NO974964D0 - Genetiske sekvenser og proteiner som er relatert til Alzheimer's sykdom, og anvendelser av disse - Google Patents

Genetiske sekvenser og proteiner som er relatert til Alzheimer's sykdom, og anvendelser av disse

Info

Publication number
NO974964D0
NO974964D0 NO974964A NO974964A NO974964D0 NO 974964 D0 NO974964 D0 NO 974964D0 NO 974964 A NO974964 A NO 974964A NO 974964 A NO974964 A NO 974964A NO 974964 D0 NO974964 D0 NO 974964D0
Authority
NO
Norway
Prior art keywords
disease
alzheimer
applications
genetic sequences
proteins related
Prior art date
Application number
NO974964A
Other languages
English (en)
Other versions
NO974964L (no
Inventor
Peter H St George-Hyslop
Paul E Fraser
Johanna M Rommens
Original Assignee
Hsc Res Dev Lp
Univ Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/431,048 external-priority patent/US6531586B1/en
Priority claimed from US08/496,841 external-priority patent/US6210919B1/en
Application filed by Hsc Res Dev Lp, Univ Toronto filed Critical Hsc Res Dev Lp
Publication of NO974964D0 publication Critical patent/NO974964D0/no
Publication of NO974964L publication Critical patent/NO974964L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0335—Genetically modified worms
    • A01K67/0336—Genetically modified Nematodes, e.g. Caenorhabditis elegans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0337—Genetically modified Arthropods
    • A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/70—Invertebrates
    • A01K2227/703—Worms, e.g. Caenorhabdities elegans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
NO974964A 1995-04-28 1997-10-27 Genetiske sekvenser og proteiner som er relatert til Alzheimer's sykdom, og anvendelser av disse NO974964L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/431,048 US6531586B1 (en) 1995-04-28 1995-04-28 Genetic sequences related to Alzheimer's Disease
US08/496,841 US6210919B1 (en) 1995-04-28 1995-06-28 Genetic sequences and proteins related to alzheimer's disease
US50935995A 1995-07-31 1995-07-31
PCT/CA1996/000263 WO1996034099A2 (en) 1995-04-28 1996-04-29 Genetic sequences and proteins related to alzheimer's disease, and uses therefor

Publications (2)

Publication Number Publication Date
NO974964D0 true NO974964D0 (no) 1997-10-27
NO974964L NO974964L (no) 1997-12-29

Family

ID=27411707

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974964A NO974964L (no) 1995-04-28 1997-10-27 Genetiske sekvenser og proteiner som er relatert til Alzheimer's sykdom, og anvendelser av disse

Country Status (19)

Country Link
US (9) US5986054A (no)
EP (2) EP0826042B1 (no)
JP (3) JP4504463B2 (no)
KR (1) KR19990008181A (no)
AT (1) ATE405645T1 (no)
AU (1) AU716307B2 (no)
BR (1) BR9608140A (no)
CA (1) CA2219214A1 (no)
CZ (1) CZ339097A3 (no)
DE (1) DE69637649D1 (no)
DK (1) DK0826042T3 (no)
ES (1) ES2314979T3 (no)
HU (1) HUP9801639A3 (no)
MX (1) MX9708270A (no)
NO (1) NO974964L (no)
NZ (2) NZ335945A (no)
PL (1) PL185549B1 (no)
SK (1) SK145397A3 (no)
WO (1) WO1996034099A2 (no)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
ATE305039T1 (de) * 1995-07-07 2005-10-15 Darwin Molecular Corp Auf chromosom 1 lokalisiertes gen dessen genprodukt mit der alzheimerschen krankheit assoziiert ist.
EP0842188A4 (en) * 1995-07-18 2001-06-20 Univ Washington GENES S182 MUTANTS
WO1997007213A2 (en) * 1995-08-16 1997-02-27 President And Fellows Of Harvard College Assay for identifying genes causing chromosome non-disjunction
US6248555B1 (en) * 1995-08-31 2001-06-19 The General Hospital Corporation Genetic alterations related to familial alzheimer's disease
EP0854881A4 (en) * 1995-09-27 2001-10-31 Univ Columbia INDICATION OF SEL-12 AND USE THEREFOR
ZA968898B (en) * 1995-10-25 1998-03-30 Washington University Of Medic Method for elucidation and detection of polymorphisms, splice variants and proximal coding mutations using intronic sequences of the mutations Alzheimer's S182 gene.
JPH10327897A (ja) * 1996-01-19 1998-12-15 Washington Univ プレセニリン−１遺伝子の配列を用いる疾患の診断および予後診断
WO1997027296A1 (en) * 1996-01-26 1997-07-31 Hsc Research And Development Limited Partnership Nucleic acids and proteins related to alzheimer's disease, and uses therefor
AU2541497A (en) * 1996-04-04 1997-10-29 Institute Of Genomic Research, The Variant presenilin-2 genes
EP0811695A3 (en) * 1996-06-06 1998-07-29 Washington University Mutant S182(PS-1) genes
WO1997046678A1 (en) * 1996-06-06 1997-12-11 Bayer Corporation Nucleic acids and polypeptides related to presenilin
EP0814157A3 (en) * 1996-06-18 1998-01-07 Smithkline Beecham Corporation Diagnostic marker for variants of presenilin genes associated with Alzheimers Disease and Familial Adult Onset Alzheimers Disease
WO1998001549A2 (en) * 1996-07-05 1998-01-15 The Governing Council Of The University Of Toronto Genetic sequences and proteins related to alzheimer's disease, and uses therefor
JP2001510991A (ja) 1996-12-02 2001-08-07 ザ ブリガム アンド ウイメンズ ホスピタル，インク． Ａｌａｒｍ関連ペプチドおよび核酸ならびにそれらを用いた診断
US6376239B1 (en) * 1997-04-04 2002-04-23 Elegene Gmbh DNA molecules comprising a promoter capable of conferring expression of a heterologous DNA sequence
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
JP2002505664A (ja) * 1997-04-24 2002-02-19 ザ ジェネラル ホスピタル コーポレイション 精製された２０ｋＤａのプレセニリン２のＣ末端フラグメント、およびプレセニリン２のタンパク質分解を阻害する化合物をスクリーニングする方法
WO1998051781A1 (en) * 1997-05-14 1998-11-19 Merck & Co., Inc. Transgenic animal expressing non-native wild-type and familial alzheimer's disease mutant presenilin 1 protein on native presenilin 1 null background
ES2128265B1 (es) * 1997-06-04 2000-03-01 Euroespes S A Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer.
US7923216B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
US7923015B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
US20100081197A1 (en) * 1997-08-14 2010-04-01 Sylvie Roux In vivo modulation of neuronal transport
PT1049712E (pt) * 1997-08-14 2007-04-30 Pasteur Institut Proteínas híbridas da toxina do tétano que migram retrogradamente e trans - sinapticamente para o snc
US6255473B1 (en) * 1997-08-29 2001-07-03 Duke University Presenilin-1 gene promoter
US6284944B1 (en) 1997-08-29 2001-09-04 Cephalon, Inc, Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
FR2768346B1 (fr) 1997-09-15 2002-04-19 Fond Jean Dausset Ceph Compose assurant l'inhibition de la preseniline 1 pour la preparation d'un medicament et agent de diagnostic
FR2770217B1 (fr) * 1997-10-24 2001-12-07 Rhone Poulenc Rorer Sa Peptides capables d'inhiber l'interaction entre les presenilines et le precurseur du peptide b-amyloide et/ou le peptide b-amyloide
WO1999021886A1 (fr) * 1997-10-24 1999-05-06 Aventis Pharma S.A. PEPTIDES CAPABLES D'INHIBER L'INTERACTION ENTRE LES PRESENILINES ET LE PEPTIDE β-AMYLOIDE OU SON PRECURSEUR
CA2317809A1 (en) * 1998-01-08 1999-07-15 Daiichi Pharmaceutical Co., Ltd. Gene mutant animals
US6383758B1 (en) 1998-01-09 2002-05-07 The Governing Council Of The University Of Toronto Alzheimer's related proteins and methods of use
EP1849477A1 (en) * 1998-02-25 2007-10-31 THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY Use of skin penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response induced by ADP-ribosylating exotoxin
DE69940906D1 (de) * 1998-05-21 2009-07-02 Mitsubishi Tanabe Pharma Corp Verfahren zur untersuchung von krankheiten des zentralen nervensystems und verfahren zum aufsuchen von arzneimitteln
AR020329A1 (es) * 1998-07-09 2002-05-08 Boehringer Ingelheim Pharma UNA SUSTANCIA, EN PARTICULAR UNA RIBOZIMA, CAPAZ DE INHIBIR LA EXPRESION DE PRESENILINA 2, UNA MOLECULA DE DNA RECOMBINANTE QUE CODIFICA DICHA RIBOZIMA, UNVECTOR RECOMBINANTE QUE COMPRENDE EL cDNA CORRESPONDIENTE A DICHA RIBOZIMA, UNA CELULA HOSPEDADORA QUE COMPRENDE DICHO VECTOR RECOMBINANTE, UNA C
CA2333467A1 (en) * 1998-07-16 2000-01-27 Incyte Pharmaceuticals, Inc. Human presenilin-associated protein
US6797480B1 (en) 1998-10-05 2004-09-28 University Of Connecticut Health Center Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents
US6723557B1 (en) 1999-01-06 2004-04-20 California Institute Of Technology Caenorhabditis elegans LOV-1 gene
US6783982B1 (en) 1999-02-12 2004-08-31 The Governing Council Of The University Of Toronto Proteins related to neuronal regeneration and uses thereof
US6812337B1 (en) 1999-04-01 2004-11-02 The Governing Council Of The University Of Toronto Presenilin associated membrane protein and uses thereof
US6890726B1 (en) 1999-04-06 2005-05-10 Oklahoma Medical Research Foundation Method for selecting recombinase variants with altered specificity
AU4078900A (en) * 1999-04-06 2000-10-23 Harrington Arthritis Research Center Methods for tracking the progression of alzheimer's disease and identifying treatments using transgenic mice
US20030131364A1 (en) * 1999-04-27 2003-07-10 Karen Duff Method for producing transgenic animal models with modulated phenotype and animals produced therefrom
AU6265600A (en) * 1999-06-22 2001-01-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method for detection of early-onset alzheimer's disease
DE60045005D1 (de) 1999-06-28 2010-11-04 Oklahoma Med Res Found Inhibitoren des memapsin 2 und ihre verwendung
US20020049303A1 (en) * 1999-06-28 2002-04-25 Tang Jordan J. N. Catalytically active recombinant memapsin and methods of use thereof
FR2798821B1 (fr) * 1999-09-27 2001-10-26 Aventis Pharma Sa Animal transgenique exprimant une forme multi-mutee de la preseniline 1
AU2001227960A1 (en) * 2000-01-21 2001-07-31 University Of Connecticut Health Center Heat shock/stress protein complexes as vaccines against neurodegenerative disorders
EP1305634A2 (en) * 2000-04-03 2003-05-02 Bristol-Myers Squibb Company Fluorescence assay for gamma-secretase activity and inhibitors
US20040248092A1 (en) * 2000-05-26 2004-12-09 Vance Jeffrey M Methods of screening for parkinsons's disease
WO2001096361A1 (en) * 2000-06-12 2001-12-20 University Of Maryland Biotechnology Institute Method of controlling the binding of calmyrin to presenilin
US7371920B2 (en) 2000-06-20 2008-05-13 The Governing Council Of The University Of Toronto Transgenic mouse model of neurodegenerative disorders
US20040053251A1 (en) * 2000-06-30 2004-03-18 Pericak-Vance Margaret A. Methods of screening for alzheimer's disease
DE10032709A1 (de) * 2000-07-07 2002-01-24 Boehringer Ingelheim Pharma Aspartyl-Protease
AU2001278919A1 (en) 2000-07-13 2002-01-30 University Of South Florida Transgenic animal and methods
JP2002142765A (ja) * 2000-07-14 2002-05-21 Tosoh Corp 新規ゲノム解析法
JP2004506429A (ja) * 2000-08-16 2004-03-04 フリッツェ，マルクス ヒトの疾患を同定する目的での微生物ｄｎａ配列の使用
WO2002018434A2 (en) * 2000-09-01 2002-03-07 The Governing Council Of The University Of Toronto Proteins related to schizophrenia and uses thereof
US6900367B2 (en) * 2000-09-29 2005-05-31 Novartis Transgenic Drosophila melanogaster expressing a β42 in the eye
US6495335B2 (en) * 2000-12-07 2002-12-17 Mario Chojkier Compositions and methods for diagnosing alzheimer's disease
US20040121947A1 (en) * 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
US6815175B2 (en) 2001-03-16 2004-11-09 Cornell Research Foundation, Inc. Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
US20030073608A1 (en) * 2001-04-10 2003-04-17 Woolf Nancy J. Process for treating disease
GB2375771A (en) * 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
JP2003012548A (ja) * 2001-06-27 2003-01-15 Japan Science & Technology Corp 医薬組成物
IL160396A0 (en) 2001-08-14 2004-07-25 Sentigen Corp Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof
JP4547152B2 (ja) * 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
ATE361471T1 (de) * 2001-12-05 2007-05-15 Sense Proteomic Ltd Protein arrays für allelvarianten und deren verwendung
EP1469717A4 (en) * 2001-12-20 2007-08-22 Univ California TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE
US20040014109A1 (en) * 2002-05-23 2004-01-22 Pericak-Vance Margaret A. Methods and genes associated with screening assays for age at onset and common neurodegenerative diseases
US20060259990A1 (en) * 2002-07-05 2006-11-16 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of tb2 gene and protein for neurodegenerative diseases
US20060183117A1 (en) * 2002-07-08 2006-08-17 Pericak-Vance Margaret A Screening for alzheimer's disease
US20040076606A1 (en) * 2002-09-14 2004-04-22 Ming-Shi Chang Methods of modulating inflammation by administration of interleukin-19 and inhibitors of IL-19 binding
US7022481B2 (en) 2002-12-19 2006-04-04 Rosetta Inpharmatics Llc Methods of using glucan synthase pathway reporter genes to screen for antifungal compounds
US20060246437A1 (en) * 2003-07-11 2006-11-02 Pericak-Vance Margaret A Genetic susceptibility genes for asthma and atopy and asthma-related and atopic-related phenotypes
US20060068428A1 (en) * 2003-11-03 2006-03-30 Duke University Identification of genetic markers associated with parkinson disease
US20050191652A1 (en) * 2003-11-03 2005-09-01 Vance Jeffery M. Identification of genetic forms of a gene that leads to high risk for parkinson disease
US20050170392A1 (en) * 2004-01-30 2005-08-04 Xenoport, Inc. OAT3 transporters expressed in blood brain barrier cells
WO2005075684A2 (en) * 2004-01-30 2005-08-18 Xenoport, Inc. Use of organic anion transporter b in screens for candidate substrates for crossing the blood brain barrier
SE0400707D0 (sv) 2004-03-22 2004-03-22 Bioarctic Neuroscience Ab Transgenic animal model
US7790390B2 (en) * 2004-10-27 2010-09-07 Duke University Methods for identifying an individual at increased risk of developing coronary artery disease
US7807465B2 (en) * 2004-10-27 2010-10-05 Duke University Methods for identifying an individual at increased risk of developing coronary artery disease
US7833725B2 (en) * 2005-01-06 2010-11-16 President And Fellows Of Harvard College Mass spectrometric methods and products
US20070092449A1 (en) * 2005-04-05 2007-04-26 Rafael Vazquez-Martinez Methods for direct visualization of active synapses
US20070148661A1 (en) * 2005-07-19 2007-06-28 Duke University LSAMP Gene Associated With Cardiovascular Disease
WO2007016144A2 (en) * 2005-07-29 2007-02-08 Xenoport, Inc. Octn2 transporters expressed in blood brain barrier cells
US7700300B2 (en) * 2005-07-29 2010-04-20 Xenoport, Inc. Screening of compounds for GAT2 transporter activity
WO2007016161A2 (en) * 2005-07-29 2007-02-08 Xenoport, Inc. Oct3 transporters expressed in blood brain barrier cells
US7704695B2 (en) * 2005-07-29 2010-04-27 Xenoport, Inc. Screening of compounds for BGT1 transporter activity
WO2007016164A2 (en) * 2005-07-29 2007-02-08 Xenoport, Inc. Cat1 transporters expressed in blood brain barrier cells
CA2618508A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating alzheimer's disease
US20090226420A1 (en) * 2005-11-10 2009-09-10 Elizabeth Hauser Methods of Determining the Risk of Developing Coronary Artery Disease
US8852585B2 (en) 2006-01-30 2014-10-07 Grifols Therapeutics Inc. Method of treatment and prophylaxis of diseases related to amyloid deposition using IgM
EP1984396A2 (en) * 2006-02-06 2008-10-29 Elan Pharmaceuticals Inc. Inhibitors specific of presenilin-1 and their uses
US8129334B2 (en) * 2006-03-31 2012-03-06 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory
US7851228B2 (en) * 2006-03-31 2010-12-14 The Regents Of The University Of California Methods for screening agents that modulate presenilin activity and A-β production
AU2007245977A1 (en) * 2006-05-01 2007-11-08 Aarhus Universitet An animal model and a method for producing an animal model
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
EP2134846B1 (en) * 2007-03-07 2018-08-08 Aarhus Universitet Transgenic pig as a model of alzheimer's disease
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2012027555A2 (en) 2010-08-25 2012-03-01 President And Fellows Of Harvard College Glycated cd59 peptides, their preparation, and uses thereof
ES2862955T3 (es) 2010-10-01 2021-10-08 Modernatx Inc Acidos nucleicos manipulados y métodos de uso de los mismos
US20140193341A1 (en) * 2011-01-19 2014-07-10 Asa Abeliovich Human induced neuronal cells
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
WO2012178183A1 (en) * 2011-06-24 2012-12-27 Board Of Regents, The University Of Texas System Human age-related neurodegenerative nematode model and methods
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013052523A1 (en) 2011-10-03 2013-04-11 modeRNA Therapeutics Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US20140343129A1 (en) * 2011-12-14 2014-11-20 Moderna Therapeutics, Inc. Modified nucleic acids, and acute care uses thereof
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
EP2833920A2 (en) 2012-04-02 2015-02-11 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
ES2530141B1 (es) * 2013-08-26 2016-01-15 Juan Carlos GALLAR RUIZ Péptido útil como diana farmacológica para el cribado de moléculas para el tratamiento y/o prevención de la enfermedad de Alzheimer, anticuerpo frente al mismo y uso del anticuerpo para el tratamiento y/o prevención de dicha enfermedad.
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
AU2016321298A1 (en) 2015-09-09 2018-03-29 The Trustees Of Columbia University In The City Of New York Reduction of ER-MAM localized APP-C99 and methods of treating Alzheimer's Disease
ES2817910T3 (es) * 2017-08-04 2021-04-08 Alzheimur 2012 S L Uso de un anticuerpo antipresenilina para la prevención y/o tratamiento del cáncer
EP3796980A4 (en) * 2018-05-22 2022-03-23 The Brigham & Women's Hospital, Inc. NEW THERAPY FOR ALZHEIMER'S DISEASE
KR102584857B1 (ko) * 2020-09-23 2023-10-06 재단법인대구경북과학기술원 알츠하이머 동물모델 및 이의 용도
KR20230009140A (ko) * 2021-07-08 2023-01-17 주식회사 엠케이바이오텍 Human mutant Presenilin-1 발현 인지장애 모델 개의 생산

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690893A (en) * 1985-05-03 1987-09-01 Dnax Research Institute Of Molecular And Cellular Biology, Inc. Hybridoma cell lines producing monoclonal antibodies which specifically bind to mouse interleukin-2
DE3752253T2 (de) * 1986-11-17 1999-05-27 Scios Inc Rekombiniertes Alzheimer Amyloid-Protein.
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
CA2085127C (en) * 1990-06-15 2002-12-10 Barbara Cordell Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
JPH05199896A (ja) * 1990-10-29 1993-08-10 Shinetsu Bio Inc モノクローナル抗体含有試薬
ATE203269T1 (de) * 1991-03-15 2001-08-15 Hsc Res Dev Ltd Partnership Genherstellung zur produktion von transgenfisch
US5297562A (en) * 1991-04-01 1994-03-29 President And Fellows Of Harvard College Method for detecting and treating Alzheimer's disease
NZ242955A (en) * 1991-06-13 1995-01-27 Ici Plc Dna containing gene sequences corresponding to sequences causing alzheimers disease, detection, recombinant yeast with such code
IL105793A0 (en) * 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
JPH07508410A (ja) * 1992-06-18 1995-09-21 ジェンファーム　インターナショナル　インコーポレイテッド 酵母人工染色体を有するトランスジェニック非ヒト動物の製造方法
US5668006A (en) * 1992-07-17 1997-09-16 American Cyanamid Company Somatostatin receptors
US5449604A (en) * 1992-10-21 1995-09-12 University Of Washington Chromosome 14 and familial Alzheimers disease genetic markers and assays
EP1298436B1 (en) * 1992-10-26 2010-07-14 Elan Pharmaceuticals, Inc. Methods for the identification of Beta-amyloid peptide (BAP) release inhibitor compounds
WO1994023049A2 (en) * 1993-04-02 1994-10-13 The Johns Hopkins University The introduction and expression of large genomic sequences in transgenic animals
US6998467B1 (en) * 1995-04-28 2006-02-14 The Hospital For Sick Children Antibody specific for presenilin 1 and method of use thereof
US6210919B1 (en) * 1995-04-28 2001-04-03 Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6531586B1 (en) * 1995-04-28 2003-03-11 The Hospital For Sick Children Genetic sequences related to Alzheimer's Disease
ATE305039T1 (de) * 1995-07-07 2005-10-15 Darwin Molecular Corp Auf chromosom 1 lokalisiertes gen dessen genprodukt mit der alzheimerschen krankheit assoziiert ist.
WO1997003086A1 (en) * 1995-07-13 1997-01-30 University Of South Florida Early onset alzheimer's disease gene and gene products
EP0842188A4 (en) * 1995-07-18 2001-06-20 Univ Washington GENES S182 MUTANTS
WO1997027296A1 (en) * 1996-01-26 1997-07-31 Hsc Research And Development Limited Partnership Nucleic acids and proteins related to alzheimer's disease, and uses therefor

Also Published As

Publication number Publication date
HUP9801639A2 (hu) 1998-10-28
SK145397A3 (en) 1998-09-09
US7846679B2 (en) 2010-12-07
JP4504463B2 (ja) 2010-07-14
EP0826042B1 (en) 2008-08-20
KR19990008181A (ko) 1999-01-25
DE69637649D1 (de) 2008-10-02
PL185549B1 (pl) 2003-05-30
JP2007297407A (ja) 2007-11-15
HUP9801639A3 (en) 2001-01-29
US6117978A (en) 2000-09-12
US6194153B1 (en) 2001-02-27
WO1996034099A3 (en) 1996-12-05
US6395960B1 (en) 2002-05-28
US5986054A (en) 1999-11-16
BR9608140A (pt) 1999-12-07
US20080286813A1 (en) 2008-11-20
CA2219214A1 (en) 1996-10-31
US5840540A (en) 1998-11-24
MX9708270A (es) 1998-06-28
CZ339097A3 (cs) 1998-02-18
US7838247B2 (en) 2010-11-23
JPH11504214A (ja) 1999-04-20
WO1996034099A2 (en) 1996-10-31
EP0826042A2 (en) 1998-03-04
AU5394096A (en) 1996-11-18
US20050214837A1 (en) 2005-09-29
US6485911B1 (en) 2002-11-26
PL323109A1 (en) 1998-03-16
US20090191650A1 (en) 2009-07-30
US7507798B2 (en) 2009-03-24
NZ335945A (en) 2000-09-29
JP5053746B2 (ja) 2012-10-17
DK0826042T3 (da) 2008-11-24
ES2314979T3 (es) 2009-03-16
EP2000479A1 (en) 2008-12-10
JP2013107890A (ja) 2013-06-06
AU716307B2 (en) 2000-02-24
NO974964L (no) 1997-12-29
NZ305822A (en) 2000-08-25
ATE405645T1 (de) 2008-09-15

Similar Documents

Publication Publication Date Title
NO974964D0 (no) Genetiske sekvenser og proteiner som er relatert til Alzheimer's sykdom, og anvendelser av disse
WO2004007722A3 (en) Transgenic animal expressing alzheimer’s tau protein
DE69635207D1 (de) Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist.
DE60036297D1 (de) Bedingtes 'gene trapping'-konstrukt zur unterbrechung von genen
WO1998001549A3 (en) Genetic sequences and proteins related to alzheimer's disease, and uses therefor
Wu et al. Clade-specific genes and the evolutionary origin of novelty; new tools in the toolkit
WO2000024768A3 (en) Genes integrating signal transduction pathways
EA199900184A1 (ru) Протеинкиназы и их применение
MXPA02000293A (es) Isoformas de la amp ciclico fosfodiesterasa y metodos de uso.
NZ242955A (en) Dna containing gene sequences corresponding to sequences causing alzheimers disease, detection, recombinant yeast with such code
NO985280D0 (no) Anvendelse av en mutasjon i genet for human G-protein 3 subenhet for diagnostisering av sykdommer
WO2002018434A3 (en) Proteins related to schizophrenia and uses thereof
WO2002101232A3 (en) Bace interacting proteins
DE60138952D1 (de) 16836, ein mitglied der humanen phospholipase c familie und seine verwendungen
WO2003044170A3 (en) Cyclic amp phosphodiesterase 4d7 isoforms and methods of use
ATE323408T1 (de) Transgenes tiermodell für neurodegenerative erkrankungen
DE50312502D1 (de) Screeningverfahren zum identifizieren protektiver substanzen für die behandlung neurodegenerativer und/oder ischämischer erkrankungen
ATE343632T1 (de) Mutiertes nurr1 gen
SE9701344D0 (sv) Transgenic, non-human animal with protein deficiency, cells derived therefrom, use of said animal and cells, and method of producing said transgenic animal
Haynes The Rb97D gene encodes a potential RNA-binding protein required for spermatogenesis in Drosophila
WO2002026817A3 (en) 33521, a human guanine nucleotide exchange family member and uses thereof
HUP0303286A2 (hu) Készítmények és eljárások biológiai információ felismerésére és szelektálására
ATE257862T1 (de) Verwendung von calculus
WO2003000717A3 (de) Identifizierung von ses-3 (spr-5) aus c. elegans sowie dessen verwendungen
SE9701345D0 (sv) Transgenic, non-human animal with protein deficiency, cells derived therefrom, use of said animal and cells, and method ofpr oducing said transgenic animal

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application