CO4750667A1 - Derivados de cefalosporina - Google Patents

Derivados de cefalosporina

Info

Publication number
CO4750667A1
CO4750667A1 CO96048398A CO96048398A CO4750667A1 CO 4750667 A1 CO4750667 A1 CO 4750667A1 CO 96048398 A CO96048398 A CO 96048398A CO 96048398 A CO96048398 A CO 96048398A CO 4750667 A1 CO4750667 A1 CO 4750667A1
Authority
CO
Colombia
Prior art keywords
substituted
fluoro
lower alkyl
hydroxyphenyl
benzyl
Prior art date
Application number
CO96048398A
Other languages
English (en)
Inventor
Paul Hebeisen
Ingrid Heinze-Kraus
Hans Richter
Valeri Runtz
Henri Stalder
Urs Weiss
George George Yiannikouros
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4750667A1 publication Critical patent/CO4750667A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Abstract

Derivados de cefalosporina de la fórmula general I:en dondeR1 es un grupo elegido entre 2-, 3- y 4-hidroxifenilo, 2- y 3-metoxifenilo, 4-carboxifenilo 4-carbamoilfenilo, 3-trifluorometilfenilo, 2- y 3-fluoro-fenilo, 3-nitrofenilo, 3-fluoro-4-hidroxifenilo, 2-fluoro-4-hidroxifenilo, 3-fluoro-2-hidroxifenilo, 3-, 4-dihidroxi-fenilo, bencilo, -CHR-fenilo, 3-hidroxibencilo, 4-amino-bencilo, 2-, 3- y 4-fluoro-bencilo, 2-, 3- y 4-metoxibencilo, 4-nitrobencilo 4-carboxi-bencilo, 4- trifluorometilbencilo, 1-naftilo y 2-naftilo, estando todos los sustituyentes hidroxilo, amino, carboxilo y carbamoilo opcionalmente sustituidos, o es piridinilo mono-sustituidos por halógeno, pirimidilo, piracinilo di-sustituido por alquilo inferior, piridacinilo mono-sustituido por halógeno, piperinilo en donde el grupo amino puede estar sustituido por un grupo acilo, tiadiazalilo, oxo-tetra-hidrofuranilo, tiofenilo mono-sustituido por alcoxicarbonilo inferior carbamoilo, tetrazolil-alquilo inferior, tetrahidrofuranil-alquilo inferior , tiofenil- alquilo inferior o bencimidazolil-alquilo inferior; y R es carboxilo o carboxilo esterificado; así como sus ésteres fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuesto e hidratos de los compuestos de fórmula I y de sus ésteres y sales.
CO96048398A 1995-09-12 1996-09-11 Derivados de cefalosporina CO4750667A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95114304 1995-09-12
EP95114303 1995-09-12

Publications (1)

Publication Number Publication Date
CO4750667A1 true CO4750667A1 (es) 1999-03-31

Family

ID=26138799

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96048398A CO4750667A1 (es) 1995-09-12 1996-09-11 Derivados de cefalosporina

Country Status (15)

Country Link
US (1) US5804577A (es)
JP (1) JPH09132578A (es)
KR (1) KR100209839B1 (es)
CN (1) CN1060778C (es)
AU (1) AU709077B2 (es)
CA (1) CA2184971A1 (es)
CO (1) CO4750667A1 (es)
CZ (1) CZ251896A3 (es)
HU (1) HUP9602433A3 (es)
IL (1) IL119215A0 (es)
MA (1) MA23970A1 (es)
NO (1) NO963805L (es)
PL (1) PL316032A1 (es)
SG (1) SG52841A1 (es)
TR (1) TR199600715A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1090013A1 (en) * 1998-06-22 2001-04-11 F. Hoffmann-La Roche Ag Propenyl cephalosporin derivatives
US6587985B1 (en) * 1998-11-30 2003-07-01 Matsushita Electric Industrial Co., Ltd. Data transmission method, data transmission apparatus, data receiving apparatus, and packet data structure
JP3989832B2 (ja) * 2000-08-14 2007-10-10 バジリア ファルマスーチカ アーゲー Ｎ−保護−３−ピロリジン−ラクタム置換ホスホニウム塩類の調製方法
KR101128065B1 (ko) * 2004-05-26 2012-04-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
WO2007058305A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド誘導体の製造方法
WO2007058304A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド化合物の塩またはそれらの溶媒和物
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP2019094A4 (en) * 2006-05-19 2011-01-05 Eisai R&D Man Co Ltd HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE
EP2019093A4 (en) * 2006-05-19 2011-02-23 Eisai R&D Man Co Ltd CINEMA ACID AMID DERIVATIVE FROM THE UREA TYPE
TW200848054A (en) * 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
JPWO2008140111A1 (ja) * 2007-05-16 2010-08-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体のワンポット製造方法
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
MX2010002098A (es) * 2007-08-31 2010-03-30 Eisai R&D Man Co Ltd Compuesto policiclico.
CA2712095A1 (en) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
EP0620225B1 (en) * 1993-04-16 2002-11-13 Basilea Pharmaceutica AG Cephalosporin derivatives

Also Published As

Publication number Publication date
PL316032A1 (en) 1997-03-17
KR100209839B1 (ko) 1999-07-15
NO963805L (no) 1997-03-13
MA23970A1 (fr) 1997-04-01
HUP9602433A2 (en) 1997-05-28
IL119215A0 (en) 1996-12-05
US5804577A (en) 1998-09-08
SG52841A1 (en) 1998-09-28
TR199600715A2 (tr) 1997-03-21
AU6550696A (en) 1997-03-20
KR970015593A (ko) 1997-04-28
CN1150950A (zh) 1997-06-04
JPH09132578A (ja) 1997-05-20
CZ251896A3 (en) 1997-04-16
NO963805D0 (no) 1996-09-11
HUP9602433A3 (en) 2001-04-28
AU709077B2 (en) 1999-08-19
CA2184971A1 (en) 1997-03-13
MX9604017A (es) 1997-07-31
HU9602433D0 (en) 1996-10-28
CN1060778C (zh) 2001-01-17

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