NO961170L - Nye oligosakkarid-inneholdende 14-aminosteroide forbindelser og ny diastereoselektiv aminosteroid prosesskjemi - Google Patents
Nye oligosakkarid-inneholdende 14-aminosteroide forbindelser og ny diastereoselektiv aminosteroid prosesskjemiInfo
- Publication number
- NO961170L NO961170L NO961170A NO961170A NO961170L NO 961170 L NO961170 L NO 961170L NO 961170 A NO961170 A NO 961170A NO 961170 A NO961170 A NO 961170A NO 961170 L NO961170 L NO 961170L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- lower alkyl
- acetoxy
- carbon lower
- benzoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Den foreliggende oppfinnelse vedrører oligosakkaridinnehol- dende 14-aminosteroidforbindelser og de farmasøytisk tålbare syresalter eller estere derav med generell formel (I), hvori: a) Rj er (i) COOR5, hvor R5 er hydrogen, en 1-6 karbon lavere alkyl, en 1-6 karbon lavere alkyl-substituert med en amino- gruppe, en arylalkyl eller heteroarylalkyl eller en karbocyk- lisk ring, eller (ii) CHR6OH, hvor R6 er et hydrogenatom eller 1-6 karbon lavere alkylgruppe, eller (iii) COR''', hvor R''' er hydrogen, 1-6 karbon lavere alkyl, 1-6 karbon lavere alkyl- substituert amino, amino eller dialkylamino, og b) R2 er - NR7R8, hvor R7 og R8, som kan være like eller forskjellige, er hydrogenatomer eller en 1-6 karbon lavere alkyl, og c) R3 er (i) en oligosakkaridsukkerrest som har struktur (II), hvor R9 er hydrogen, metyl, hydroksy, karboksy, acetoksy, arylalkylok- sy, heteroarylalkyloksy eller benzoksy, R10 er hydrogen, metyl, karboksy, acetoksy, arylalkyloksy, heteroarylalkyloksy, ben- zoksy eller hydroksy, Ru er oksygen, hvori videre når Rn er en substituent på den terminals monosakkaridsukkerrest, er R,, OH, metyl, acetoksy, arylalkyloksy, heteroarylalkyloksy, og R12 er et hydrogen, metyl, metylhydroksymetyl eller acetoksymetyl, eller (ii) en oligosakkaridsukkerrest som har struktur (III), hvor R14 og R15, som kan være like eller forskjellige, er hyd- rogen, 1-6 karbon lavere alkyl, heteroarylalkyl, arylalkyl, heteroaryl eller aryl, R17 kan være hydrogen, hydroksy, ace- toksy eller benzoksy, Rig og R19 er hydroksy, acetoksy og ben- zoksy, eller (iii) en oligosakkaridrest som har struktur (IV), hvor R14 og R15, som kan være like eller forskjellige, er hydrogen, 1-6 karbon lavere alkyl, heteroarylalkyl, arylalkyl. heteroaryl eller aryl, R14a er oksygen, hvori videre når R14a er en substituent på den terminale monosakkarid-sukkerrest, må R14a være hydroksy, metyl, acetoksy, arylalkyloksy eller heteroarylalkyloksy, og d) R4 er (i) OH, eller (ii) H, eller (iii) OR13, hvor R13 er en monosakkarid-sukkerrest, acetoksy, benzoksy, arylalkyl eller heteroarylalkyl, og e) Z er (i) -CH-, hvor a og b er enkeltbindinger, eller (ii) =C, hvor enten a eller b er en dobbeltbinding. Den foreliggende opp- finnelse vedrører også en fremgangsmåte for innføring av en aminogruppe ved 14-stillingen på en steroidkjerne hvori nevnte aminogruppe diastereoselektivt innføres på 14-stillingen av steroidkjernen via en jodisocyanat-addisjon omfattende trin- nene: a) tilføring av jodisocyanatet til 14-15 stilling- dobbeltbindingen på steroidkjernen, og b) dehalogenering, og c) Lsocyanatomdannelse til amindelen på 14-stillingen av steroidkjernen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12645993A | 1993-09-24 | 1993-09-24 | |
| PCT/US1994/010778 WO1995008557A1 (en) | 1993-09-24 | 1994-09-23 | Novel oligosaccharide-containing 14-aminosteroid compounds and novel diastereoselective aminosteroid process chemistry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO961170D0 NO961170D0 (no) | 1996-03-22 |
| NO961170L true NO961170L (no) | 1996-05-24 |
Family
ID=22424936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO961170A NO961170L (no) | 1993-09-24 | 1996-03-22 | Nye oligosakkarid-inneholdende 14-aminosteroide forbindelser og ny diastereoselektiv aminosteroid prosesskjemi |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5710259A (no) |
| EP (2) | EP0721459B1 (no) |
| JP (1) | JPH09502982A (no) |
| KR (1) | KR960704914A (no) |
| CN (1) | CN1135758A (no) |
| AT (1) | ATE193538T1 (no) |
| AU (1) | AU692187B2 (no) |
| BR (1) | BR9407612A (no) |
| CA (1) | CA2182530A1 (no) |
| CZ (1) | CZ86696A3 (no) |
| DE (1) | DE69424794D1 (no) |
| DK (1) | DK0721459T3 (no) |
| ES (1) | ES2146665T3 (no) |
| GR (1) | GR3034028T3 (no) |
| HU (1) | HUT74623A (no) |
| NO (1) | NO961170L (no) |
| PL (1) | PL313620A1 (no) |
| RU (1) | RU2153503C2 (no) |
| WO (1) | WO1995008557A1 (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922703A (en) * | 1993-09-24 | 1999-07-13 | The Procter & Gamble Company | Urethane-containing aminosteroid compounds |
| MY186844A (en) | 2014-07-09 | 2021-08-25 | Cadena Bio Inc | Oligosaccharide compositions and methods for producing thereof |
| RU2767077C2 (ru) * | 2015-01-26 | 2022-03-16 | Кадена Байо, Инк. | Олигосахаридные композиции для применения в качестве пищевых ингредиентов и способы их получения |
| MX2017009730A (es) | 2015-01-26 | 2018-06-11 | Cadena Bio Inc | Composiciones de oligosacaridos para el uso como alimento para animales y sus metodos para producirlas. |
| JP2018517677A (ja) | 2015-04-23 | 2018-07-05 | カレイド・バイオサイエンシズ・インコーポレイテッド | グリカン治療剤及び治療方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3567712A (en) * | 1966-10-31 | 1971-03-02 | Lepetit Spa | 10beta-amino-estranes and method for the preparation thereof |
| FR2464270A1 (fr) * | 1979-08-31 | 1981-03-06 | Nativelle Sa Ets | Nouveaux derives d'amino-14 steroides, et procede pour leur preparation |
| ES524614A0 (es) * | 1982-08-12 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos amino-14 esteroides. |
| NZ205293A (en) * | 1982-08-20 | 1986-12-05 | Nativelle Sa Ets | 14-aminosteroids and pharmaceutical compositions |
| ES8404694A1 (es) * | 1982-08-20 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos derivos de amino-14 esteroides |
| DD256134A1 (de) * | 1985-06-06 | 1988-04-27 | Akad Wissenschaften Ddr | Verfahren zur herstellung von derivaten von cardenoliden und cardenolidanalogen verbindungen |
| US5175281A (en) * | 1985-09-12 | 1992-12-29 | The Upjohn Company | Pharmaceutically active pyrimidinylpiperazinylsterioids |
| GB8600490D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid lactams |
| FR2621316B1 (fr) * | 1987-10-02 | 1991-06-21 | Nativelle Sa Ets | Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant |
| US5144017A (en) * | 1988-07-13 | 1992-09-01 | University Of Manitoba | Compounds that bind to digitalis receptor |
| FR2642973A1 (fr) * | 1989-02-03 | 1990-08-17 | Cote Ivoire Ministere Rech Sc | Composition medicamenteuse renfermant comme principe actif un derive glucidique dioxymethyle de la strophanthidine |
| AU7794391A (en) * | 1990-05-07 | 1991-11-27 | Board Of Regents Of The University Of Washington, The | Novel steroid glycosides useful in the early detection of hypertension |
| JPH0429089A (ja) * | 1990-05-25 | 1992-01-31 | Toshiba Corp | 燃料集合体 |
| AU2675092A (en) * | 1991-09-27 | 1993-04-27 | Procter & Gamble Pharmaceuticals, Inc. | Use of 14-aminosteroids for the manufacture of a medicament to slow the rate of progression of myocardial structural damages characteristic of congestive heart failure |
| US5922703A (en) * | 1993-09-24 | 1999-07-13 | The Procter & Gamble Company | Urethane-containing aminosteroid compounds |
| KR960704915A (ko) * | 1993-09-24 | 1996-10-09 | 제이코버스 코넬리스 레이서 | 신규한 데옥시 및 산소 치환된 당 함유 14- 아미노스테로이드 화합물 (novel deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds) |
-
1994
- 1994-09-23 ES ES94929315T patent/ES2146665T3/es not_active Expired - Lifetime
- 1994-09-23 BR BR9407612A patent/BR9407612A/pt not_active Application Discontinuation
- 1994-09-23 EP EP94929315A patent/EP0721459B1/en not_active Expired - Lifetime
- 1994-09-23 EP EP98103012A patent/EP0863149A1/en not_active Withdrawn
- 1994-09-23 DE DE69424794T patent/DE69424794D1/de not_active Expired - Lifetime
- 1994-09-23 RU RU96108236/04A patent/RU2153503C2/ru active
- 1994-09-23 DK DK94929315T patent/DK0721459T3/da active
- 1994-09-23 AT AT94929315T patent/ATE193538T1/de not_active IP Right Cessation
- 1994-09-23 KR KR1019960701529A patent/KR960704914A/ko not_active Application Discontinuation
- 1994-09-23 JP JP7509952A patent/JPH09502982A/ja active Pending
- 1994-09-23 CZ CZ96866A patent/CZ86696A3/cs unknown
- 1994-09-23 CN CN94194217A patent/CN1135758A/zh active Pending
- 1994-09-23 HU HU9600734A patent/HUT74623A/hu unknown
- 1994-09-23 AU AU78414/94A patent/AU692187B2/en not_active Ceased
- 1994-09-23 CA CA002182530A patent/CA2182530A1/en not_active Abandoned
- 1994-09-23 PL PL94313620A patent/PL313620A1/xx unknown
- 1994-09-23 WO PCT/US1994/010778 patent/WO1995008557A1/en not_active Application Discontinuation
-
1995
- 1995-06-02 US US08/459,911 patent/US5710259A/en not_active Expired - Fee Related
-
1996
- 1996-03-22 NO NO961170A patent/NO961170L/no unknown
-
1997
- 1997-02-20 US US08/802,491 patent/US5849889A/en not_active Expired - Fee Related
-
2000
- 2000-07-26 GR GR20000401719T patent/GR3034028T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT74623A (en) | 1997-01-28 |
| JPH09502982A (ja) | 1997-03-25 |
| ES2146665T3 (es) | 2000-08-16 |
| AU7841494A (en) | 1995-04-10 |
| CZ86696A3 (en) | 1996-10-16 |
| DE69424794D1 (de) | 2000-07-06 |
| CA2182530A1 (en) | 1995-03-30 |
| WO1995008557A1 (en) | 1995-03-30 |
| PL313620A1 (en) | 1996-07-08 |
| US5710259A (en) | 1998-01-20 |
| CN1135758A (zh) | 1996-11-13 |
| RU2153503C2 (ru) | 2000-07-27 |
| NO961170D0 (no) | 1996-03-22 |
| DK0721459T3 (da) | 2000-08-07 |
| US5849889A (en) | 1998-12-15 |
| KR960704914A (ko) | 1996-10-09 |
| GR3034028T3 (en) | 2000-11-30 |
| BR9407612A (pt) | 1997-01-14 |
| EP0863149A1 (en) | 1998-09-09 |
| EP0721459B1 (en) | 2000-05-31 |
| ATE193538T1 (de) | 2000-06-15 |
| AU692187B2 (en) | 1998-06-04 |
| HU9600734D0 (en) | 1996-05-28 |
| EP0721459A1 (en) | 1996-07-17 |
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