NO953279L - Transmucosal levering av makromolekylære medikamenter - Google Patents

Transmucosal levering av makromolekylære medikamenter

Info

Publication number
NO953279L
NO953279L NO953279A NO953279A NO953279L NO 953279 L NO953279 L NO 953279L NO 953279 A NO953279 A NO 953279A NO 953279 A NO953279 A NO 953279A NO 953279 L NO953279 L NO 953279L
Authority
NO
Norway
Prior art keywords
macromolecular
polymer
drug
enhancer
macromolecular drugs
Prior art date
Application number
NO953279A
Other languages
English (en)
Other versions
NO953279D0 (no
Inventor
Sonia J Heiber
Charles D Ebert
Sirish C Dave
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratech Inc filed Critical Theratech Inc
Publication of NO953279D0 publication Critical patent/NO953279D0/no
Publication of NO953279L publication Critical patent/NO953279L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En fremgangsmåte og et system for mukosal administrering av et makromolekylært medikament til slimhinnen i oralhulrommet er vist. Systemet omfatter et indre medikament/enhancer/polymerlag (11) som har en overflate tilpasset for å kontakte og adherere til slimhinnevevet i oralhulrommet og en motstående overflate i kontakt med og adhererende til et overliggende inert lag (12). Det indre laget (11) inneholder fra omtrent to til seksti vekt-% av en gallesaltenhancer, 5 til 65 vekt-% av en hydrofil polymer som er vannoppløselig eller svellbar og en effektiv mengde av et makromolekylært medikament som har en molekylvekt på minst 500 dalton. Polysaccharider, polypeptider og proteiner er foretrukne former for makromolekylære medikamenter. Gallesaltenhanceren letter leveringen av makromolekyler slik som lav molekylært heparin og kalsitonin. Polymeren virker som et plastifiserende middel for å forhindre krystallisering og/eller agregering av slike makromolekylære medikamenter. Hydroksypropylcellulose er en spesielt egnet polymer.
NO953279A 1993-02-22 1995-08-21 Transmucosal levering av makromolekylære medikamenter NO953279L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/027,508 US5346701A (en) 1993-02-22 1993-02-22 Transmucosal delivery of macromolecular drugs
PCT/US1994/001372 WO1994018925A1 (en) 1993-02-22 1994-02-03 Transmucosal delivery of macromolecular drugs

Publications (2)

Publication Number Publication Date
NO953279D0 NO953279D0 (no) 1995-08-21
NO953279L true NO953279L (no) 1995-10-19

Family

ID=21838122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953279A NO953279L (no) 1993-02-22 1995-08-21 Transmucosal levering av makromolekylære medikamenter

Country Status (16)

Country Link
US (2) US5346701A (no)
EP (1) EP0684806B1 (no)
JP (1) JP2795749B2 (no)
KR (1) KR960700670A (no)
AT (1) ATE190216T1 (no)
AU (1) AU674571B2 (no)
CA (1) CA2156708C (no)
DE (1) DE69423342T2 (no)
DK (1) DK0684806T3 (no)
ES (1) ES2148320T3 (no)
GR (1) GR3033601T3 (no)
HK (1) HK1010680A1 (no)
NO (1) NO953279L (no)
PT (1) PT684806E (no)
WO (1) WO1994018925A1 (no)
ZA (1) ZA941197B (no)

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DE69423342T2 (de) 2000-10-12
EP0684806A4 (en) 1997-04-23
PT684806E (pt) 2000-08-31
NO953279D0 (no) 1995-08-21
GR3033601T3 (en) 2000-10-31
CA2156708A1 (en) 1994-09-01
AU6171694A (en) 1994-09-14
EP0684806B1 (en) 2000-03-08
DE69423342D1 (de) 2000-04-13
JPH08507759A (ja) 1996-08-20
CA2156708C (en) 2005-05-03
ES2148320T3 (es) 2000-10-16
WO1994018925A1 (en) 1994-09-01
ZA941197B (en) 1994-09-19
HK1010680A1 (en) 1999-06-25
KR960700670A (ko) 1996-02-24
US5516523A (en) 1996-05-14
US5346701A (en) 1994-09-13
ATE190216T1 (de) 2000-03-15
EP0684806A1 (en) 1995-12-06
JP2795749B2 (ja) 1998-09-10
DK0684806T3 (da) 2000-08-14
AU674571B2 (en) 1997-01-02

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