NO985668L - Modifisert faktor VII - Google Patents
Modifisert faktor VIIInfo
- Publication number
- NO985668L NO985668L NO985668A NO985668A NO985668L NO 985668 L NO985668 L NO 985668L NO 985668 A NO985668 A NO 985668A NO 985668 A NO985668 A NO 985668A NO 985668 L NO985668 L NO 985668L
- Authority
- NO
- Norway
- Prior art keywords
- factor vii
- modified factor
- modified
- vii
- factor
- Prior art date
Links
- 102100023804 Coagulation factor VII Human genes 0.000 title 1
- 108010023321 Factor VII Proteins 0.000 title 1
- 229940012413 factor vii Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/660,289 US5833982A (en) | 1991-02-28 | 1996-06-07 | Modified factor VII |
| PCT/DK1997/000251 WO1997047651A1 (en) | 1996-06-07 | 1997-06-06 | Modified factor vii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO985668D0 NO985668D0 (no) | 1998-12-04 |
| NO985668L true NO985668L (no) | 1999-02-04 |
Family
ID=24648892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO985668A NO985668L (no) | 1996-06-07 | 1998-12-04 | Modifisert faktor VII |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5833982A (enExample) |
| EP (1) | EP0910580A1 (enExample) |
| JP (1) | JP2000513720A (enExample) |
| KR (1) | KR20000016415A (enExample) |
| CN (2) | CN1515318A (enExample) |
| AU (1) | AU735012B2 (enExample) |
| BR (1) | BR9709661A (enExample) |
| CA (1) | CA2256761A1 (enExample) |
| CZ (1) | CZ394698A3 (enExample) |
| HU (1) | HUP0003077A3 (enExample) |
| IL (1) | IL127099A0 (enExample) |
| NO (1) | NO985668L (enExample) |
| PL (1) | PL330365A1 (enExample) |
| RU (1) | RU2211704C2 (enExample) |
| UA (1) | UA68333C2 (enExample) |
| WO (1) | WO1997047651A1 (enExample) |
| ZA (1) | ZA975013B (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040087498A1 (en) * | 1991-02-28 | 2004-05-06 | Novo Nordisk Health Care Ag | Modified factor VII |
| US5997864A (en) | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
| WO1999003498A1 (en) * | 1997-07-18 | 1999-01-28 | Novo Nordisk A/S | USE OF FVIIa OR FVIIai FOR THE TREATMENT OF ADVERSE CONDITIONS RELATED TO THE FVIIa MEDIATED INTRACELLULAR SIGNALLING PATHWAY |
| US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6693075B1 (en) | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6406488B1 (en) | 1998-08-27 | 2002-06-18 | Heartstent Corporation | Healing transmyocardial implant |
| EP0987274A1 (en) | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Factor VIIa Inhibitors |
| EP1059302A1 (en) | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitors |
| US6924359B1 (en) | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
| EP1095933A1 (en) | 1999-10-30 | 2001-05-02 | Aventis Pharma Deutschland GmbH | Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them |
| WO2001058935A2 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| ES2529300T3 (es) * | 2000-04-12 | 2015-02-18 | Novozymes Biopharma Dk A/S | Proteínas de fusión de albúmina |
| US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| EP1162194A1 (en) | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| WO2001097752A2 (en) * | 2000-06-20 | 2001-12-27 | The Trustees Of The University Of Pennsylvania | Compositions comprising urokinase for modulating muscle contractility and angiogenisis |
| US7160540B2 (en) * | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
| US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
| US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| RU2003120070A (ru) | 2000-12-06 | 2004-12-27 | Авентис Фармаа Дойчланд Гмбх (De) | Производные гуанидина и амидина в качестве ингибиторов фактора ха |
| US6825323B2 (en) * | 2001-01-10 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Army | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same |
| US7235638B2 (en) | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
| JP2004529640A (ja) * | 2001-03-22 | 2004-09-30 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii凝固因子誘導体 |
| CN1522151A (zh) * | 2001-05-02 | 2004-08-18 | ŵ��Ų�ڿ˹�˾ | 经修饰的fvii用于治疗ards |
| EP1270551A1 (en) | 2001-06-26 | 2003-01-02 | Aventis Pharma Deutschland GmbH | Urea derivatives with antiproteolytic activity |
| WO2003022122A2 (en) * | 2001-09-10 | 2003-03-20 | Florence Medical Ltd. | Individual ffr determination for lesions of a multi-lesioned blood vessel |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| BRPI0213207B1 (pt) | 2001-10-10 | 2021-06-15 | Novo Nordisk A/S | Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação |
| JP2005507008A (ja) * | 2001-11-02 | 2005-03-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | アポトーシスに関連した症状の治療のための、組織因子アゴニストまたは組織因子アンタゴニストの使用 |
| EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| EP1458408B1 (en) | 2001-12-21 | 2009-04-15 | Novo Nordisk Health Care AG | Liquid composition of factor vii polypeptides |
| WO2003055511A1 (en) * | 2001-12-21 | 2003-07-10 | Novo Nordisk A/S | Liquid composition of modified factor vii polypeptides |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
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| EP1503798B8 (en) * | 2002-05-03 | 2012-03-14 | Novo Nordisk Health Care AG | Stabilised solid compositions of modified factor vii |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| PL207018B1 (pl) | 2002-06-21 | 2010-10-29 | Novo Nordisk Helth Care Ag | Kompozycja farmaceutyczna, sposób przygotowania stabilnego polipeptydu czynnika VII i zastosowanie polipeptydu czynnika VII |
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| JP5627832B2 (ja) * | 2003-05-23 | 2014-11-19 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 溶液中におけるタンパク質の安定化 |
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| US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
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| KR101792032B1 (ko) | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Tfpi 억제제 및 사용 방법 |
| EP2470559B1 (en) | 2009-08-24 | 2017-03-22 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
| NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
| KR101294351B1 (ko) * | 2010-05-27 | 2013-08-07 | 동국대학교 산학협력단 | 뇌혈전 형광영상기술을 이용한 뇌졸중 동물모델의 뇌경색 영역의 크기 예측 방법 |
| HUE043537T2 (hu) | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Rekombináns VIII faktor fehérjék |
| PT2814840T (pt) | 2012-02-15 | 2020-01-28 | Bioverativ Therapeutics Inc | Composições de fator viii e métodos de produção e utilização das mesmas |
| AU2013235741C1 (en) | 2012-03-21 | 2017-12-21 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
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| JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子融合タンパク質及びそれらの製造方法及び使用方法 |
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| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
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-
1996
- 1996-06-07 US US08/660,289 patent/US5833982A/en not_active Expired - Fee Related
-
1997
- 1997-06-06 AU AU30906/97A patent/AU735012B2/en not_active Ceased
- 1997-06-06 CN CNA031066089A patent/CN1515318A/zh active Pending
- 1997-06-06 JP JP10501082A patent/JP2000513720A/ja not_active Ceased
- 1997-06-06 CA CA002256761A patent/CA2256761A1/en not_active Abandoned
- 1997-06-06 PL PL97330365A patent/PL330365A1/xx unknown
- 1997-06-06 ZA ZA9705013A patent/ZA975013B/xx unknown
- 1997-06-06 HU HU0003077A patent/HUP0003077A3/hu unknown
- 1997-06-06 KR KR1019980709998A patent/KR20000016415A/ko not_active Ceased
- 1997-06-06 UA UA98126442A patent/UA68333C2/uk unknown
- 1997-06-06 EP EP97925917A patent/EP0910580A1/en not_active Withdrawn
- 1997-06-06 RU RU99100089/14A patent/RU2211704C2/ru not_active IP Right Cessation
- 1997-06-06 CZ CZ983946A patent/CZ394698A3/cs unknown
- 1997-06-06 CN CN97195294A patent/CN1131872C/zh not_active Expired - Fee Related
- 1997-06-06 BR BR9709661-0A patent/BR9709661A/pt not_active IP Right Cessation
- 1997-06-06 WO PCT/DK1997/000251 patent/WO1997047651A1/en not_active Ceased
- 1997-06-06 IL IL12709997A patent/IL127099A0/xx unknown
-
1998
- 1998-11-10 US US09/189,607 patent/US6168789B1/en not_active Expired - Fee Related
- 1998-12-04 NO NO985668A patent/NO985668L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1515318A (zh) | 2004-07-28 |
| PL330365A1 (en) | 1999-05-10 |
| CN1221427A (zh) | 1999-06-30 |
| ZA975013B (en) | 1997-12-08 |
| KR20000016415A (ko) | 2000-03-25 |
| CA2256761A1 (en) | 1997-12-18 |
| CN1131872C (zh) | 2003-12-24 |
| EP0910580A1 (en) | 1999-04-28 |
| US5833982A (en) | 1998-11-10 |
| HUP0003077A3 (en) | 2003-01-28 |
| IL127099A0 (en) | 1999-09-22 |
| RU2211704C2 (ru) | 2003-09-10 |
| UA68333C2 (en) | 2004-08-16 |
| AU735012B2 (en) | 2001-06-28 |
| WO1997047651A1 (en) | 1997-12-18 |
| US6168789B1 (en) | 2001-01-02 |
| BR9709661A (pt) | 2000-04-25 |
| CZ394698A3 (cs) | 1999-04-14 |
| HUP0003077A2 (hu) | 2000-12-28 |
| AU3090697A (en) | 1998-01-07 |
| JP2000513720A (ja) | 2000-10-17 |
| NO985668D0 (no) | 1998-12-04 |
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