BR9808588A - Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo - Google Patents

Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo

Info

Publication number
BR9808588A
BR9808588A BR9808588-3A BR9808588A BR9808588A BR 9808588 A BR9808588 A BR 9808588A BR 9808588 A BR9808588 A BR 9808588A BR 9808588 A BR9808588 A BR 9808588A
Authority
BR
Brazil
Prior art keywords
ecteinascidins
compounds
oxide
nucleophile
substituted
Prior art date
Application number
BR9808588-3A
Other languages
English (en)
Inventor
Kenneth L Rinehart
Tong Zhou
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of BR9808588A publication Critical patent/BR9808588A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"ECTEINASCIDINAS E ECTEINASCIDINAS DE N-óXIDO SUBSTITUìDAS POR NUCLEóFILO"<D>. Cinco novos compostos de ecteinascidina (Et) substituída por nucleófilo foram isolados de Ecteinascidia turbinata. Estes compostos foram purificados por técnicas cromatográficas e foram determinadas suas estruturas e bioatividades. Os cinco compostos de Et substituída por nucleófilo foram designados neste caso como Et 802 (1), Et 788 (2), Et 760 (3), Et 858 (4) e Et 815 (5). Também foram obtidos três novos compostos de ecteinascidinas de N-óxido, que foram designados neste caso como Et 717 (6), Et 775 (7) e Et 789 (8). Alguns destes compostos de Et recentemente verificados apresentam citotoxicidez excessivamente potente contra L1210.
BR9808588-3A 1997-04-15 1998-04-14 Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo BR9808588A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4359697P 1997-04-15 1997-04-15
PCT/US1998/007340 WO1998046080A1 (en) 1997-04-15 1998-04-14 Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Publications (1)

Publication Number Publication Date
BR9808588A true BR9808588A (pt) 2000-05-23

Family

ID=21927969

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808588-3A BR9808588A (pt) 1997-04-15 1998-04-14 Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo

Country Status (20)

Country Link
US (1) US5985876A (pt)
EP (2) EP1668985B1 (pt)
JP (1) JP4382164B2 (pt)
KR (1) KR100513668B1 (pt)
CN (1) CN100343235C (pt)
AT (1) ATE420092T1 (pt)
AU (1) AU747303B2 (pt)
BR (1) BR9808588A (pt)
CA (1) CA2286796C (pt)
CY (1) CY1108958T1 (pt)
CZ (1) CZ298842B6 (pt)
DE (1) DE69840458D1 (pt)
DK (1) DK1668985T3 (pt)
ES (1) ES2321019T3 (pt)
HU (1) HUP0103590A3 (pt)
IL (1) IL132403A (pt)
NO (1) NO327455B1 (pt)
PL (2) PL197708B1 (pt)
PT (1) PT1668985E (pt)
WO (1) WO1998046080A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
AU759281B2 (en) * 1998-05-11 2003-04-10 Pharma Mar S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
SI1280809T1 (sl) * 2000-04-12 2005-12-31 Pharma Mar Sa Antitumorski ekteinascidin derivati
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2428160C (en) * 2000-11-06 2009-10-13 Pharma Mar, S.A. Compositions for antitumor treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
US20080255132A1 (en) * 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2006005602A2 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
PL1827500T3 (pl) * 2004-10-26 2009-09-30 Pharma Mar Sa Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743
ES2290844T3 (es) 2004-10-29 2008-02-16 Pharma Mar S.A., Sociedad Unipersonal Composiciones que comprenden ecteinascidinas y un disacarido.
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
ES2790414T3 (es) 2010-11-12 2020-10-27 Pharma Mar Sa Terapia de combinación con un inhibidor de topoisomerasa
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
DE69313931T2 (de) * 1992-06-19 1998-02-19 Hoechst Ag Polycyclische 31668P- und 31668U-Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als antibiotische oder antitumorale Arzneistoffe
US5426108A (en) * 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
BR9909488B1 (pt) * 1998-04-06 2011-02-08 ecteinascidinas semi-sintéticas e composição farmacêutica.

Also Published As

Publication number Publication date
CA2286796C (en) 2008-08-05
KR20010006402A (ko) 2001-01-26
PL197708B1 (pl) 2008-04-30
JP2001523228A (ja) 2001-11-20
NO327455B1 (no) 2009-07-06
NO995016L (no) 1999-12-10
EP1668985A2 (en) 2006-06-14
CY1108958T1 (el) 2012-05-23
ATE420092T1 (de) 2009-01-15
EP0975218A4 (en) 2001-08-08
PL338508A1 (en) 2000-11-06
HUP0103590A2 (hu) 2002-01-28
AU7111498A (en) 1998-11-11
IL132403A0 (en) 2001-03-19
US5985876A (en) 1999-11-16
CN100343235C (zh) 2007-10-17
CZ298842B6 (cs) 2008-02-20
EP1668985A3 (en) 2006-11-22
DE69840458D1 (de) 2009-02-26
WO1998046080A1 (en) 1998-10-22
AU747303B2 (en) 2002-05-16
IL132403A (en) 2004-09-27
JP4382164B2 (ja) 2009-12-09
NO995016D0 (no) 1999-10-14
CN1261254A (zh) 2000-07-26
ES2321019T3 (es) 2009-06-01
HUP0103590A3 (en) 2002-07-29
EP0975218A1 (en) 2000-02-02
PT1668985E (pt) 2009-04-09
DK1668985T3 (da) 2009-05-04
KR100513668B1 (ko) 2005-09-08
CZ367999A3 (cs) 2000-07-12
CA2286796A1 (en) 1998-10-22
EP1668985B1 (en) 2009-01-07

Similar Documents

Publication Publication Date Title
BR9808588A (pt) Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo
DK1353672T3 (da) Syntese af 4-amino-thalidomidenantiomerer
NO990708L (no) Bisykliske pyrimidinderivater og deres anvendelse som antikoagulanter
BR0112030A (pt) Novos compostos que possuem atividade antibacteriana, antifúngica ou antitumor
ES2184070T3 (es) Derivados de oximas sustituidas utiles como antagonistas de la neuroquinina.
DE69806696T2 (de) N,N&#39;,N&#39;&#39;-Tris(2,4-Bis(1-Hydrocarbyloxy-2,2,6,6-tetramethylpiperidin-4-yl)alkylamino)-s-triazin-6-yl)-3,3&#39;-ethylenediiminodipropylamine, ihre Isomere und überbrückte Derivate, sowie damit stabilisierte Polymerzusammensetzungen
TR200201057T2 (tr) P38 protein kinazı inhibitörleri olarak heteroalkilamino ikameli bisiklik nitrojen heterosaykılları.
BR9916896A (pt) Diaril aminas substituìdas com 1-heterociclo
ECSP044997A (es) DERIVADOS SUSTITUIDOS DEL INDENO [1,2-c] ISOQUINOLINA
DK1414828T3 (da) Antitumoranaloger
NO20004978D0 (no) Semi-syntetiske ecteinascidiner
CY1111567T1 (el) Ενδιαμεσα διβενζο (b,f) αζεπινης
ES2165846T3 (es) Triazolinonas substituidas.
ES2119203T3 (es) Derivados de poliamina n-alquiltio utilizados como agentes radioprotectores.
UY27902A1 (es) Derivados aldehido de polietilenglicol
ECSP034532A (es) Derivados del 1-aminobutan-3-ol sustituido
TR200001080T2 (tr) 2 ile ikame edilmiş 1,2-Benisotiyazol türevleri ve bunların serrotonın antagonistleri
DK1289999T3 (da) Antitumoranaloger af ET-743
ES2093760T3 (es) Procedimiento para la obtencion de fosfinas terciarias.
DK0915858T3 (da) Mellemprodukter til fremstilling af 2-imidazolin-5-oner
ES2104783T3 (es) Procedimiento para la purificacion de estreptolisina o, estreptolisina o intacta obtenible segun este procedimiento y su utilizacion.
BR9814993A (pt) Pirazolilpirazóis substituìdos por 1-metil-5-alquilsulfonila, 1-metil-5-alquilsulfinila e 1-metil-5-alquiltio, processos para a sua preparação e seu emprego como herbicidas
PE20001466A1 (es) Nuevas 3-fenoxi- y 3-fenilalquiloxi-2-fenil-propilaminas sustituidas como bloqueadores del canal de sodio
ES2096661T3 (es) Uso de triazoles biciclicos sustituidos herbicidas en cultivos perennes de plantacion.
ES2169480T3 (es) Procedimiento mejorado para la preparacion de compuestos asimetricos de 4,6-bis(ariloxi)pirimidina.

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CI: A61K 35/56; A61P 35/00; C07D 519/00

Ipc: A61K 35/56 (2008.04), A61P 35/00 (2008.04), C07D 5

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 37, INDEFIRO O PRESENTE PEDIDO, TENDO POR BASE OS ARTIGOS 8O E 13 DA LEI 9279 DE 14/05/1996.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 14A, 15A E 16A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2256 DE 01/04/2014 POR TER SIDO INDEVIDA.