NO995016L - Nukleofilsubstituerte ecteinascidiner og N-oksydecteinascidiner - Google Patents

Nukleofilsubstituerte ecteinascidiner og N-oksydecteinascidiner

Info

Publication number
NO995016L
NO995016L NO995016A NO995016A NO995016L NO 995016 L NO995016 L NO 995016L NO 995016 A NO995016 A NO 995016A NO 995016 A NO995016 A NO 995016A NO 995016 L NO995016 L NO 995016L
Authority
NO
Norway
Prior art keywords
nucleophile
oxydectin
ascidins
ecteinascidins
substituted
Prior art date
Application number
NO995016A
Other languages
English (en)
Other versions
NO995016D0 (no
NO327455B1 (no
Inventor
Kenneth L Rinehart
Tong Zhou
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of NO995016D0 publication Critical patent/NO995016D0/no
Publication of NO995016L publication Critical patent/NO995016L/no
Publication of NO327455B1 publication Critical patent/NO327455B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
NO19995016A 1997-04-15 1999-10-14 Ecteinascidin forbindelser, anvendelser derav samt farmasoytiske preparat NO327455B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4359697P 1997-04-15 1997-04-15
PCT/US1998/007340 WO1998046080A1 (en) 1997-04-15 1998-04-14 Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Publications (3)

Publication Number Publication Date
NO995016D0 NO995016D0 (no) 1999-10-14
NO995016L true NO995016L (no) 1999-12-10
NO327455B1 NO327455B1 (no) 2009-07-06

Family

ID=21927969

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19995016A NO327455B1 (no) 1997-04-15 1999-10-14 Ecteinascidin forbindelser, anvendelser derav samt farmasoytiske preparat

Country Status (20)

Country Link
US (1) US5985876A (no)
EP (2) EP1668985B1 (no)
JP (1) JP4382164B2 (no)
KR (1) KR100513668B1 (no)
CN (1) CN100343235C (no)
AT (1) ATE420092T1 (no)
AU (1) AU747303B2 (no)
BR (1) BR9808588A (no)
CA (1) CA2286796C (no)
CY (1) CY1108958T1 (no)
CZ (1) CZ298842B6 (no)
DE (1) DE69840458D1 (no)
DK (1) DK1668985T3 (no)
ES (1) ES2321019T3 (no)
HU (1) HUP0103590A3 (no)
IL (1) IL132403A (no)
NO (1) NO327455B1 (no)
PL (2) PL197708B1 (no)
PT (1) PT1668985E (no)
WO (1) WO1998046080A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
EP1077698B1 (en) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
PT1280809E (pt) * 2000-04-12 2005-11-30 Pharma Mar Sa Derivados antitumorais de ecteinascidina
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
DK1365808T3 (da) * 2000-11-06 2011-05-16 Pharma Mar Sa Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
ATE406897T1 (de) * 2003-11-13 2008-09-15 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (en) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
EP1768671A2 (en) * 2004-07-09 2007-04-04 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
ATE430586T1 (de) * 2004-10-26 2009-05-15 Pharma Mar Sa Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
RS58609B1 (sr) 2010-11-12 2019-05-31 Pharma Mar Sa Kombinovana terapija sa inhibitorom mitoze
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
DE69313931T2 (de) * 1992-06-19 1998-02-19 Hoechst Ag Polycyclische 31668P- und 31668U-Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als antibiotische oder antitumorale Arzneistoffe
US5426108A (en) * 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
DE69936845T2 (de) * 1998-04-06 2008-05-08 The Board Of Trustees Of The University Of Illinois, Urbana Halbsynthetische ectein-ascidine

Also Published As

Publication number Publication date
NO995016D0 (no) 1999-10-14
ES2321019T3 (es) 2009-06-01
CY1108958T1 (el) 2012-05-23
EP0975218A1 (en) 2000-02-02
HUP0103590A2 (hu) 2002-01-28
IL132403A0 (en) 2001-03-19
US5985876A (en) 1999-11-16
JP4382164B2 (ja) 2009-12-09
KR100513668B1 (ko) 2005-09-08
HUP0103590A3 (en) 2002-07-29
EP0975218A4 (en) 2001-08-08
JP2001523228A (ja) 2001-11-20
CZ367999A3 (cs) 2000-07-12
DK1668985T3 (da) 2009-05-04
PT1668985E (pt) 2009-04-09
AU747303B2 (en) 2002-05-16
DE69840458D1 (de) 2009-02-26
WO1998046080A1 (en) 1998-10-22
CZ298842B6 (cs) 2008-02-20
CN100343235C (zh) 2007-10-17
EP1668985A2 (en) 2006-06-14
PL338508A1 (en) 2000-11-06
NO327455B1 (no) 2009-07-06
EP1668985A3 (en) 2006-11-22
IL132403A (en) 2004-09-27
CA2286796C (en) 2008-08-05
AU7111498A (en) 1998-11-11
CN1261254A (zh) 2000-07-26
KR20010006402A (ko) 2001-01-26
PL197708B1 (pl) 2008-04-30
BR9808588A (pt) 2000-05-23
CA2286796A1 (en) 1998-10-22
ATE420092T1 (de) 2009-01-15
EP1668985B1 (en) 2009-01-07

Similar Documents

Publication Publication Date Title
DK1668985T3 (da) Nukleofil-substituerede ecteinascidiner og N-oxid-ecteinascidiner
GB0119243D0 (en) Antitumoral analogs of ET-743
DE3776063D1 (en) Bryostatine.
NO20004978D0 (no) Semi-syntetiske ecteinascidiner
ES2181730T3 (es) Piridilpirazoles substituidos.
DK0559838T3 (da) Ecteinascidin 736 og 722
DK0461079T3 (da) Substituerede phthalider og heterocykliske phthalider
UA7140A1 (uk) Спосіб отримання похідних піридіну
NO990708L (no) Bisykliske pyrimidinderivater og deres anvendelse som antikoagulanter
DK0579507T3 (da) Isoxazolderivater til behandling af colon irritabile
DK0429627T3 (da) Derivater af quinolin-3-carboxanilider
CA2093078A1 (en) 2-substituted tertiary carbinol derivatives of 1,5-iminosugars
ATE277017T1 (de) 1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen
DK0736009T3 (da) N-oxider af 4-arylpiperaziner og 4-arylpiperidiner som antipsykotiske medikamenter
DK0593285T3 (da) Mellemprodukter og fremgangsmåder dertil til fremstilling af 5,6-dihydropyrrolo-(2,3-d)pyrimidiner
DK0566557T3 (da) 2- og 3-amino- og azidoderivater af 1,5- iminosukkere som antivirale forbindelser
ES2055303T3 (es) Compuestos de azoxima biocidas.
IT8119584A0 (it) Derivati di metossipirazolo(3,4-b)piridine ad azione antimicrobica.
DK0582977T3 (da) Fremgangsmåde til fremstilling af 1,3-dialkyl-5-hydroxyoxindoler og etherderivater deraf

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees