NO995016D0 - Nukleofilsubstituerte ecteinascidiner og N-oksydecteinascidiner - Google Patents

Nukleofilsubstituerte ecteinascidiner og N-oksydecteinascidiner

Info

Publication number
NO995016D0
NO995016D0 NO995016A NO995016A NO995016D0 NO 995016 D0 NO995016 D0 NO 995016D0 NO 995016 A NO995016 A NO 995016A NO 995016 A NO995016 A NO 995016A NO 995016 D0 NO995016 D0 NO 995016D0
Authority
NO
Norway
Prior art keywords
nucleophile
oxydectin
ascidins
ecteinascidins
substituted
Prior art date
Application number
NO995016A
Other languages
English (en)
Other versions
NO327455B1 (no
NO995016L (no
Inventor
Kenneth L Rinehart
Tong Zhou
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of NO995016D0 publication Critical patent/NO995016D0/no
Publication of NO995016L publication Critical patent/NO995016L/no
Publication of NO327455B1 publication Critical patent/NO327455B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
NO19995016A 1997-04-15 1999-10-14 Ecteinascidin forbindelser, anvendelser derav samt farmasoytiske preparat NO327455B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4359697P 1997-04-15 1997-04-15
PCT/US1998/007340 WO1998046080A1 (en) 1997-04-15 1998-04-14 Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Publications (3)

Publication Number Publication Date
NO995016D0 true NO995016D0 (no) 1999-10-14
NO995016L NO995016L (no) 1999-12-10
NO327455B1 NO327455B1 (no) 2009-07-06

Family

ID=21927969

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19995016A NO327455B1 (no) 1997-04-15 1999-10-14 Ecteinascidin forbindelser, anvendelser derav samt farmasoytiske preparat

Country Status (20)

Country Link
US (1) US5985876A (no)
EP (2) EP0975218A4 (no)
JP (1) JP4382164B2 (no)
KR (1) KR100513668B1 (no)
CN (1) CN100343235C (no)
AT (1) ATE420092T1 (no)
AU (1) AU747303B2 (no)
BR (1) BR9808588A (no)
CA (1) CA2286796C (no)
CY (1) CY1108958T1 (no)
CZ (1) CZ298842B6 (no)
DE (1) DE69840458D1 (no)
DK (1) DK1668985T3 (no)
ES (1) ES2321019T3 (no)
HU (1) HUP0103590A3 (no)
IL (1) IL132403A (no)
NO (1) NO327455B1 (no)
PL (2) PL338508A1 (no)
PT (1) PT1668985E (no)
WO (1) WO1998046080A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
HUP0101960A3 (en) * 1998-05-11 2003-03-28 Pharma Mar Sa Metabolites of ecteinascidin 743, their use and pharmaceutical compositions containing them
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
CZ304749B6 (cs) * 2000-04-12 2014-09-24 Pharma Mar, S. A. Ecteinascidin mající pět spojených kruhů s 1,4-můstkem, farmaceutický prostředek, použití a způsob
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CZ20031327A3 (cs) * 2000-11-06 2003-11-12 Pharma Mar, S. A. Užití ET-743 k výrobě léků pro účinnou protinádorovou léčbu
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
JP2007511509A (ja) * 2003-11-14 2007-05-10 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
EP1812114A2 (en) * 2004-09-29 2007-08-01 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti-inflammatory agents
CA2582452C (en) * 2004-10-26 2010-09-07 Erard Gilles Pegylated liposomal doxorubicin in combination with ecteinascidin 743
ATE368461T1 (de) 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
BR122017028570B1 (pt) 2010-11-12 2022-03-03 Pharma Mar, S.A Uso de pm01183, ou um sal farmaceuticamente aceitável do mesmo, em combinação sinérgica com um inibidor da topoisomerase i e/ou ii e kit
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
DK0574857T3 (da) * 1992-06-19 1998-05-04 Hoechst Ag Polycycliske 31668P- og 31668U-forbindelser, fremgangsmåder til deres fremstilling samt deres anvendelse som antibiotiske eller antitumorale lægemidler
US5426108A (en) * 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
PT1067933E (pt) * 1998-04-06 2007-11-15 Univ Illinois Ecteinascidinas semi-sintéticas

Also Published As

Publication number Publication date
DK1668985T3 (da) 2009-05-04
IL132403A0 (en) 2001-03-19
PL338508A1 (en) 2000-11-06
NO327455B1 (no) 2009-07-06
NO995016L (no) 1999-12-10
EP1668985B1 (en) 2009-01-07
EP0975218A4 (en) 2001-08-08
KR100513668B1 (ko) 2005-09-08
US5985876A (en) 1999-11-16
CA2286796A1 (en) 1998-10-22
CY1108958T1 (el) 2012-05-23
CZ367999A3 (cs) 2000-07-12
EP1668985A3 (en) 2006-11-22
EP0975218A1 (en) 2000-02-02
DE69840458D1 (de) 2009-02-26
EP1668985A2 (en) 2006-06-14
CN1261254A (zh) 2000-07-26
CA2286796C (en) 2008-08-05
AU747303B2 (en) 2002-05-16
ES2321019T3 (es) 2009-06-01
JP2001523228A (ja) 2001-11-20
AU7111498A (en) 1998-11-11
KR20010006402A (ko) 2001-01-26
PL197708B1 (pl) 2008-04-30
BR9808588A (pt) 2000-05-23
JP4382164B2 (ja) 2009-12-09
HUP0103590A2 (hu) 2002-01-28
IL132403A (en) 2004-09-27
HUP0103590A3 (en) 2002-07-29
CN100343235C (zh) 2007-10-17
CZ298842B6 (cs) 2008-02-20
WO1998046080A1 (en) 1998-10-22
PT1668985E (pt) 2009-04-09
ATE420092T1 (de) 2009-01-15

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Legal Events

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