NO963805L - Cefalosporinderivater - Google Patents

Cefalosporinderivater

Info

Publication number
NO963805L
NO963805L NO963805A NO963805A NO963805L NO 963805 L NO963805 L NO 963805L NO 963805 A NO963805 A NO 963805A NO 963805 A NO963805 A NO 963805A NO 963805 L NO963805 L NO 963805L
Authority
NO
Norway
Prior art keywords
fluoro
lower alkyl
hydroxyphenyl
carboxy
substituted
Prior art date
Application number
NO963805A
Other languages
English (en)
Other versions
NO963805D0 (no
Inventor
Paul Hebeisen
Ingrid Heinze-Krauss
Hans Richter
Valeri Runtz
Henri Stalder
Urs Weiss
George Petros Yiannikouros
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO963805D0 publication Critical patent/NO963805D0/no
Publication of NO963805L publication Critical patent/NO963805L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Abstract

Det beskrives cefalosporinderivater med den generelle formel I hvor R1 er en gruppe valgt fra 2-, 3- og 4-hydroksyfenyl, 2- og 3-metoksyfenyl, 4-karboksyfenyl, 4-karba- moylfenyl, 3-trifluormetylfenyl, 2- og 3-fluor-fenyl, 3-nitrofenyl, 3-fluor-4-hydroksyfenyl, 2- fluor-4-hydroksyfenyl, 3-fluor-2-hydroksyfenyl, 3- og 4-dihydroksyfenyl, benzyl, -CHR-fenyl, 3- hydroksybenzyl, 4-aminobenzyl, 2-, 3- og 4-fluor-benzyl, 2-, 3- og 4-metoksybenzyl, 4-nitrobenzyl, 4-karboksybenzyl, 4-trifluormetylbenzyl, 1-naftyl og 2-naftyl, idet alle hydroksy-, amino-, karboksy- og karbamoylsubstituenter eventuelt er substituert, eller den er pyridinyl monosubsti- tuert med halogen, pyrimidyl, pyrazinyl disubsti- tuert med lavere alkyl, pyridazinyl monosubstituert med halogen, piperidinyl hvor aminogruppen kan være substituert med en acylgruppe, tiadia-zolyl, okso-tetrahydrofuranyl, tiofenyl mono-substituert med lavere alkoksykarbonyl eller karbamoyl, tetrazolyl-lavere alkyl, tetrahydro- furanyl-lavere alkyl, tiofenyl-lavere alkyl eller benzimidazolyl-lavere alkyl; og R er karboksy eller esterifisert karboksy; samt lett hydrolyserbare estere derav, farmasøytisk akseptable salter av nevnte forbindelser og hydrater av forbindelsene med formel I og av deres estere og salter, samt deres anvendelse og fremgangsmåten ved deres fremstilling.
NO963805A 1995-09-12 1996-09-11 Cefalosporinderivater NO963805L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95114304 1995-09-12
EP95114303 1995-09-12

Publications (2)

Publication Number Publication Date
NO963805D0 NO963805D0 (no) 1996-09-11
NO963805L true NO963805L (no) 1997-03-13

Family

ID=26138799

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963805A NO963805L (no) 1995-09-12 1996-09-11 Cefalosporinderivater

Country Status (15)

Country Link
US (1) US5804577A (no)
JP (1) JPH09132578A (no)
KR (1) KR100209839B1 (no)
CN (1) CN1060778C (no)
AU (1) AU709077B2 (no)
CA (1) CA2184971A1 (no)
CO (1) CO4750667A1 (no)
CZ (1) CZ251896A3 (no)
HU (1) HUP9602433A3 (no)
IL (1) IL119215A0 (no)
MA (1) MA23970A1 (no)
NO (1) NO963805L (no)
PL (1) PL316032A1 (no)
SG (1) SG52841A1 (no)
TR (1) TR199600715A2 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1090013A1 (en) * 1998-06-22 2001-04-11 F. Hoffmann-La Roche Ag Propenyl cephalosporin derivatives
US6587985B1 (en) * 1998-11-30 2003-07-01 Matsushita Electric Industrial Co., Ltd. Data transmission method, data transmission apparatus, data receiving apparatus, and packet data structure
JP3989832B2 (ja) * 2000-08-14 2007-10-10 バジリア ファルマスーチカ アーゲー Ｎ−保護−３−ピロリジン−ラクタム置換ホスホニウム塩類の調製方法
KR101128065B1 (ko) * 2004-05-26 2012-04-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
WO2007058305A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド誘導体の製造方法
WO2007058304A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド化合物の塩またはそれらの溶媒和物
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP2019094A4 (en) * 2006-05-19 2011-01-05 Eisai R&D Man Co Ltd HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE
EP2019093A4 (en) * 2006-05-19 2011-02-23 Eisai R&D Man Co Ltd CINEMA ACID AMID DERIVATIVE FROM THE UREA TYPE
TW200848054A (en) * 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
JPWO2008140111A1 (ja) * 2007-05-16 2010-08-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体のワンポット製造方法
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
MX2010002098A (es) * 2007-08-31 2010-03-30 Eisai R&D Man Co Ltd Compuesto policiclico.
CA2712095A1 (en) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
EP0620225B1 (en) * 1993-04-16 2002-11-13 Basilea Pharmaceutica AG Cephalosporin derivatives

Also Published As

Publication number Publication date
PL316032A1 (en) 1997-03-17
KR100209839B1 (ko) 1999-07-15
MA23970A1 (fr) 1997-04-01
HUP9602433A2 (en) 1997-05-28
IL119215A0 (en) 1996-12-05
US5804577A (en) 1998-09-08
SG52841A1 (en) 1998-09-28
TR199600715A2 (tr) 1997-03-21
AU6550696A (en) 1997-03-20
KR970015593A (ko) 1997-04-28
CN1150950A (zh) 1997-06-04
JPH09132578A (ja) 1997-05-20
CZ251896A3 (en) 1997-04-16
NO963805D0 (no) 1996-09-11
HUP9602433A3 (en) 2001-04-28
AU709077B2 (en) 1999-08-19
CA2184971A1 (en) 1997-03-13
MX9604017A (es) 1997-07-31
HU9602433D0 (en) 1996-10-28
CN1060778C (zh) 2001-01-17
CO4750667A1 (es) 1999-03-31

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Legal Events

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