NO990304L - Substituerte triazol-pyridazolderivater som ligander for GABA reseptorer - Google Patents

Substituerte triazol-pyridazolderivater som ligander for GABA reseptorer

Info

Publication number
NO990304L
NO990304L NO990304A NO990304A NO990304L NO 990304 L NO990304 L NO 990304L NO 990304 A NO990304 A NO 990304A NO 990304 A NO990304 A NO 990304A NO 990304 L NO990304 L NO 990304L
Authority
NO
Norway
Prior art keywords
ligands
pyridazole
derivatives
substituted triazole
substituted
Prior art date
Application number
NO990304A
Other languages
English (en)
Norwegian (no)
Other versions
NO990304D0 (no
Inventor
Howard Barff Broughton
William Robert Carling
Jose Luis Castro Pineiro
Alexander Richard Guiblin
Andrew Madin
Kevin William Moore
Michael Geoffrey Russell
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en
Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en
Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NO990304D0 publication Critical patent/NO990304D0/no
Publication of NO990304L publication Critical patent/NO990304L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO990304A 1996-07-25 1999-01-22 Substituerte triazol-pyridazolderivater som ligander for GABA reseptorer NO990304L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9615645.0A GB9615645D0 (en) 1996-07-25 1996-07-25 Therapeutic agents
GBGB9625397.6A GB9625397D0 (en) 1996-12-06 1996-12-06 Therapeutic agents
GBGB9714420.8A GB9714420D0 (en) 1997-07-09 1997-07-09 Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en) 1996-07-25 1997-07-17 Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
NO990304D0 NO990304D0 (no) 1999-01-22
NO990304L true NO990304L (no) 1999-03-25

Family

ID=27268403

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990304A NO990304L (no) 1996-07-25 1999-01-22 Substituerte triazol-pyridazolderivater som ligander for GABA reseptorer

Country Status (24)

Country Link
US (1) US6255305B1 (ja)
EP (1) EP0915875B1 (ja)
JP (1) JP4216905B2 (ja)
KR (1) KR20000029548A (ja)
CN (1) CN1251589A (ja)
AT (1) ATE236904T1 (ja)
AU (1) AU723098B2 (ja)
BG (1) BG103112A (ja)
BR (1) BR9710729A (ja)
CZ (1) CZ18199A3 (ja)
DE (1) DE69720732T2 (ja)
EA (1) EA002436B1 (ja)
EE (1) EE9900027A (ja)
ES (1) ES2194205T3 (ja)
HU (1) HUP0600527A2 (ja)
IL (1) IL127911A0 (ja)
IS (1) IS4949A (ja)
NO (1) NO990304L (ja)
NZ (1) NZ333768A (ja)
PL (1) PL331072A1 (ja)
SK (1) SK9399A3 (ja)
TR (1) TR199900047T2 (ja)
WO (1) WO1998004559A2 (ja)
YU (1) YU2899A (ja)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0986562B1 (en) * 1997-05-08 2002-08-07 MERCK SHARP & DOHME LTD. Substituted 1,2,4-triazolo 3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
US6297235B1 (en) * 1997-08-28 2001-10-02 Merck Sharp & Dohme Ltd. Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en) 1997-08-28 1997-11-05 Merck Sharp & Dohme Therapeutic agents
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
WO1999025353A1 (en) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Therapeutic uses of triazolo-pyridazine derivatives
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
US6303597B1 (en) 1998-01-14 2001-10-16 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
EA002755B1 (ru) * 1998-01-21 2002-08-29 Мерк Шарп Энд Домэ Лимитед Производные триазолопиридазина в качестве лигандов для гамк рецепторов
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) * 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
EP1087968A1 (en) * 1998-06-16 2001-04-04 MERCK SHARP & DOHME LTD. Triazolo-pyridine derivatives as ligands for gaba receptors
GB9813006D0 (en) 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
GB9813576D0 (en) 1998-06-24 1998-08-19 Merck Sharp & Dohme Therapeutic agents
GB9821179D0 (en) * 1998-09-30 1998-11-25 Merck Sharp & Dohme Therapeutic use
CA2346659A1 (en) * 1998-10-06 2000-04-13 Michiyo Gyoten Condensed pyridazine compounds, their production and use
AU760688B2 (en) 1998-10-16 2003-05-22 Merck Sharp & Dohme Limited Pyrazolo-triazine derivatives as ligands for GABA receptors
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) * 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US6500828B1 (en) 1999-01-27 2002-12-31 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9903119D0 (en) * 1999-02-11 1999-04-07 Merck Sharp & Dohme Therapeutic agents
US6737242B1 (en) 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) * 1999-08-23 1999-10-27 Merck Sharp & Dohme Therapeutic agents
GB9921351D0 (en) * 1999-09-09 1999-11-10 Merck Sharp & Dohme Therapeutic agents
US6355638B1 (en) * 1999-11-25 2002-03-12 Merck Sharp & Dohme Ltd. Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en) 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB9929685D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB9929687D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
GB0008696D0 (en) * 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
GB0017518D0 (en) 2000-07-17 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0018473D0 (en) 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
WO2002083675A2 (en) 2001-04-10 2002-10-24 Merck Sharp & Dohme Limited Inhibitors of akt activity
JP2004527531A (ja) * 2001-04-10 2004-09-09 メルク　エンド　カムパニー　インコーポレーテッド 癌を治療する方法
WO2002083140A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
WO2002083139A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
GB0122696D0 (en) 2001-09-20 2001-11-14 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
EP1496981A2 (en) * 2002-04-08 2005-01-19 Merck & Co., Inc. Method of treating cancer
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
AU2003246979B8 (en) * 2002-08-13 2009-08-06 Merck Sharp & Dohme Limited Phenylpyridazine derivatives as ligands for GABA receptors
KR101075812B1 (ko) * 2002-12-18 2011-10-25 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서의 트리아졸로피리다진
PL1697371T3 (pl) 2003-12-19 2007-09-28 Bristol Myers Squibb Co Azabicykliczne heterocykle jako modulatory receptora kanabinoidowego
KR101368093B1 (ko) * 2004-09-02 2014-03-14 다케다 게엠베하 트리아졸로프탈라진
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP1874775B1 (en) 2005-01-05 2012-10-10 Nycomed GmbH Triazolophthalazines as pde2-inhibitors
BRPI0606379A2 (pt) 2005-01-05 2009-06-23 Nycomed Gmbh triazolftalazinas
US7572807B2 (en) * 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
JP5489997B2 (ja) * 2007-07-19 2014-05-14 シマベイ セラピューティクス， インコーポレーテッド 糖尿病および代謝疾患の治療のためのＲＵＰ３またはＧＰＲｌ１９受容体のアゴニストとしてのＮ−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体
US8809355B2 (en) 2008-04-04 2014-08-19 Innovationspatent Sverige Ab GABAA receptor modulators
CN104098578A (zh) 2008-08-29 2014-10-15 康瑟特制药公司 取代的三唑并哒嗪衍生物
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8501738B2 (en) 2009-06-23 2013-08-06 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
WO2011041154A1 (en) 2009-10-01 2011-04-07 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
SG182297A1 (en) 2009-12-31 2012-08-30 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
RU2015118286A (ru) * 2012-11-07 2016-12-27 Ф. Хоффманн-Ля Рош Аг Соединения триазола
UA125463C2 (uk) * 2016-01-27 2022-03-16 Універсітет Цюріх ЗАСТОСУВАННЯ МОДУЛЯТОРІВ GABA<sub>A</sub>-РЕЦЕПТОРА ДЛЯ ЛІКУВАННЯ СВЕРБЕЖУ
CN107344938B (zh) * 2016-05-06 2022-05-06 上海赛默罗生物科技有限公司 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
WO2018026890A1 (en) 2016-08-03 2018-02-08 Cymabay Therapeutics Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
EP3796907A4 (en) 2018-05-22 2021-11-03 Neurocycle Therapeutics, Inc. GABAA POSITIVE ALLOSTERIC MODULATING COMPOUNDS FOR THE TREATMENT OF PRURITUS AND / OR DERMATITIS
CN115003301A (zh) * 2019-10-23 2022-09-02 纽罗塞克医疗公司 用gabaa受体调节剂的癫痫状况的治疗
WO2023150377A1 (en) * 2022-02-07 2023-08-10 The Regents Of The University Of Colorado, A Body Corporate Small molecule cxcr4 agonists, method of synthesis, and method of use
CN114591352B (zh) * 2022-05-11 2022-09-09 上海赛默罗生物科技有限公司 一种三唑并哒嗪类化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1080712A (en) 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
PH21834A (en) 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
IT1194310B (it) 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4578464A (en) * 1983-11-22 1986-03-25 Merrell Dow Pharmaceuticals Inc. 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9321162D0 (en) 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
GB9507348D0 (en) * 1995-04-08 1995-05-31 Knoll Ag Therapeutic agents
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use

Also Published As

Publication number Publication date
ES2194205T3 (es) 2003-11-16
DE69720732D1 (de) 2003-05-15
AU723098B2 (en) 2000-08-17
EA199900164A1 (ru) 2000-04-24
WO1998004559A2 (en) 1998-02-05
JP2002514169A (ja) 2002-05-14
YU2899A (sh) 2000-03-21
CN1251589A (zh) 2000-04-26
JP4216905B2 (ja) 2009-01-28
PL331072A1 (en) 1999-06-21
EP0915875A2 (en) 1999-05-19
EE9900027A (et) 1999-08-16
AU3553997A (en) 1998-02-20
TR199900047T2 (xx) 1999-03-22
SK9399A3 (en) 2000-04-10
IL127911A0 (en) 1999-11-30
IS4949A (is) 1999-01-19
EP0915875B1 (en) 2003-04-09
HUP0600527A2 (en) 2006-11-28
KR20000029548A (ko) 2000-05-25
BR9710729A (pt) 1999-08-17
EA002436B1 (ru) 2002-04-25
NZ333768A (en) 2000-09-29
BG103112A (en) 1999-09-30
CZ18199A3 (cs) 1999-06-16
US6255305B1 (en) 2001-07-03
ATE236904T1 (de) 2003-04-15
DE69720732T2 (de) 2004-01-29
NO990304D0 (no) 1999-01-22

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