV PREPARAT. | |
| DK248287A (en) | PROCEDURE FOR THE PREPARATION OF CHEPHALOSPORINE DERIVATIVES |