NO950985L - Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer - Google Patents

Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer

Info

Publication number
NO950985L
NO950985L NO950985A NO950985A NO950985L NO 950985 L NO950985 L NO 950985L NO 950985 A NO950985 A NO 950985A NO 950985 A NO950985 A NO 950985A NO 950985 L NO950985 L NO 950985L
Authority
NO
Norway
Prior art keywords
metabolizable
tamoxifen
treatment
resistant tumors
clomiphene analogues
Prior art date
Application number
NO950985A
Other languages
English (en)
Other versions
NO950985D0 (no
Inventor
Alan Joseph Bitonti
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO950985D0 publication Critical patent/NO950985D0/no
Publication of NO950985L publication Critical patent/NO950985L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/48—N-alkylated amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Forbindelser av formel (I) hvori R1 og R2 hver er valgt fra gruppen bestående av Cl-C4-lavere alkyl; X er NH eller S; og n er et helt tall innen om- rådet 1-4; og når n er O, er X (CH2)3, og farmasøytisk akseptable salter der- av, er blitt vist å være effektive ved behandling av tamoxifenresistente tumorer.
NO950985A 1992-09-15 1995-03-14 Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer NO950985L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94530592A 1992-09-15 1992-09-15
PCT/US1993/007697 WO1994006762A1 (en) 1992-09-15 1993-08-16 Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors

Publications (2)

Publication Number Publication Date
NO950985D0 NO950985D0 (no) 1995-03-14
NO950985L true NO950985L (no) 1995-03-14

Family

ID=25482938

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950985A NO950985L (no) 1992-09-15 1995-03-14 Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer

Country Status (16)

Country Link
US (2) US5410080A (no)
EP (1) EP0660821B1 (no)
JP (1) JPH09500863A (no)
KR (1) KR100326962B1 (no)
AT (1) ATE162516T1 (no)
AU (1) AU672234B2 (no)
CA (1) CA2143000C (no)
DE (1) DE69316633T2 (no)
DK (1) DK0660821T3 (no)
ES (1) ES2112994T3 (no)
FI (1) FI951193A0 (no)
GR (1) GR3026236T3 (no)
HU (1) HUT71244A (no)
NO (1) NO950985L (no)
NZ (1) NZ255785A (no)
WO (1) WO1994006762A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR008155A1 (es) * 1996-09-06 1999-12-09 Smithkline Beecham Corp Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres.
CA2301032C (en) 1997-08-15 2009-01-13 Duke University A method of preventing or treating estrogen-dependent diseases and disorders
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
JP2015535283A (ja) 2012-11-02 2015-12-10 レプロス セラピューティクス インコーポレイティド 癌療法における使用のためのトランス−クロミフェン
CN106068121A (zh) * 2014-03-11 2016-11-02 利普生物药剂公司 使用单一溶剂进行克罗米芬合成

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2750416A (en) * 1950-12-21 1956-06-12 Rohm & Haas Aminomethylphenols and method for their preparation
US3143568A (en) * 1961-01-25 1964-08-04 Vismara Francesco Spa Diarylamino-acetyl-aryl derivatives
US3244705A (en) * 1962-11-14 1966-04-05 Richardson Merrell Inc Triphenylhaloethylene derivatives
CH373975A (de) * 1963-07-20 1963-12-15 Heierle Werner Kronen-Verschluss für Flaschen
FR3575M (fr) * 1964-01-28 1965-10-04 Richardson Merrell Triphénylhalogénoéthylenes substitués.
US3631109A (en) * 1968-12-04 1971-12-28 Uniroyal Inc Beta beta'-bis(dialkylaminomethyl-4-hydroxy-benzylthio)dialkylethers
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
US5114951A (en) * 1989-04-11 1992-05-19 Burroughs Wellcome Company Agents for combating multiple drug resistance
US5130424A (en) * 1990-08-01 1992-07-14 Merrell Dow Pharmaceuticals Inc. 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

Also Published As

Publication number Publication date
FI951193A (fi) 1995-03-14
NZ255785A (en) 1997-05-26
WO1994006762A1 (en) 1994-03-31
HUT71244A (en) 1995-11-28
DE69316633D1 (de) 1998-02-26
AU672234B2 (en) 1996-09-26
GR3026236T3 (en) 1998-05-29
DE69316633T2 (de) 1998-05-20
US5681863A (en) 1997-10-28
EP0660821B1 (en) 1998-01-21
AU5015093A (en) 1994-04-12
ES2112994T3 (es) 1998-04-16
JPH09500863A (ja) 1997-01-28
CA2143000A1 (en) 1994-03-31
FI951193A0 (fi) 1995-03-14
EP0660821A1 (en) 1995-07-05
US5410080A (en) 1995-04-25
DK0660821T3 (da) 1998-09-21
NO950985D0 (no) 1995-03-14
KR950703524A (ko) 1995-09-20
ATE162516T1 (de) 1998-02-15
KR100326962B1 (ko) 2002-12-02
HU9500775D0 (en) 1995-05-29
CA2143000C (en) 2000-03-28

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application