MX9604017A - Derivados de cefalosporina y procedimiento para su preparacion. - Google Patents

Derivados de cefalosporina y procedimiento para su preparacion.

Info

Publication number
MX9604017A
MX9604017A MX9604017A MX9604017A MX9604017A MX 9604017 A MX9604017 A MX 9604017A MX 9604017 A MX9604017 A MX 9604017A MX 9604017 A MX9604017 A MX 9604017A MX 9604017 A MX9604017 A MX 9604017A
Authority
MX
Mexico
Prior art keywords
substituted
alkyl
hydroxyphenyl
fluoro
carboxyl
Prior art date
Application number
MX9604017A
Other languages
English (en)
Other versions
MXPA96004017A (es
Inventor
Paul Hebeisen
Ingrid Heinze-Krauss
Hans Richter
Valeri Runtz
Henri Stalder
Urs Weiss
George Petros Yiannikouros
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX9604017A publication Critical patent/MX9604017A/es
Publication of MXPA96004017A publication Critical patent/MXPA96004017A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El presente invento se refiere a derivados de cefalosporina de la formula general I: en donde R1 es un grupo elegido entre 2-, 3- y 4-hidroxifenilo, 2- y 3-metoxifenilo, 4-carboxifenilo, 4-carbamoilfenilo, 3-trifluorometilfenilo, 2- y 3-fluoro-fenilo, 3-nitrofenilo, 3-fluoro-4-hidroxifenilo, 2-fluoro-4-hidroxifenilo, 3-fluoro-2-hidroxifenilo, 3-, 4-dihidroxi-fenilo, bencilo, -CHR-fenilo, 3-hidroxibencilo, 4-amino-bencilo, 2-, 3- y 4-fluorobencilo, 2-, 3- y 4-metoxibencilo, 4-nitrobencilo, 4-carboxibencilo, 4-trifluorometilbencilo, 1-naftilo y 2-naftilo, estando todos los sustituyentes hidroxilo, amino, carboxilo y carbamoilo opcionalmente sustituidos, o es piridinilo mono-sustituido por halogeno, pirimidilo, piracinilo di-sustituido por alquilo inferior, piridacinilo mono-sustituido por halogeno, piperidinilo en donde el grupo amino puede estar sustituido por un grupo acilo, tiadiazolilo, oxo-tetra-hidrofuranilo, tiofenilo mono-sustituido por alcoxicarbonilo inferior o carbamoilo, tetrazolil-alquilo inferior, tetrahidrofuranil-alquilo inferior, tiofenil-alquilo inferior o bencimidazolil-alquilo inferior; y R es carboxilo o carboxilo esterificado; sus ésteres fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de formula I y de sus ésteres y sales, así como su empleo y el procedimiento para la preparacion de estos compuestos.
MXPA/A/1996/004017A 1995-09-12 1996-09-11 Derivados de cefalosporina y procedimiento para su preparacion MXPA96004017A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP95114303 1995-09-12
EP95114303.1 1995-09-12
EP95114304.9 1995-09-12
EP95114304 1995-09-12

Publications (2)

Publication Number Publication Date
MX9604017A true MX9604017A (es) 1997-07-31
MXPA96004017A MXPA96004017A (es) 1997-12-01

Family

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Also Published As

Publication number Publication date
CN1150950A (zh) 1997-06-04
CN1060778C (zh) 2001-01-17
HU9602433D0 (en) 1996-10-28
CZ251896A3 (en) 1997-04-16
KR100209839B1 (ko) 1999-07-15
KR970015593A (ko) 1997-04-28
HUP9602433A2 (en) 1997-05-28
HUP9602433A3 (en) 2001-04-28
CO4750667A1 (es) 1999-03-31
SG52841A1 (en) 1998-09-28
TR199600715A2 (tr) 1997-03-21
MA23970A1 (fr) 1997-04-01
AU709077B2 (en) 1999-08-19
CA2184971A1 (en) 1997-03-13
PL316032A1 (en) 1997-03-17
JPH09132578A (ja) 1997-05-20
IL119215A0 (en) 1996-12-05
AU6550696A (en) 1997-03-20
NO963805L (no) 1997-03-13
NO963805D0 (no) 1996-09-11
US5804577A (en) 1998-09-08

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