NO974335L - Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease - Google Patents

Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease

Info

Publication number
NO974335L
NO974335L NO974335A NO974335A NO974335L NO 974335 L NO974335 L NO 974335L NO 974335 A NO974335 A NO 974335A NO 974335 A NO974335 A NO 974335A NO 974335 L NO974335 L NO 974335L
Authority
NO
Norway
Prior art keywords
alkyl
carbocycle
heterocycle
hydrogen
heteroalkyl
Prior art date
Application number
NO974335A
Other languages
English (en)
Other versions
NO974335D0 (no
Inventor
Biswanath De
Menyen Cheng
Michael George Natchus
Christopher Thomas Wahl
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO974335D0 publication Critical patent/NO974335D0/no
Publication of NO974335L publication Critical patent/NO974335L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Den foreliggende oppfinnelse vedrører forbindelser som utviser inhiberende aktivitet mot matriks-metallproteaser ("MMP'er"). Fordi MMP'er er kjent å spille en rolle i nedbrytning av vev, kan forbindelsene ifølge den foreliggende oppfinnelse være anvendbare i forbygging eller behandling av sykdommer assosiert med overdreven MMP aktivitet. Særlig har forbindelsene en struktur i samsvar med formel (I) , hvori (A) (1) (a) R^ er hydrogen, alkyl, heteroalkyl, alkenyl, en heterocyklisk ring, en karbocyklisk ring, alkoksy, karbosyklus-alkyl, heterosyklus-alkyl, karbosyklus- heteroalkyl eller heterosyklus-heteroalkyl, og (b) R^ er hydrogen, hydroksy, alkyl, alkenyl, alkynyl, heteroalkyl, en heterocyklisk ring, en karbocyklisk ring, karbosyklus-alkyl, heterosyklus-alkyl, eller -OR hvor R er alkyl, alkenyl eller karbosyklus-alkyl, eller (2) r'- og R^ sammen danner en cykloalkylring med fra 3 til 8 ring-atomer, (B) R-' er hydrogen, alkyl eller karbosyklus-alkyl, (C) R'' er (1) alkyl, (2) karbosyklus-alkyl, (3) -X-C(=Y)-Z-R^ eller -X-CH2-Z-R^ hvor (a) X er kovalent binding eller alkyl, (b) Y er O, S eller NH, (c) Z er 0, S eller fffl, og (d) R^ er hydrogen, alkyl, alkenyl, karbosyklus-alkyl eller aryl, eller (4) -SOj-R^ hvor R^ er alkyl, karbosyklus-alkyl, heterosyklus- alkyl eller aryl, og (D) Q er - [-C (r'') j-1-¿ hvor (1) n er et helt tall 2, 3 eller 4, og (2) hver r' er uavhengig hydrogen eller alkyl slik at den Q-holdige heterosyklus er mettet. eller R''-delen på to nærliggende karbonatomer er en kovalent binding slik at den Q-holdige heterosyklus i formel (I) er umettet, eller et farmasøytisk akseptabelt salt, eller biohydrolyserbart alkoksyamid, acyloksyamid eller imid derav. Oppfinnelsen vedrører også farmasøytiske preparater omfattende disse forbindelser, og fremgangsmåter for å hindre eller behandle sykdommer
NO974335A 1995-03-21 1997-09-19 Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease NO974335L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/407,839 US5672598A (en) 1995-03-21 1995-03-21 Lactam-containing hydroxamic acids
PCT/US1996/003726 WO1996029313A1 (en) 1995-03-21 1996-03-19 Lactam-containing hydroxamic acid derivatives, their preparation and their use as inhibitors of matrix metalloprotease

Publications (2)

Publication Number Publication Date
NO974335D0 NO974335D0 (no) 1997-09-19
NO974335L true NO974335L (no) 1997-11-21

Family

ID=23613737

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974335A NO974335L (no) 1995-03-21 1997-09-19 Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease

Country Status (17)

Country Link
US (1) US5672598A (no)
EP (1) EP0815084B1 (no)
JP (1) JPH11502523A (no)
KR (1) KR19980703151A (no)
AR (1) AR002718A1 (no)
AT (1) ATE248150T1 (no)
AU (1) AU711889B2 (no)
BR (1) BR9607772A (no)
CA (1) CA2216129C (no)
CZ (1) CZ295197A3 (no)
DE (1) DE69629670T2 (no)
HU (1) HUP9800813A3 (no)
IL (1) IL117527A (no)
NO (1) NO974335L (no)
NZ (1) NZ304689A (no)
WO (1) WO1996029313A1 (no)
ZA (1) ZA962253B (no)

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Also Published As

Publication number Publication date
NO974335D0 (no) 1997-09-19
MX9707214A (es) 1997-11-29
IL117527A0 (en) 1996-07-23
EP0815084A1 (en) 1998-01-07
WO1996029313A1 (en) 1996-09-26
DE69629670D1 (de) 2003-10-02
HUP9800813A2 (hu) 1998-07-28
DE69629670T2 (de) 2004-06-17
CA2216129A1 (en) 1996-09-26
JPH11502523A (ja) 1999-03-02
AR002718A1 (es) 1998-04-29
KR19980703151A (ko) 1998-10-15
NZ304689A (en) 1999-05-28
AU711889B2 (en) 1999-10-21
ZA962253B (en) 1996-09-30
IL117527A (en) 1999-12-22
BR9607772A (pt) 1998-07-07
EP0815084B1 (en) 2003-08-27
CZ295197A3 (cs) 1998-05-13
ATE248150T1 (de) 2003-09-15
AU5255896A (en) 1996-10-08
CA2216129C (en) 2002-08-20
US5672598A (en) 1997-09-30
HUP9800813A3 (en) 1998-09-28

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