NO961725L - Endoteliareseptorantagonister - Google Patents

Endoteliareseptorantagonister

Info

Publication number
NO961725L
NO961725L NO961725A NO961725A NO961725L NO 961725 L NO961725 L NO 961725L NO 961725 A NO961725 A NO 961725A NO 961725 A NO961725 A NO 961725A NO 961725 L NO961725 L NO 961725L
Authority
NO
Norway
Prior art keywords
lower alkyl
aryl
cycloalkyl
hydrogen
heteroaryl
Prior art date
Application number
NO961725A
Other languages
English (en)
Other versions
NO961725D0 (no
Inventor
Hideyuki Saika
Toshiki Murata
Thomas Pitterna
Thomas Fruh
Lene D Svensson
Yoshihiro Urade
Takaki Yamamura
Toshikazu Okada
Original Assignee
Japat Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japat Ltd filed Critical Japat Ltd
Publication of NO961725L publication Critical patent/NO961725L/no
Publication of NO961725D0 publication Critical patent/NO961725D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det blir fremskaffet nye forbindelser representert ved den generelle formel I: hvor R1 er rettledet eller forgrenet lavere alkyl, en cykloalkyl lavere alkyl, en aryllavere alkyl, en cykloalkyl, en aryl, en arylcykloalkyl, lavere alkokey, en aryloksy, eller en heteroaryl; R2 er hydrogen, en rett eller forgrenet lavere alkyl, en cykloalkyl eller en cykloalkyl lavere alkyl; R3 og R3, er hver Ilke eller forskjellige og er hver hydrogen, en rettkjedet eller forgrenet lavere alkyl, en cykloalkyl, en aryl lavere alkyl, en aryl, eller en heteroaryl; eller R3 og R3> danner sammen en rlngstruktur; R3» er hydrogen, lavere alkyl eller en aryl; eller R2 og R3« danner sammen en lavere alkylengruppe -(CH2)n- hvor n er et helt tall på l, 2,4 eller 3; eller R2 og R3« danner sammen en gruppe representert ved formelen: -(CHo^-Ar- eller -Ar-(CH2)p, hvor p er null eller et helt tall på l eller 2, og Ar er en arylen eller heteroarylen; C(-X) er C(-0), C(-S), C(-NH)-, C(-N-lavere alkyl); C-NH-OH, eller CH2; Y er en dlrekteblndlng, -NH-, en lavere alkyl-N<^ , et oksygenatom, eller metylen; eller C(-X) er CHOH og Y er en direkte binding eller metylen; 84 er -(CH2)s-Ar' hvor s er null eller et helt tall på l, 2 eller 3; og Ar' er aryl, eller en heteroaryl; og RS er karboksy, substituert eller ikke- substltuert karboksamld, PO(OH)2t tetrazol, C^OH, CN, eller hydrogen; og salter derav.
NO961725A 1993-11-01 1996-04-29 Endoteliareseptorantagonister NO961725D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810760 1993-11-01
PCT/EP1994/003418 WO1995012611A1 (en) 1993-11-01 1994-10-17 Endothelin receptor antagonists

Publications (2)

Publication Number Publication Date
NO961725L true NO961725L (no) 1996-04-29
NO961725D0 NO961725D0 (no) 1996-04-29

Family

ID=8215056

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961725A NO961725D0 (no) 1993-11-01 1996-04-29 Endoteliareseptorantagonister

Country Status (12)

Country Link
US (1) US5780498A (no)
EP (1) EP0728145A1 (no)
JP (1) JPH09504302A (no)
AU (1) AU691201B2 (no)
BR (1) BR9407933A (no)
CA (1) CA2173875A1 (no)
FI (1) FI961804A (no)
IL (1) IL111431A0 (no)
NO (1) NO961725D0 (no)
RU (1) RU2126418C1 (no)
WO (1) WO1995012611A1 (no)
ZA (1) ZA948541B (no)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033170A1 (en) * 1995-04-21 1996-10-24 Novarits Ag N-aroylamino acid amides as endothelin inhibitors
AU7130296A (en) * 1995-09-28 1997-04-17 Ciba-Geigy Japan Limited Antagonists of endothelin receptors
IT1291823B1 (it) * 1997-04-08 1999-01-21 Menarini Ricerche Spa Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche
GB9708119D0 (en) * 1997-04-22 1997-06-11 Glaxo Group Ltd Chemical compounds
US6221888B1 (en) 1997-05-29 2001-04-24 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
US6291511B1 (en) 1997-05-29 2001-09-18 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
DE19745146A1 (de) 1997-10-14 1999-04-15 Basf Ag Neue pharmazeutisch wirksame Verbindungen, ihre Herstellung und Verwendung
GB9723407D0 (en) * 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
US6191171B1 (en) 1997-11-20 2001-02-20 Merck & Co., Inc. Para-aminomethylaryl carboxamide derivatives
US6090841A (en) * 1997-11-21 2000-07-18 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
EP1073674A1 (en) * 1998-04-23 2001-02-07 Novartis AG Thiol inhibitors of endothelin-converting enzyme
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
GB9811159D0 (en) * 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
SI1178958T1 (en) * 1999-03-15 2004-08-31 Axys Pharmaceuticals, Inc. N-cyanomethyl amides as protease inhibitors
KR100679878B1 (ko) * 1999-04-26 2007-02-07 아지노모토 가부시키가이샤 멜라노사이트-자극 호르몬 억제제
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
GB0003111D0 (en) 2000-02-10 2000-03-29 Novartis Ag Organic compounds
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
WO2002100846A1 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Compounds and methods for the treatment or prevention of flavivirus infections
MY140707A (en) * 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
US7122580B2 (en) 2002-08-09 2006-10-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
CA2505098A1 (en) 2002-11-12 2004-05-27 Merck & Co., Inc. Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005014534A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014533A2 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
GB0514071D0 (en) * 2005-07-07 2005-08-17 Zealand Pharma As N- or C- terminally modified small peptides
US20090012010A1 (en) * 2007-05-18 2009-01-08 Neuromed Phramaceuticals Ltd. Amino acid derivatives as calcium channel blockers
KR20130004579A (ko) * 2010-02-23 2013-01-11 제넨테크, 인크. 종양의 진단 및 치료를 위한 조성물 및 방법
US9260427B2 (en) * 2013-06-11 2016-02-16 Receptos, Inc. GLP-1 receptor modulators
WO2015106242A2 (en) * 2014-01-13 2015-07-16 The General Hospital Corporation Bisamide compounds as allosteric effectors for reducing the oxygen-binding affinity of hemoglobin
US10758569B2 (en) 2014-01-13 2020-09-01 The General Hospital Corporation Heteroaryl disulfide compounds as allosteric effectors for increasing the oxygen-binding affinity of hemoglobin
US10829440B2 (en) * 2015-06-12 2020-11-10 Brown University Antibacterial compounds and methods of making and using same
CN108821994A (zh) * 2018-05-24 2018-11-16 三峡大学 一类双羟基酰氧基双酰胺类药物中间体及其制备方法
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents
RU2716258C1 (ru) * 2019-07-30 2020-03-11 Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий Пептидный антагонист нмда-рецептора
EP4165037A1 (en) 2020-06-10 2023-04-19 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
FR3111544A1 (fr) * 2020-06-18 2021-12-24 Universite Paris-Saclay Nouveaux composés dipeptidiques, leur procédé de fabrication et une nouvelle application thérapeutique de composés dipeptidiques.
RU2769051C1 (ru) * 2021-06-30 2022-03-28 Общество с ограниченной ответственностью "ТЕРРАНОВА КАПИТАЛ" Пептид, улучшающий функциональные свойства эндотелия сосудов, фармацевтическая композиция на его основе и способ ее применения
KR20240035513A (ko) 2021-07-09 2024-03-15 알리고스 테라퓨틱스 인코포레이티드 항바이러스 화합물

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623142B2 (no) * 1974-07-01 1981-05-29
US4025644A (en) * 1974-12-18 1977-05-24 Daiichi Seiyaku Co., Ltd. Tyrosine derivatives and use
DE2901667A1 (de) * 1979-01-17 1980-07-31 Troponwerke Gmbh & Co Kg Pharmazeutische verwendung von dipeptiden
EP0072058A1 (en) * 1981-08-10 1983-02-16 Duphar International Research B.V Multiple-compartment syringe
US4395401A (en) * 1981-09-09 1983-07-26 Smithkline Beckman Corporation Renally active dipeptides
JPS58133260A (ja) * 1982-02-02 1983-08-08 河村　純郎 多段注射器
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel
AU589665B2 (en) * 1985-08-14 1989-10-19 G.D. Searle & Co. Substituted dipeptide amides
CA1297633C (en) * 1985-09-27 1992-03-17 Shosuke Okamoto Phenylalanine derivative and proteinase inhibitor
ES2017924B3 (es) * 1985-10-11 1991-03-16 Duphar Int Res B V Inyector automatico.
DE3770294D1 (de) * 1986-03-14 1991-07-04 Syntex Inc 3,5-disubstituierte 4,5-dihydroisoxazole als transglutaminasehemmer.
US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
JPH0347163A (ja) * 1989-06-30 1991-02-28 Fujisawa Pharmaceut Co Ltd アントラキノン誘導体およびその製造
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
US5284828A (en) * 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
EP0668770A1 (en) * 1991-04-24 1995-08-30 Warner-Lambert Company $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY
TW270116B (no) * 1991-04-25 1996-02-11 Hoffmann La Roche
DE69231404T2 (de) * 1991-05-16 2001-02-08 Warner Lambert Co Endothelinantagonisten
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
RO117847B1 (ro) * 1991-11-05 2002-08-30 Smithkline Beecham Corp Derivati de indan, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament
TW224462B (no) * 1992-02-24 1994-06-01 Squibb & Sons Inc
US5550138A (en) * 1992-03-25 1996-08-27 Takeda Chemical Industries, Ltd. Condensed thiadiazole derivative, method of its production, and use thereof
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
WO1994002474A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
NO961725D0 (no) 1996-04-29
CA2173875A1 (en) 1995-05-11
BR9407933A (pt) 1996-11-26
EP0728145A1 (en) 1996-08-28
WO1995012611A1 (en) 1995-05-11
FI961804A (fi) 1996-04-30
AU691201B2 (en) 1998-05-14
JPH09504302A (ja) 1997-04-28
ZA948541B (en) 1995-05-02
AU7856594A (en) 1995-05-23
IL111431A0 (en) 1994-12-29
RU2126418C1 (ru) 1999-02-20
US5780498A (en) 1998-07-14
FI961804A0 (fi) 1996-04-26

Similar Documents

Publication Publication Date Title
NO961725L (no) Endoteliareseptorantagonister
NO20054516L (no) Fremgangsmate for fremstilling av blokkholdig merkaptosilan
US4960678A (en) Photochromic compounds
TWI255944B (en) Photosensitive resin composition, color filter, and copolymer resin useful for them
HK1055302A1 (en) Aliphatic nitrogenous five-membered ring compounds
NO993981L (no) Sammensetning og fremgangsmÕte for fremstilling av brenselsbestandig flytende polytioeterpolymerer med god lav-temperatur-fleksibilitet
DE69824194D1 (de) Substituierte kondensierte heterocyclische verbindungen
EP1026149A4 (en) AMIDOCARBONSÄUREDERIVATE
DK0870765T3 (da) Aminothiazolderivat, lægemiddel indeholdende samme og mellemprodukt til fremstilling af forbindelsen
NZ585454A (en) Fluoroalkyl silanes generally derived from an isocyanate precursor
Mukkala et al. Influence of Chelating Groups on the Luminescence Properties of Europium (III) and Terbium (III) chelates in the 2, 2′‐bipyridine series
WO2007080055A3 (en) Fluorous telomeric compounds and polymers containing same
DE3875058D1 (de) Organopolysiloxane mit buntesalzgruppen.
EA200100310A1 (ru) Кислородсодержащие гетероциклические соединения
CA1197127A (en) Colourphotographic recording material
CA2344134A1 (en) Hydrolysis-stable and polymerizable acrylophosphonic acid
NO974567L (no) 9-substituerte porfycener
Choi et al. Novel one‐pot polymer syntheses based on dithiols obtained from a five‐membered cyclic dithiocarbonate and diamines
KR940010018B1 (ko) 폴리(티우람 디술피드)류, 그의 제조방법 및 비닐 단량체의 중합 반응에서의 그의 용도
ATE103266T1 (de) Chalkonderivate.
Ho et al. Novel aryl cyanide synthesis using trichloroacetonitrile
EP1708026A4 (en) PHOTOSENSITIVE POLYMER COMPOSITION, METHOD FOR GENERATING A PATTERN, AND ELECTRONIC COMPONENT
US5194646A (en) Polymerizable silicones having acetylenic unsaturation
EP0303279A3 (en) Reactive hindered amine light stabilizers
US3920685A (en) Dialkoxyphosphonalkyl derivatives of cyclicureides containing glycidyl groups