NO970748D0 - Forbindelser, farmasöytisk blanding og diagnostisk anordning som omfatter de samme, og deres anordning - Google Patents
Forbindelser, farmasöytisk blanding og diagnostisk anordning som omfatter de samme, og deres anordningInfo
- Publication number
- NO970748D0 NO970748D0 NO970748A NO970748A NO970748D0 NO 970748 D0 NO970748 D0 NO 970748D0 NO 970748 A NO970748 A NO 970748A NO 970748 A NO970748 A NO 970748A NO 970748 D0 NO970748 D0 NO 970748D0
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- same
- pharmaceutical composition
- bond
- diagnostic device
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000003834 intracellular effect Effects 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Multicomponent Fibers (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9400752A BE1008581A3 (fr) | 1994-08-19 | 1994-08-19 | Prodrogues, composition pharmaceutique les comprenant et leur utilisation. |
BE9400751A BE1008580A3 (fr) | 1994-08-19 | 1994-08-19 | Prodrogues, composition pharmaceutiques les comprenant et leur utilisation. |
PCT/BE1995/000076 WO1996005863A1 (fr) | 1994-08-19 | 1995-08-21 | Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation |
Publications (3)
Publication Number | Publication Date |
---|---|
NO970748D0 true NO970748D0 (no) | 1997-02-18 |
NO970748L NO970748L (no) | 1997-04-10 |
NO324045B1 NO324045B1 (no) | 2007-08-06 |
Family
ID=25662908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19970748A NO324045B1 (no) | 1994-08-19 | 1997-02-18 | Forbindelser, farmasoytisk blanding og den anvendelse og diagnostisk anordning som omfatter forbindelsene |
Country Status (14)
Country | Link |
---|---|
US (5) | US5962216A (no) |
EP (2) | EP1880737A1 (no) |
JP (2) | JP4157600B2 (no) |
AT (1) | ATE380559T1 (no) |
AU (1) | AU694546C (no) |
CA (1) | CA2203622C (no) |
DE (1) | DE69535665T2 (no) |
DK (1) | DK0769967T3 (no) |
ES (1) | ES2297832T3 (no) |
NO (1) | NO324045B1 (no) |
NZ (1) | NZ291368A (no) |
PT (1) | PT769967E (no) |
SI (1) | SI0769967T1 (no) |
WO (1) | WO1996005863A1 (no) |
Families Citing this family (70)
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US6517824B1 (en) * | 1990-05-14 | 2003-02-11 | University Of Medicine & Denistry Of New Jersey | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
DE69535665T2 (de) * | 1994-08-19 | 2009-04-02 | La Region Wallonne | Konjugate enthaltend ein antitumorales mittel und deren verwendung |
AU3434497A (en) * | 1996-07-16 | 1998-02-09 | Novo Nordisk A/S | Oligopeptide transporters |
US5998362A (en) * | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6127333A (en) * | 1997-07-10 | 2000-10-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6174858B1 (en) * | 1998-11-17 | 2001-01-16 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
ATE460180T1 (de) | 1998-12-11 | 2010-03-15 | Coulter Pharm Inc | Prodrugs und verfahren zu deren herstellung |
US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
GB9924759D0 (en) | 1999-10-19 | 1999-12-22 | Merck Sharp & Dohme | Process for preparing peptide intermediates |
WO2001030804A2 (en) | 1999-10-27 | 2001-05-03 | Merck & Co., Inc. | Salt form of a conjugate useful in the treatment of prostate cancer |
WO2001068145A2 (en) * | 2000-03-15 | 2001-09-20 | Bristol-Myers Squibb Pharma Company | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
US20040014652A1 (en) * | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
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EP1294404A2 (en) | 2000-06-14 | 2003-03-26 | Corixa Corporation | Prodrug compounds with an oligopeptide having an isoleucine residue |
WO2001095945A2 (en) * | 2000-06-14 | 2001-12-20 | Medarex, Inc. | Prodrug compounds cleavable by thimet oligopeptidase |
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EA006741B1 (ru) | 2000-11-09 | 2006-04-28 | Неофарм, Инк. | Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение |
CA2428971A1 (en) * | 2000-11-14 | 2003-05-01 | New River Pharmaceuticals Inc. | Conjugates of a therapeutic agent and a peptide carrier |
EP1355675A1 (en) * | 2001-01-30 | 2003-10-29 | Universite Catholique De Louvain | Anti-tumor compounds |
GB0105929D0 (en) * | 2001-03-09 | 2001-04-25 | Btg Int Ltd | Physiologically activated prodrugs |
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CN106074556B (zh) * | 2016-06-14 | 2018-11-16 | 河南师范大学 | L型胞嘧啶丙氨酸在制备抗癌药物中的应用 |
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CA2153987A1 (en) | 1993-01-14 | 1994-07-21 | U. Prasad Kari | Amino acids and peptides having modified terminals |
US6143864A (en) | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
US5599686A (en) | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
DE69535665T2 (de) * | 1994-08-19 | 2009-04-02 | La Region Wallonne | Konjugate enthaltend ein antitumorales mittel und deren verwendung |
US5659061A (en) * | 1995-04-20 | 1997-08-19 | Drug Innovation & Design, Inc. | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities |
EP1181055A2 (en) | 1999-05-14 | 2002-02-27 | Boehringer Ingelheim Pharmaceuticals Inc. | Enzyme-activated anti-tumor prodrug compounds |
US6552166B1 (en) | 1999-10-19 | 2003-04-22 | Merck & Co., Inc. | Process for the preparation of conjugates useful in the treatment of prostate cancer |
WO2001030804A2 (en) | 1999-10-27 | 2001-05-03 | Merck & Co., Inc. | Salt form of a conjugate useful in the treatment of prostate cancer |
-
1995
- 1995-08-21 DE DE69535665T patent/DE69535665T2/de not_active Expired - Lifetime
- 1995-08-21 EP EP07119790A patent/EP1880737A1/fr not_active Withdrawn
- 1995-08-21 PT PT95928905T patent/PT769967E/pt unknown
- 1995-08-21 DK DK95928905T patent/DK0769967T3/da active
- 1995-08-21 JP JP50766296A patent/JP4157600B2/ja not_active Expired - Lifetime
- 1995-08-21 EP EP95928905A patent/EP0769967B1/fr not_active Expired - Lifetime
- 1995-08-21 CA CA2203622A patent/CA2203622C/en not_active Expired - Lifetime
- 1995-08-21 AT AT95928905T patent/ATE380559T1/de active
- 1995-08-21 US US08/793,910 patent/US5962216A/en not_active Expired - Lifetime
- 1995-08-21 NZ NZ291368A patent/NZ291368A/en not_active IP Right Cessation
- 1995-08-21 ES ES95928905T patent/ES2297832T3/es not_active Expired - Lifetime
- 1995-08-21 AU AU32486/95A patent/AU694546C/en not_active Expired
- 1995-08-21 SI SI9530732T patent/SI0769967T1/sl unknown
- 1995-08-21 WO PCT/BE1995/000076 patent/WO1996005863A1/fr active IP Right Grant
-
1997
- 1997-02-18 NO NO19970748A patent/NO324045B1/no not_active IP Right Cessation
-
1999
- 1999-04-23 US US09/298,330 patent/US6342480B1/en not_active Expired - Lifetime
-
2001
- 2001-11-09 US US10/012,576 patent/US7037898B2/en not_active Expired - Fee Related
-
2006
- 2006-03-08 US US11/370,290 patent/US7390629B2/en not_active Expired - Fee Related
-
2007
- 2007-11-21 JP JP2007301893A patent/JP2008069175A/ja active Pending
-
2008
- 2008-06-10 US US12/157,363 patent/US7951772B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2203622C (en) | 2011-11-01 |
NO324045B1 (no) | 2007-08-06 |
ES2297832T3 (es) | 2008-05-01 |
SI0769967T1 (sl) | 2008-06-30 |
EP1880737A1 (fr) | 2008-01-23 |
US5962216A (en) | 1999-10-05 |
DE69535665T2 (de) | 2009-04-02 |
AU694546C (en) | 2001-09-06 |
JP4157600B2 (ja) | 2008-10-01 |
EP0769967A1 (fr) | 1997-05-02 |
JPH10508291A (ja) | 1998-08-18 |
US20020160943A1 (en) | 2002-10-31 |
US7037898B2 (en) | 2006-05-02 |
US7390629B2 (en) | 2008-06-24 |
US20090137494A1 (en) | 2009-05-28 |
MX9701283A (es) | 1997-09-30 |
US7951772B2 (en) | 2011-05-31 |
WO1996005863A1 (fr) | 1996-02-29 |
US6342480B1 (en) | 2002-01-29 |
DK0769967T3 (da) | 2008-03-31 |
NO970748L (no) | 1997-04-10 |
AU3248695A (en) | 1996-03-14 |
US20060148682A1 (en) | 2006-07-06 |
DE69535665D1 (de) | 2008-01-24 |
JP2008069175A (ja) | 2008-03-27 |
NZ291368A (en) | 1999-04-29 |
EP0769967B1 (fr) | 2007-12-12 |
PT769967E (pt) | 2008-02-18 |
AU694546B2 (en) | 1998-07-23 |
ATE380559T1 (de) | 2007-12-15 |
CA2203622A1 (en) | 1996-02-29 |
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MK1K | Patent expired |