NO995065L - Indolderivater med kombinert 5HT1A-, 5HT1B- og 5HT1D- reseptorantagonistaktivitet - Google Patents
Indolderivater med kombinert 5HT1A-, 5HT1B- og 5HT1D- reseptorantagonistaktivitetInfo
- Publication number
- NO995065L NO995065L NO995065A NO995065A NO995065L NO 995065 L NO995065 L NO 995065L NO 995065 A NO995065 A NO 995065A NO 995065 A NO995065 A NO 995065A NO 995065 L NO995065 L NO 995065L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- nitrogen
- oxygen
- sulfur
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Forbindelser med formel(l), fremgangsmåter for deres fremstilling og anvendelse av dem som CNS-midler er beskrevet: hvor Ra er en gruppe med formel (i) hvor P1 er fenyl, bicyklisk aryl, en 5- til 7-leddet heterocyklisk ring inneholdende 1 til 3 heteroatomer valgt fra oksygen, nitrogen og svovel eller en bicyklisk, heterocyklisk ring inneholdende 1 til 3 heteroatomer valgt fra oksygen, nitrogen og svovel; R1 er hydrogen, halogen, C-j^alkyl. Cs.øcykloalkyl, COCi^alkyl, C-i.galkoksy, hydroksy, hydroksyCi.ealkyl, hydroksyC-i-ealkoksy, Ci_6alkoksyCi_6alkoksy, C-|_6alkanoyl, nitro, trifluormetyl, cyano, SR9, SOR9, SO2R9. SO2NR10R11, CO2R10, CONR1°R11, C02NR10R11, (CH2)cNR10R11. (CH2)CCONR1°R11, 6alkyl, CO2(CH2)COR10, NR10R11, NR1°CO2R11, NR10CONR10R11, CR1°=NOR11, NR10COOR11, CNR1°=NOR11. hvor R10 og R11 uavhengig er hydrogen eller C-j.salkyl og c er 1 til 4 R2 er hydrogen, halogen, C^alkyl, Cs.ecykloalkyl, Cs.gcykloalkenyl, C-i.galkoksy, acyl, aryl, acyloksy, hydroksy, nitro, trinuormetyl, cyano, CO2R10PCONR1 OR! 1, NR1°R11 hvor R10 og R11 er som definert for R1; aerl, 2 eller 3; eller Ra er en gruppe med formel (ii) (ii) hvor P2 og P3 uavhengig er fenyl, bicyklisk aryl, en 5- til 7- leddet heterocyklisk ring inneholdende 1 til 3 heteroatomer valgt fra oksygen, nitrogen og svovel eller en bicyklisk heterocyklisk gruppe inneholdende 1 til 3 heteroatomer valgt fra oksygen, nitrogen eller svovel; A er en binding eller oksygen, S (O)m hvor m er O til 2, karbonyl, CH2 eller NR4 hvor R4 er hydrogen eller C-i-øalkyl; R1 er som definert ovenfor for formel (l) eller R"! er en eventuelt substituert 5- til 7-leddet heterocyklisk ring inneholdende 1 til 3 heteroatomer valgt fra oksygen, nitrogen eller svovel; R2 og R3 er uavhengig hydrogen, halogen, C-i-salkyl, Cs.øcykloalkyl, C3_6cykloalkenyl, C^alkoksy, acyl, aryl, acyloksy, hydroksy, nitro, trifluormetyl, cyano, CO2R10, CONR10R11, NR10R11 hvor R10 og R11 er som definert for R1; og a og b er uavhengig 1, 2 eller 3; Y er - NH -, NR$ hvor R5 er C-|_6alkyl eller Y er - CH2 - eller - O -; V er oksygen eller svovel; D er nitrogen, karbon eller en CH gruppe; Wer (CR16R17)t hvor t er 2, 3 eller 4 og R16 og R17 er uavhengig hydrogen eller Ci^alkyl eller Wer (CR16R17)U-J hvor u er O, 1, 2 eller 3 og J er oksygen, svovel, CR16=CR17, CR16=N, =CR16Q, =CR16S eller =CR16-NR17; X er nitrogen eller karbon; Rb er hydrogen, halogen, hydroksy, Ci-galkyl, trifluormetyl, C-^alkoksy, C2- salkenyl, Cs.ycykloalkyl eventuelt substituert med C^alkyl eller aryl; Rc er hydrogen eller Ci_salkyl; og ¿ er en enkeltbinding når X er nitrogen eller en enkelt- eller dobbeltbinding når X er karbon.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9707829.9A GB9707829D0 (en) | 1997-04-18 | 1997-04-18 | Novel compounds |
GBGB9801882.3A GB9801882D0 (en) | 1998-01-29 | 1998-01-29 | Novel compounds |
PCT/EP1998/002262 WO1998050358A1 (en) | 1997-04-18 | 1998-04-14 | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO995065D0 NO995065D0 (no) | 1999-10-15 |
NO995065L true NO995065L (no) | 1999-10-15 |
Family
ID=26311401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO995065A NO995065L (no) | 1997-04-18 | 1999-10-15 | Indolderivater med kombinert 5HT1A-, 5HT1B- og 5HT1D- reseptorantagonistaktivitet |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0975593A1 (no) |
JP (1) | JP2001524116A (no) |
KR (1) | KR20010006487A (no) |
CN (1) | CN1260781A (no) |
AR (1) | AR013076A1 (no) |
AU (1) | AU732863B2 (no) |
BR (1) | BR9809092A (no) |
CA (1) | CA2288662A1 (no) |
CO (1) | CO4950608A1 (no) |
HU (1) | HUP0001123A3 (no) |
IL (1) | IL132409A0 (no) |
NO (1) | NO995065L (no) |
NZ (1) | NZ500252A (no) |
PL (1) | PL336317A1 (no) |
TR (1) | TR199902590T2 (no) |
TW (1) | TW509687B (no) |
WO (1) | WO1998050358A1 (no) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9725931D0 (en) * | 1997-12-05 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
WO2000006550A1 (fr) * | 1998-07-31 | 2000-02-10 | Nippon Soda Co., Ltd. | Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie |
GB9827882D0 (en) * | 1998-12-17 | 1999-02-10 | Smithkline Beecham Plc | Novel compounds |
UA62015C2 (en) * | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
CA2378047A1 (en) * | 1999-07-15 | 2001-01-25 | Methvin Isaac | Heterocyclic compounds for the treatment of migraine |
DK1216239T3 (da) * | 1999-09-25 | 2004-06-14 | Smithkline Beecham Plc | Antagonister af piperazin-derivater AS 5-HT1B |
ES2234683T3 (es) * | 1999-11-05 | 2005-07-01 | Smithkline Beecham Plc | Derivados de isoquinolina y quinazolina con actividad combinada sobre los receptores 5ht1a, 5ht1b y 5ht1d. |
GB9926303D0 (en) * | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
DE10051981A1 (de) | 2000-10-20 | 2002-05-02 | Bayer Ag | Substituierte Phenyluracile |
GB0106419D0 (en) * | 2001-03-15 | 2001-05-02 | Smithkline Beecham Plc | Novel compounds |
GB0106586D0 (en) * | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
DE60218037T2 (de) * | 2001-06-07 | 2007-08-23 | F. Hoffmann-La Roche Ag | Neue indolderivate mit affinität zum 5-ht6-rezeptor |
ES2316777T3 (es) * | 2002-02-15 | 2009-04-16 | Glaxo Group Limited | Moduladores de receptores vainilloides. |
PL211057B1 (pl) | 2002-05-13 | 2012-04-30 | Hoffmann La Roche | Pochodne benzoksazyny, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych benzoksazyny |
ES2291984T3 (es) | 2003-12-09 | 2008-03-01 | F. Hoffmann-La Roche Ag | Derivados de benzoxazina y su empleo. |
US20110166132A1 (en) * | 2007-12-13 | 2011-07-07 | Amgen Inc. | Gamma Secretase Modulators |
BR112012024380A2 (pt) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | compostos químicos |
GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
CN102924330A (zh) * | 2012-09-03 | 2013-02-13 | 华东理工大学 | 一种规模化制备5-氨基-1-萘腈的方法 |
GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
CN103467374A (zh) * | 2013-08-30 | 2013-12-25 | 江苏弘和药物研发有限公司 | 一种8-溴-4-羧基喹啉的合成方法 |
SG11201604795RA (en) | 2013-12-20 | 2016-07-28 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
CN115197099A (zh) * | 2022-05-30 | 2022-10-18 | 安徽昊帆生物有限公司 | N-Boc-1,4-苯二胺的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
ATE204262T1 (de) * | 1991-09-18 | 2001-09-15 | Glaxo Group Ltd | Benzanilidderivate als 5-ht1d-antagonisten |
EP0712397B1 (en) * | 1993-08-06 | 1999-04-21 | Smithkline Beecham Plc | Amide derivatives as 5ht1d receptor antagonists |
DE69411176T2 (de) * | 1993-08-20 | 1998-11-12 | Smithkline Beecham Plc | Amide und harnstoffderivate als 5ht1d rezeptor antagonisten |
EP0716650B1 (en) * | 1993-09-03 | 1999-03-24 | Smithkline Beecham Plc | Indole and indoline derivatives as 5ht1d receptor antagonists |
-
1998
- 1998-04-14 TR TR1999/02590T patent/TR199902590T2/xx unknown
- 1998-04-14 PL PL98336317A patent/PL336317A1/xx unknown
- 1998-04-14 IL IL13240998A patent/IL132409A0/xx unknown
- 1998-04-14 EP EP98921462A patent/EP0975593A1/en not_active Withdrawn
- 1998-04-14 CA CA002288662A patent/CA2288662A1/en not_active Abandoned
- 1998-04-14 KR KR1019997009577A patent/KR20010006487A/ko not_active Application Discontinuation
- 1998-04-14 JP JP54766098A patent/JP2001524116A/ja active Pending
- 1998-04-14 WO PCT/EP1998/002262 patent/WO1998050358A1/en not_active Application Discontinuation
- 1998-04-14 CN CN98806185A patent/CN1260781A/zh active Pending
- 1998-04-14 NZ NZ500252A patent/NZ500252A/en unknown
- 1998-04-14 HU HU0001123A patent/HUP0001123A3/hu unknown
- 1998-04-14 BR BR9809092-5A patent/BR9809092A/pt not_active IP Right Cessation
- 1998-04-14 AU AU74310/98A patent/AU732863B2/en not_active Ceased
- 1998-04-16 AR ARP980101760A patent/AR013076A1/es not_active Application Discontinuation
- 1998-04-17 TW TW087105843A patent/TW509687B/zh active
- 1998-04-17 CO CO98021149A patent/CO4950608A1/es unknown
-
1999
- 1999-10-15 NO NO995065A patent/NO995065L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO995065D0 (no) | 1999-10-15 |
CN1260781A (zh) | 2000-07-19 |
WO1998050358A1 (en) | 1998-11-12 |
CO4950608A1 (es) | 2000-09-01 |
TW509687B (en) | 2002-11-11 |
IL132409A0 (en) | 2001-03-19 |
NZ500252A (en) | 2001-07-27 |
AU7431098A (en) | 1998-11-27 |
KR20010006487A (ko) | 2001-01-26 |
CA2288662A1 (en) | 1998-11-12 |
AR013076A1 (es) | 2000-12-13 |
TR199902590T2 (xx) | 2000-06-21 |
HUP0001123A2 (hu) | 2001-04-28 |
HUP0001123A3 (en) | 2002-04-29 |
EP0975593A1 (en) | 2000-02-02 |
JP2001524116A (ja) | 2001-11-27 |
BR9809092A (pt) | 2002-01-22 |
PL336317A1 (en) | 2000-06-19 |
AU732863B2 (en) | 2001-05-03 |
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