NO980700L - Perifert aktive anti-hyperalgesi opiater - Google Patents

Perifert aktive anti-hyperalgesi opiater

Info

Publication number
NO980700L
NO980700L NO980700A NO980700A NO980700L NO 980700 L NO980700 L NO 980700L NO 980700 A NO980700 A NO 980700A NO 980700 A NO980700 A NO 980700A NO 980700 L NO980700 L NO 980700L
Authority
NO
Norway
Prior art keywords
opiates
hyperalgesia
active anti
peripherally active
peripherally
Prior art date
Application number
NO980700A
Other languages
English (en)
Norwegian (no)
Other versions
NO980700D0 (no
Inventor
Tony L Yaksh
John J Farrar
Alan L Maycock
Michael E Lewis
Gordon J Dow
Original Assignee
Univ California
Adolor Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Adolor Corp filed Critical Univ California
Publication of NO980700D0 publication Critical patent/NO980700D0/no
Publication of NO980700L publication Critical patent/NO980700L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO980700A 1995-09-12 1998-02-19 Perifert aktive anti-hyperalgesi opiater NO980700L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/528,510 US5849761A (en) 1995-09-12 1995-09-12 Peripherally active anti-hyperalgesic opiates
PCT/US1996/014727 WO1997009973A2 (fr) 1995-09-12 1996-09-12 Opiaces anti-hyperalgesiques a action peripherique

Publications (2)

Publication Number Publication Date
NO980700D0 NO980700D0 (no) 1998-02-19
NO980700L true NO980700L (no) 1998-05-12

Family

ID=24105973

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980700A NO980700L (no) 1995-09-12 1998-02-19 Perifert aktive anti-hyperalgesi opiater

Country Status (9)

Country Link
US (4) US5849761A (fr)
EP (1) EP0852494A2 (fr)
JP (2) JP3553083B2 (fr)
KR (1) KR19990044182A (fr)
AU (1) AU727982C (fr)
BR (1) BR9610345A (fr)
CA (2) CA2229814C (fr)
NO (1) NO980700L (fr)
WO (1) WO1997009973A2 (fr)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US20040127884A1 (en) * 1994-12-12 2004-07-01 Omeros Corporation Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
US6413961B1 (en) * 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6524805B1 (en) * 1997-11-10 2003-02-25 George B. Stefano Methods for identifying estrogen surface receptor agonists
GB9802542D0 (en) * 1998-02-05 1998-04-01 Smithkline Beecham Plc New use
US6458777B1 (en) 1998-03-13 2002-10-01 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
AU4572999A (en) 1998-06-18 2000-01-05 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
CN1309562A (zh) * 1998-07-16 2001-08-22 纪念斯隆-凯特林癌症中心 包括一种阿片样物质镇痛剂和一种nmda拮抗剂的局部给药组合物
US6328765B1 (en) * 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US6355657B1 (en) 1998-12-30 2002-03-12 Atrix Laboratories, Inc. System for percutaneous delivery of opioid analgesics
IL144144A0 (en) 1999-01-13 2002-05-23 Bayer Ag Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
SE9900961D0 (sv) * 1999-03-16 1999-03-16 Astra Ab Novel compounds
US6187822B1 (en) * 1999-06-11 2001-02-13 University Of Medicine & Dentistry Of Nj Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
US6696078B1 (en) * 1999-07-21 2004-02-24 Edwin J. Masters System and methods for local intradermal treatment
AU6730500A (en) * 1999-08-25 2001-03-19 Daiichi Fine Chemical Co., Ltd. Medicinal composition for percutaneous/permucosal absorption
US6309662B1 (en) * 1999-09-23 2001-10-30 Janet Buchanan Use of anti-inflammatory drugs for treatment of dermatological conditions
CA2324330A1 (fr) 1999-11-08 2001-05-08 Ssp Co., Ltd. Derives de la 4-hydroxy-4-phenylpiperidine et produits pharmaceutiques a base de ceux-ci
US6582724B2 (en) * 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
WO2001070684A2 (fr) 2000-03-16 2001-09-27 Sepracor, Inc. Ligands peptidomimetiques pour recepteurs cellulaires et canaux ioniques
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
AU2001294240A1 (en) * 2000-10-12 2002-04-22 Ssp Co., Ltd. 2,2-diphenylbutanamide derivatives and medicines containing the same
KR20010103057A (ko) * 2001-01-31 2001-11-23 우원홍 미코나졸 함유 피부 미백용 외용제 조성물
CN100379473C (zh) * 2001-04-04 2008-04-09 阿尔扎公司 包括抗菌相容储液组合物的跨皮肤的电迁移输送装置
WO2002089765A1 (fr) * 2001-05-04 2002-11-14 Morepen Laboratories Ltd Procede de preparation d'un gel antibacterien et d'un gel de cotrimoxazole
ATE329655T1 (de) * 2001-09-06 2006-07-15 Wolfgang Dr Friedrich Verwendung eines gemisches von lidocain und prilocain, sowie mittel zur tumeszenz- lokalanästhesie
US20030080191A1 (en) * 2001-10-26 2003-05-01 Allen Lubow Method and apparatus for applying bar code information to products during production
US20050131733A1 (en) * 2001-12-17 2005-06-16 Allen Lubow Sealable individual bar coded packets
EP1466297A4 (fr) * 2001-12-17 2005-10-19 Int Barcode Corp Dedoublement de codes a barres double face servant de code a barres unique
WO2003068229A1 (fr) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase
EP2324825A1 (fr) 2002-02-11 2011-05-25 Bayer Healthcare LLC Arylurées dotées d'une activité d'inhibition de l'angiogenèse
US6537590B1 (en) * 2002-02-19 2003-03-25 Troy J. Lee Solution and the method of making the same for the treatment of osteoarthritis
US20040122008A1 (en) * 2002-09-05 2004-06-24 Protter Andrew A. Treatment of pain by inhibition of p38 MAP kinase
WO2004010894A2 (fr) 2002-07-30 2004-02-05 Omeros Corporation Solutions et procede d'irrigation ophtalmologique
US20080039461A1 (en) * 2002-09-05 2008-02-14 Protter Andrew A Treatment of pain by inhibition of p38 map kinase
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US20050020690A1 (en) * 2002-12-18 2005-01-27 Algorx Infiltration of capsaicin into surgical sites and open wounds
HUE027110T2 (en) * 2003-02-04 2016-08-29 Cornell Res Foundation Inc Use of an aromatic cationic peptide
PT2604286E (pt) 2003-05-01 2014-11-28 Cornell Res Foundation Inc Método e complexos transportadores para entregar moléculas às células
ATE384264T1 (de) 2003-05-20 2008-02-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe mit kinasehemmender wirkung
NZ580384A (en) 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
ITMI20031640A1 (it) * 2003-08-08 2005-02-09 Mipharm S P A Base per gel bioadesivi.
CA2541302A1 (fr) * 2003-10-06 2005-04-14 Ophtecs Corporation Composition ophtalmique pour le traitement des troubles lacrymaux
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
US7622844B1 (en) * 2003-12-30 2009-11-24 Hipercon, Llc Metal fiber brush interface conditioning
CN1938042B (zh) * 2004-01-23 2010-06-02 科内尔研究基金会 芳香族阳离子肽在制备用于减轻氧化性损伤药物中的应用
CA2552087C (fr) * 2004-01-30 2011-01-25 Euro-Celtique S.A. Procedes d'elaboration de composes de 4-tetrazolyl-4-phenylpiperidine
US7454007B2 (en) * 2004-03-26 2008-11-18 Samsung Electronics Co., Ltd. Telecommunication switch using generic API to support multiple protocol-specific signal control functions
UA88464C2 (ru) * 2004-04-29 2009-10-26 Колдуэлл Гейлер, Инк. Способ дермального введения метадоновой композиции с обеспечением системного действия
US7854943B2 (en) * 2004-06-24 2010-12-21 Idexx Laboratories Phospholipid gel compositions for drug delivery and methods of treating conditions using same
US7858115B2 (en) * 2004-06-24 2010-12-28 Idexx Laboratories Phospholipid gel compositions for drug delivery and methods of treating conditions using same
US7618651B2 (en) * 2004-06-24 2009-11-17 Idexx Laboratories Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
CA2582346A1 (fr) * 2004-10-01 2006-04-13 The Research Foundation Of State University Of New York Morphine et precurseurs de morphine
US20060115785A1 (en) 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
US7947508B2 (en) * 2004-11-30 2011-05-24 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US7766658B2 (en) 2004-11-30 2010-08-03 Align Technology, Inc. Systems and methods for intra-oral diagnosis
EP1890732B1 (fr) * 2005-06-17 2018-03-28 Wisconsin Alumni Research Foundation Preparations vasoconstrictrices topiques et methodes destinees a proteger les cellules pendant une chimiotherapie et une radiotherapie anticancereuses
EP1749528A1 (fr) 2005-08-05 2007-02-07 Pharma C S.A. Combinaisons pharmaceutiques comprenant un agoniste de l'opioide mu et un inhibiteur de la production de monoxide d'azote
US20070093420A1 (en) * 2005-08-26 2007-04-26 Yeomans David C Therapy procedure for drug delivery for trigeminal pain
KR20150013353A (ko) 2005-09-16 2015-02-04 코넬 리서치 화운데이션,인크. Ｃｄ36 발현을 감소시키는 방법
ME01106B (me) 2005-09-21 2013-03-20 Pfizer Ltd Derivati karboksamida kao antagonisti muskarinskih receptora
US20080319020A1 (en) * 2005-11-21 2008-12-25 Purdue Pharma L.P. 4-Oxadiazolyl-Piperidine Compounds and Use Thereof
MX2009004822A (es) 2006-11-01 2009-10-19 Purdue Pharma Lp Compuestos de fenilpropionamida y usos de los mismos.
SI2252312T1 (sl) 2008-02-07 2014-08-29 Cornell University, Postopki za preprečevanje ali zdravljenje insulinske rezistence
CN101951936A (zh) 2008-02-26 2011-01-19 康奈尔大学 用于防止和治疗急性肾损伤的方法
US8158682B2 (en) * 2008-09-12 2012-04-17 Vallinex, Inc. Instillation administration of capsaicinoids for the treatment of pain
WO2010075416A1 (fr) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Compositions antibiotiques destinées au traitement d'infections à gram négatif
WO2010120431A2 (fr) 2009-03-20 2010-10-21 The General Hospital Corporation D/B/A Massachusetts General Hospital Procédés destinés à la prévention et au traitement des brûlures et des complications secondaires
CN102647994A (zh) * 2009-08-12 2012-08-22 康奈尔大学 预防或治疗代谢综合症的方法
PL3708178T3 (pl) 2009-08-24 2024-05-13 Stealth Biotherapeutics Inc. Peptyd do stosowania w zapobieganiu lub leczeniu zwyrodnienia plamki żółtej
JP2013506696A (ja) 2009-10-05 2013-02-28 コーネル ユニヴァーシティー 心不全の予防又は処置の方法
EP2536690B1 (fr) * 2010-02-19 2018-08-08 Arizona Board Of Regents Desactivateurs de radicaux multifonctions et leur utilisations
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
EP2995614B8 (fr) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Processus catalysés par des métaux de transition pour la préparation de composés de n-allyle et leur utilisation
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
CA2916492A1 (fr) * 2013-06-27 2014-12-31 Stealth Biotherapeutics Corp Agents therapeutiques peptidiques, et leurs procedes d'utilisation
WO2015184109A1 (fr) * 2014-05-29 2015-12-03 Jaguar Animal Health, Inc. Méthodes de traitement de la diarrhée chez des animaux adultes non humains
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN107847552B (zh) 2015-01-07 2022-07-01 三叉神经股份公司 含镁的催产素制剂和使用方法
US20180318279A1 (en) * 2015-10-23 2018-11-08 Rush University Medical Center Topical compositions providing pain relief and methods of use thereof
CN110357808A (zh) * 2019-06-13 2019-10-22 上海上药新亚药业有限公司 一种盐酸洛哌丁胺的结晶工艺

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275510A (en) * 1966-09-27 Topical antitussive preparations
US3789072A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Carboxamides
NL173848C (nl) 1970-06-01 1984-03-16 Janssen Pharmaceutica Nv Werkwijze ter bereiding van 2.2-diaryl 4-piperidino butyramiden; werkwijze ter bereiding van therapeutisch werkzame preparaten en de door toepassing daarvan verkregen gevormde voortbrengselen.
US3714159A (en) * 1971-03-30 1973-01-30 Janssen Pharmaceutica Nv 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
US3884916A (en) * 1971-03-30 1975-05-20 Janssen Pharmaceutica Nv 2,2-Diaryl-4-(4-aryl-4-hydroxy-piperidino)-butyramides
US4025652A (en) * 1975-03-31 1977-05-24 William H. Rorer, Inc. Amidinoureas
US4326074A (en) * 1972-09-22 1982-04-20 William H. Rorer, Inc. Amidinoureas
US3950537A (en) * 1973-06-29 1976-04-13 Rohm And Haas Company Gastrointestinally active thioureas
US4060635A (en) * 1975-03-31 1977-11-29 William H. Rorer, Inc. Amidinoureas for treating diarrhea
US3914238A (en) * 1974-01-18 1975-10-21 Janssen Pharmaceutica Nv 4-Aryl-{60 -(1,4-benzodioxan-2-yl)-4-hydroxy-1-piperidineethanols
US3998815A (en) * 1974-06-24 1976-12-21 Interx Research Corporation 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts
US4203920A (en) * 1975-03-31 1980-05-20 William H. Rorer, Inc. Amidinoureas
US4147804A (en) * 1975-03-31 1979-04-03 William H. Rorer, Inc. Amidinourea local anesthetics
US4066654A (en) * 1975-04-16 1978-01-03 G. D. Searle & Co. 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives
US4057549A (en) * 1975-04-16 1977-11-08 G. D. Searle & Co. Triarylpropyl-azabicyclooctanes
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds
US4072686A (en) * 1975-04-16 1978-02-07 G. D. Searle & Co. 1-(3,3,3-Triarylalkyl)-4-phenyl-piperidinealkanols
US4012374A (en) * 1975-09-29 1977-03-15 E. R. Squibb & Sons, Inc. 1-[[4-Phenyl-piperidinyl (or tetrahydropyridinyl)]alkyl]-2,6-piperidinedione and analogs
US3996214A (en) * 1976-02-23 1976-12-07 G. D. Searle & Co. 5-(1,1-Diphenyl-4-(cyclic amino) but-2-trans-en-1-yl)-2-alkyl-1,3,4-oxadiazoles and intermediates thereto
US4013668A (en) * 1976-03-10 1977-03-22 G. D. Searle & Co. 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds
US4012393A (en) * 1976-03-22 1977-03-15 G. D. Searle & Co. 2-[5-(CYCLIC AMINO) ETHYL-10,11-DIHYDRO-5H-dibenzo[a,d]-cyclohepten-5- yl]-5
US4371463A (en) * 1977-02-17 1983-02-01 The United States Of America As Represented By The Department Of Health And Human Services Enzyme-resistant opiate pentapeptides
US4125531A (en) * 1977-04-18 1978-11-14 G. D. Searle & Co. 2-Substituted-1-azabicyclo[2.2.2]octanes
US4069223A (en) * 1977-05-02 1978-01-17 G. D. Searle & Co. 4-Aminomethyl-1-(3,3,3-triarylpropyl)-4-arylpiperidine and derivatives thereof
US4116963A (en) * 1977-05-23 1978-09-26 G.D. Searle & Co. 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy piperidines and related compounds
US4218454A (en) * 1977-07-08 1980-08-19 Sri International N-αMethylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives
US4194045A (en) * 1977-12-27 1980-03-18 G. D. Searle & Co. 1-(3,3-Diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds
US4269843A (en) * 1978-05-24 1981-05-26 Sri International N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives
US4238390A (en) * 1979-05-09 1980-12-09 Hoffmann-La Roche Inc. Synthesis and biological activity of [D-Thr2, Δ3 Pro5 ]-enkephalinamide
US4277605A (en) * 1980-03-07 1981-07-07 Bristol-Myers Company Chemical compounds
US4384000A (en) * 1980-08-07 1983-05-17 Lanier Earl W Method for treatment of various dermatological conditions
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
US4328803B1 (en) * 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
US4416886A (en) * 1981-07-29 1983-11-22 Dermall Limited Method of treating pruritis and composition therefor
US4870084A (en) * 1982-03-16 1989-09-26 Pfizer Inc. Bicyclic benzo fused pyran compounds used for nausea treatment and prevention
US4430327A (en) * 1982-05-18 1984-02-07 Eli Lilly And Company Method for treating pregnant females for pain and anxiety
US4533739A (en) * 1982-10-12 1985-08-06 G. D. Searle & Co. 2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
GB8314646D0 (en) * 1983-05-26 1983-06-29 Wellcome Found Pharmaceutical amides
US4493848A (en) * 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
CH667657A5 (de) 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
US4824853A (en) * 1985-10-11 1989-04-25 Janssen Pharmaceutica N.V. α,α-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides and method of treating diarrhea
US4749706A (en) * 1986-03-24 1988-06-07 Sri International Orally active nonaddicting analgesics
US4990521A (en) * 1986-07-03 1991-02-05 Janssen Pharmaceutica 4-(aroylamino)piperidine-butanimide derivatives
US4917896A (en) * 1986-08-15 1990-04-17 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agents
US5214080A (en) * 1987-05-15 1993-05-25 Dainippon Ink And Chemicals, Inc. Process for producing nonaqueous dispersion-type resin
US4897260A (en) * 1987-05-22 1990-01-30 The Rockefeller University Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same
GB2205745B (en) * 1987-06-16 1990-09-19 Nat Res Dev Use of dioxopiperidine derivatives as analgesics
US5282851A (en) * 1987-07-07 1994-02-01 Jacob Labarre Jean Intraocular prostheses
US5196405A (en) * 1987-07-08 1993-03-23 Norman H. Oskman Compositions and methods of treating hemorrhoids and wounds
US5286751A (en) * 1987-12-24 1994-02-15 Analgesic Associates Sustained/enhanced antipyretic response
HU202195B (en) * 1987-12-31 1991-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing new substituted styrene derivatives and medical compositions comprising such compounds
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
GB8806224D0 (en) * 1988-03-16 1988-04-13 Johnson Matthey Plc Platinum chemotherapeutic product
US5273751A (en) * 1988-03-25 1993-12-28 Seymour Dubroff Composition for preventing clouding of paosterior capsule after extracapsular cataract eye surgery and method of performing cataract surgery
EP0351897A3 (fr) * 1988-06-17 1990-03-21 The Procter & Gamble Company Système de pénétration cutanée pour des sels d'agents pharmaceutiques à fonction amine
ES2085865T3 (es) * 1988-06-30 1996-06-16 Astra Ab Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.
FR2634376B1 (fr) * 1988-07-21 1992-04-17 Farmalyoc Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
DE3833572A1 (de) * 1988-10-03 1990-04-05 Pfersee Chem Fab Stabile, feinteilige, waessrige einkomponenten-silikonkatalysatoren, verfahren zu deren herstellung und deren verwendung
US5432176A (en) * 1988-11-29 1995-07-11 The John Hopkins University Method of retarding the progression of chronic renal failure
US5025796A (en) * 1988-12-01 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Apparatus and methods for determining in vivo response to thermal stimulation in in an unrestrained subject
US5109135A (en) * 1988-12-29 1992-04-28 Sterling Drug Inc. 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates
ATE124867T1 (de) 1989-02-16 1995-07-15 Sankyo Co Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung.
US5229127A (en) * 1989-03-03 1993-07-20 Mckinzie James W Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives
US5278126A (en) * 1989-03-31 1994-01-11 Ricoh Company, Ltd. Recording process and apparatus and recording medium in the same
US5116868A (en) * 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US5437994A (en) * 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5266465A (en) * 1989-06-23 1993-11-30 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5202130A (en) * 1989-08-31 1993-04-13 The Johns Hopkins University Suppression of eczematous dermatitis by calcium transport inhibition
NZ235876A (en) * 1989-11-01 1992-06-25 Mcneil Ppc Inc Pharmaceutical compositions containing effective amount of antidiarrheal composition and antiflatulent effective amount of simethicone
US5236947A (en) * 1990-02-28 1993-08-17 Jouveinal S.A. Propanamines, their pharmacological properties and their application as an antidiarrheal
FR2658821B1 (fr) * 1990-02-28 1994-09-16 Jouveinal Sa Nouvelles propanamines, leurs proprietes pharmacologiques et leur application a des fins therapeutiques, notamment antidiarrheuiques.
WO1991015241A1 (fr) * 1990-03-30 1991-10-17 Yasunori Morimoto Composition absorbable par voie percutanee d'analgesiques narcotiques et non narcotiques .
US5112596A (en) * 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5366979A (en) * 1990-06-07 1994-11-22 Pharmaco Development Partners Orally active nonaddicting analgesics
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
US5292362A (en) * 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
US5116847A (en) * 1991-01-25 1992-05-26 The Procter & Gamble Company Use of loperamide and related compounds for treatment of respiratory disease symptoms
JPH04261119A (ja) 1991-02-13 1992-09-17 Lintec Corp 経皮吸収型貼付剤
IT1247529B (it) * 1991-04-24 1994-12-17 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5149538A (en) * 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5242944A (en) * 1991-06-20 1993-09-07 Korea Research Institute Of Chemical Technology Phenylacetamide derivatives and pharmaceutical compositions thereof
ATE144976T1 (de) * 1991-08-10 1996-11-15 Hisamitsu Pharmaceutical Co Phenylalkansäurederivat, seine herstellung und die trennung seiner optischen isomere
IL99368A (en) 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
NL9102142A (nl) * 1991-12-20 1993-07-16 Dagra Pharma Bv Zetpillen met vertraagde afgifte en werkwijze voor de bereiding daarvan.
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5403867A (en) * 1992-02-07 1995-04-04 Kaken Pharmaceutical Co., Ltd. Preparation for treating wounds or hemorrhoids
US5273056A (en) * 1992-06-12 1993-12-28 Alcon Laboratories, Inc. Use of combinations of viscoelastics during surgery
US5460821A (en) * 1993-06-23 1995-10-24 Masiz; John J. Molecular transdermal transport system
US5645854A (en) * 1993-06-23 1997-07-08 Masiz; John J. Molecular transdermal transport system
US5965732A (en) 1993-08-30 1999-10-12 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
GB2287404A (en) 1994-03-15 1995-09-20 Pfizer Antiinflammatory and analgesic compositions
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5589480A (en) * 1994-08-17 1996-12-31 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
US5618557A (en) * 1994-11-22 1997-04-08 E.R. Squibb & Sons, Inc. Prophylactic treatment of allergic contact dermatitis
US5866143A (en) 1995-03-24 1999-02-02 El Khoury And Stein, Ltd. Topical application of opioid drugs such as morphine for relief of itching and skin disease
US5686106A (en) * 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5667773A (en) * 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US5888494A (en) 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
US5811078A (en) 1997-03-14 1998-09-22 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions therewith
US5798093A (en) 1997-03-14 1998-08-25 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
US5855907A (en) 1997-03-24 1999-01-05 Peyman; Gholam A. Method of treatment of migraine
US5919473A (en) 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US5834480A (en) 1997-06-13 1998-11-10 Elkhoury; George F. Topical application of opioids for treatment of acne and sebaceous gland disorders
US5849762A (en) 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith

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AU7071096A (en) 1997-04-01
EP0852494A2 (fr) 1998-07-15
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BR9610345A (pt) 1999-06-01
CA2229814A1 (fr) 1997-03-20
WO1997009973A2 (fr) 1997-03-20
CA2356097A1 (fr) 1997-03-20
AU727982B2 (en) 2001-01-04
AU727982C (en) 2001-10-18
KR19990044182A (ko) 1999-06-25
MX9801514A (es) 1998-10-31
NO980700D0 (no) 1998-02-19
JPH11512438A (ja) 1999-10-26
US5994372A (en) 1999-11-30
JP3553083B2 (ja) 2004-08-11
WO1997009973A3 (fr) 1997-06-05
US6166039A (en) 2000-12-26
CA2229814C (fr) 2001-12-04
US5849761A (en) 1998-12-15
US6576650B1 (en) 2003-06-10

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