NO974335D0 - Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease - Google Patents

Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease

Info

Publication number
NO974335D0
NO974335D0 NO974335A NO974335A NO974335D0 NO 974335 D0 NO974335 D0 NO 974335D0 NO 974335 A NO974335 A NO 974335A NO 974335 A NO974335 A NO 974335A NO 974335 D0 NO974335 D0 NO 974335D0
Authority
NO
Norway
Prior art keywords
lactam
inhibitors
preparation
acid derivatives
hydroxamic acid
Prior art date
Application number
NO974335A
Other languages
English (en)
Other versions
NO974335L (no
Inventor
Biswanath De
Menyen Cheng
Michael George Natchus
Christopher Thomas Wahl
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO974335D0 publication Critical patent/NO974335D0/no
Publication of NO974335L publication Critical patent/NO974335L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO974335A 1995-03-21 1997-09-19 Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease NO974335L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/407,839 US5672598A (en) 1995-03-21 1995-03-21 Lactam-containing hydroxamic acids
PCT/US1996/003726 WO1996029313A1 (en) 1995-03-21 1996-03-19 Lactam-containing hydroxamic acid derivatives, their preparation and their use as inhibitors of matrix metalloprotease

Publications (2)

Publication Number Publication Date
NO974335D0 true NO974335D0 (no) 1997-09-19
NO974335L NO974335L (no) 1997-11-21

Family

ID=23613737

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974335A NO974335L (no) 1995-03-21 1997-09-19 Laktam-holdige hydroksaminsyrederivater, deres fremstilling og deres anvendelse som inhibitorer for matriksmetallprotease

Country Status (17)

Country Link
US (1) US5672598A (no)
EP (1) EP0815084B1 (no)
JP (1) JPH11502523A (no)
KR (1) KR19980703151A (no)
AR (1) AR002718A1 (no)
AT (1) ATE248150T1 (no)
AU (1) AU711889B2 (no)
BR (1) BR9607772A (no)
CA (1) CA2216129C (no)
CZ (1) CZ295197A3 (no)
DE (1) DE69629670T2 (no)
HU (1) HUP9800813A3 (no)
IL (1) IL117527A (no)
NO (1) NO974335L (no)
NZ (1) NZ304689A (no)
WO (1) WO1996029313A1 (no)
ZA (1) ZA962253B (no)

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US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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AU2003203805B8 (en) * 1998-08-07 2007-02-15 Bristol-Myers Squibb Pharma Company Succinoylamino lactams as inhibitors of ABeta protein production
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6737038B1 (en) * 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
DE69926254D1 (de) * 1998-11-12 2005-08-25 Bristol Myers Squibb Pharma Co Verwendung von radioliganden zum screening von inhibitoren der herstellung von beta-amyloid peptiden
BR9917082A (pt) * 1998-12-24 2001-11-06 Du Pont Pharm Co Compostos inibidores da produção de proteìnas a"beta", método de tratamento de disfunções neurológicas associadas com a produção de "beta"-amilóide, composição farmacêutica e, método de inibição da atividade de y-secretase
WO2000040564A1 (en) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
PT1150976E (pt) * 1998-12-31 2003-07-31 Aventis Pharma Inc Lactamas 3-(tio amido substituidas) uteis como inibidores da metaloproteinase da matriz
US6262080B1 (en) * 1998-12-31 2001-07-17 Avantis Pharmaceuticals Inc. 3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
US6344450B1 (en) 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
CA2360305A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company Lactam inhibitors of fxa and method
WO2000047563A1 (en) * 1999-02-09 2000-08-17 Bristol-Myers Squibb Co. LACTAM INHIBITORS OF FXa AND METHOD
GB9929527D0 (en) * 1999-12-14 2000-02-09 Smithkline Beecham Plc Novel compounds
US6509330B2 (en) * 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
IL151576A0 (en) 2000-04-03 2003-04-10 Bristol Myers Squibb Pharma Co Cyclic lactams as inhibitors of a-beta protein production
US6632812B2 (en) 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
WO2001085716A1 (en) * 2000-05-11 2001-11-15 Kyowa Hakko Kogyo Co., Ltd 2-piperidone compounds for the treatment of cancer
US6878363B2 (en) 2000-05-17 2005-04-12 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
DK1294383T3 (da) * 2000-06-30 2008-11-10 Procter & Gamble Orale sammensætninger omfattende antimikrobielle midler til at forhindre systemiske sygdomme
DE60134854D1 (de) * 2000-06-30 2008-08-28 Procter & Gamble Orale zubereitungen, die wirtsantwortmodulierenden wirkstoffe enthalten
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
WO2003033018A1 (en) * 2001-10-18 2003-04-24 Warner-Lambert Company Llc Method for preparing purified matrix metalloproteinase
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
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KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법

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Also Published As

Publication number Publication date
DE69629670D1 (de) 2003-10-02
IL117527A (en) 1999-12-22
MX9707214A (es) 1997-11-29
US5672598A (en) 1997-09-30
HUP9800813A3 (en) 1998-09-28
BR9607772A (pt) 1998-07-07
EP0815084B1 (en) 2003-08-27
ZA962253B (en) 1996-09-30
WO1996029313A1 (en) 1996-09-26
NO974335L (no) 1997-11-21
CA2216129C (en) 2002-08-20
CA2216129A1 (en) 1996-09-26
ATE248150T1 (de) 2003-09-15
DE69629670T2 (de) 2004-06-17
EP0815084A1 (en) 1998-01-07
AU5255896A (en) 1996-10-08
CZ295197A3 (cs) 1998-05-13
IL117527A0 (en) 1996-07-23
HUP9800813A2 (hu) 1998-07-28
AU711889B2 (en) 1999-10-21
JPH11502523A (ja) 1999-03-02
AR002718A1 (es) 1998-04-29
NZ304689A (en) 1999-05-28
KR19980703151A (ko) 1998-10-15

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