NO950985L - Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer - Google Patents

Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer

Info

Publication number
NO950985L
NO950985L NO950985A NO950985A NO950985L NO 950985 L NO950985 L NO 950985L NO 950985 A NO950985 A NO 950985A NO 950985 A NO950985 A NO 950985A NO 950985 L NO950985 L NO 950985L
Authority
NO
Norway
Prior art keywords
tamoxifen
treatment
metabolizable
resistant tumors
clomiphene analogues
Prior art date
Application number
NO950985A
Other languages
English (en)
Other versions
NO950985D0 (no
Inventor
Alan Joseph Bitonti
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO950985D0 publication Critical patent/NO950985D0/no
Publication of NO950985L publication Critical patent/NO950985L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/48—N-alkylated amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Forbindelser av formel (I) hvori R1 og R2 hver er valgt fra gruppen bestående av Cl-C4-lavere alkyl; X er NH eller S; og n er et helt tall innen om- rådet 1-4; og når n er O, er X (CH2)3, og farmasøytisk akseptable salter der- av, er blitt vist å være effektive ved behandling av tamoxifenresistente tumorer.
NO950985A 1992-09-15 1995-03-14 Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer NO950985L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94530592A 1992-09-15 1992-09-15
PCT/US1993/007697 WO1994006762A1 (en) 1992-09-15 1993-08-16 Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors

Publications (2)

Publication Number Publication Date
NO950985D0 NO950985D0 (no) 1995-03-14
NO950985L true NO950985L (no) 1995-03-14

Family

ID=25482938

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950985A NO950985L (no) 1992-09-15 1995-03-14 Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer

Country Status (16)

Country Link
US (2) US5410080A (no)
EP (1) EP0660821B1 (no)
JP (1) JPH09500863A (no)
KR (1) KR100326962B1 (no)
AT (1) ATE162516T1 (no)
AU (1) AU672234B2 (no)
CA (1) CA2143000C (no)
DE (1) DE69316633T2 (no)
DK (1) DK0660821T3 (no)
ES (1) ES2112994T3 (no)
FI (1) FI951193A7 (no)
GR (1) GR3026236T3 (no)
HU (1) HUT71244A (no)
NO (1) NO950985L (no)
NZ (1) NZ255785A (no)
WO (1) WO1994006762A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR008155A1 (es) * 1996-09-06 1999-12-09 Smithkline Beecham Corp Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres.
CZ300929B6 (cs) * 1997-08-15 2009-09-16 Duke University Sloucenina pro použití pri lécení nebo prevenci estrogenem stimulované rakoviny
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
CA2889770A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Trans-clomiphene for use in cancer therapy
US9914696B2 (en) 2014-03-11 2018-03-13 Repros Therapeutics Inc. Clomiphene synthesis using a single solvent

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2750416A (en) * 1950-12-21 1956-06-12 Rohm & Haas Aminomethylphenols and method for their preparation
US3143568A (en) * 1961-01-25 1964-08-04 Vismara Francesco Spa Diarylamino-acetyl-aryl derivatives
US3244705A (en) * 1962-11-14 1966-04-05 Richardson Merrell Inc Triphenylhaloethylene derivatives
CH373975A (de) * 1963-07-20 1963-12-15 Heierle Werner Kronen-Verschluss für Flaschen
FR3575M (fr) * 1964-01-28 1965-10-04 Richardson Merrell Triphénylhalogénoéthylenes substitués.
US3631109A (en) * 1968-12-04 1971-12-28 Uniroyal Inc Beta beta'-bis(dialkylaminomethyl-4-hydroxy-benzylthio)dialkylethers
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
US5114951A (en) * 1989-04-11 1992-05-19 Burroughs Wellcome Company Agents for combating multiple drug resistance
US5130424A (en) * 1990-08-01 1992-07-14 Merrell Dow Pharmaceuticals Inc. 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

Also Published As

Publication number Publication date
WO1994006762A1 (en) 1994-03-31
KR100326962B1 (ko) 2002-12-02
DE69316633D1 (de) 1998-02-26
DK0660821T3 (da) 1998-09-21
HU9500775D0 (en) 1995-05-29
FI951193L (fi) 1995-03-14
NZ255785A (en) 1997-05-26
AU672234B2 (en) 1996-09-26
ATE162516T1 (de) 1998-02-15
CA2143000C (en) 2000-03-28
FI951193A0 (fi) 1995-03-14
ES2112994T3 (es) 1998-04-16
AU5015093A (en) 1994-04-12
HUT71244A (en) 1995-11-28
DE69316633T2 (de) 1998-05-20
US5681863A (en) 1997-10-28
US5410080A (en) 1995-04-25
KR950703524A (ko) 1995-09-20
GR3026236T3 (en) 1998-05-29
JPH09500863A (ja) 1997-01-28
EP0660821A1 (en) 1995-07-05
NO950985D0 (no) 1995-03-14
CA2143000A1 (en) 1994-03-31
EP0660821B1 (en) 1998-01-21
FI951193A7 (fi) 1995-03-14

Similar Documents

Publication Publication Date Title
CA2153979A1 (en) Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
MY102087A (en) Phenethanolamine derivatives.
EP0087098A3 (en) S-triazine derivatives and their use as sunscreen agents
CA2012686A1 (en) Treatment and compounds
MY101021A (en) Novel compounds and compositions useful for producing analgesia.
ES8303291A1 (es) Un procedimiento para la preparacion de nuevos derivados de ariletanolamina.
RU94045271A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера
NO950985L (no) Ikke-metaboliserbare klomifenanaloger for behandling av tamoxifenresistente tumorer
ZA816259B (en) 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
HUT62563A (en) Process for producing 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydroproin derivatives and pharmaceutical compositions comprising same
KR910004557A (ko) 2,4,6-치환 페놀 유도체
FR2677983B1 (fr) Composes alkylthiopoly(ethylimidazolium), procede de preparation et leur utilisation comme agents biocides.
SE8205868D0 (sv) A titre de medicaments, certains derives de lŸacide 4-phenyl 4-oxo 2-butenoique et compositions les renfermant
KR840005444A (ko) 트리사이클릭 화합물의 제조방법
PT73331A (en) Process for the preparation of propanolamine derivatives
EP0134112A3 (en) Pharmaceutical composition for prophylaxis or treatment of ketosis in livestock
ES8605799A1 (es) Procedimiento para la fabricacion de nuevos compuestos cinamoicos
JPS52100470A (en) Synthesis of hydantoin derivatives
JPS5716852A (en) Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same
IL69448A (en) Process for combating phytopathogenic fungi with azolylphenoxy-tetrahydrofuran-2-ylidene methane derivatives
SE8302452D0 (sv) Method for treatment of senile dementia
DE3175939D1 (en) Use of gamma-piperidino-butyrophenones for the preparation of medicaments for treating diarrhoea
SE8205767D0 (sv) A titre de medicaments, certains derives mono substitues de lŸacide 4-phenyl 4-oxo buten-2-oigue, ainsi que les compositions les renfermant
KR910000786A (ko) 콜레스타디엔 유도체, 이의 제조방법 및 HMG-CoA 환원제를 저해하는 작용을 하는 약제로서의 이의 용도
JPS5430167A (en) 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application