NO982055D0 - 2-alkylpyrrolidiner - Google Patents
2-alkylpyrrolidinerInfo
- Publication number
- NO982055D0 NO982055D0 NO982055A NO982055A NO982055D0 NO 982055 D0 NO982055 D0 NO 982055D0 NO 982055 A NO982055 A NO 982055A NO 982055 A NO982055 A NO 982055A NO 982055 D0 NO982055 D0 NO 982055D0
- Authority
- NO
- Norway
- Prior art keywords
- alkylpyrrolidine
- methylpyrrolidines
- hydroxymethylpyrrolidine
- dihydroxy
- diabetes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Plural Heterocyclic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK99295 | 1995-09-08 | ||
PCT/DK1996/000373 WO1997009040A1 (fr) | 1995-09-08 | 1996-09-06 | 2-alkylpyrrolidines |
Publications (2)
Publication Number | Publication Date |
---|---|
NO982055L NO982055L (no) | 1998-05-06 |
NO982055D0 true NO982055D0 (no) | 1998-05-06 |
Family
ID=8099807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO982055A NO982055D0 (no) | 1995-09-08 | 1998-05-06 | 2-alkylpyrrolidiner |
Country Status (12)
Country | Link |
---|---|
US (2) | US5854272A (fr) |
EP (3) | EP0858335B1 (fr) |
JP (2) | JP3043430B2 (fr) |
CN (1) | CN1202105A (fr) |
AT (1) | ATE234092T1 (fr) |
AU (1) | AU724003B2 (fr) |
CZ (1) | CZ120398A3 (fr) |
DE (1) | DE69626660T2 (fr) |
HU (1) | HUP9901132A2 (fr) |
IL (1) | IL124109A (fr) |
NO (1) | NO982055D0 (fr) |
WO (1) | WO1997009040A1 (fr) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9901132A2 (hu) * | 1995-09-08 | 1999-07-28 | Novo Nordisk A/S | 2-Alkilpirrolidinek |
US5952363A (en) * | 1997-03-04 | 1999-09-14 | Novo Nordisk A/S | Pyrrolidine compounds useful in the treatment of diabetes |
AU6291098A (en) * | 1997-03-07 | 1998-09-29 | Novo Nordisk A/S | Novel heterocyclic compounds |
EP1150674A1 (fr) * | 1999-02-12 | 2001-11-07 | Novo Nordisk A/S | Utilisation de derives de pyrrolidine pour la preparation d'une composition pharmaceutique destinee au traitement ou a la prevention de l'obesite ou a la regulation de l'appetit |
US6239163B1 (en) | 1999-03-15 | 2001-05-29 | Novo Nordisk A/S | Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
WO2000055132A1 (fr) * | 1999-03-15 | 2000-09-21 | Novo Nordisk A/S | Nouveau sel de (2r,3r,4r)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
US6316489B1 (en) * | 1999-03-15 | 2001-11-13 | Novo Nordisk A/S | Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
JP2002539194A (ja) * | 1999-03-15 | 2002-11-19 | ノボ ノルディスク アクティーゼルスカブ | 新規の(2r,3r,4r)−3,4−ジヒドロキシ−2−ヒドロキシメチルピロリジンの塩 |
WO2001068095A1 (fr) * | 1999-05-24 | 2001-09-20 | Abaron Biosciences, Inc. | Inhibiteurs de glycosyltransferase |
US6043091A (en) * | 1999-07-19 | 2000-03-28 | Isis Pharmaceuticals Inc. | Antisense modulation of liver glycogen phosphorylase expression |
CO5271699A1 (es) | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa |
US6414163B1 (en) * | 2000-08-02 | 2002-07-02 | Board Of Trustees Of Michigan State University | Process and intermediate compounds for the preparation of pyrrolidines |
CN100506807C (zh) | 2001-12-21 | 2009-07-01 | 诺沃挪第克公司 | 作为gk活化剂的酰胺衍生物 |
GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
AU2003243921B2 (en) | 2002-06-27 | 2009-05-07 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
US6960610B2 (en) | 2002-10-28 | 2005-11-01 | Novo Nordick, A/S | Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases |
JP2006507359A (ja) * | 2002-10-28 | 2006-03-02 | ノボ・ノルデイスク・エー/エス | 心循環器疾患の治療のためのグリコーゲンホスホリラーゼ阻害剤の使用 |
EP1625112B1 (fr) | 2003-05-14 | 2009-07-22 | High Point Pharmaceuticals, LLC | Nouveaux composes pour le traitement de l'obesite |
JP4486792B2 (ja) * | 2003-06-12 | 2010-06-23 | 学校法人近畿大学 | 環状オニウム化合物およびグルコシダーゼ阻害剤 |
CA2539596A1 (fr) | 2003-09-30 | 2005-04-07 | Kilian Waldemar Conde-Frieboes | Nouveaux agonistes du recepteur de la melanocortine |
JP4865565B2 (ja) | 2003-12-09 | 2012-02-01 | ノヴォ ノルディスク アー/エス | Glp−1アゴニストを用いた食物選択の制御 |
WO2005066145A1 (fr) | 2004-01-06 | 2005-07-21 | Novo Nordisk A/S | Heteroaryl-urees et leur utilisation en tant qu'activateurs de glucokinase |
JP2007536344A (ja) | 2004-05-04 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | 新規のインドール誘導体 |
EP1758575A1 (fr) | 2004-06-11 | 2007-03-07 | Novo Nordisk A/S | Remede contre l'obesite induite par les medicaments au moyen d'agonistes glp-1 |
US20090298745A1 (en) * | 2004-12-02 | 2009-12-03 | Gerard Hugh Thomas | Treatment of Diabetes with Glycogen Phosphorylase Inhibitors |
EP1824835A1 (fr) | 2004-12-03 | 2007-08-29 | Novo Nordisk A/S | Composes heteroaromatiques activants de glukokinase |
KR100696187B1 (ko) | 2005-05-03 | 2007-03-20 | (주)리드젠 | 2-(2-아미노에틸)-1-메틸피롤리딘의 제조방법 |
WO2007006814A1 (fr) | 2005-07-14 | 2007-01-18 | Novo Nordisk A/S | Activateurs de l'uree glucokinase |
US7915299B2 (en) | 2006-11-15 | 2011-03-29 | High Point Pharmaceuticals, Llc | 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
AU2008204530B2 (en) | 2007-01-11 | 2013-08-01 | Vtv Therapeutics Llc | Urea glucokinase activators |
WO2010049678A2 (fr) * | 2008-10-31 | 2010-05-06 | Summit Corporation Plc | Traitement de maladies utilisant de l’énergie |
JP5645137B2 (ja) * | 2009-11-11 | 2014-12-24 | 国立大学法人富山大学 | 食後過血糖改善剤、およびピロリジン型イミノ糖またはその塩 |
US20130012432A1 (en) | 2010-02-26 | 2013-01-10 | Novo Nordisk A/S | Peptides for Treatment of Obesity |
BR112012021231A2 (pt) | 2010-02-26 | 2015-09-08 | Basf Plant Science Co Gmbh | método para acentuar o rendimento em plantas, planta, construto, uso de um construto, método para a produção de uma planta transgênica, partes coletáveis de uma planta, produtos derivados de uma planta, uso de um ácido nucleíco e método para a produção de um produto |
AU2011231503C1 (en) | 2010-03-26 | 2016-03-03 | Novo Nordisk A/S | Novel glucagon analogues |
KR101979036B1 (ko) | 2010-12-23 | 2019-05-15 | 알렉토스 테라퓨틱스 인크. | 선택적인 글리코시다아제 저해제 및 이의 용도 |
BR112013024076A2 (pt) | 2011-03-28 | 2016-12-06 | Novo Nordisk As | análogos de glucagon |
US9718854B2 (en) | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
WO2013000086A1 (fr) | 2011-06-27 | 2013-01-03 | Alectos Therapeutics Inc. | Inhibiteurs de glycosidases sélectifs et leurs utilisations |
RU2610175C2 (ru) | 2011-09-23 | 2017-02-08 | Ново Нордиск А/С | Новые аналоги глюкагона |
MY188344A (en) | 2012-03-09 | 2021-12-01 | Biotropics Malaysia Berhad | Extract formulations of rhodamnia cinerea and uses thereof |
US9809537B2 (en) | 2012-08-31 | 2017-11-07 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
US9670195B2 (en) | 2012-08-31 | 2017-06-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
RU2672873C2 (ru) | 2012-10-31 | 2018-11-20 | Алектос Терапьютикс Инк. | Ингибиторы гликозидаз и их применения |
MX362275B (es) | 2013-04-18 | 2019-01-10 | Novo Nordisk As | Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. |
EP3151852A1 (fr) | 2014-06-04 | 2017-04-12 | Novo Nordisk A/S | Co-agonistes de récepteur du glucagon/glp-1 à usage médical |
CN106349141B (zh) * | 2016-08-30 | 2020-10-27 | 中国科学院化学研究所 | 多羟基吡咯烷类化合物及其制备方法和应用 |
CN111032680A (zh) | 2017-03-15 | 2020-04-17 | 诺和诺德股份有限公司 | 能够与黑皮质素4受体结合的双环化合物 |
US20210221867A1 (en) | 2018-05-15 | 2021-07-22 | Novo Nordisk A/S | Compounds Capable of Binding to Melanocortin 4 Receptor |
US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
WO2020053414A1 (fr) | 2018-09-14 | 2020-03-19 | Novo Nordisk A/S | Composés bicycliques aptes à se lier aux agonistes du récepteur de la mélanocortine 4 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1602744A (fr) | 1968-02-16 | 1971-01-18 | ||
JPS5346967A (en) | 1976-10-08 | 1978-04-27 | Kyowa Hakko Kogyo Co Ltd | R-2-(beta-halogenoethyl)-1-methyl-pyrrolidine |
JPS6058749B2 (ja) | 1978-02-09 | 1985-12-21 | 日清製粉株式会社 | 光学活性n‐メチル‐2‐ピロリジンエタノ−ルの製造法 |
JPS61118360A (ja) | 1984-11-13 | 1986-06-05 | Mitsubishi Chem Ind Ltd | ピロリジン誘導体またはその塩 |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
ES2086323T3 (es) * | 1988-11-03 | 1996-07-01 | Searle & Co | Derivados del didesoxi-arabinitol como compuestos antiviricos. |
US4876268A (en) * | 1988-11-03 | 1989-10-24 | G. D. Searle & Co. | Antiviral compounds and use thereof |
US4973602A (en) * | 1988-11-03 | 1990-11-27 | G. D. Searle & Co. | Antiviral compounds and a method of use thereas |
US4894388A (en) | 1988-12-22 | 1990-01-16 | Monsanto Company | Glycosidase inhibitors and use thereof |
EP0389723A1 (fr) * | 1989-03-29 | 1990-10-03 | Merrell Dow Pharmaceuticals Inc. | Inhibiteurs d'alpha-glucosidases |
FR2648486B1 (fr) * | 1989-06-16 | 1991-08-30 | Gerland Sa | Composition pour le traitement antifeutrant de la laine |
EP0422307A1 (fr) * | 1989-10-10 | 1991-04-17 | Merrell Dow Pharmaceuticals Inc. | Inhibiteurs de alpha-glucosidase |
US5013842A (en) * | 1990-01-22 | 1991-05-07 | Monsanto Company | Synthesis of chiral pyrrolidine and piperidine glycosidase inhibitors |
US5290948A (en) * | 1990-09-17 | 1994-03-01 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
US5401645A (en) | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
JPH0625157A (ja) | 1992-07-13 | 1994-02-01 | Taisho Pharmaceut Co Ltd | ポリヒドロキシピロリジン誘導体類およびその製造方法 |
HUP9901132A2 (hu) * | 1995-09-08 | 1999-07-28 | Novo Nordisk A/S | 2-Alkilpirrolidinek |
-
1996
- 1996-09-06 HU HU9901132A patent/HUP9901132A2/hu unknown
- 1996-09-06 WO PCT/DK1996/000373 patent/WO1997009040A1/fr not_active Application Discontinuation
- 1996-09-06 EP EP96928360A patent/EP0858335B1/fr not_active Expired - Lifetime
- 1996-09-06 AT AT96928360T patent/ATE234092T1/de not_active IP Right Cessation
- 1996-09-06 CZ CZ981203A patent/CZ120398A3/cs unknown
- 1996-09-06 JP JP9510787A patent/JP3043430B2/ja not_active Expired - Fee Related
- 1996-09-06 DE DE69626660T patent/DE69626660T2/de not_active Expired - Fee Related
- 1996-09-06 IL IL12410996A patent/IL124109A/en not_active IP Right Cessation
- 1996-09-06 CN CN96198204A patent/CN1202105A/zh active Pending
- 1996-09-06 EP EP00113261A patent/EP1040827A3/fr not_active Withdrawn
- 1996-09-06 EP EP97120546A patent/EP0884050A1/fr not_active Withdrawn
- 1996-09-06 AU AU67859/96A patent/AU724003B2/en not_active Ceased
-
1997
- 1997-07-14 US US08/892,660 patent/US5854272A/en not_active Expired - Fee Related
-
1998
- 1998-05-06 NO NO982055A patent/NO982055D0/no not_active Application Discontinuation
- 1998-08-24 US US09/138,712 patent/US6451836B1/en not_active Expired - Fee Related
-
1999
- 1999-09-29 JP JP11276958A patent/JP2000095686A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2000095686A (ja) | 2000-04-04 |
NO982055L (no) | 1998-05-06 |
IL124109A (en) | 2001-10-31 |
CZ120398A3 (cs) | 1998-12-16 |
EP0858335B1 (fr) | 2003-03-12 |
EP1040827A2 (fr) | 2000-10-04 |
AU6785996A (en) | 1997-03-27 |
EP0858335A1 (fr) | 1998-08-19 |
AU724003B2 (en) | 2000-09-07 |
HUP9901132A2 (hu) | 1999-07-28 |
US5854272A (en) | 1998-12-29 |
JPH11503762A (ja) | 1999-03-30 |
CN1202105A (zh) | 1998-12-16 |
DE69626660D1 (en) | 2003-04-17 |
DE69626660T2 (de) | 2003-08-21 |
JP3043430B2 (ja) | 2000-05-22 |
WO1997009040A1 (fr) | 1997-03-13 |
US6451836B1 (en) | 2002-09-17 |
EP1040827A3 (fr) | 2000-10-11 |
EP0884050A1 (fr) | 1998-12-16 |
IL124109A0 (en) | 1998-12-06 |
ATE234092T1 (de) | 2003-03-15 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |