DE69020752D1 - Peptide, die eine reninhemmende Aktivität besitzen, deren Herstellung und Verwendung. - Google Patents

Peptide, die eine reninhemmende Aktivität besitzen, deren Herstellung und Verwendung.

Info

Publication number
DE69020752D1
DE69020752D1 DE69020752T DE69020752T DE69020752D1 DE 69020752 D1 DE69020752 D1 DE 69020752D1 DE 69020752 T DE69020752 T DE 69020752T DE 69020752 T DE69020752 T DE 69020752T DE 69020752 D1 DE69020752 D1 DE 69020752D1
Authority
DE
Germany
Prior art keywords
renin
alkyl
optionally substituted
peptides
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69020752T
Other languages
English (en)
Other versions
DE69020752T2 (de
Inventor
Yasuhiro Morisawa
Mitsuru Kataoka
Yuichiro Yabe
Hiroyuki Koike
Hidekuni Takahagi
Yasuteru Iijima
Tatsuo Kokubu
Kunio Hiwada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE69020752D1 publication Critical patent/DE69020752D1/de
Publication of DE69020752T2 publication Critical patent/DE69020752T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69020752T 1989-02-16 1990-02-16 Peptide, die eine reninhemmende Aktivität besitzen, deren Herstellung und Verwendung. Expired - Fee Related DE69020752T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3709789 1989-02-16
JP14957789 1989-06-14

Publications (2)

Publication Number Publication Date
DE69020752D1 true DE69020752D1 (de) 1995-08-17
DE69020752T2 DE69020752T2 (de) 1996-03-28

Family

ID=26376195

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69020752T Expired - Fee Related DE69020752T2 (de) 1989-02-16 1990-02-16 Peptide, die eine reninhemmende Aktivität besitzen, deren Herstellung und Verwendung.

Country Status (10)

Country Link
US (1) US5378689A (de)
EP (1) EP0383635B1 (de)
KR (1) KR900012945A (de)
AT (1) ATE124867T1 (de)
CA (1) CA2010260A1 (de)
DE (1) DE69020752T2 (de)
DK (1) DK0383635T3 (de)
ES (1) ES2077021T3 (de)
GR (1) GR3017697T3 (de)
IE (1) IE70080B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587388A (en) * 1992-12-02 1996-12-24 Lucky Limited Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
CA2191924A1 (en) 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
JP4727770B2 (ja) * 1997-09-26 2011-07-20 カルピス株式会社 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5839149A (ja) * 1981-09-02 1983-03-07 Nec Corp ４線式割込接続方式
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
CA1269523A (en) * 1984-07-23 1990-05-29 Corning Glass Works Photoelectrodes for solar energy conversion
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
JPS61275256A (ja) * 1984-11-27 1986-12-05 Sankyo Co Ltd レニン阻害ペプチド
SU1676454A3 (ru) * 1984-11-30 1991-09-07 Санкио Компани Лимитед (Фирма) Способ получени пептидов или их фармацевтически приемлемых солей
CA1286846C (en) * 1985-02-12 1991-07-23 Catherine Cazaubon Peptide derivatives which inhibit renin and acid proteases
KR870005013A (ko) * 1985-11-29 1987-06-04 가와무라 요시부미 레닌-억제 올리고펩티드, 그의 제조방법 및 용도
WO1987004349A1 (en) * 1986-01-16 1987-07-30 Joseph Dellaria Peptide analogs
EP0278158A3 (de) * 1986-11-12 1990-05-23 Merck & Co. Inc. Renin-Inhibitoren enthaltende Phenylalanin-Histidin-Stellvertreter
DE3789101T2 (de) * 1986-12-19 1994-07-21 Sankyo Co Renin inhibierende Oligopeptide, ihre Präparation und ihre Anwendung.
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
DE3888031T2 (de) * 1987-07-01 1994-06-09 Pfizer Homocyclostatin und Cyclostatin enthaltende Polypeptide als Antihypertensiva.
US4839357A (en) * 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
ES2058489T3 (es) * 1988-01-26 1994-11-01 Sankyo Co Oligopeptidos con actividades inhibidoras de la renina, su preparacion y su uso.

Also Published As

Publication number Publication date
DK0383635T3 (da) 1995-11-20
DE69020752T2 (de) 1996-03-28
CA2010260A1 (en) 1990-08-16
EP0383635A2 (de) 1990-08-22
US5378689A (en) 1995-01-03
ATE124867T1 (de) 1995-07-15
GR3017697T3 (en) 1996-01-31
KR900012945A (ko) 1990-09-03
ES2077021T3 (es) 1995-11-16
EP0383635B1 (de) 1995-07-12
EP0383635A3 (de) 1991-12-27
IE900585L (en) 1990-08-16
IE70080B1 (en) 1996-10-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee