JP2000513720A - 修飾された第ｖｉｉ因子 - Google Patents
修飾された第ｖｉｉ因子Info
- Publication number
- JP2000513720A JP2000513720A JP10501082A JP50108298A JP2000513720A JP 2000513720 A JP2000513720 A JP 2000513720A JP 10501082 A JP10501082 A JP 10501082A JP 50108298 A JP50108298 A JP 50108298A JP 2000513720 A JP2000513720 A JP 2000513720A
- Authority
- JP
- Japan
- Prior art keywords
- factor
- factor vii
- phe
- dansyl
- protease inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Epidemiology (AREA)
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- Wood Science & Technology (AREA)
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- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/660,289 | 1996-06-07 | ||
| US08/660,289 US5833982A (en) | 1991-02-28 | 1996-06-07 | Modified factor VII |
| PCT/DK1997/000251 WO1997047651A1 (en) | 1996-06-07 | 1997-06-06 | Modified factor vii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000513720A true JP2000513720A (ja) | 2000-10-17 |
| JP2000513720A5 JP2000513720A5 (enExample) | 2005-03-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10501082A Ceased JP2000513720A (ja) | 1996-06-07 | 1997-06-06 | 修飾された第ｖｉｉ因子 |
Country Status (17)
| Country | Link |
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- 1997-06-06 IL IL12709997A patent/IL127099A0/xx unknown
- 1997-06-06 CA CA002256761A patent/CA2256761A1/en not_active Abandoned
- 1997-06-06 UA UA98126442A patent/UA68333C2/uk unknown
- 1997-06-06 CN CNA031066089A patent/CN1515318A/zh active Pending
- 1997-06-06 CZ CZ983946A patent/CZ394698A3/cs unknown
- 1997-06-06 KR KR1019980709998A patent/KR20000016415A/ko not_active Ceased
- 1997-06-06 RU RU99100089/14A patent/RU2211704C2/ru not_active IP Right Cessation
- 1997-06-06 WO PCT/DK1997/000251 patent/WO1997047651A1/en not_active Ceased
- 1997-06-06 EP EP97925917A patent/EP0910580A1/en not_active Withdrawn
- 1997-06-06 AU AU30906/97A patent/AU735012B2/en not_active Ceased
- 1997-06-06 HU HU0003077A patent/HUP0003077A3/hu unknown
- 1997-06-06 BR BR9709661-0A patent/BR9709661A/pt not_active IP Right Cessation
- 1997-06-06 JP JP10501082A patent/JP2000513720A/ja not_active Ceased
- 1997-06-06 PL PL97330365A patent/PL330365A1/xx unknown
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1998
- 1998-11-10 US US09/189,607 patent/US6168789B1/en not_active Expired - Fee Related
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|---|---|---|---|---|
| US8461116B2 (en) | 2001-12-21 | 2013-06-11 | Novo Nordisk Healthcare Ag | Liquid composition of factor VII polypeptides |
| US8022031B2 (en) | 2001-12-21 | 2011-09-20 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
| JP2005530752A (ja) * | 2002-05-03 | 2005-10-13 | ノボ ノルディスク アクティーゼルスカブ | 修飾第ｖｉｉ因子の安定化された固体組成物 |
| US8729022B2 (en) | 2002-06-21 | 2014-05-20 | Novo Nordisk Healthcare Ag | Stabilised solid compositions of factor VII polypeptides |
| US8299029B2 (en) | 2002-06-21 | 2012-10-30 | Novo Nordisk Health Care Ag | Stabilised solid compositions of factor VII polypeptides |
| US8084587B2 (en) | 2003-03-26 | 2011-12-27 | Novo Nordisk Health Care Ag | Method for the production of proteins |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| US8536127B2 (en) | 2003-05-23 | 2013-09-17 | Novo Nordisk Healthcare Ag | Protein stabilization in solution |
| US7790852B2 (en) | 2003-06-25 | 2010-09-07 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
| US8026214B2 (en) | 2003-08-14 | 2011-09-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
| US8318904B2 (en) | 2003-08-14 | 2012-11-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
| US8658597B2 (en) | 2003-12-19 | 2014-02-25 | Novo Nordisk Healthcare Ag | Stabilised compositions of factor VII polypeptides |
| JP2013056891A (ja) * | 2004-09-29 | 2013-03-28 | Novo Nordisk Health Care Ag | 陰イオン交換物質からの分画溶出によるｖｉｉ因子ポリペプチドのバルクの精製 |
| JP2008514677A (ja) * | 2004-09-29 | 2008-05-08 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 陰イオン交換物質からの分画溶出によるｖｉｉ因子ポリペプチドのバルクの精製 |
| JP2016006074A (ja) * | 2004-09-29 | 2016-01-14 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 陰イオン交換物質からの分画溶出によるｖｉｉ因子ポリペプチドのバルクの精製 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000016415A (ko) | 2000-03-25 |
| CZ394698A3 (cs) | 1999-04-14 |
| HUP0003077A3 (en) | 2003-01-28 |
| WO1997047651A1 (en) | 1997-12-18 |
| PL330365A1 (en) | 1999-05-10 |
| CN1515318A (zh) | 2004-07-28 |
| ZA975013B (en) | 1997-12-08 |
| UA68333C2 (en) | 2004-08-16 |
| BR9709661A (pt) | 2000-04-25 |
| US5833982A (en) | 1998-11-10 |
| CN1221427A (zh) | 1999-06-30 |
| US6168789B1 (en) | 2001-01-02 |
| CN1131872C (zh) | 2003-12-24 |
| AU735012B2 (en) | 2001-06-28 |
| NO985668L (no) | 1999-02-04 |
| RU2211704C2 (ru) | 2003-09-10 |
| CA2256761A1 (en) | 1997-12-18 |
| IL127099A0 (en) | 1999-09-22 |
| NO985668D0 (no) | 1998-12-04 |
| AU3090697A (en) | 1998-01-07 |
| HUP0003077A2 (hu) | 2000-12-28 |
| EP0910580A1 (en) | 1999-04-28 |
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