NO953286L - Benstimulerende faktor - Google Patents
Benstimulerende faktorInfo
- Publication number
- NO953286L NO953286L NO953286A NO953286A NO953286L NO 953286 L NO953286 L NO 953286L NO 953286 A NO953286 A NO 953286A NO 953286 A NO953286 A NO 953286A NO 953286 L NO953286 L NO 953286L
- Authority
- NO
- Norway
- Prior art keywords
- gly
- polypeptide
- lys
- ala
- pro
- Prior art date
Links
- 230000004936 stimulating effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 9
- 229920001184 polypeptide Polymers 0.000 abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 8
- 241000700159 Rattus Species 0.000 abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 3
- PEZMQPADLFXCJJ-ZETCQYMHSA-N 2-[[2-[[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]acetyl]amino]acetic acid Chemical compound NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(O)=O PEZMQPADLFXCJJ-ZETCQYMHSA-N 0.000 abstract 2
- BEMGNWZECGIJOI-WDSKDSINSA-N Ala-Gly-Glu Chemical compound [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O BEMGNWZECGIJOI-WDSKDSINSA-N 0.000 abstract 2
- VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 abstract 2
- 108010043293 glycyl-prolyl-glycyl-glycine Proteins 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- XYTNPQNAZREREP-XQXXSGGOSA-N Ala-Glu-Thr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XYTNPQNAZREREP-XQXXSGGOSA-N 0.000 abstract 1
- OGMDXNFGPOPZTK-GUBZILKMSA-N Asn-Glu-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)N)N OGMDXNFGPOPZTK-GUBZILKMSA-N 0.000 abstract 1
- YXPNKXFOBHRUBL-BJDJZHNGSA-N Cys-Lys-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)N YXPNKXFOBHRUBL-BJDJZHNGSA-N 0.000 abstract 1
- HMHRTKOWRUPPNU-RCOVLWMOSA-N Gly-Ile-Gly Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(O)=O HMHRTKOWRUPPNU-RCOVLWMOSA-N 0.000 abstract 1
- GLYJPWIRLBAIJH-UHFFFAOYSA-N Ile-Lys-Pro Natural products CCC(C)C(N)C(=O)NC(CCCCN)C(=O)N1CCCC1C(O)=O GLYJPWIRLBAIJH-UHFFFAOYSA-N 0.000 abstract 1
- NJMXCOOEFLMZSR-AVGNSLFASA-N Leu-Met-Val Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(O)=O NJMXCOOEFLMZSR-AVGNSLFASA-N 0.000 abstract 1
- SWWCDAGDQHTKIE-RHYQMDGZSA-N Lys-Arg-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O SWWCDAGDQHTKIE-RHYQMDGZSA-N 0.000 abstract 1
- XOQMURBBIXRRCR-SRVKXCTJSA-N Lys-Lys-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN XOQMURBBIXRRCR-SRVKXCTJSA-N 0.000 abstract 1
- OBZHNHBAAVEWKI-DCAQKATOSA-N Lys-Pro-Asn Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(O)=O OBZHNHBAAVEWKI-DCAQKATOSA-N 0.000 abstract 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 1
- NJEMRSFGDNECGF-GCJQMDKQSA-N Thr-Ala-Asp Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC(O)=O NJEMRSFGDNECGF-GCJQMDKQSA-N 0.000 abstract 1
- XIULAFZYEKSGAJ-IXOXFDKPSA-N Thr-Leu-His Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CNC=N1 XIULAFZYEKSGAJ-IXOXFDKPSA-N 0.000 abstract 1
- WFAUDCSNCWJJAA-KXNHARMFSA-N Thr-Lys-Pro Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(O)=O WFAUDCSNCWJJAA-KXNHARMFSA-N 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000010256 bone deposition Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 231100000673 dose–response relationship Toxicity 0.000 abstract 1
- 230000001605 fetal effect Effects 0.000 abstract 1
- 108010015792 glycyllysine Proteins 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000002853 nucleic acid probe Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 108010071097 threonyl-lysyl-proline Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En polypeptidsubstans som isoleres fra rotteserum og som, ved administrering til rotter som er ute av stand til å produsere PTH (paratyroidectomiserte rotter), frembringer en økning i den observerte hastighet for benmineralapposisjon. Stoffet har blitt isolert i to former, et første større polypeptid med en molekylvekt på ca. det dobbelte av et andre mindre polypeptid. De første elleve aminosyrer fra det mindre polypeptids sekvens er bestemt å være Gly Pro Gly Gly Ala Gly Glu Thr Lys Pro Ile. De første syv aminosyrer fra det større polypeptid er bestemt å være Gly Pro Gly Gly Ala Gly Glu. Det større polypeptid kan være dimeren av det mindre polypeptid. En nukleinsyreprobe som er basert på rottepeptidets aminosyresekvens ble benyttet for å gjennomsøke et fetalt humant cDNA-leverbibliotek. Et polypeptid ble således kjemisk syntetisert ifølge sekvensen Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu Met Val Leu Asp Gin Asn Gin Pro. Benapposisjonshastigheten i rotter øker på en doseavhengig måte ved administrering av denne kjemisk syntetiserte forbindelse.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3138693A | 1993-03-12 | 1993-03-12 | |
| US12021793A | 1993-09-13 | 1993-09-13 | |
| PCT/CA1994/000144 WO1994020615A1 (en) | 1993-03-12 | 1994-03-14 | Bone stimulating factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO953286D0 NO953286D0 (no) | 1995-08-22 |
| NO953286L true NO953286L (no) | 1995-10-25 |
Family
ID=26707172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953286A NO953286L (no) | 1993-03-12 | 1995-08-22 | Benstimulerende faktor |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0688360B1 (no) |
| JP (1) | JP3733381B2 (no) |
| KR (1) | KR960701201A (no) |
| CN (1) | CN1119457A (no) |
| AT (1) | ATE208818T1 (no) |
| AU (1) | AU678441B2 (no) |
| BR (1) | BR9406447A (no) |
| CA (1) | CA2157901A1 (no) |
| CZ (1) | CZ234295A3 (no) |
| DE (1) | DE69429082T2 (no) |
| ES (1) | ES2168295T3 (no) |
| FI (1) | FI954252A0 (no) |
| HU (1) | HUT73297A (no) |
| IL (1) | IL108947A0 (no) |
| NO (1) | NO953286L (no) |
| NZ (1) | NZ262352A (no) |
| PL (1) | PL182236B1 (no) |
| TW (1) | TW385314B (no) |
| WO (1) | WO1994020615A1 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786327A (en) | 1993-03-12 | 1998-07-28 | Gensci Regeneration Sciences Inc. | Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same |
| US5880094A (en) * | 1995-06-07 | 1999-03-09 | Osteopharm Limited | Polypeptides that stimulate bone growth |
| US6117839A (en) * | 1995-06-07 | 2000-09-12 | Gensci Regeneration Sciences, Inc. | Bone stimulating factor |
| US6352973B1 (en) | 1995-06-07 | 2002-03-05 | Osteopharm Inc. | Bone stimulating factor |
| US6693081B2 (en) * | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| EP1015565B1 (en) | 1997-09-19 | 2006-04-12 | Metabolix, Inc. | Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| WO2000075185A1 (en) * | 1999-06-02 | 2000-12-14 | Osteopharm Inc. | Bone stimulating factor |
| JP2004504802A (ja) | 1999-08-30 | 2004-02-19 | インターロイキン・ジェネティクス・インコーポレーテッド | 骨粗鬆症の診断および療法 |
| US6815421B1 (en) | 2001-03-22 | 2004-11-09 | Osteopharm Inc. | Polypeptides for use in ameliorating effects of aging in mammals |
| ATE490339T1 (de) | 2003-08-08 | 2010-12-15 | Interleukin Genetics Inc | Diagnostikum für osteoporose |
| ATE475670T1 (de) * | 2006-12-21 | 2010-08-15 | Numat As | Konsensus-peptid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0128041A3 (en) * | 1983-06-06 | 1986-12-03 | David Jeston Baylink | Polypeptides exhibiting skeletal growth factor activity |
| CA2020729A1 (en) * | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
-
1994
- 1994-03-11 IL IL10894794A patent/IL108947A0/xx unknown
- 1994-03-14 DE DE69429082T patent/DE69429082T2/de not_active Expired - Fee Related
- 1994-03-14 CA CA002157901A patent/CA2157901A1/en not_active Abandoned
- 1994-03-14 EP EP94908917A patent/EP0688360B1/en not_active Expired - Lifetime
- 1994-03-14 KR KR1019950703855A patent/KR960701201A/ko not_active Application Discontinuation
- 1994-03-14 HU HU9502659A patent/HUT73297A/hu unknown
- 1994-03-14 BR BR9406447A patent/BR9406447A/pt not_active Application Discontinuation
- 1994-03-14 NZ NZ262352A patent/NZ262352A/en unknown
- 1994-03-14 AT AT94908917T patent/ATE208818T1/de not_active IP Right Cessation
- 1994-03-14 CZ CZ952342A patent/CZ234295A3/cs unknown
- 1994-03-14 ES ES94908917T patent/ES2168295T3/es not_active Expired - Lifetime
- 1994-03-14 JP JP51844794A patent/JP3733381B2/ja not_active Expired - Fee Related
- 1994-03-14 AU AU61797/94A patent/AU678441B2/en not_active Ceased
- 1994-03-14 PL PL94310617A patent/PL182236B1/pl unknown
- 1994-03-14 WO PCT/CA1994/000144 patent/WO1994020615A1/en not_active Application Discontinuation
- 1994-03-14 CN CN94191456A patent/CN1119457A/zh active Pending
- 1994-03-21 TW TW083102552A patent/TW385314B/zh not_active IP Right Cessation
-
1995
- 1995-08-22 NO NO953286A patent/NO953286L/no not_active Application Discontinuation
- 1995-09-11 FI FI954252A patent/FI954252A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI954252A (fi) | 1995-09-11 |
| HUT73297A (en) | 1996-07-29 |
| AU678441B2 (en) | 1997-05-29 |
| HU9502659D0 (en) | 1995-11-28 |
| PL310617A1 (en) | 1995-12-27 |
| KR960701201A (ko) | 1996-02-24 |
| FI954252A0 (fi) | 1995-09-11 |
| DE69429082T2 (de) | 2002-07-25 |
| NO953286D0 (no) | 1995-08-22 |
| TW385314B (en) | 2000-03-21 |
| PL182236B1 (pl) | 2001-11-30 |
| ES2168295T3 (es) | 2002-06-16 |
| NZ262352A (en) | 1997-10-24 |
| WO1994020615A1 (en) | 1994-09-15 |
| CN1119457A (zh) | 1996-03-27 |
| EP0688360B1 (en) | 2001-11-14 |
| JPH08508158A (ja) | 1996-09-03 |
| DE69429082D1 (de) | 2001-12-20 |
| AU6179794A (en) | 1994-09-26 |
| CZ234295A3 (en) | 1996-04-17 |
| EP0688360A1 (en) | 1995-12-27 |
| BR9406447A (pt) | 1996-02-13 |
| CA2157901A1 (en) | 1994-09-15 |
| JP3733381B2 (ja) | 2006-01-11 |
| ATE208818T1 (de) | 2001-11-15 |
| IL108947A0 (en) | 1994-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |