MX9701283A - Compuestos, composicion farmaceutica y dispositivo de diagnostico que los contiene y su uso. - Google Patents

Compuestos, composicion farmaceutica y dispositivo de diagnostico que los contiene y su uso.

Info

Publication number
MX9701283A
MX9701283A MX9701283A MX9701283A MX9701283A MX 9701283 A MX9701283 A MX 9701283A MX 9701283 A MX9701283 A MX 9701283A MX 9701283 A MX9701283 A MX 9701283A MX 9701283 A MX9701283 A MX 9701283A
Authority
MX
Mexico
Prior art keywords
compound
compounds
same
pharmaceutical composition
diagnostic device
Prior art date
Application number
MX9701283A
Other languages
English (en)
Other versions
MXPA97001283A (es
Inventor
Andre Trouet
Roger Baurain
Original Assignee
Wallone Region
Univ Catholique Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25662908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9701283(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from BE9400752A external-priority patent/BE1008581A3/fr
Priority claimed from BE9400751A external-priority patent/BE1008580A3/fr
Application filed by Wallone Region, Univ Catholique Louvain filed Critical Wallone Region
Publication of MX9701283A publication Critical patent/MX9701283A/es
Publication of MXPA97001283A publication Critical patent/MXPA97001283A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Multicomponent Fibers (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

El compuesto (W-Z-M) de conformidad con la invencion comprende un componente (M) seleccionado a partir del grupo que consiste de marcadores y agentes terapéuticos que poseen un lugar de actividad intracelular (A.S.), ligado a un ligando (W-Z) que comprende un brazo (Z) ligado a un grupo terminal (W), caracterizado además porque la ligadura entre el brazo (Z) del ligando (W-Z) y el componente (M) previene entrada intracelular del compuesto (W-Z-M) y/o inhibe expresion del marcador (M), en donde dicha ligadura puede ser inclinada selectivamente por factores segregados por células objetivo para así permitir expresion del marcador (M) o entrada del agente terapéutico (M) en dichas células objetivo, y en donde el grupo terminal (W) provee para la estabilidad del compuesto (W-Z-M) en el suero y la sangre circulante.
MXPA/A/1997/001283A 1994-08-19 1997-02-18 Compuestos, composicion farmaceutica y dispositivo de diagnostico que los contiene y su uso MXPA97001283A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
BE9400751 1994-08-19
BE9400752A BE1008581A3 (fr) 1994-08-19 1994-08-19 Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
BE9400751A BE1008580A3 (fr) 1994-08-19 1994-08-19 Prodrogues, composition pharmaceutiques les comprenant et leur utilisation.
BE9400752 1994-08-19
PCT/BE1995/000076 WO1996005863A1 (fr) 1994-08-19 1995-08-21 Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation

Publications (2)

Publication Number Publication Date
MX9701283A true MX9701283A (es) 1997-09-30
MXPA97001283A MXPA97001283A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
CA2203622C (en) 2011-11-01
NO324045B1 (no) 2007-08-06
ES2297832T3 (es) 2008-05-01
SI0769967T1 (sl) 2008-06-30
EP1880737A1 (fr) 2008-01-23
US5962216A (en) 1999-10-05
DE69535665T2 (de) 2009-04-02
AU694546C (en) 2001-09-06
JP4157600B2 (ja) 2008-10-01
EP0769967A1 (fr) 1997-05-02
JPH10508291A (ja) 1998-08-18
US20020160943A1 (en) 2002-10-31
US7037898B2 (en) 2006-05-02
US7390629B2 (en) 2008-06-24
NO970748D0 (no) 1997-02-18
US20090137494A1 (en) 2009-05-28
US7951772B2 (en) 2011-05-31
WO1996005863A1 (fr) 1996-02-29
US6342480B1 (en) 2002-01-29
DK0769967T3 (da) 2008-03-31
NO970748L (no) 1997-04-10
AU3248695A (en) 1996-03-14
US20060148682A1 (en) 2006-07-06
DE69535665D1 (de) 2008-01-24
JP2008069175A (ja) 2008-03-27
NZ291368A (en) 1999-04-29
EP0769967B1 (fr) 2007-12-12
PT769967E (pt) 2008-02-18
AU694546B2 (en) 1998-07-23
ATE380559T1 (de) 2007-12-15
CA2203622A1 (en) 1996-02-29

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