ATE124867T1 - Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung. - Google Patents

Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung.

Info

Publication number
ATE124867T1
ATE124867T1 AT90301735T AT90301735T ATE124867T1 AT E124867 T1 ATE124867 T1 AT E124867T1 AT 90301735 T AT90301735 T AT 90301735T AT 90301735 T AT90301735 T AT 90301735T AT E124867 T1 ATE124867 T1 AT E124867T1
Authority
AT
Austria
Prior art keywords
renin
alkyl
optionally substituted
production
inhibiting activity
Prior art date
Application number
AT90301735T
Other languages
English (en)
Inventor
Yasuhiro C O Sankyo C Morisawa
Mitsuru C O Sankyo Com Kataoka
Yuichiro C O Sankyo Compa Yabe
Hiroyuki C O Sankyo Comp Koike
Hidekuni C O Sankyo C Takahagi
Yasuteru C O Sankyo Com Iijima
Tatsuo Kokubu
Kunio Hiwada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE124867T1 publication Critical patent/ATE124867T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90301735T 1989-02-16 1990-02-16 Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung. ATE124867T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3709789 1989-02-16
JP14957789 1989-06-14

Publications (1)

Publication Number Publication Date
ATE124867T1 true ATE124867T1 (de) 1995-07-15

Family

ID=26376195

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90301735T ATE124867T1 (de) 1989-02-16 1990-02-16 Peptide, die eine reninhemmende aktivität besitzen, deren herstellung und verwendung.

Country Status (10)

Country Link
US (1) US5378689A (de)
EP (1) EP0383635B1 (de)
KR (1) KR900012945A (de)
AT (1) ATE124867T1 (de)
CA (1) CA2010260A1 (de)
DE (1) DE69020752T2 (de)
DK (1) DK0383635T3 (de)
ES (1) ES2077021T3 (de)
GR (1) GR3017697T3 (de)
IE (1) IE70080B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587388A (en) * 1992-12-02 1996-12-24 Lucky Limited Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
CA2191924A1 (en) 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
JP4727770B2 (ja) * 1997-09-26 2011-07-20 カルピス株式会社 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5839149A (ja) * 1981-09-02 1983-03-07 Nec Corp ４線式割込接続方式
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
CA1269523A (en) * 1984-07-23 1990-05-29 Corning Glass Works Photoelectrodes for solar energy conversion
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
JPS61275256A (ja) * 1984-11-27 1986-12-05 Sankyo Co Ltd レニン阻害ペプチド
SU1676454A3 (ru) * 1984-11-30 1991-09-07 Санкио Компани Лимитед (Фирма) Способ получени пептидов или их фармацевтически приемлемых солей
CA1286846C (en) * 1985-02-12 1991-07-23 Catherine Cazaubon Peptide derivatives which inhibit renin and acid proteases
KR870005013A (ko) * 1985-11-29 1987-06-04 가와무라 요시부미 레닌-억제 올리고펩티드, 그의 제조방법 및 용도
EP0258289A4 (en) * 1986-01-16 1991-01-02 Joseph Dellaria Peptide analogs
EP0278158A3 (de) * 1986-11-12 1990-05-23 Merck & Co. Inc. Renin-Inhibitoren enthaltende Phenylalanin-Histidin-Stellvertreter
ES2062988T3 (es) * 1986-12-19 1995-01-01 Sankyo Co Nuevos oligopeptidos inhibidores de la renina, su preparacion y su uso.
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
EP0297816B1 (de) * 1987-07-01 1994-03-02 Pfizer Inc. Homocyclostatin und Cyclostatin enthaltende Polypeptide als Antihypertensiva
US4839357A (en) * 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
DE68916271T2 (de) * 1988-01-26 1995-02-23 Sankyo Co Renin inhibierende Polypeptide, ihre Herstellung und Anwendung.

Also Published As

Publication number Publication date
KR900012945A (ko) 1990-09-03
IE70080B1 (en) 1996-10-30
DE69020752T2 (de) 1996-03-28
EP0383635B1 (de) 1995-07-12
ES2077021T3 (es) 1995-11-16
GR3017697T3 (en) 1996-01-31
US5378689A (en) 1995-01-03
DE69020752D1 (de) 1995-08-17
DK0383635T3 (da) 1995-11-20
IE900585L (en) 1990-08-16
EP0383635A2 (de) 1990-08-22
EP0383635A3 (de) 1991-12-27
CA2010260A1 (en) 1990-08-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee